ENSG00000012983

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-6 / 6
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000013125	ENSG00000012983	HEK293_OSMI2_2hA	HEK293_TMG_2hB	MAP4K5	protein_coding	protein_coding	12.42552	4.158857	20.69435	0.2502163	0.5053433	2.31221	1.2440685	0.7481423	1.642490	0.2998083	0.5339569	1.1241008	0.10925833	0.1739667	0.07860000	-0.09536667	5.674954e-01	5.644598e-07	FALSE	TRUE
ENST00000682126	ENSG00000012983	HEK293_OSMI2_2hA	HEK293_TMG_2hB	MAP4K5	protein_coding	protein_coding	12.42552	4.158857	20.69435	0.2502163	0.5053433	2.31221	4.9011916	1.7261729	8.843162	0.3482221	0.3988291	2.3502822	0.44922083	0.4106667	0.42843333	0.01776667	9.437559e-01	5.644598e-07	FALSE	TRUE
MSTRG.9520.1	ENSG00000012983	HEK293_OSMI2_2hA	HEK293_TMG_2hB	MAP4K5	protein_coding		12.42552	4.158857	20.69435	0.2502163	0.5053433	2.31221	1.4771383	0.9947764	1.691664	0.6290290	0.6617600	0.7600718	0.14022083	0.2486667	0.08083333	-0.16783333	8.606653e-01	5.644598e-07	FALSE	TRUE
MSTRG.9520.5	ENSG00000012983	HEK293_OSMI2_2hA	HEK293_TMG_2hB	MAP4K5	protein_coding		12.42552	4.158857	20.69435	0.2502163	0.5053433	2.31221	0.8277695	0.4377787	1.520915	0.1377326	0.3446206	1.7735367	0.07729167	0.1051667	0.07280000	-0.03236667	7.286286e-01	5.644598e-07	FALSE	TRUE
MSTRG.9520.7	ENSG00000012983	HEK293_OSMI2_2hA	HEK293_TMG_2hB	MAP4K5	protein_coding		12.42552	4.158857	20.69435	0.2502163	0.5053433	2.31221	0.5048423	0.0000000	1.917273	0.0000000	0.9595127	7.5904170	0.02588333	0.0000000	0.09236667	0.09236667	3.698349e-01	5.644598e-07	FALSE	TRUE
MSTRG.9520.9	ENSG00000012983	HEK293_OSMI2_2hA	HEK293_TMG_2hB	MAP4K5	protein_coding		12.42552	4.158857	20.69435	0.2502163	0.5053433	2.31221	2.2555018	0.0000000	3.751645	0.0000000	0.9092847	8.5552198	0.10839583	0.0000000	0.18333333	0.18333333	5.644598e-07	5.644598e-07	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 54
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featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
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width
strand
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HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000012983	E001	1.7005031	0.0091343567	1.073750e-01	2.016682e-01	14	50418501	50418520	20	-	0.275	0.589	1.703
ENSG00000012983	E002	2.8903891	0.0120148227	3.151279e-01	4.578855e-01	14	50418521	50418524	4	-	0.465	0.663	0.908
ENSG00000012983	E003	224.1194162	0.0106599098	5.410534e-13	1.385522e-11	14	50418525	50419559	1035	-	2.136	2.549	1.379
ENSG00000012983	E004	47.1985481	0.0005127269	1.601862e-09	2.286591e-08	14	50419560	50419679	120	-	1.484	1.849	1.242
ENSG00000012983	E005	23.5536124	0.0008534502	2.310576e-04	1.096083e-03	14	50419680	50419680	1	-	1.205	1.523	1.106
ENSG00000012983	E006	54.0269133	0.0004547002	1.466444e-05	9.377665e-05	14	50419681	50419739	59	-	1.573	1.836	0.892
