ENSG00000011485

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000012443 ENSG00000011485 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP5C protein_coding protein_coding 150.0185 221.4213 109.8598 7.193723 1.459641 -1.011065 56.14695 111.04175 25.90663 1.459389 0.6365382 -2.0992820 0.3412542 0.5024000 0.2360333 -0.26636667 2.340965e-22 2.340965e-22 FALSE TRUE
MSTRG.17355.3 ENSG00000011485 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP5C protein_coding   150.0185 221.4213 109.8598 7.193723 1.459641 -1.011065 34.32937 59.50430 20.70665 3.367342 3.9437781 -1.5224454 0.2213583 0.2684667 0.1876333 -0.08083333 2.185856e-01 2.340965e-22 TRUE TRUE
MSTRG.17355.4 ENSG00000011485 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP5C protein_coding   150.0185 221.4213 109.8598 7.193723 1.459641 -1.011065 31.97984 29.22222 38.33197 3.368608 0.5524204 0.3913651 0.2350417 0.1312667 0.3491333 0.21786667 7.919113e-13 2.340965e-22 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000011485 E001 9.7271479 1.431275e-02 7.642723e-01 8.473938e-01 19 46347000 46347033 34 + 0.989 0.949 -0.148
ENSG00000011485 E002 13.1583536 3.587515e-02 6.084826e-01 7.282026e-01 19 46347034 46347039 6 + 1.126 1.063 -0.225
ENSG00000011485 E003 67.9021429 5.831508e-03 1.831635e-01 3.051576e-01 19 46347040 46347086 47 + 1.707 1.788 0.275
ENSG00000011485 E004 194.3868916 8.097672e-03 9.216973e-04 3.691056e-03 19 46347087 46347100 14 + 2.346 2.176 -0.567
ENSG00000011485 E005 374.1955644 8.649986e-03 7.399384e-04 3.042675e-03 19 46347101 46347107 7 + 2.627 2.462 -0.549
ENSG00000011485 E006 984.4482606 4.877011e-03 3.229356e-02 7.641842e-02 19 46347108 46347217 110 + 2.985 2.910 -0.249
ENSG00000011485 E007 1693.7269842 2.421856e-03 6.624936e-04 2.761284e-03 19 46353748 46353989 242 + 3.226 3.143 -0.277
ENSG00000011485 E008 620.0479277 1.189769e-03 7.445568e-04 3.059364e-03 19 46375604 46375626 23 + 2.786 2.707 -0.262
ENSG00000011485 E009 1214.8026163 9.456925e-04 2.192962e-04 1.046526e-03 19 46375627 46375751 125 + 3.071 3.002 -0.230
ENSG00000011485 E010 1384.3506538 1.338393e-03 9.271635e-02 1.793684e-01 19 46376453 46376574 122 + 3.105 3.069 -0.119
ENSG00000011485 E011 10.8968350 3.338340e-03 4.256266e-25 4.696196e-23 19 46376575 46376703 129 + 1.531 0.423 -4.322
ENSG00000011485 E012 15.6473469 1.145760e-03 7.750239e-14 2.240250e-12 19 46381511 46381725 215 + 1.537 0.903 -2.256
ENSG00000011485 E013 56.4630131 4.316354e-04 2.454647e-46 1.214166e-43 19 46381726 46382771 1046 + 2.088 1.413 -2.285
ENSG00000011485 E014 25.2514581 5.205411e-03 1.392412e-06 1.120596e-05 19 46382772 46383155 384 + 1.609 1.241 -1.271
ENSG00000011485 E015 13.6011876 3.656155e-02 5.224140e-04 2.243500e-03 19 46383156 46383322 167 + 1.393 0.959 -1.550
ENSG00000011485 E016 17.5813684 3.109084e-02 1.010091e-02 2.900989e-02 19 46383323 46383410 88 + 1.419 1.119 -1.053
ENSG00000011485 E017 882.9132593 7.473611e-04 8.375703e-01 8.984547e-01 19 46383411 46383462 52 + 2.888 2.881 -0.020
ENSG00000011485 E018 804.8119443 1.166823e-04 1.077929e-01 2.022785e-01 19 46383463 46383476 14 + 2.862 2.836 -0.087
