ENSG00000011304

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000349038 ENSG00000011304 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP1 protein_coding protein_coding 427.4923 608.3158 342.5445 33.4681 6.129441 -0.8285107 141.058301 209.156738 108.55171 29.30136 5.907395 -0.946138 0.3226417 0.340600000 0.31763333 -0.02296667 8.525816e-01 1.683836e-34 FALSE TRUE
ENST00000356948 ENSG00000011304 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP1 protein_coding protein_coding 427.4923 608.3158 342.5445 33.4681 6.129441 -0.8285107 184.271699 283.763996 117.64946 25.10298 5.882562 -1.270125 0.4204667 0.464766667 0.34316667 -0.12160000 5.131980e-04 1.683836e-34 FALSE TRUE
ENST00000589575 ENSG00000011304 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP1 protein_coding protein_coding 427.4923 608.3158 342.5445 33.4681 6.129441 -0.8285107 9.367787 0.000000 19.39174 0.00000 4.296574 10.921970 0.0277750 0.000000000 0.05623333 0.05623333 1.683836e-34 1.683836e-34 FALSE FALSE
ENST00000590887 ENSG00000011304 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP1 protein_coding retained_intron 427.4923 608.3158 342.5445 33.4681 6.129441 -0.8285107 27.572281 4.847696 47.32940 1.46056 4.481805 3.284697 0.0781500 0.007733333 0.13793333 0.13020000 2.995334e-16 1.683836e-34 TRUE TRUE
MSTRG.16010.2 ENSG00000011304 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP1 protein_coding   427.4923 608.3158 342.5445 33.4681 6.129441 -0.8285107 15.068929 54.722025 0.00000 11.90378 0.000000 -12.418170 0.0269875 0.092666667 0.00000000 -0.09266667 2.829080e-26 1.683836e-34 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000011304 E001 6.664265e-01 1.678419e-02 4.785525e-01 6.169686e-01 19 797075 797347 273 + 0.275 0.170 -0.881
ENSG00000011304 E002 4.997407e+00 1.962414e-02 8.476131e-01 9.053622e-01 19 797348 797391 44 + 0.697 0.764 0.276
ENSG00000011304 E003 7.458027e+00 3.374574e-02 5.296432e-01 6.623876e-01 19 797392 797397 6 + 0.929 0.876 -0.203
ENSG00000011304 E004 4.518183e+01 8.696618e-03 1.607294e-02 4.289838e-02 19 797398 797424 27 + 1.710 1.589 -0.413
ENSG00000011304 E005 1.088274e+02 3.419171e-04 6.853816e-18 3.424142e-16 19 797425 797426 2 + 2.163 1.910 -0.846
ENSG00000011304 E006 1.421051e+02 3.348990e-04 8.000245e-22 6.237129e-20 19 797427 797427 1 + 2.275 2.027 -0.831
ENSG00000011304 E007 6.097655e+02 1.585144e-04 2.065812e-37 6.039535e-35 19 797428 797451 24 + 2.849 2.697 -0.508
ENSG00000011304 E008 8.206243e+02 4.362774e-04 2.564848e-51 1.687162e-48 19 797452 797461 10 + 3.002 2.810 -0.641
ENSG00000011304 E009 2.429404e+03 4.176329e-04 1.208906e-29 1.974342e-27 19 797462 797489 28 + 3.408 3.321 -0.287
ENSG00000011304 E010 2.648251e+03 5.876048e-04 6.742690e-22 5.304744e-20 19 797490 797505 16 + 3.440 3.362 -0.258
ENSG00000011304 E011 1.892109e+01 8.080778e-03 6.761093e-01 7.811820e-01 19 798428 798545 118 + 1.250 1.259 0.031
ENSG00000011304 E012 6.860788e+01 5.736765e-04 5.406676e-39 1.756910e-36 19 799406 799412 7 + 2.091 1.571 -1.756
ENSG00000011304 E013 2.860772e+03 5.586793e-04 5.334808e-21 3.847215e-19 19 799413 799443 31 + 3.469 3.398 -0.235
ENSG00000011304 E014 2.118528e+01 2.911634e-02 2.782451e-03 9.621916e-03 19 799444 800081 638 + 1.479 1.206 -0.952
ENSG00000011304 E015 2.574903e+03 1.015639e-03 3.158139e-14 9.656230e-13 19 803561 803574 14 + 3.426 3.352 -0.246
ENSG00000011304 E016 1.943835e+03 1.373981e-03 5.676711e-12 1.229772e-10 19 803575 803576 2 + 3.309 3.227 -0.271
ENSG00000011304 E017 3.179690e+03 1.366975e-03 2.930102e-10 4.776279e-09 19 803577 803636 60 + 3.511 3.447 -0.211
