ENSG00000012983

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000013125 ENSG00000012983 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K5 protein_coding protein_coding 12.42552 4.158857 20.69435 0.2502163 0.5053433 2.31221 1.2440685 0.7481423 1.642490 0.2998083 0.5339569 1.1241008 0.10925833 0.1739667 0.07860000 -0.09536667 5.674954e-01 5.644598e-07 FALSE TRUE
ENST00000682126 ENSG00000012983 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K5 protein_coding protein_coding 12.42552 4.158857 20.69435 0.2502163 0.5053433 2.31221 4.9011916 1.7261729 8.843162 0.3482221 0.3988291 2.3502822 0.44922083 0.4106667 0.42843333 0.01776667 9.437559e-01 5.644598e-07 FALSE TRUE
MSTRG.9520.1 ENSG00000012983 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K5 protein_coding   12.42552 4.158857 20.69435 0.2502163 0.5053433 2.31221 1.4771383 0.9947764 1.691664 0.6290290 0.6617600 0.7600718 0.14022083 0.2486667 0.08083333 -0.16783333 8.606653e-01 5.644598e-07 FALSE TRUE
MSTRG.9520.5 ENSG00000012983 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K5 protein_coding   12.42552 4.158857 20.69435 0.2502163 0.5053433 2.31221 0.8277695 0.4377787 1.520915 0.1377326 0.3446206 1.7735367 0.07729167 0.1051667 0.07280000 -0.03236667 7.286286e-01 5.644598e-07 FALSE TRUE
MSTRG.9520.7 ENSG00000012983 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K5 protein_coding   12.42552 4.158857 20.69435 0.2502163 0.5053433 2.31221 0.5048423 0.0000000 1.917273 0.0000000 0.9595127 7.5904170 0.02588333 0.0000000 0.09236667 0.09236667 3.698349e-01 5.644598e-07 FALSE TRUE
MSTRG.9520.9 ENSG00000012983 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K5 protein_coding   12.42552 4.158857 20.69435 0.2502163 0.5053433 2.31221 2.2555018 0.0000000 3.751645 0.0000000 0.9092847 8.5552198 0.10839583 0.0000000 0.18333333 0.18333333 5.644598e-07 5.644598e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000012983 E001 1.7005031 0.0091343567 1.073750e-01 2.016682e-01 14 50418501 50418520 20 - 0.275 0.589 1.703
ENSG00000012983 E002 2.8903891 0.0120148227 3.151279e-01 4.578855e-01 14 50418521 50418524 4 - 0.465 0.663 0.908
ENSG00000012983 E003 224.1194162 0.0106599098 5.410534e-13 1.385522e-11 14 50418525 50419559 1035 - 2.136 2.549 1.379
ENSG00000012983 E004 47.1985481 0.0005127269 1.601862e-09 2.286591e-08 14 50419560 50419679 120 - 1.484 1.849 1.242
ENSG00000012983 E005 23.5536124 0.0008534502 2.310576e-04 1.096083e-03 14 50419680 50419680 1 - 1.205 1.523 1.106
ENSG00000012983 E006 54.0269133 0.0004547002 1.466444e-05 9.377665e-05 14 50419681 50419739 59 - 1.573 1.836 0.892
ENSG00000012983 E007 165.9526482 0.0002104427 3.662713e-04 1.643705e-03 14 50419740 50420106 367 - 2.091 2.234 0.479
ENSG00000012983 E008 70.5445622 0.0004091719 2.271705e-01 3.590287e-01 14 50423121 50423176 56 - 1.738 1.827 0.301
ENSG00000012983 E009 80.6966102 0.0047919764 2.070607e-01 3.350160e-01 14 50425907 50425977 71 - 1.793 1.892 0.337
ENSG00000012983 E010 75.7754434 0.0004090677 3.116099e-01 4.540774e-01 14 50428662 50428754 93 - 1.771 1.849 0.263
ENSG00000012983 E011 69.2513995 0.0004000147 4.892194e-01 6.266879e-01 14 50429192 50429256 65 - 1.734 1.798 0.216
ENSG00000012983 E012 44.8159919 0.0005130267 7.514543e-01 8.378992e-01 14 50429257 50429260 4 - 1.552 1.600 0.164
ENSG00000012983 E013 106.7153488 0.0004996271 8.394180e-02 1.657151e-01 14 50434394 50434571 178 - 1.909 2.010 0.339
ENSG00000012983 E014 44.1342167 0.0030648529 3.150679e-01 4.578260e-01 14 50434962 50434963 2 - 1.534 1.631 0.333
ENSG00000012983 E015 88.3729899 0.0086502828 1.585830e-01 2.732356e-01 14 50434964 50435065 102 - 1.823 1.946 0.413
ENSG00000012983 E016 69.8537989 0.0118396787 5.353251e-01 6.671824e-01 14 50437476 50437534 59 - 1.735 1.812 0.261
ENSG00000012983 E017 87.8841386 0.0103744718 8.991023e-01 9.396248e-01 14 50437894 50438008 115 - 1.840 1.884 0.148
ENSG00000012983 E018 26.8274173 0.0009519581 9.401359e-02 1.814024e-01 14 50438092 50438094 3 - 1.367 1.244 -0.429
ENSG00000012983 E019 9.1773128 0.0042893124 3.429748e-01 4.870073e-01 14 50438095 50438401 307 - 0.938 0.829 -0.415
