ENSG00000011332

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355526 ENSG00000011332 HEK293_OSMI2_2hA HEK293_TMG_2hB DPF1 protein_coding protein_coding 16.60048 26.8043 9.79172 2.03632 0.5066837 -1.451896 2.7227144 6.4190190 0.4875335 0.7860125 0.4875335 -3.69173304 0.13626250 0.24650000 0.04513333 -0.20136667 8.944035e-02 1.156249e-08 FALSE TRUE
ENST00000456296 ENSG00000011332 HEK293_OSMI2_2hA HEK293_TMG_2hB DPF1 protein_coding protein_coding 16.60048 26.8043 9.79172 2.03632 0.5066837 -1.451896 1.0944483 2.3707206 0.4757283 0.4792318 0.4757283 -2.29317683 0.05749583 0.08730000 0.05066667 -0.03663333 2.660927e-01 1.156249e-08 FALSE TRUE
ENST00000471976 ENSG00000011332 HEK293_OSMI2_2hA HEK293_TMG_2hB DPF1 protein_coding retained_intron 16.60048 26.8043 9.79172 2.03632 0.5066837 -1.451896 0.3204679 0.0000000 0.6275647 0.0000000 0.2107217 5.99449994 0.02609167 0.00000000 0.06570000 0.06570000 1.156249e-08 1.156249e-08 TRUE TRUE
ENST00000475938 ENSG00000011332 HEK293_OSMI2_2hA HEK293_TMG_2hB DPF1 protein_coding retained_intron 16.60048 26.8043 9.79172 2.03632 0.5066837 -1.451896 0.7476096 0.3573355 0.3695773 0.1786825 0.1900841 0.04729539 0.05377083 0.01243333 0.03716667 0.02473333 8.110829e-01 1.156249e-08 FALSE TRUE
ENST00000494031 ENSG00000011332 HEK293_OSMI2_2hA HEK293_TMG_2hB DPF1 protein_coding retained_intron 16.60048 26.8043 9.79172 2.03632 0.5066837 -1.451896 0.7743077 0.6323553 0.5409418 0.1941289 0.1345406 -0.22147169 0.05058333 0.02400000 0.05643333 0.03243333 2.703523e-01 1.156249e-08   FALSE
ENST00000614244 ENSG00000011332 HEK293_OSMI2_2hA HEK293_TMG_2hB DPF1 protein_coding protein_coding 16.60048 26.8043 9.79172 2.03632 0.5066837 -1.451896 3.1318737 4.0689980 1.4710313 1.3406344 0.3562972 -1.46161266 0.19233750 0.14560000 0.15460000 0.00900000 9.787178e-01 1.156249e-08 FALSE TRUE
MSTRG.17085.12 ENSG00000011332 HEK293_OSMI2_2hA HEK293_TMG_2hB DPF1 protein_coding   16.60048 26.8043 9.79172 2.03632 0.5066837 -1.451896 4.4745915 8.7914706 2.4202925 1.3170353 1.2132243 -1.85661463 0.27044583 0.32410000 0.24026667 -0.08383333 8.200803e-01 1.156249e-08 FALSE TRUE
MSTRG.17085.13 ENSG00000011332 HEK293_OSMI2_2hA HEK293_TMG_2hB DPF1 protein_coding   16.60048 26.8043 9.79172 2.03632 0.5066837 -1.451896 1.1453564 1.6121654 0.9138070 0.3367284 0.5308281 -0.81225758 0.07683750 0.06043333 0.09456667 0.03413333 9.865374e-01 1.156249e-08 FALSE TRUE
MSTRG.17085.14 ENSG00000011332 HEK293_OSMI2_2hA HEK293_TMG_2hB DPF1 protein_coding   16.60048 26.8043 9.79172 2.03632 0.5066837 -1.451896 0.7591968 0.0000000 1.6341598 0.0000000 0.9203655 7.36120674 0.04730417 0.00000000 0.16853333 0.16853333 1.112466e-01 1.156249e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000011332 E001 1.244849 0.0204786534 1.218853e-01 2.226027e-01 19 38211006 38211008 3 - 0.001 0.347 9.513
ENSG00000011332 E002 15.703304 0.0088425871 8.646869e-03 2.540186e-02 19 38211009 38211042 34 - 0.848 1.180 1.222
ENSG00000011332 E003 144.432301 0.0002330589 1.500750e-07 1.473122e-06 19 38211043 38211699 657 - 1.881 2.087 0.692
ENSG00000011332 E004 9.051054 0.0260859353 6.638102e-01 7.717994e-01 19 38211700 38211701 2 - 0.848 0.915 0.257
ENSG00000011332 E005 10.568630 0.0186631850 4.916679e-01 6.289459e-01 19 38211702 38211716 15 - 0.884 0.982 0.370
ENSG00000011332 E006 13.706181 0.0129358963 5.426497e-01 6.733742e-01 19 38211717 38211754 38 - 1.004 1.081 0.284
ENSG00000011332 E007 50.475101 0.0040297931 6.721942e-03 2.049987e-02 19 38211755 38211961 207 - 1.442 1.639 0.677
