ENSG00000011523

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377990 ENSG00000011523 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP68 protein_coding protein_coding 9.795858 11.96167 8.873321 0.7785585 0.4066701 -0.4304531 1.719343 0.000000 3.3936273 0.0000000 0.1219619 8.4109293 0.1992750 0.0000000 0.3849667 0.38496667 1.064453e-36 1.064453e-36 FALSE TRUE
MSTRG.18538.4 ENSG00000011523 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP68 protein_coding   9.795858 11.96167 8.873321 0.7785585 0.4066701 -0.4304531 3.970305 4.847977 3.8780122 0.2177887 0.2257350 -0.3213228 0.4076167 0.4075333 0.4367667 0.02923333 7.556044e-01 1.064453e-36 FALSE TRUE
MSTRG.18538.6 ENSG00000011523 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP68 protein_coding   9.795858 11.96167 8.873321 0.7785585 0.4066701 -0.4304531 3.162456 5.924548 0.9163495 0.5903793 0.2479775 -2.6795097 0.2941958 0.4937000 0.1012333 -0.39246667 1.014412e-09 1.064453e-36 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000011523 E001 0.5202097 0.0202996274 4.472325e-01 5.886344e-01 2 65056366 65056399 34 + 0.246 0.107 -1.454
ENSG00000011523 E002 0.8512514 0.0144451162 2.562635e-01 3.932218e-01 2 65056400 65056414 15 + 0.140 0.324 1.543
ENSG00000011523 E003 0.8512514 0.0144451162 2.562635e-01 3.932218e-01 2 65056415 65056415 1 + 0.140 0.324 1.543
ENSG00000011523 E004 0.8512514 0.0144451162 2.562635e-01 3.932218e-01 2 65056416 65056421 6 + 0.140 0.324 1.543
ENSG00000011523 E005 4.9349635 0.0034596632 3.475015e-02 8.116924e-02 2 65056422 65056430 9 + 0.564 0.835 1.130
ENSG00000011523 E006 7.6932241 0.0021948812 2.943870e-03 1.009900e-02 2 65056431 65056436 6 + 0.682 1.019 1.310
ENSG00000011523 E007 14.6869172 0.0012158017 9.463580e-03 2.744629e-02 2 65056437 65056451 15 + 1.038 1.241 0.727
ENSG00000011523 E008 36.5903186 0.0006088465 6.559375e-02 1.360337e-01 2 65056452 65056464 13 + 1.514 1.582 0.235
ENSG00000011523 E009 61.7008092 0.0016167938 8.400271e-02 1.658112e-01 2 65056465 65056524 60 + 1.750 1.794 0.148
ENSG00000011523 E010 25.0052600 0.0019366821 4.739587e-01 6.128341e-01 2 65056525 65056528 4 + 1.385 1.397 0.042
ENSG00000011523 E011 198.5202865 0.0067150510 1.085133e-02 3.080840e-02 2 65069399 65069801 403 + 2.238 2.313 0.250
ENSG00000011523 E012 1.0704193 0.2690102047 2.282025e-01 3.602850e-01 2 65070729 65071453 725 + 0.140 0.413 2.058
ENSG00000011523 E013 129.9150526 0.0003047595 1.239628e-04 6.319799e-04 2 65071454 65071616 163 + 2.050 2.131 0.270
ENSG00000011523 E014 78.0361118 0.0030230037 3.012324e-04 1.384732e-03 2 65071617 65071706 90 + 1.795 1.929 0.453
ENSG00000011523 E015 126.9536136 0.0002917392 8.774431e-03 2.571969e-02 2 65071707 65071989 283 + 2.065 2.107 0.142
ENSG00000011523 E016 244.8045707 0.0001807689 2.726877e-03 9.453378e-03 2 65071990 65072569 580 + 2.358 2.383 0.086
ENSG00000011523 E017 174.2440209 0.0004401748 2.380114e-05 1.450930e-04 2 65072570 65072879 310 + 2.178 2.255 0.257
ENSG00000011523 E018 51.1257681 0.0014272973 1.760182e-03 6.472337e-03 2 65072880 65072883 4 + 1.621 1.746 0.424
ENSG00000011523 E019 103.7886917 0.0039986097 3.557160e-04 1.602219e-03 2 65072884 65072980 97 + 1.923 2.047 0.417
ENSG00000011523 E020 5.6240083 0.0108671476 8.588061e-01 9.129091e-01 2 65072981 65073935 955 + 0.827 0.816 -0.045
ENSG00000011523 E021 5.3111373 0.0145865837 7.963859e-01 8.700339e-01 2 65073936 65074149 214 + 0.827 0.758 -0.274
ENSG00000011523 E022 1.3985440 0.0437358539 5.264053e-01 6.596370e-01 2 65074150 65074178 29 + 0.463 0.324 -0.784
ENSG00000011523 E023 93.2730281 0.0012851608 3.388980e-03 1.140559e-02 2 65074282 65074404 123 + 1.905 1.982 0.261
ENSG00000011523 E024 24.4179449 0.0052843111 1.170187e-02 3.282426e-02 2 65074405 65075251 847 + 1.277 1.439 0.564
ENSG00000011523 E025 64.4673912 0.0047350830 3.047280e-01 4.467610e-01 2 65077868 65077964 97 + 1.854 1.759 -0.321
ENSG00000011523 E026 3.9209502 0.0676561664 4.134829e-01 5.569564e-01 2 65080276 65080349 74 + 0.608 0.731 0.523
ENSG00000011523 E027 90.4154036 0.0003567798 6.132279e-02 1.288562e-01 2 65082536 65082709 174 + 2.007 1.897 -0.371
ENSG00000011523 E028 414.5832187 0.0031791208 1.113608e-37 3.317134e-35 2 65083639 65087004 3366 + 2.802 2.418 -1.277