ENSG00000011304 E018 4.797856e+03 6.048665e-04 3.804551e-11 7.201126e-10 19 804036 804208 173 + 3.667 3.637 -0.098
ENSG00000011304 E019 3.422971e+01 1.715109e-02 3.187697e-05 1.884477e-04 19 804209 804291 83 + 1.696 1.387 -1.057
ENSG00000011304 E020 2.831852e+03 1.184813e-03 1.088150e-05 7.169075e-05 19 804292 804388 97 + 3.434 3.410 -0.079
ENSG00000011304 E021 2.287688e+03 1.541630e-03 1.107846e-03 4.329327e-03 19 804389 804438 50 + 3.333 3.321 -0.038
ENSG00000011304 E022 2.026487e+01 9.322472e-03 1.318490e-02 3.634021e-02 19 804439 804531 93 + 1.395 1.224 -0.601
ENSG00000011304 E023 1.368616e+03 3.208170e-03 1.349445e-01 2.410162e-01 19 804532 804540 9 + 3.092 3.106 0.046
ENSG00000011304 E024 2.255441e+03 2.155288e-03 8.375763e-02 1.654291e-01 19 804541 804622 82 + 3.308 3.324 0.052
ENSG00000011304 E025 2.354945e+03 2.049688e-03 4.056387e-02 9.205663e-02 19 804623 804702 80 + 3.331 3.341 0.031
ENSG00000011304 E026 1.805651e+03 9.471614e-04 2.058235e-03 7.405870e-03 19 804829 804857 29 + 3.221 3.222 0.002
ENSG00000011304 E027 2.405176e+03 1.802625e-04 1.128491e-07 1.135425e-06 19 804858 804939 82 + 3.346 3.345 -0.005
ENSG00000011304 E028 6.619488e+00 2.872494e-03 1.100685e-01 2.056424e-01 19 804940 805012 73 + 0.952 0.798 -0.592
ENSG00000011304 E029 2.386338e+03 1.834883e-04 1.318973e-04 6.671354e-04 19 805013 805095 83 + 3.333 3.346 0.043
ENSG00000011304 E030 2.585962e+03 6.704987e-05 7.976709e-05 4.267498e-04 19 805096 805187 92 + 3.364 3.382 0.058
ENSG00000011304 E031 8.882361e+01 1.560960e-02 7.645034e-03 2.288617e-02 19 805188 805491 304 + 2.002 1.872 -0.438
ENSG00000011304 E032 9.239907e+02 1.409292e-04 8.227558e-01 8.882526e-01 19 805492 805507 16 + 2.892 2.945 0.177
ENSG00000011304 E033 8.655028e+02 5.810161e-04 6.434061e-01 7.559712e-01 19 805508 805512 5 + 2.859 2.919 0.197
ENSG00000011304 E034 1.212252e+03 1.304013e-03 6.119462e-01 7.309855e-01 19 805513 805569 57 + 3.004 3.067 0.209
ENSG00000011304 E035 6.589403e+01 1.348459e-02 1.703802e-06 1.345815e-05 19 805570 805831 262 + 1.970 1.673 -1.001
ENSG00000011304 E036 2.752873e+01 1.051412e-02 5.525096e-07 4.847913e-06 19 805832 805902 71 + 1.633 1.270 -1.252
ENSG00000011304 E037 5.119297e+01 1.916252e-02 4.292729e-06 3.099728e-05 19 805903 806407 505 + 1.879 1.547 -1.124
ENSG00000011304 E038 2.684889e+03 1.324293e-03 6.406718e-01 7.538764e-01 19 806408 806556 149 + 3.362 3.408 0.154
ENSG00000011304 E039 2.649395e+02 2.283215e-03 1.272479e-51 8.488287e-49 19 806557 807858 1302 + 2.637 2.203 -1.448
ENSG00000011304 E040 4.933277e+01 5.789228e-03 7.406837e-08 7.715842e-07 19 807859 807868 10 + 1.844 1.562 -0.957
ENSG00000011304 E041 1.686003e+03 7.736969e-04 9.214674e-01 9.544257e-01 19 807869 807902 34 + 3.155 3.207 0.171
ENSG00000011304 E042 1.196230e+02 2.683732e-04 8.515135e-43 3.476652e-40 19 807903 808359 457 + 2.281 1.880 -1.344
ENSG00000011304 E043 1.581369e+03 7.433421e-05 4.211657e-01 5.642876e-01 19 808360 808379 20 + 3.133 3.174 0.138
ENSG00000011304 E044 2.622483e+03 6.755012e-05 3.344705e-01 4.782113e-01 19 808380 808452 73 + 3.341 3.399 0.194
ENSG00000011304 E045 3.094027e+03 2.365411e-04 4.050663e-03 1.328232e-02 19 808546 808649 104 + 3.398 3.478 0.268
ENSG00000011304 E046 3.845195e+03 3.465662e-04 5.804447e-04 2.461686e-03 19 808650 808762 113 + 3.486 3.576 0.296
ENSG00000011304 E047 3.102958e+03 1.780918e-04 3.951945e-07 3.566521e-06 19 810543 810620 78 + 3.386 3.484 0.329
ENSG00000011304 E048 2.095911e+04 4.302570e-03 4.466148e-17 2.002600e-15 19 810694 812366 1673 + 4.085 4.355 0.896