ENSG00000012211

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376310 ENSG00000012211 HEK293_OSMI2_2hA HEK293_TMG_2hB PRICKLE3 protein_coding retained_intron 8.871496 12.60849 6.078528 1.305952 0.05731056 -1.051373 0.9820108 0.6984414 0.9917665 0.1206391 0.21282269 0.49982599 0.12161250 0.05486667 0.16256667 0.10770000 0.0042859017 0.0003076964 FALSE TRUE
ENST00000453382 ENSG00000012211 HEK293_OSMI2_2hA HEK293_TMG_2hB PRICKLE3 protein_coding protein_coding 8.871496 12.60849 6.078528 1.305952 0.05731056 -1.051373 1.4694931 1.1293743 1.1828343 0.6324688 0.13705427 0.06615193 0.18180000 0.09303333 0.19453333 0.10150000 0.6098013863 0.0003076964 FALSE TRUE
ENST00000599218 ENSG00000012211 HEK293_OSMI2_2hA HEK293_TMG_2hB PRICKLE3 protein_coding protein_coding 8.871496 12.60849 6.078528 1.305952 0.05731056 -1.051373 4.6251039 8.8053607 2.5822260 0.8268606 0.28831597 -1.76582810 0.49182500 0.70046667 0.42486667 -0.27560000 0.0003076964 0.0003076964 FALSE TRUE
ENST00000611313 ENSG00000012211 HEK293_OSMI2_2hA HEK293_TMG_2hB PRICKLE3 protein_coding retained_intron 8.871496 12.60849 6.078528 1.305952 0.05731056 -1.051373 0.2817376 0.1249378 0.5523140 0.0641297 0.10193771 2.05908154 0.03792500 0.01056667 0.09113333 0.08056667 0.0025350151 0.0003076964 FALSE FALSE
ENST00000614014 ENSG00000012211 HEK293_OSMI2_2hA HEK293_TMG_2hB PRICKLE3 protein_coding retained_intron 8.871496 12.60849 6.078528 1.305952 0.05731056 -1.051373 0.8763600 0.7576750 0.5891425 0.2817104 0.21292095 -0.35759653 0.10149167 0.06046667 0.09706667 0.03660000 0.7025460072 0.0003076964 TRUE FALSE
MSTRG.34237.3 ENSG00000012211 HEK293_OSMI2_2hA HEK293_TMG_2hB PRICKLE3 protein_coding   8.871496 12.60849 6.078528 1.305952 0.05731056 -1.051373 0.5404031 1.0043687 0.1802449 0.8621197 0.09042218 -2.41465268 0.05388333 0.07420000 0.02993333 -0.04426667 0.9881255825 0.0003076964 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000012211 E001 92.6302983 0.0029078186 3.925557e-02 0.0896379807 X 49174802 49175263 462 - 1.801 1.903 0.342
ENSG00000012211 E002 80.4079439 0.0003673055 1.469271e-01 0.2574993076 X 49175264 49175620 357 - 1.765 1.830 0.222
ENSG00000012211 E003 167.6915168 0.0008612336 6.631960e-02 0.1372505716 X 49175621 49176265 645 - 2.091 2.150 0.199
ENSG00000012211 E004 97.2710972 0.0044089428 1.995545e-01 0.3256664811 X 49176903 49177136 234 - 1.852 1.919 0.223
ENSG00000012211 E005 53.3573263 0.0010673529 4.034327e-01 0.5472121518 X 49177137 49177202 66 - 1.609 1.655 0.158
ENSG00000012211 E006 0.9440995 0.7298156395 3.208916e-01 0.4640606260 X 49177989 49177992 4 - 0.511 0.139 -2.568
ENSG00000012211 E007 93.1281009 0.0003064566 4.112848e-01 0.5548750540 X 49177993 49178179 187 - 1.856 1.889 0.111
ENSG00000012211 E008 5.6240199 0.0910547632 2.089927e-01 0.3373122131 X 49178180 49178271 92 - 0.922 0.691 -0.911
ENSG00000012211 E009 103.2699782 0.0007633870 9.697288e-01 0.9850443701 X 49178272 49178475 204 - 1.922 1.923 0.002
ENSG00000012211 E010 95.0426742 0.0003766812 8.411142e-01 0.9008891339 X 49179251 49179388 138 - 1.882 1.889 0.022
ENSG00000012211 E011 14.4516673 0.0048867173 1.603555e-06 0.0000127364 X 49179405 49179692 288 - 1.414 0.965 -1.597
ENSG00000012211 E012 75.4147529 0.0004274083 4.846012e-01 0.6225629193 X 49179693 49179805 113 - 1.816 1.782 -0.115
ENSG00000012211 E013 35.6747065 0.0006923705 1.969318e-01 0.3223944579 X 49179806 49179806 1 - 1.537 1.450 -0.298
ENSG00000012211 E014 2.5023626 0.0355477897 4.439545e-02 0.0990984484 X 49179807 49179836 30 - 0.743 0.396 -1.606
ENSG00000012211 E015 1.9960453 0.0088500501 1.569045e-02 0.0420415978 X 49183594 49183656 63 - 0.696 0.287 -2.081
ENSG00000012211 E016 2.7647832 0.0053873564 6.508078e-04 0.0027187118 X 49183657 49183733 77 - 0.859 0.327 -2.471
ENSG00000012211 E017 87.4454169 0.0019887079 1.186951e-01 0.2180734532 X 49183734 49183917 184 - 1.907 1.837 -0.239
ENSG00000012211 E018 46.2200621 0.0028480996 3.335325e-01 0.4772699543 X 49184625 49184710 86 - 1.632 1.571 -0.209
ENSG00000012211 E019 0.4439371 0.0215876822 7.688586e-03 0.0229965670 X 49184711 49184789 79 - 0.431 0.000 -12.413
ENSG00000012211 E020 1.5844011 0.0101548680 9.299740e-02 0.1798075088 X 49184826 49184963 138 - 0.583 0.287 -1.598
ENSG00000012211 E021 38.4852537 0.0113132430 5.221697e-01 0.6560130205 X 49186256 49186528 273 - 1.543 1.494 -0.168