ENSG00000012232

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000220562 ENSG00000012232 HEK293_OSMI2_2hA HEK293_TMG_2hB EXTL3 protein_coding protein_coding 26.87347 27.30503 24.86376 3.178717 0.6438689 -0.1350705 4.578005 6.545268 2.9882246 0.4243145 0.2347962 -1.1285464 0.17149167 0.24386667 0.12010000 -0.12376667 0.0001250601 0.0001250601 FALSE TRUE
ENST00000517738 ENSG00000012232 HEK293_OSMI2_2hA HEK293_TMG_2hB EXTL3 protein_coding processed_transcript 26.87347 27.30503 24.86376 3.178717 0.6438689 -0.1350705 10.278513 10.889419 9.7990694 1.5584183 0.7972822 -0.1520631 0.38306250 0.39723333 0.39293333 -0.00430000 1.0000000000 0.0001250601 FALSE TRUE
ENST00000521473 ENSG00000012232 HEK293_OSMI2_2hA HEK293_TMG_2hB EXTL3 protein_coding protein_coding 26.87347 27.30503 24.86376 3.178717 0.6438689 -0.1350705 1.498016 1.505366 0.7191987 0.8898341 0.3984828 -1.0552821 0.05558333 0.05390000 0.02973333 -0.02416667 0.9280639978 0.0001250601 FALSE TRUE
ENST00000696178 ENSG00000012232 HEK293_OSMI2_2hA HEK293_TMG_2hB EXTL3 protein_coding protein_coding 26.87347 27.30503 24.86376 3.178717 0.6438689 -0.1350705 1.601784 3.009735 1.0498389 0.2704649 0.2179347 -1.5105767 0.05831250 0.11120000 0.04186667 -0.06933333 0.0003470284 0.0001250601 FALSE TRUE
ENST00000696185 ENSG00000012232 HEK293_OSMI2_2hA HEK293_TMG_2hB EXTL3 protein_coding processed_transcript 26.87347 27.30503 24.86376 3.178717 0.6438689 -0.1350705 6.615300 2.331211 8.4464169 1.3705930 0.4803517 1.8527913 0.24469583 0.07556667 0.33916667 0.26360000 0.3418445184 0.0001250601 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000012232 E001 0.0000000       8 28600469 28600714 246 +      
ENSG00000012232 E002 0.0000000       8 28607691 28607758 68 +      
ENSG00000012232 E003 0.8576959 0.3087115840 5.615430e-01 6.893193e-01 8 28622732 28622749 18 + 0.335 0.194 -1.051
ENSG00000012232 E004 1.1866493 0.1056298081 4.223146e-01 5.654486e-01 8 28622750 28622760 11 + 0.406 0.263 -0.894
ENSG00000012232 E005 6.9989056 0.0024562620 4.884812e-01 6.260362e-01 8 28622761 28622810 50 + 0.920 0.864 -0.214
ENSG00000012232 E006 0.0000000       8 28631406 28631431 26 +      
ENSG00000012232 E007 0.1451727 0.0437568096 3.313411e-01   8 28631432 28631550 119 + 0.142 0.000 -13.021
ENSG00000012232 E008 0.1451727 0.0437568096 3.313411e-01   8 28631551 28631674 124 + 0.142 0.000 -13.021
ENSG00000012232 E009 0.5117906 0.2664590109 4.407457e-01 5.824152e-01 8 28637302 28637336 35 + 0.248 0.107 -1.460
ENSG00000012232 E010 2.1254226 0.1669631789 9.828142e-01 9.933179e-01 8 28637337 28637429 93 + 0.466 0.475 0.046
ENSG00000012232 E011 0.1451727 0.0437568096 3.313411e-01   8 28678086 28678193 108 + 0.142 0.000 -13.021
ENSG00000012232 E012 0.7353267 0.1269572665 9.816156e-02 1.877250e-01 8 28685886 28686008 123 + 0.405 0.105 -2.499
ENSG00000012232 E013 0.1482932 0.0420847940 7.021543e-01   8 28699530 28699829 300 + 0.000 0.105 11.630
ENSG00000012232 E014 0.1451727 0.0437568096 3.313411e-01   8 28701482 28701499 18 + 0.142 0.000 -13.021
ENSG00000012232 E015 0.1451727 0.0437568096 3.313411e-01   8 28701500 28701500 1 + 0.142 0.000 -13.021
ENSG00000012232 E016 0.2924217 0.0272373937 1.114366e-01   8 28701501 28701502 2 + 0.248 0.000 -14.192
ENSG00000012232 E017 1.2533463 0.0102120232 4.659801e-02 1.031147e-01 8 28701503 28701512 10 + 0.520 0.190 -2.074