ENSG00000012983	E007	165.9526482	0.0002104427	3.662713e-04	1.643705e-03	14	50419740	50420106	367	-	2.091	2.234	0.479
ENSG00000012983	E008	70.5445622	0.0004091719	2.271705e-01	3.590287e-01	14	50423121	50423176	56	-	1.738	1.827	0.301
ENSG00000012983	E009	80.6966102	0.0047919764	2.070607e-01	3.350160e-01	14	50425907	50425977	71	-	1.793	1.892	0.337
ENSG00000012983	E010	75.7754434	0.0004090677	3.116099e-01	4.540774e-01	14	50428662	50428754	93	-	1.771	1.849	0.263
ENSG00000012983	E011	69.2513995	0.0004000147	4.892194e-01	6.266879e-01	14	50429192	50429256	65	-	1.734	1.798	0.216
ENSG00000012983	E012	44.8159919	0.0005130267	7.514543e-01	8.378992e-01	14	50429257	50429260	4	-	1.552	1.600	0.164
ENSG00000012983	E013	106.7153488	0.0004996271	8.394180e-02	1.657151e-01	14	50434394	50434571	178	-	1.909	2.010	0.339
ENSG00000012983	E014	44.1342167	0.0030648529	3.150679e-01	4.578260e-01	14	50434962	50434963	2	-	1.534	1.631	0.333
ENSG00000012983	E015	88.3729899	0.0086502828	1.585830e-01	2.732356e-01	14	50434964	50435065	102	-	1.823	1.946	0.413
ENSG00000012983	E016	69.8537989	0.0118396787	5.353251e-01	6.671824e-01	14	50437476	50437534	59	-	1.735	1.812	0.261
ENSG00000012983	E017	87.8841386	0.0103744718	8.991023e-01	9.396248e-01	14	50437894	50438008	115	-	1.840	1.884	0.148
ENSG00000012983	E018	26.8274173	0.0009519581	9.401359e-02	1.814024e-01	14	50438092	50438094	3	-	1.367	1.244	-0.429
ENSG00000012983	E019	9.1773128	0.0042893124	3.429748e-01	4.870073e-01	14	50438095	50438401	307	-	0.938	0.829	-0.415
ENSG00000012983	E020	49.1023348	0.0004575290	8.927219e-01	9.354537e-01	14	50440013	50440073	61	-	1.596	1.615	0.065
ENSG00000012983	E021	59.5734529	0.0004195423	8.627383e-01	9.154789e-01	14	50440362	50440441	80	-	1.680	1.698	0.060
ENSG00000012983	E022	70.9940786	0.0005232758	6.237592e-02	1.306489e-01	14	50442732	50442816	85	-	1.772	1.698	-0.252
ENSG00000012983	E023	57.2512325	0.0009115398	1.181939e-02	3.310227e-02	14	50443729	50443770	42	-	1.691	1.559	-0.448
ENSG00000012983	E024	71.4593517	0.0003521640	5.600429e-04	2.385092e-03	14	50443939	50444036	98	-	1.791	1.623	-0.572
ENSG00000012983	E025	100.0514332	0.0004968334	1.016803e-02	2.917846e-02	14	50445041	50445194	154	-	1.924	1.831	-0.312
ENSG00000012983	E026	66.2621335	0.0003892461	2.067379e-01	3.346481e-01	14	50446079	50446121	43	-	1.740	1.698	-0.143
ENSG00000012983	E027	74.5191770	0.0003249531	7.316032e-03	2.203989e-02	14	50447414	50447481	68	-	1.803	1.685	-0.398
ENSG00000012983	E028	65.8713190	0.0003753960	1.071252e-01	2.012948e-01	14	50448774	50448832	59	-	1.741	1.679	-0.212
ENSG00000012983	E029	4.3111480	0.0120221297	3.008393e-01	4.426043e-01	14	50448833	50450600	1768	-	0.671	0.499	-0.773
ENSG00000012983	E030	83.8642667	0.0036757866	1.414526e-03	5.355057e-03	14	50456516	50456594	79	-	1.860	1.697	-0.550
