ENSG00000011405

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265970 ENSG00000011405 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3C2A protein_coding protein_coding 8.188698 1.444772 15.08168 0.115551 0.4545697 3.374889 0.7333359 1.35719602 0.000000 0.13028455 0.0000000 -7.095076 0.37973750 0.93676667 0.0000 -0.9367667 2.934228e-37 2.934228e-37 FALSE TRUE
ENST00000691414 ENSG00000011405 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3C2A protein_coding protein_coding 8.188698 1.444772 15.08168 0.115551 0.4545697 3.374889 5.7752113 0.02573081 12.083535 0.02573081 0.6658555 8.402852 0.49063333 0.02116667 0.8000 0.7788333 1.680220e-25 2.934228e-37 FALSE TRUE
MSTRG.5224.5 ENSG00000011405 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3C2A protein_coding   8.188698 1.444772 15.08168 0.115551 0.4545697 3.374889 1.0293979 0.00000000 1.806159 0.00000000 0.1103644 7.504747 0.07097083 0.00000000 0.1201 0.1201000 1.113913e-05 2.934228e-37 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000011405 E001 0.5212538 0.0205316532 1.149367e-02 3.233455e-02 11 17077730 17077922 193 - 0.036 0.541 4.853
ENSG00000011405 E002 0.3299976 0.0258959845 2.464637e-03   11 17086572 17086574 3 - 0.000 0.541 15.788
ENSG00000011405 E003 467.8772216 0.0220163532 2.268816e-12 5.253245e-11 11 17086575 17089297 2723 - 2.324 2.863 1.797
ENSG00000011405 E004 165.2374140 0.0009035305 4.029984e-02 9.158710e-02 11 17089298 17089920 623 - 1.927 2.149 0.744
ENSG00000011405 E005 76.7482492 0.0003360538 2.327947e-01 3.657540e-01 11 17091334 17091459 126 - 1.602 1.807 0.696
ENSG00000011405 E006 68.9561221 0.0063866749 2.427978e-01 3.774662e-01 11 17091547 17091656 110 - 1.553 1.774 0.749
ENSG00000011405 E007 53.2667919 0.0049384930 2.978687e-01 4.392433e-01 11 17091996 17092068 73 - 1.444 1.660 0.738
ENSG00000011405 E008 63.4674042 0.0062706696 9.025428e-01 9.419310e-01 11 17092159 17092276 118 - 1.528 1.649 0.414
ENSG00000011405 E009 61.7361789 0.0396861238 5.861251e-01 7.097498e-01 11 17094261 17094385 125 - 1.520 1.609 0.305
ENSG00000011405 E010 78.2269380 0.0014279375 3.785742e-03 1.254236e-02 11 17097057 17097264 208 - 1.636 1.537 -0.336
ENSG00000011405 E011 59.5167690 0.0006195009 1.400989e-01 2.481587e-01 11 17099860 17099969 110 - 1.514 1.521 0.023
ENSG00000011405 E012 64.0780043 0.0021008920 1.372800e-01 2.442869e-01 11 17101278 17101434 157 - 1.546 1.552 0.021
ENSG00000011405 E013 62.1600378 0.0029302637 1.377804e-01 2.449841e-01 11 17102662 17102831 170 - 1.534 1.537 0.009
ENSG00000011405 E014 57.3816065 0.0004818543 3.844125e-01 5.285658e-01 11 17105169 17105305 137 - 1.494 1.552 0.197
ENSG00000011405 E015 59.6184701 0.0005007250 3.733359e-01 5.177774e-01 11 17110432 17110561 130 - 1.510 1.567 0.196
ENSG00000011405 E016 48.0662715 0.0005018290 4.867307e-01 6.244546e-01 11 17112574 17112666 93 - 1.421 1.487 0.229
ENSG00000011405 E017 45.2628486 0.0004922350 1.386679e-01 2.462571e-01 11 17114361 17114465 105 - 1.402 1.389 -0.043