ENSG00000012232 E018 12.2786986 0.0014175705 2.082510e-02 5.322217e-02 8 28701513 28701579 67 + 1.216 1.026 -0.682
ENSG00000012232 E019 14.2287726 0.0012566255 2.206838e-02 5.582274e-02 8 28701580 28701595 16 + 1.264 1.089 -0.623
ENSG00000012232 E020 12.4843615 0.0014554226 1.040181e-01 1.966242e-01 8 28701596 28701597 2 + 1.184 1.058 -0.450
ENSG00000012232 E021 18.7596769 0.0009587528 4.035648e-04 1.788317e-03 8 28701598 28701604 7 + 1.416 1.168 -0.868
ENSG00000012232 E022 20.4537632 0.0009262923 2.490489e-04 1.171195e-03 8 28701605 28701612 8 + 1.453 1.207 -0.858
ENSG00000012232 E023 44.1646976 0.0007153494 3.602557e-04 1.619932e-03 8 28701613 28701659 47 + 1.731 1.571 -0.543
ENSG00000012232 E024 0.3289534 0.0295823307 7.654993e-01   8 28701660 28701678 19 + 0.142 0.105 -0.489
ENSG00000012232 E025 16.3373949 0.0132890345 3.574488e-03 1.193998e-02 8 28701965 28702709 745 + 0.977 1.319 1.224
ENSG00000012232 E026 0.0000000       8 28710355 28710357 3 +      
ENSG00000012232 E027 0.0000000       8 28710358 28710503 146 +      
ENSG00000012232 E028 75.7647683 0.0040025694 2.158617e-06 1.666429e-05 8 28713457 28713550 94 + 1.987 1.781 -0.693
ENSG00000012232 E029 0.5244761 0.2635932016 4.402434e-01 5.819179e-01 8 28713551 28713580 30 + 0.249 0.107 -1.469
ENSG00000012232 E030 126.1837538 0.0010807127 1.068544e-12 2.608329e-11 8 28715585 28715765 181 + 2.210 1.996 -0.716
ENSG00000012232 E031 158.0664308 0.0032730193 5.179693e-08 5.568596e-07 8 28715766 28716066 301 + 2.287 2.110 -0.593
ENSG00000012232 E032 265.2739588 0.0036251515 5.069665e-05 2.853081e-04 8 28716067 28716684 618 + 2.472 2.365 -0.359
ENSG00000012232 E033 158.1827532 0.0039038082 1.633786e-05 1.033822e-04 8 28716685 28716897 213 + 2.266 2.125 -0.474
ENSG00000012232 E034 523.2302345 0.0026393345 1.545950e-05 9.836955e-05 8 28716898 28718059 1162 + 2.751 2.670 -0.270
ENSG00000012232 E035 168.1304056 0.0005242662 3.617922e-02 8.392983e-02 8 28718060 28718207 148 + 2.228 2.198 -0.101
ENSG00000012232 E036 0.2214452 0.0397421166 7.003524e-01   8 28730160 28730218 59 + 0.000 0.106 11.657
ENSG00000012232 E037 0.0000000       8 28730925 28731027 103 +      
ENSG00000012232 E038 151.9168870 0.0002233846 3.681453e-02 8.511182e-02 8 28731223 28731350 128 + 2.187 2.156 -0.102
ENSG00000012232 E039 0.4439371 0.0215553304 3.776072e-02 8.688790e-02 8 28733584 28733700 117 + 0.334 0.000 -14.858
ENSG00000012232 E040 149.6442321 0.0003661645 1.921842e-01 3.164957e-01 8 28737519 28737663 145 + 2.167 2.158 -0.029
ENSG00000012232 E041 1.5542982 0.0786254627 8.038678e-01 8.752061e-01 8 28739901 28743085 3185 + 0.405 0.377 -0.158
ENSG00000012232 E042 98.1841122 0.0003177775 8.013648e-02 1.597560e-01 8 28743086 28743121 36 + 1.997 1.964 -0.112
ENSG00000012232 E043 152.2063700 0.0002530397 9.797773e-05 5.125528e-04 8 28743122 28743214 93 + 2.217 2.134 -0.278
ENSG00000012232 E044 0.4396707 0.0264105354 3.834029e-02 8.798747e-02 8 28743215 28743975 761 + 0.334 0.000 -14.784
ENSG00000012232 E045 0.1482932 0.0420847940 7.021543e-01   8 28743976 28744083 108 + 0.000 0.105 11.630
ENSG00000012232 E046 0.5858876 0.0236849488 1.604218e-01 2.756918e-01 8 28744084 28744779 696 + 0.334 0.105 -2.076
ENSG00000012232 E047 1289.3005087 0.0000874910 3.994211e-19 2.305580e-17 8 28750657 28752660 2004 + 3.018 3.132 0.380
ENSG00000012232 E048 844.1953756 0.0100209753 5.157074e-09 6.712877e-08 8 28752661 28756561 3901 + 2.711 2.998 0.953