ENSG00000011426

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265748 ENSG00000011426 HEK293_OSMI2_2hA HEK293_TMG_2hB ANLN protein_coding protein_coding 31.15777 6.842913 51.11235 0.3988711 0.4005678 2.899165 18.1421027 2.3293065 29.8669657 0.3353636 1.04043777 3.6748808 0.53887917 0.3392333 0.584200000 0.24496667 1.488948e-04 6.835556e-06 FALSE TRUE
ENST00000396068 ENSG00000011426 HEK293_OSMI2_2hA HEK293_TMG_2hB ANLN protein_coding protein_coding 31.15777 6.842913 51.11235 0.3988711 0.4005678 2.899165 8.7943758 1.3017307 16.0433414 0.3940929 0.80450113 3.6133301 0.22824583 0.1908000 0.314133333 0.12333333 3.396671e-01 6.835556e-06 FALSE TRUE
ENST00000491782 ENSG00000011426 HEK293_OSMI2_2hA HEK293_TMG_2hB ANLN protein_coding retained_intron 31.15777 6.842913 51.11235 0.3988711 0.4005678 2.899165 0.4313331 0.8562155 0.2337106 0.6873565 0.03519496 -1.8295572 0.05235417 0.1234000 0.004600000 -0.11880000 3.086452e-01 6.835556e-06   FALSE
MSTRG.29734.10 ENSG00000011426 HEK293_OSMI2_2hA HEK293_TMG_2hB ANLN protein_coding   31.15777 6.842913 51.11235 0.3988711 0.4005678 2.899165 0.7117091 1.3860751 0.0845127 0.1090418 0.08451270 -3.8847245 0.07529167 0.2021667 0.001633333 -0.20053333 6.835556e-06 6.835556e-06 FALSE TRUE
MSTRG.29734.3 ENSG00000011426 HEK293_OSMI2_2hA HEK293_TMG_2hB ANLN protein_coding   31.15777 6.842913 51.11235 0.3988711 0.4005678 2.899165 0.4140659 0.6817093 0.4640340 0.2027271 0.15331801 -0.5451753 0.02695417 0.1038000 0.009033333 -0.09476667 6.555113e-04 6.835556e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000011426 E001 19.8255767 0.0008856942 3.365600e-02 7.907265e-02 7 36389821 36389861 41 + 1.145 0.914 -0.848
ENSG00000011426 E002 29.6214603 0.0006502588 6.243579e-02 1.307468e-01 7 36389862 36389871 10 + 1.300 1.158 -0.501
ENSG00000011426 E003 173.2296198 0.0004374712 1.107098e-03 4.327050e-03 7 36389872 36390005 134 + 2.043 1.957 -0.287
ENSG00000011426 E004 135.0198579 0.0010072711 1.555708e-02 4.175122e-02 7 36390006 36390044 39 + 1.932 1.870 -0.210
ENSG00000011426 E005 0.1472490 0.0431272017 6.574584e-01   7 36390171 36390211 41 + 0.043 0.000 -6.489
ENSG00000011426 E006 0.0000000       7 36390235 36390541 307 +      
ENSG00000011426 E007 204.2943891 0.0035755557 3.198729e-04 1.460427e-03 7 36396266 36396419 154 + 2.117 1.996 -0.405
ENSG00000011426 E008 0.0000000       7 36396420 36396421 2 +      
ENSG00000011426 E009 169.8308842 0.0003984027 1.261352e-07 1.256821e-06 7 36399079 36399218 140 + 2.043 1.845 -0.667
ENSG00000011426 E010 191.7224317 0.0002183615 8.410464e-05 4.474912e-04 7 36399219 36399393 175 + 2.089 1.981 -0.361
ENSG00000011426 E011 0.1451727 0.0431384989 6.568811e-01   7 36403493 36403566 74 + 0.043 0.000 -6.488
ENSG00000011426 E012 227.4333630 0.0016126769 1.340635e-09 1.940106e-08 7 36406181 36406401 221 + 2.171 1.948 -0.748
ENSG00000011426 E013 78.0802475 0.0036837386 3.290902e-06 2.442322e-05 7 36406402 36406402 1 + 1.720 1.392 -1.119
ENSG00000011426 E014 177.8792767 0.0002825048 6.138795e-09 7.882448e-08 7 36406403 36406532 130 + 2.065 1.845 -0.740
ENSG00000011426 E015 111.1798234 0.0002859593 1.722434e-05 1.084230e-04 7 36406533 36406550 18 + 1.862 1.665 -0.663
ENSG00000011426 E016 96.0091008 0.0002967236 3.344959e-05 1.966096e-04 7 36406551 36406566 16 + 1.800 1.592 -0.704
ENSG00000011426 E017 0.0000000       7 36406567 36406570 4 +      