ENSG00000011405 E018 69.0674226 0.0020081372 6.577366e-03 2.012765e-02 11 17117491 17117671 181 - 1.586 1.487 -0.340
ENSG00000011405 E019 54.6025609 0.0146711446 6.436000e-02 1.339690e-01 11 17118645 17118739 95 - 1.485 1.410 -0.257
ENSG00000011405 E020 48.1162812 0.0009368269 6.672608e-03 2.037204e-02 11 17119220 17119313 94 - 1.436 1.291 -0.502
ENSG00000011405 E021 55.8672871 0.0030258910 1.784281e-03 6.549255e-03 11 17119786 17119974 189 - 1.499 1.318 -0.627
ENSG00000011405 E022 57.7767003 0.0003931177 1.395996e-03 5.293351e-03 11 17122188 17122333 146 - 1.512 1.343 -0.583
ENSG00000011405 E023 55.6009949 0.0004323033 2.741413e-03 9.496297e-03 11 17122702 17122813 112 - 1.496 1.343 -0.527
ENSG00000011405 E024 53.8595629 0.0004918535 2.311210e-03 8.185954e-03 11 17129300 17129467 168 - 1.482 1.318 -0.568
ENSG00000011405 E025 36.2307071 0.0005843376 3.042157e-02 7.278793e-02 11 17131916 17132038 123 - 1.316 1.200 -0.407
ENSG00000011405 E026 57.9858740 0.0003903297 8.045485e-02 1.602748e-01 11 17134819 17135029 211 - 1.506 1.487 -0.066
ENSG00000011405 E027 33.4909494 0.0006816040 3.006506e-01 4.423804e-01 11 17135111 17135159 49 - 1.276 1.291 0.053
ENSG00000011405 E028 56.1084694 0.0005351265 9.050883e-03 2.640461e-02 11 17136482 17136625 144 - 1.498 1.389 -0.374
ENSG00000011405 E029 0.2214452 0.0374693450 2.533851e-02   11 17141322 17141381 60 - 0.000 0.350 14.793
ENSG00000011405 E030 39.0195189 0.0012946220 9.547501e-04 3.804121e-03 11 17145668 17145731 64 - 1.353 1.084 -0.953
ENSG00000011405 E031 42.9930590 0.0540749782 3.686790e-03 1.225826e-02 11 17145863 17145942 80 - 1.396 1.047 -1.234
ENSG00000011405 E032 49.2469969 0.0031848146 3.102854e-03 1.056861e-02 11 17147517 17147628 112 - 1.446 1.263 -0.636
ENSG00000011405 E033 2.0961797 0.0546823726 3.167186e-02 7.520949e-02 11 17148239 17148666 428 - 0.248 0.777 2.692
ENSG00000011405 E034 44.0494471 0.0004811299 1.085563e-02 3.081923e-02 11 17148667 17148787 121 - 1.399 1.263 -0.474
ENSG00000011405 E035 64.7315497 0.0003776261 1.333472e-03 5.087961e-03 11 17150498 17150655 158 - 1.561 1.411 -0.515
ENSG00000011405 E036 51.7273692 0.0022790794 6.050770e-02 1.274857e-01 11 17155526 17155629 104 - 1.459 1.411 -0.164
ENSG00000011405 E037 146.5555782 0.0003616539 1.140885e-07 1.146799e-06 11 17168677 17169351 675 - 1.910 1.724 -0.626
ENSG00000011405 E038 99.4718828 0.0017467258 8.910668e-08 9.131771e-07 11 17169352 17169806 455 - 1.749 1.451 -1.018
ENSG00000011405 E039 0.3030308 0.3571421323 1.000000e+00   11 17194389 17194393 5 - 0.069 0.000 -8.364
ENSG00000011405 E040 0.3030308 0.3571421323 1.000000e+00   11 17194394 17194414 21 - 0.069 0.000 -8.364
ENSG00000011405 E041 1.9166549 0.0076578313 2.703826e-01 4.090229e-01 11 17204307 17204375 69 - 0.325 0.000 -11.058
ENSG00000011405 E042 27.9933090 0.0008947260 4.399414e-06 3.171204e-05 11 17207848 17208014 167 - 1.231 0.541 -2.694