ENSG00000011275

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389902 ENSG00000011275 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF216 protein_coding protein_coding 17.8405 16.9829 18.19758 0.4797299 0.3476684 0.09960696 5.974230 5.08107570 7.029132 1.15053860 0.8410454 0.4674270 0.33582083 0.299333333 0.38476667 0.08543333 6.179820e-01 1.712154e-09 FALSE TRUE
ENST00000425013 ENSG00000011275 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF216 protein_coding protein_coding 17.8405 16.9829 18.19758 0.4797299 0.3476684 0.09960696 8.394806 11.05426570 6.891748 0.93818952 0.7554195 -0.6808739 0.47645417 0.651966667 0.38060000 -0.27136667 1.580634e-02 1.712154e-09 FALSE TRUE
MSTRG.29444.6 ENSG00000011275 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF216 protein_coding   17.8405 16.9829 18.19758 0.4797299 0.3476684 0.09960696 1.336313 0.00000000 1.395425 0.00000000 0.4141317 7.1348625 0.06857083 0.000000000 0.07606667 0.07606667 7.915717e-09 1.712154e-09 FALSE TRUE
MSTRG.29444.8 ENSG00000011275 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF216 protein_coding   17.8405 16.9829 18.19758 0.4797299 0.3476684 0.09960696 1.282817 0.09354702 2.254499 0.05790124 0.2707230 4.4508340 0.07077917 0.005466667 0.12453333 0.11906667 1.712154e-09 1.712154e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000011275 E001 2.5633086 0.0538449780 7.909565e-01 8.663099e-01 7 5616167 5616208 42 - 0.577 0.535 -0.192
ENSG00000011275 E002 2.2109574 0.0324786597 9.970159e-02 1.900237e-01 7 5619215 5619271 57 - 0.309 0.608 1.554
ENSG00000011275 E003 2.1057410 0.0190552739 3.681772e-01 5.125779e-01 7 5619868 5619907 40 - 0.378 0.538 0.822
ENSG00000011275 E004 3.0698852 0.1589037672 3.069514e-01 4.491262e-01 7 5619908 5620046 139 - 0.437 0.679 1.122
ENSG00000011275 E005 1072.0791266 0.0046797498 5.812352e-06 4.076609e-05 7 5620047 5622694 2648 - 2.942 3.077 0.449
ENSG00000011275 E006 150.9899387 0.0029516928 5.494778e-04 2.345001e-03 7 5622695 5622835 141 - 2.090 2.232 0.474
ENSG00000011275 E007 146.8875839 0.0049364499 5.892591e-07 5.142605e-06 7 5622836 5622926 91 - 2.015 2.251 0.787
ENSG00000011275 E008 243.6177837 0.0010871116 3.561553e-11 6.770954e-10 7 5622927 5623179 253 - 2.265 2.454 0.631
ENSG00000011275 E009 146.4323470 0.0003323290 5.614938e-03 1.759051e-02 7 5624056 5624125 70 - 2.111 2.200 0.298
ENSG00000011275 E010 221.9359831 0.0021689308 1.053169e-02 3.004888e-02 7 5641154 5641347 194 - 2.290 2.377 0.292
ENSG00000011275 E011 89.0233003 0.0004236166 1.509599e-03 5.667188e-03 7 5641348 5641376 29 - 1.868 1.996 0.432
ENSG00000011275 E012 0.8470867 0.0144574893 5.525625e-01 6.818386e-01 7 5649640 5650015 376 - 0.310 0.207 -0.764
ENSG00000011275 E013 132.3854378 0.0002490369 5.890142e-02 1.247507e-01 7 5652413 5652510 98 - 2.080 2.145 0.216