ENSG00000012983 E020 49.1023348 0.0004575290 8.927219e-01 9.354537e-01 14 50440013 50440073 61 - 1.596 1.615 0.065
ENSG00000012983 E021 59.5734529 0.0004195423 8.627383e-01 9.154789e-01 14 50440362 50440441 80 - 1.680 1.698 0.060
ENSG00000012983 E022 70.9940786 0.0005232758 6.237592e-02 1.306489e-01 14 50442732 50442816 85 - 1.772 1.698 -0.252
ENSG00000012983 E023 57.2512325 0.0009115398 1.181939e-02 3.310227e-02 14 50443729 50443770 42 - 1.691 1.559 -0.448
ENSG00000012983 E024 71.4593517 0.0003521640 5.600429e-04 2.385092e-03 14 50443939 50444036 98 - 1.791 1.623 -0.572
ENSG00000012983 E025 100.0514332 0.0004968334 1.016803e-02 2.917846e-02 14 50445041 50445194 154 - 1.924 1.831 -0.312
ENSG00000012983 E026 66.2621335 0.0003892461 2.067379e-01 3.346481e-01 14 50446079 50446121 43 - 1.740 1.698 -0.143
ENSG00000012983 E027 74.5191770 0.0003249531 7.316032e-03 2.203989e-02 14 50447414 50447481 68 - 1.803 1.685 -0.398
ENSG00000012983 E028 65.8713190 0.0003753960 1.071252e-01 2.012948e-01 14 50448774 50448832 59 - 1.741 1.679 -0.212
ENSG00000012983 E029 4.3111480 0.0120221297 3.008393e-01 4.426043e-01 14 50448833 50450600 1768 - 0.671 0.499 -0.773
ENSG00000012983 E030 83.8642667 0.0036757866 1.414526e-03 5.355057e-03 14 50456516 50456594 79 - 1.860 1.697 -0.550
ENSG00000012983 E031 65.4335711 0.0107109178 1.254472e-02 3.483926e-02 14 50462665 50462692 28 - 1.756 1.590 -0.565
ENSG00000012983 E032 83.0917530 0.0004832896 2.572462e-03 8.981500e-03 14 50462693 50462781 89 - 1.851 1.722 -0.437
ENSG00000012983 E033 55.9887657 0.0004405348 2.799669e-03 9.673861e-03 14 50464052 50464077 26 - 1.687 1.523 -0.558
ENSG00000012983 E034 64.8534560 0.0011930609 1.955095e-02 5.051994e-02 14 50464078 50464133 56 - 1.742 1.630 -0.380
ENSG00000012983 E035 69.7476411 0.0009090475 1.812830e-01 3.028503e-01 14 50466583 50466645 63 - 1.763 1.716 -0.157
ENSG00000012983 E036 62.1974416 0.0018028169 3.317738e-02 7.815570e-02 14 50468651 50468689 39 - 1.721 1.616 -0.356
ENSG00000012983 E037 80.9068494 0.0011784417 6.584207e-03 2.014565e-02 14 50468690 50468782 93 - 1.837 1.716 -0.406
ENSG00000012983 E038 45.2250136 0.0014909872 2.547837e-03 8.906031e-03 14 50475077 50475091 15 - 1.601 1.405 -0.671
ENSG00000012983 E039 56.9114471 0.0031693235 2.169013e-02 5.503053e-02 14 50475092 50475149 58 - 1.688 1.559 -0.439
ENSG00000012983 E040 53.3703236 0.0007966393 4.044061e-03 1.326526e-02 14 50476128 50476170 43 - 1.667 1.504 -0.555
ENSG00000012983 E041 41.9872222 0.0054059523 9.177403e-04 3.676903e-03 14 50476259 50476306 48 - 1.580 1.324 -0.880
ENSG00000012983 E042 52.1253969 0.0072400963 1.100116e-03 4.303755e-03 14 50482361 50482416 56 - 1.668 1.429 -0.815
ENSG00000012983 E043 1.3455410 0.0607196813 5.955172e-01 7.175911e-01 14 50482652 50483149 498 - 0.339 0.235 -0.722
ENSG00000012983 E044 57.3384835 0.0015062114 1.193478e-03 4.618613e-03 14 50485578 50485642 65 - 1.701 1.514 -0.638
ENSG00000012983 E045 0.1482932 0.0417799015 8.997812e-02   14 50485929 50486103 175 - 0.000 0.235 10.513
ENSG00000012983 E046 47.2666751 0.0008421495 2.653233e-02 6.501708e-02 14 50486104 50486194 91 - 1.609 1.484 -0.428
ENSG00000012983 E047 36.0591065 0.0048706684 2.379078e-01 3.717037e-01 14 50504800 50504857 58 - 1.488 1.417 -0.244
ENSG00000012983 E048 0.0000000       14 50504858 50505128 271 -      
ENSG00000012983 E049 50.8479721 0.0005620664 2.129126e-01 3.419637e-01 14 50531942 50532158 217 - 1.627 1.576 -0.176
ENSG00000012983 E050 5.1265316 0.0033303797 3.248599e-01 4.682722e-01 14 50532400 50532447 48 - 0.657 0.830 0.702
ENSG00000012983 E051 12.0371106 0.0014275390 1.104608e-01 2.062148e-01 14 50532448 50532461 14 - 1.054 0.873 -0.674
ENSG00000012983 E052 20.7477980 0.0008645272 8.474541e-02 1.669958e-01 14 50532462 50532619 158 - 1.268 1.121 -0.522
ENSG00000012983 E053 0.6235652 0.0224373440 7.129183e-01 8.095049e-01 14 50542499 50542584 86 - 0.159 0.235 0.701
ENSG00000012983 E054 4.1265008 0.0118573241 1.437489e-08 1.720655e-07 14 50561040 50561126 87 - 0.308 1.143 3.644