ENSG00000011332 E008 32.520168 0.0006448463 2.229797e-02 5.629264e-02 19 38211962 38211973 12 - 1.269 1.452 0.636
ENSG00000011332 E009 101.369395 0.0003578879 1.026827e-01 1.945936e-01 19 38211974 38212064 91 - 1.845 1.917 0.241
ENSG00000011332 E010 70.941515 0.0023697958 5.664715e-01 6.934499e-01 19 38212065 38212071 7 - 1.725 1.758 0.112
ENSG00000011332 E011 90.506502 0.0005451695 7.764898e-02 1.556883e-01 19 38212072 38212133 62 - 1.785 1.868 0.281
ENSG00000011332 E012 120.107034 0.0002798106 1.096681e-01 2.050784e-01 19 38212280 38212361 82 - 1.921 1.985 0.215
ENSG00000011332 E013 20.743800 0.0018946941 2.588135e-01 3.961345e-01 19 38212362 38212391 30 - 1.137 1.247 0.389
ENSG00000011332 E014 143.551066 0.0002553749 4.081377e-03 1.337139e-02 19 38213644 38213756 113 - 1.963 2.070 0.360
ENSG00000011332 E015 1.860939 0.3023351756 9.457870e-01 9.699721e-01 19 38213757 38213979 223 - 0.344 0.409 0.370
ENSG00000011332 E016 130.716220 0.0003828569 8.799654e-01 9.270225e-01 19 38216140 38216241 102 - 2.019 2.013 -0.021
ENSG00000011332 E017 76.730397 0.0007980656 7.094670e-01 8.068385e-01 19 38216242 38216259 18 - 1.802 1.783 -0.063
ENSG00000011332 E018 69.521053 0.0006566961 3.652365e-01 5.095699e-01 19 38216353 38216403 51 - 1.781 1.734 -0.157
ENSG00000011332 E019 4.261167 0.0039855593 8.637574e-03 2.537901e-02 19 38216404 38216510 107 - 0.917 0.538 -1.569
ENSG00000011332 E020 1.212572 0.1113659045 2.805065e-01 4.203604e-01 19 38217391 38217459 69 - 0.450 0.232 -1.362
ENSG00000011332 E021 150.566960 0.0002863268 2.693772e-01 4.078959e-01 19 38217460 38217591 132 - 2.044 2.082 0.129
ENSG00000011332 E022 8.945396 0.0493469951 4.125790e-04 1.822549e-03 19 38217592 38217797 206 - 1.255 0.737 -1.930
ENSG00000011332 E023 149.269996 0.0002632202 7.948905e-01 8.689935e-01 19 38217798 38217876 79 - 2.062 2.071 0.029
ENSG00000011332 E024 146.683894 0.0002789265 4.169983e-01 5.603885e-01 19 38218573 38218627 55 - 2.082 2.053 -0.097
ENSG00000011332 E025 122.171109 0.0002978806 5.108920e-01 6.460432e-01 19 38218628 38218656 29 - 2.001 1.975 -0.087
ENSG00000011332 E026 89.304928 0.0003138174 6.306581e-01 7.458131e-01 19 38218657 38218662 6 - 1.830 1.851 0.072
ENSG00000011332 E027 190.636207 0.0002962539 2.563568e-02 6.319421e-02 19 38218931 38219028 98 - 2.227 2.159 -0.227
ENSG00000011332 E028 110.484551 0.0003608742 2.190772e-04 1.045587e-03 19 38219029 38219058 30 - 2.051 1.908 -0.481
ENSG00000011332 E029 7.129084 0.0030786083 3.189977e-01 4.620307e-01 19 38219059 38219939 881 - 0.917 0.784 -0.517
ENSG00000011332 E030 152.176451 0.0002261556 7.352649e-03 2.213455e-02 19 38222357 38222464 108 - 2.149 2.059 -0.300
ENSG00000011332 E031 133.427119 0.0004209591 7.834252e-03 2.336585e-02 19 38222548 38222703 156 - 2.097 2.001 -0.322
ENSG00000011332 E032 51.746977 0.0004971565 1.086453e-01 2.035335e-01 19 38222704 38222708 5 - 1.689 1.597 -0.313
ENSG00000011332 E033 1.852961 0.0217665861 3.073599e-01 4.495813e-01 19 38222835 38223082 248 - 0.534 0.347 -0.985
ENSG00000011332 E034 2.586098 0.0168038394 1.982965e-02 5.112643e-02 19 38223083 38223298 216 - 0.767 0.380 -1.793
ENSG00000011332 E035 3.940503 0.1296489094 6.080808e-01 7.279333e-01 19 38223756 38224113 358 - 0.719 0.581 -0.589
ENSG00000011332 E036 42.472104 0.0006456668 5.037464e-01 6.396973e-01 19 38224114 38224250 137 - 1.565 1.521 -0.149
ENSG00000011332 E037 0.000000       19 38227946 38228042 97 -      
ENSG00000011332 E038 0.000000       19 38228662 38228693 32 -      
ENSG00000011332 E039 9.725731 0.0019475342 1.103717e-02 3.125027e-02 19 38229559 38229714 156 - 1.156 0.873 -1.042