ENSG00000011451

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389282 ENSG00000011451 HEK293_OSMI2_2hA HEK293_TMG_2hB WIZ protein_coding protein_coding 42.97261 61.65433 30.48873 5.774273 0.7938213 -1.015687 9.108538 11.952731 5.570129 1.0601281 0.3691731 -1.1001764 0.21812083 0.19410000 0.18350000 -0.01060000 8.567068e-01 9.672606e-06 FALSE  
ENST00000545156 ENSG00000011451 HEK293_OSMI2_2hA HEK293_TMG_2hB WIZ protein_coding protein_coding 42.97261 61.65433 30.48873 5.774273 0.7938213 -1.015687 9.443853 13.805885 6.982429 2.4844471 0.1559907 -0.9824624 0.22125833 0.22030000 0.22950000 0.00920000 9.229554e-01 9.672606e-06 FALSE  
ENST00000599910 ENSG00000011451 HEK293_OSMI2_2hA HEK293_TMG_2hB WIZ protein_coding protein_coding 42.97261 61.65433 30.48873 5.774273 0.7938213 -1.015687 2.589901 2.525347 3.072198 0.1857670 0.2713402 0.2817762 0.06355417 0.04143333 0.10073333 0.05930000 9.672606e-06 9.672606e-06 FALSE  
ENST00000674001 ENSG00000011451 HEK293_OSMI2_2hA HEK293_TMG_2hB WIZ protein_coding protein_coding 42.97261 61.65433 30.48873 5.774273 0.7938213 -1.015687 2.668405 3.352539 2.468947 0.3106879 0.1232668 -0.4398239 0.06650417 0.05440000 0.08086667 0.02646667 8.502189e-03 9.672606e-06 FALSE  
MSTRG.16614.8 ENSG00000011451 HEK293_OSMI2_2hA HEK293_TMG_2hB WIZ protein_coding   42.97261 61.65433 30.48873 5.774273 0.7938213 -1.015687 17.131911 27.751553 10.819088 2.2736479 0.8836180 -1.3581765 0.38046250 0.45336667 0.35386667 -0.09950000 1.473806e-01 9.672606e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000011451 E001 129.8606359 0.0005588051 2.173921e-03 7.762124e-03 19 15419978 15421507 1530 - 2.110 2.058 -0.176
ENSG00000011451 E002 9.4347393 0.0083050843 5.855040e-01 7.091881e-01 19 15421508 15421522 15 - 0.887 1.002 0.432
ENSG00000011451 E003 126.7067926 0.0003914138 2.365931e-01 3.702450e-01 19 15421523 15422090 568 - 1.997 2.091 0.315
ENSG00000011451 E004 23.4403770 0.0111347823 2.042240e-01 3.314539e-01 19 15422091 15422093 3 - 1.221 1.394 0.605
ENSG00000011451 E005 2077.8649335 0.0077072950 2.629640e-07 2.462591e-06 19 15422094 15423235 1142 - 3.115 3.338 0.742
ENSG00000011451 E006 4.5381843 0.0040056524 8.810933e-01 9.277793e-01 19 15424060 15424182 123 - 0.701 0.721 0.083
ENSG00000011451 E007 373.1125308 0.0005273796 2.915527e-01 4.324159e-01 19 15424183 15424378 196 - 2.473 2.551 0.260
ENSG00000011451 E008 673.8883777 0.0079230154 1.139450e-01 2.112662e-01 19 15424613 15425032 420 - 2.790 2.792 0.009
ENSG00000011451 E009 929.1661877 0.0016098961 1.334541e-05 8.612076e-05 19 15425241 15425768 528 - 2.949 2.921 -0.095
ENSG00000011451 E010 988.7597344 0.0001339401 7.269390e-15 2.447422e-13 19 15426982 15427533 552 - 2.981 2.941 -0.132
ENSG00000011451 E011 310.1982957 0.0017193780 5.875330e-03 1.828441e-02 19 15428110 15428508 399 - 2.467 2.445 -0.072
ENSG00000011451 E012 562.0292319 0.0022557167 1.108777e-02 3.137716e-02 19 15429586 15430089 504 - 2.716 2.709 -0.024
ENSG00000011451 E013 145.2381109 0.0050243943 1.466639e-01 2.571498e-01 19 15431012 15431182 171 - 2.134 2.123 -0.035
ENSG00000011451 E014 36.7795062 0.0220265696 1.063135e-02 3.028734e-02 19 15432434 15432761 328 - 1.656 1.479 -0.603
ENSG00000011451 E015 11.8295741 0.0015273469 2.348273e-02 5.874479e-02 19 15433165 15433290 126 - 1.185 1.010 -0.631
ENSG00000011451 E016 0.3697384 0.0246901236 4.930112e-01 6.300882e-01 19 15436475 15436805 331 - 0.001 0.168 8.277
ENSG00000011451 E017 9.4049116 0.0018214731 7.188193e-02 1.464733e-01 19 15436806 15436933 128 - 0.772 1.040 1.018
ENSG00000011451 E018 12.2669635 0.0014314623 1.695222e-01 2.875669e-01 19 15436934 15437129 196 - 1.145 1.058 -0.315
ENSG00000011451 E019 31.6665104 0.0048961296 3.077780e-02 7.347972e-02 19 15438578 15440715 2138 - 1.538 1.435 -0.354
ENSG00000011451 E020 5.7058926 0.0032018105 3.766393e-01 5.209631e-01 19 15442676 15442748 73 - 0.833 0.759 -0.293
ENSG00000011451 E021 11.5930982 0.0143553418 9.491254e-01 9.721138e-01 19 15448103 15448367 265 - 1.035 1.076 0.151
ENSG00000011451 E022 0.7675920 0.0163430362 2.045551e-01 3.318548e-01 19 15449467 15449797 331 - 0.369 0.168 -1.502
ENSG00000011451 E023 2.1003418 0.0072438620 6.003073e-01 7.215502e-01 19 15449798 15449956 159 - 0.369 0.496 0.669