ENSG00000011258

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000415868 ENSG00000011258 HEK293_OSMI2_2hA HEK293_TMG_2hB MBTD1 protein_coding protein_coding 6.406555 1.774386 10.25143 0.0414176 0.4504223 2.523732 2.7260577 1.0297557 3.205111 0.276826 0.6986653 1.628624 0.52296667 0.5769667 0.3080333 -0.2689333 2.853305e-01 1.655455e-05 FALSE TRUE
ENST00000586178 ENSG00000011258 HEK293_OSMI2_2hA HEK293_TMG_2hB MBTD1 protein_coding protein_coding 6.406555 1.774386 10.25143 0.0414176 0.4504223 2.523732 1.1855861 0.2573885 2.616512 0.144343 0.4936500 3.296139 0.13900417 0.1490000 0.2600333 0.1110333 6.436632e-01 1.655455e-05 FALSE TRUE
MSTRG.14697.2 ENSG00000011258 HEK293_OSMI2_2hA HEK293_TMG_2hB MBTD1 protein_coding   6.406555 1.774386 10.25143 0.0414176 0.4504223 2.523732 0.7659540 0.2684053 1.727507 0.202621 0.3972021 2.641760 0.12590000 0.1499000 0.1701000 0.0202000 7.804220e-01 1.655455e-05 FALSE TRUE
MSTRG.14697.9 ENSG00000011258 HEK293_OSMI2_2hA HEK293_TMG_2hB MBTD1 protein_coding   6.406555 1.774386 10.25143 0.0414176 0.4504223 2.523732 0.5398321 0.0000000 1.121865 0.000000 0.1608447 6.822558 0.05409167 0.0000000 0.1091667 0.1091667 1.655455e-05 1.655455e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000011258 E001 1.1395190 0.1720736954 1.145706e-03 4.456617e-03 17 51177425 51177426 2 - 0.053 0.714 5.005
ENSG00000011258 E002 107.5533540 0.0186184936 8.053464e-13 2.008299e-11 17 51177427 51178117 691 - 1.755 2.308 1.857
ENSG00000011258 E003 100.6150730 0.0018774246 1.782510e-08 2.097070e-07 17 51178118 51178448 331 - 1.814 2.112 1.002
ENSG00000011258 E004 165.4928944 0.0002402605 1.256062e-03 4.830047e-03 17 51178449 51179652 1204 - 2.060 2.217 0.526
ENSG00000011258 E005 65.2647056 0.0005227373 9.026001e-01 9.419752e-01 17 51179653 51180095 443 - 1.682 1.726 0.150
ENSG00000011258 E006 46.2661467 0.0005884059 3.185316e-01 4.614968e-01 17 51180096 51180450 355 - 1.521 1.637 0.396
ENSG00000011258 E007 50.3764942 0.0004950448 2.574350e-04 1.206230e-03 17 51180451 51180694 244 - 1.612 1.392 -0.755
ENSG00000011258 E008 2.7409369 0.0059571077 1.433024e-01 2.525112e-01 17 51191584 51192105 522 - 0.408 0.706 1.387
ENSG00000011258 E009 1.4749052 0.1198100169 2.142307e-01 3.435188e-01 17 51192106 51192202 97 - 0.250 0.540 1.664
ENSG00000011258 E010 39.1878773 0.0005236365 7.032093e-03 2.130853e-02 17 51192203 51192252 50 - 1.499 1.330 -0.583
ENSG00000011258 E011 34.2168333 0.0005736000 1.813970e-03 6.643813e-03 17 51192253 51192280 28 - 1.447 1.217 -0.803
ENSG00000011258 E012 2.5873478 0.0058054369 6.814733e-01 7.851456e-01 17 51192281 51192656 376 - 0.470 0.420 -0.257
ENSG00000011258 E013 0.8878743 0.0131305476 3.557354e-01 5.000780e-01 17 51192657 51192657 1 - 0.250 0.000 -10.603
ENSG00000011258 E014 1.8520211 0.0077162921 4.790969e-01 6.175058e-01 17 51192658 51192781 124 - 0.385 0.259 -0.809