ENSG00000012983	E031	65.4335711	0.0107109178	1.254472e-02	3.483926e-02	14	50462665	50462692	28	-	1.756	1.590	-0.565
ENSG00000012983	E032	83.0917530	0.0004832896	2.572462e-03	8.981500e-03	14	50462693	50462781	89	-	1.851	1.722	-0.437
ENSG00000012983	E033	55.9887657	0.0004405348	2.799669e-03	9.673861e-03	14	50464052	50464077	26	-	1.687	1.523	-0.558
ENSG00000012983	E034	64.8534560	0.0011930609	1.955095e-02	5.051994e-02	14	50464078	50464133	56	-	1.742	1.630	-0.380
ENSG00000012983	E035	69.7476411	0.0009090475	1.812830e-01	3.028503e-01	14	50466583	50466645	63	-	1.763	1.716	-0.157
ENSG00000012983	E036	62.1974416	0.0018028169	3.317738e-02	7.815570e-02	14	50468651	50468689	39	-	1.721	1.616	-0.356
ENSG00000012983	E037	80.9068494	0.0011784417	6.584207e-03	2.014565e-02	14	50468690	50468782	93	-	1.837	1.716	-0.406
ENSG00000012983	E038	45.2250136	0.0014909872	2.547837e-03	8.906031e-03	14	50475077	50475091	15	-	1.601	1.405	-0.671
ENSG00000012983	E039	56.9114471	0.0031693235	2.169013e-02	5.503053e-02	14	50475092	50475149	58	-	1.688	1.559	-0.439
ENSG00000012983	E040	53.3703236	0.0007966393	4.044061e-03	1.326526e-02	14	50476128	50476170	43	-	1.667	1.504	-0.555
ENSG00000012983	E041	41.9872222	0.0054059523	9.177403e-04	3.676903e-03	14	50476259	50476306	48	-	1.580	1.324	-0.880
ENSG00000012983	E042	52.1253969	0.0072400963	1.100116e-03	4.303755e-03	14	50482361	50482416	56	-	1.668	1.429	-0.815
ENSG00000012983	E043	1.3455410	0.0607196813	5.955172e-01	7.175911e-01	14	50482652	50483149	498	-	0.339	0.235	-0.722
ENSG00000012983	E044	57.3384835	0.0015062114	1.193478e-03	4.618613e-03	14	50485578	50485642	65	-	1.701	1.514	-0.638
ENSG00000012983	E045	0.1482932	0.0417799015	8.997812e-02		14	50485929	50486103	175	-	0.000	0.235	10.513
ENSG00000012983	E046	47.2666751	0.0008421495	2.653233e-02	6.501708e-02	14	50486104	50486194	91	-	1.609	1.484	-0.428
ENSG00000012983	E047	36.0591065	0.0048706684	2.379078e-01	3.717037e-01	14	50504800	50504857	58	-	1.488	1.417	-0.244
ENSG00000012983	E048	0.0000000				14	50504858	50505128	271	-
ENSG00000012983	E049	50.8479721	0.0005620664	2.129126e-01	3.419637e-01	14	50531942	50532158	217	-	1.627	1.576	-0.176
ENSG00000012983	E050	5.1265316	0.0033303797	3.248599e-01	4.682722e-01	14	50532400	50532447	48	-	0.657	0.830	0.702
ENSG00000012983	E051	12.0371106	0.0014275390	1.104608e-01	2.062148e-01	14	50532448	50532461	14	-	1.054	0.873	-0.674
ENSG00000012983	E052	20.7477980	0.0008645272	8.474541e-02	1.669958e-01	14	50532462	50532619	158	-	1.268	1.121	-0.522
ENSG00000012983	E053	0.6235652	0.0224373440	7.129183e-01	8.095049e-01	14	50542499	50542584	86	-	0.159	0.235	0.701
ENSG00000012983	E054	4.1265008	0.0118573241	1.437489e-08	1.720655e-07	14	50561040	50561126	87	-	0.308	1.143	3.644

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000012983

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3