ENSG00000011485 E019 33.5179207 5.778383e-04 9.477519e-13 2.336049e-11 19 46383477 46383779 303 + 1.756 1.322 -1.489
ENSG00000011485 E020 664.8405237 1.217457e-04 1.206206e-02 3.368349e-02 19 46383780 46383783 4 + 2.790 2.748 -0.142
ENSG00000011485 E021 721.8358945 1.009799e-04 7.734275e-02 1.552222e-01 19 46383784 46383793 10 + 2.817 2.787 -0.099
ENSG00000011485 E022 1318.0753936 8.380228e-04 4.583581e-01 5.986915e-01 19 46383794 46383878 85 + 3.048 3.059 0.036
ENSG00000011485 E023 8.5032169 7.764652e-03 1.819785e-01 3.036935e-01 19 46383879 46383998 120 + 1.032 0.869 -0.613
ENSG00000011485 E024 19.1138591 9.573504e-04 6.671776e-08 7.013750e-07 19 46384377 46384803 427 + 1.517 1.091 -1.494
ENSG00000011485 E025 1541.1837171 1.442368e-04 5.810312e-01 7.056472e-01 19 46384804 46384909 106 + 3.121 3.125 0.013
ENSG00000011485 E026 1.6262182 9.729537e-03 1.639081e-01 2.802416e-01 19 46384910 46384943 34 + 0.553 0.307 -1.321
ENSG00000011485 E027 6.4097826 2.574884e-03 1.621272e-01 2.778990e-01 19 46386718 46387092 375 + 0.940 0.759 -0.704
ENSG00000011485 E028 1945.0965084 8.463475e-05 3.721857e-01 5.166436e-01 19 46387093 46387235 143 + 3.220 3.225 0.020
ENSG00000011485 E029 1307.1951602 7.501087e-05 9.295044e-03 2.702149e-02 19 46387366 46387453 88 + 3.031 3.058 0.090
ENSG00000011485 E030 13.3312777 1.416677e-03 3.848864e-01 5.290447e-01 19 46387454 46387925 472 + 1.158 1.069 -0.320
ENSG00000011485 E031 11.3968854 7.240417e-03 2.728924e-01 4.118594e-01 19 46387926 46388407 482 + 1.125 1.002 -0.448
ENSG00000011485 E032 1029.8605102 9.233437e-05 3.931893e-01 5.370827e-01 19 46388408 46388448 41 + 2.942 2.951 0.028
ENSG00000011485 E033 3.0926027 5.413431e-03 9.120327e-02 1.770106e-01 19 46388449 46388552 104 + 0.750 0.485 -1.169
ENSG00000011485 E034 2063.3444897 1.103045e-03 8.766239e-03 2.569846e-02 19 46388553 46388731 179 + 3.217 3.262 0.148
ENSG00000011485 E035 1430.0001527 3.188022e-03 7.213754e-04 2.975255e-03 19 46390051 46390132 82 + 3.018 3.114 0.320
ENSG00000011485 E036 22.9152738 4.320449e-03 3.416412e-02 8.007774e-02 19 46390133 46390283 151 + 1.443 1.271 -0.598
ENSG00000011485 E037 1679.5865791 9.471928e-04 4.508062e-21 3.280979e-19 19 46390284 46390568 285 + 3.033 3.198 0.549
ENSG00000011485 E038 444.1767105 1.967886e-04 5.899520e-36 1.528928e-33 19 46390569 46390775 207 + 2.363 2.638 0.915
ENSG00000011485 E039 193.9559874 2.947451e-03 1.498293e-16 6.311922e-15 19 46390776 46390975 200 + 1.936 2.294 1.198
ENSG00000011485 E040 14.0661854 1.232200e-03 9.705567e-01 9.855918e-01 19 46391151 46391155 5 + 1.125 1.119 -0.023
ENSG00000011485 E041 38.8595265 1.745194e-02 3.034930e-01 4.454176e-01 19 46391156 46391258 103 + 1.608 1.521 -0.297
ENSG00000011485 E042 44.4361302 2.279221e-02 2.885834e-01 4.291846e-01 19 46392637 46392803 167 + 1.665 1.577 -0.299
ENSG00000011485 E043 15.4961408 1.926238e-02 9.189911e-01 9.528321e-01 19 46392804 46392981 178 + 1.173 1.165 -0.029
ENSG00000011485 E044 0.5181333 2.148502e-02 1.787708e-01 2.996071e-01 19 46393174 46393296 123 + 0.307 0.081 -2.318