ENSG00000011258 E015 61.8610372 0.0004092439 2.664104e-03 9.264921e-03 17 51192782 51193016 235 - 1.688 1.547 -0.482
ENSG00000011258 E016 24.1252131 0.0008736285 3.374507e-01 4.813498e-01 17 51193428 51193510 83 - 1.280 1.238 -0.147
ENSG00000011258 E017 30.1577208 0.0006334171 1.323835e-01 2.374045e-01 17 51195214 51195361 148 - 1.378 1.296 -0.286
ENSG00000011258 E018 30.9424947 0.0006724150 5.932339e-02 1.254802e-01 17 51201592 51201696 105 - 1.394 1.277 -0.407
ENSG00000011258 E019 24.4688342 0.0014425169 7.968528e-02 1.590607e-01 17 51202022 51202077 56 - 1.298 1.172 -0.443
ENSG00000011258 E020 52.9613681 0.0099494255 3.218143e-03 1.090913e-02 17 51202701 51202935 235 - 1.629 1.420 -0.718
ENSG00000011258 E021 28.8175575 0.0006976666 8.556037e-04 3.457437e-03 17 51203140 51203228 89 - 1.380 1.094 -1.010
ENSG00000011258 E022 33.1759747 0.0006253544 7.137297e-04 2.947829e-03 17 51203791 51203925 135 - 1.437 1.172 -0.928
ENSG00000011258 E023 29.9576723 0.0006850319 2.364548e-03 8.351321e-03 17 51206888 51207005 118 - 1.392 1.148 -0.858
ENSG00000011258 E024 2.9477367 0.1684773582 8.643868e-01 9.165812e-01 17 51209314 51209430 117 - 0.488 0.541 0.256
ENSG00000011258 E025 23.2884083 0.0058359087 8.263498e-03 2.445169e-02 17 51217334 51217413 80 - 1.289 1.033 -0.912
ENSG00000011258 E026 12.1407798 0.0374780368 1.534015e-01 2.663012e-01 17 51217414 51217416 3 - 1.025 0.826 -0.749
ENSG00000011258 E027 31.0971264 0.0025333401 2.274148e-02 5.721640e-02 17 51218930 51219044 115 - 1.401 1.238 -0.567
ENSG00000011258 E028 3.3946831 0.0046335420 9.576648e-02 1.840457e-01 17 51220324 51220329 6 - 0.586 0.259 -1.810
ENSG00000011258 E029 32.1727000 0.0007509223 1.250173e-03 4.810624e-03 17 51220330 51220463 134 - 1.425 1.172 -0.885
ENSG00000011258 E030 35.6471771 0.0005652879 2.322477e-02 5.821310e-02 17 51225008 51225182 175 - 1.454 1.313 -0.486
ENSG00000011258 E031 14.4787326 0.0025889553 3.313587e-01 4.749639e-01 17 51225183 51225183 1 - 1.071 0.999 -0.265
ENSG00000011258 E032 16.2587475 0.0028422353 1.511019e-01 2.631652e-01 17 51225184 51225209 26 - 1.125 0.999 -0.460
ENSG00000011258 E033 0.0000000       17 51225210 51225224 15 -      
ENSG00000011258 E034 2.4441627 0.0081355873 3.186958e-01 4.616605e-01 17 51254671 51254811 141 - 0.408 0.629 1.063
ENSG00000011258 E035 0.5997190 0.1538349294 6.820755e-01 7.856084e-01 17 51256307 51256829 523 - 0.182 0.000 -9.432
ENSG00000011258 E036 17.5864158 0.0074414604 2.363335e-01 3.699211e-01 17 51259143 51259206 64 - 1.158 1.064 -0.336
ENSG00000011258 E037 10.9998024 0.0015516135 1.953788e-03 7.083193e-03 17 51259835 51260119 285 - 1.010 0.537 -1.915
ENSG00000011258 E038 19.8711020 0.0117866672 1.151495e-01 2.130654e-01 17 51260120 51260504 385 - 1.210 1.066 -0.517