ENSG00000011275 E014 109.3999252 0.0031335624 4.643135e-01 6.040530e-01 7 5711761 5711839 79 - 2.051 2.026 -0.086
ENSG00000011275 E015 135.8182081 0.0006956047 4.105720e-01 5.541738e-01 7 5712715 5712863 149 - 2.111 2.144 0.108
ENSG00000011275 E016 0.0000000       7 5713305 5713441 137 -      
ENSG00000011275 E017 152.3172619 0.0017781059 7.306334e-01 8.225210e-01 7 5715053 5715190 138 - 2.182 2.176 -0.020
ENSG00000011275 E018 108.7173090 0.0107605185 3.050236e-01 4.470648e-01 7 5716716 5716766 51 - 2.064 2.009 -0.185
ENSG00000011275 E019 160.0082182 0.0018284044 1.818394e-02 4.752757e-02 7 5721033 5721172 140 - 2.240 2.166 -0.249
ENSG00000011275 E020 146.1318896 0.0002553561 1.699667e-02 4.492582e-02 7 5725324 5725438 115 - 2.197 2.132 -0.216
ENSG00000011275 E021 133.2659083 0.0002208320 4.739690e-02 1.045393e-01 7 5729432 5729529 98 - 2.152 2.097 -0.184
ENSG00000011275 E022 95.2277973 0.0003201253 9.549731e-01 9.757608e-01 7 5729530 5729596 67 - 1.971 1.979 0.026
ENSG00000011275 E023 88.5316362 0.0004609243 4.794178e-01 6.177988e-01 7 5730715 5730817 103 - 1.956 1.935 -0.072
ENSG00000011275 E024 0.2924217 0.0270945772 1.662217e-01   7 5732970 5733162 193 - 0.229 0.000 -11.554
ENSG00000011275 E025 64.8630222 0.0028020933 7.505482e-01 8.371987e-01 7 5739276 5739352 77 - 1.816 1.805 -0.036
ENSG00000011275 E026 8.4697984 0.0789841470 8.885259e-02 1.733648e-01 7 5739353 5739621 269 - 1.094 0.827 -0.999
ENSG00000011275 E027 2.9872751 0.0052134061 1.799874e-02 4.712999e-02 7 5739622 5739625 4 - 0.767 0.403 -1.666
ENSG00000011275 E028 372.1817803 0.0045683486 1.039619e-07 1.052603e-06 7 5740973 5741578 606 - 2.661 2.480 -0.605
ENSG00000011275 E029 113.3682407 0.0062758094 8.768753e-06 5.904020e-05 7 5741579 5741644 66 - 2.164 1.947 -0.726
ENSG00000011275 E030 70.3345011 0.0169712182 6.232149e-06 4.341626e-05 7 5741645 5741815 171 - 2.009 1.677 -1.121
ENSG00000011275 E031 139.3172714 0.0067415230 7.681829e-06 5.238791e-05 7 5752846 5752979 134 - 2.251 2.039 -0.710
ENSG00000011275 E032 0.0000000       7 5760391 5760511 121 -      
ENSG00000011275 E033 73.8815710 0.0050136834 1.050673e-05 6.950934e-05 7 5761003 5761010 8 - 1.985 1.758 -0.763
ENSG00000011275 E034 106.6795418 0.0132856784 1.539370e-04 7.646276e-04 7 5761011 5761087 77 - 2.146 1.910 -0.792
ENSG00000011275 E035 72.0544426 0.0199365981 3.864286e-03 1.276063e-02 7 5761088 5761138 51 - 1.970 1.751 -0.737
ENSG00000011275 E036 0.7363589 0.0154591377 1.148736e-02 3.232305e-02 7 5766895 5766939 45 - 0.437 0.000 -12.876
ENSG00000011275 E037 0.1515154 0.0430278365 4.312724e-01   7 5775005 5775179 175 - 0.129 0.000 -10.555
ENSG00000011275 E038 4.3391799 0.1242325746 7.368046e-01 8.271763e-01 7 5777487 5777628 142 - 0.769 0.674 -0.389
ENSG00000011275 E039 0.0000000       7 5779985 5780292 308 -      
ENSG00000011275 E040 59.7849038 0.0075463840 2.222536e-05 1.363424e-04 7 5781541 5781696 156 - 1.905 1.650 -0.863