ENSG00000012660

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304434 ENSG00000012660 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOVL5 protein_coding protein_coding 46.86348 30.91884 65.52254 2.512 1.036212 1.083259 43.306821 26.13082 61.797958 2.6850497 1.0438356 1.241488 0.89604583 0.8426333 0.94316667 0.1005333 3.067953e-04 1.920842e-09 FALSE TRUE
ENST00000370913 ENSG00000012660 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOVL5 protein_coding protein_coding 46.86348 30.91884 65.52254 2.512 1.036212 1.083259 2.572496 4.57499 1.365983 0.5573169 0.2422422 -1.736455 0.08382917 0.1505000 0.02083333 -0.1296667 1.920842e-09 1.920842e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000012660 E001 0.1472490 0.0437683849 1.000000e+00   6 53261810 53261871 62 - 0.080 0.000 -9.083
ENSG00000012660 E002 0.1817044 0.0423349243 2.133048e-01   6 53267398 53267403 6 - 0.000 0.184 11.584
ENSG00000012660 E003 1580.9898351 0.0064673893 3.980641e-09 5.281326e-08 6 53267404 53268507 1104 - 3.077 3.318 0.801
ENSG00000012660 E004 584.9488024 0.0005983472 3.177390e-01 4.606231e-01 6 53268508 53268878 371 - 2.710 2.795 0.282
ENSG00000012660 E005 407.2160589 0.0001631758 4.125809e-02 9.335476e-02 6 53268879 53269086 208 - 2.572 2.600 0.094
ENSG00000012660 E006 495.6278574 0.0024655349 2.306080e-06 1.770035e-05 6 53269087 53269270 184 - 2.687 2.615 -0.241
ENSG00000012660 E007 353.8722329 0.0028868251 1.377383e-05 8.859277e-05 6 53270593 53270727 135 - 2.543 2.463 -0.268
ENSG00000012660 E008 373.2956393 0.0009230965 5.520458e-06 3.891621e-05 6 53273220 53273344 125 - 2.556 2.512 -0.147
ENSG00000012660 E009 238.3713569 0.0002364506 1.522551e-06 1.215776e-05 6 53275090 53275124 35 - 2.365 2.309 -0.186
ENSG00000012660 E010 284.5246606 0.0002455464 4.944532e-07 4.376614e-06 6 53275125 53275183 59 - 2.440 2.389 -0.171
ENSG00000012660 E011 288.6777756 0.0001897642 7.853494e-05 4.210782e-04 6 53275184 53275261 78 - 2.439 2.415 -0.078
ENSG00000012660 E012 277.9640576 0.0040585371 1.673123e-02 4.434734e-02 6 53276179 53276256 78 - 2.424 2.394 -0.101
ENSG00000012660 E013 0.4439371 0.0215541728 3.052349e-01 4.472845e-01 6 53277646 53277743 98 - 0.205 0.000 -10.663
ENSG00000012660 E014 2.9644611 0.0052286973 1.361187e-01 2.426421e-01 6 53287862 53287942 81 - 0.625 0.412 -1.024
ENSG00000012660 E015 1.2145359 0.5304900479 5.892010e-01 7.122680e-01 6 53290095 53290189 95 - 0.302 0.402 0.603
ENSG00000012660 E016 1.7358017 0.0086730745 2.839948e-02 6.881719e-02 6 53290401 53290535 135 - 0.256 0.670 2.195
ENSG00000012660 E017 369.9222529 0.0005295828 6.373750e-10 9.808343e-09 6 53291776 53291963 188 - 2.561 2.488 -0.243
ENSG00000012660 E018 55.8727937 0.0165866407 1.175888e-28 1.754083e-26 6 53294088 53294491 404 - 1.154 2.132 3.344
ENSG00000012660 E019 222.8886737 0.0004674150 5.598252e-05 3.115756e-04 6 53295642 53295707 66 - 2.333 2.288 -0.147
ENSG00000012660 E020 196.9441993 0.0081866930 7.602194e-02 1.531451e-01 6 53348817 53349202 386 - 2.275 2.241 -0.115