ENSG00000011426 E018 0.0000000       7 36407718 36407733 16 +      
ENSG00000011426 E019 246.9127614 0.0001962496 4.556582e-07 4.061880e-06 7 36407734 36407956 223 + 2.199 2.066 -0.447
ENSG00000011426 E020 109.8825679 0.0008064930 7.060522e-04 2.920449e-03 7 36410514 36410559 46 + 1.851 1.711 -0.470
ENSG00000011426 E021 182.2054140 0.0012024143 5.624099e-05 3.128854e-04 7 36410560 36410655 96 + 2.067 1.937 -0.437
ENSG00000011426 E022 159.2044950 0.0010172833 1.290127e-03 4.943081e-03 7 36410656 36410704 49 + 2.006 1.911 -0.321
ENSG00000011426 E023 221.4744011 0.0001654631 6.300052e-04 2.643527e-03 7 36411059 36411166 108 + 2.148 2.077 -0.238
ENSG00000011426 E024 233.3619578 0.0001896496 8.174040e-04 3.321922e-03 7 36415758 36415884 127 + 2.170 2.106 -0.215
ENSG00000011426 E025 0.0000000       7 36415885 36415885 1 +      
ENSG00000011426 E026 155.8368516 0.0006925947 1.748398e-03 6.435251e-03 7 36417080 36417190 111 + 1.999 1.910 -0.300
ENSG00000011426 E027 324.7635584 0.0007244614 3.837117e-03 1.268357e-02 7 36419244 36419467 224 + 2.309 2.275 -0.111
ENSG00000011426 E028 103.7816611 0.0023564005 4.904495e-02 1.074587e-01 7 36419468 36419479 12 + 1.819 1.761 -0.193
ENSG00000011426 E029 161.1197849 0.0002439294 2.944677e-02 7.086819e-02 7 36420169 36420223 55 + 2.006 1.971 -0.117
ENSG00000011426 E030 210.5935009 0.0001913138 2.140009e-02 5.443317e-02 7 36420224 36420314 91 + 2.122 2.095 -0.088
ENSG00000011426 E031 112.9048400 0.0002606273 2.286944e-01 3.608862e-01 7 36420597 36420611 15 + 1.850 1.851 0.002
ENSG00000011426 E032 240.0895603 0.0044419425 2.198854e-01 3.502706e-01 7 36420612 36420744 133 + 2.174 2.182 0.024
ENSG00000011426 E033 232.4518566 0.0002043796 3.878702e-01 5.320034e-01 7 36421857 36421992 136 + 2.158 2.191 0.113
ENSG00000011426 E034 182.9399527 0.0001842250 8.523023e-01 9.084604e-01 7 36422633 36422722 90 + 2.051 2.109 0.194
ENSG00000011426 E035 137.6333473 0.0008919702 3.853985e-01 5.295826e-01 7 36422723 36422809 87 + 1.923 2.030 0.358
ENSG00000011426 E036 168.9312182 0.0002063207 8.528356e-03 2.510873e-02 7 36423817 36423943 127 + 2.000 2.171 0.571
ENSG00000011426 E037 135.2973952 0.0009334429 1.042373e-01 1.969475e-01 7 36424545 36424593 49 + 1.908 2.050 0.477
ENSG00000011426 E038 164.1534377 0.0039271466 3.124069e-02 7.436926e-02 7 36424686 36424742 57 + 1.987 2.161 0.585
ENSG00000011426 E039 153.5555985 0.0003323639 1.278708e-01 2.312132e-01 7 36425702 36425740 39 + 1.964 2.095 0.440
ENSG00000011426 E040 131.0649046 0.0004844747 3.128736e-01 4.553889e-01 7 36426015 36426036 22 + 1.899 2.013 0.380
ENSG00000011426 E041 168.1416312 0.0017565227 4.052399e-03 1.328778e-02 7 36426916 36427028 113 + 1.995 2.187 0.641
ENSG00000011426 E042 3.7289325 0.0041628000 3.560428e-01 5.004395e-01 7 36428307 36428360 54 + 0.485 0.709 1.001
ENSG00000011426 E043 107.2895617 0.0002816577 2.759017e-05 1.655332e-04 7 36439204 36439290 87 + 1.790 2.054 0.888
ENSG00000011426 E044 156.6956290 0.0003821735 8.986302e-04 3.609538e-03 7 36443755 36443862 108 + 1.963 2.165 0.678
ENSG00000011426 E045 5.8353925 0.1222355670 3.822172e-02 8.776745e-02 7 36448939 36449664 726 + 0.577 1.082 1.998
ENSG00000011426 E046 293.0546531 0.0003201354 1.990056e-03 7.195950e-03 7 36449665 36449837 173 + 2.240 2.402 0.539
ENSG00000011426 E047 793.7127438 0.0167369434 5.651640e-11 1.039501e-09 7 36452477 36453791 1315 + 2.617 3.061 1.478