ENSG00000011243

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397410 ENSG00000011243 HEK293_OSMI2_2hA HEK293_TMG_2hB AKAP8L protein_coding protein_coding 68.01582 94.93731 49.92121 1.342547 0.8214248 -0.9271854 49.823938 74.641727 34.142045 1.9136583 0.8039140 -1.128204 0.71592917 0.7860 0.68460000 -0.10140000 0.01419208 2.392804e-09 FALSE TRUE
ENST00000681744 ENSG00000011243 HEK293_OSMI2_2hA HEK293_TMG_2hB AKAP8L protein_coding retained_intron 68.01582 94.93731 49.92121 1.342547 0.8214248 -0.9271854 3.766158 3.587392 2.994401 0.3374654 0.1747825 -0.259874 0.05935833 0.0379 0.05993333 0.02203333 0.04102172 2.392804e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000011243 E001 0.5180316 0.0217414411 2.940931e-01 4.351786e-01 19 15380050 15380050 1 - 0.000 0.219 10.298
ENSG00000011243 E002 11.0823906 0.0015882312 2.445757e-01 3.795480e-01 19 15380051 15380065 15 - 1.117 0.999 -0.430
ENSG00000011243 E003 11.0823906 0.0015882312 2.445757e-01 3.795480e-01 19 15380066 15380071 6 - 1.117 0.999 -0.430
ENSG00000011243 E004 13.9805409 0.0012290592 1.753507e-01 2.951259e-01 19 15380072 15380072 1 - 1.217 1.093 -0.444
ENSG00000011243 E005 29.1136918 0.0059010402 1.676324e-02 4.441539e-02 19 15380073 15380085 13 - 1.548 1.369 -0.616
ENSG00000011243 E006 655.0103549 0.0010024906 2.229727e-06 1.716716e-05 19 15380086 15380430 345 - 2.687 2.792 0.348
ENSG00000011243 E007 389.3262018 0.0027546093 4.672022e-05 2.651430e-04 19 15380517 15380525 9 - 2.437 2.574 0.458
ENSG00000011243 E008 628.7830429 0.0014007859 1.782196e-09 2.520956e-08 19 15380526 15380612 87 - 2.636 2.785 0.494
ENSG00000011243 E009 23.6956417 0.0127515454 2.658750e-01 4.039756e-01 19 15380864 15382049 1186 - 1.265 1.380 0.399
ENSG00000011243 E010 527.9774074 0.0007006646 1.202690e-07 1.203496e-06 19 15397150 15397203 54 - 2.586 2.703 0.389
ENSG00000011243 E011 521.5841181 0.0001575357 5.208126e-09 6.774211e-08 19 15397204 15397280 77 - 2.587 2.697 0.364
ENSG00000011243 E012 7.0749589 0.0024311184 3.540365e-01 4.983146e-01 19 15397281 15397320 40 - 0.766 0.891 0.488
ENSG00000011243 E013 751.7612140 0.0009185078 3.769690e-05 2.186907e-04 19 15397520 15397625 106 - 2.763 2.849 0.288
ENSG00000011243 E014 801.9033265 0.0003140495 1.621301e-07 1.581864e-06 19 15397714 15397855 142 - 2.790 2.876 0.288
ENSG00000011243 E015 113.3812986 0.0263700317 1.710191e-02 4.516996e-02 19 15397856 15398562 707 - 2.144 1.942 -0.677
ENSG00000011243 E016 21.5195921 0.0261256884 6.479865e-03 1.987165e-02 19 15398563 15398629 67 - 1.485 1.197 -1.004
ENSG00000011243 E017 62.7553453 0.0128272756 4.929274e-02 1.079118e-01 19 15398630 15398703 74 - 1.852 1.708 -0.487
ENSG00000011243 E018 45.8073275 0.0055416122 3.746483e-02 8.633709e-02 19 15398704 15398731 28 - 1.710 1.576 -0.456
ENSG00000011243 E019 44.1827230 0.0008978551 8.866635e-03 2.594861e-02 19 15398732 15398766 35 - 1.702 1.557 -0.494
ENSG00000011243 E020 94.0437879 0.0041912663 2.260949e-06 1.738211e-05 19 15398767 15399301 535 - 2.077 1.849 -0.768
ENSG00000011243 E021 676.0608223 0.0002865642 3.357408e-06 2.487002e-05 19 15399302 15399410 109 - 2.721 2.802 0.272
ENSG00000011243 E022 29.7781319 0.0398264987 7.518362e-05 4.051114e-04 19 15399411 15399831 421 - 1.722 1.254 -1.607
ENSG00000011243 E023 13.0176019 0.0275596973 3.074555e-05 1.824708e-04 19 15399832 15399934 103 - 1.401 0.902 -1.789
ENSG00000011243 E024 8.4106668 0.0408790257 3.865261e-04 1.722645e-03 19 15399935 15399984 50 - 1.229 0.731 -1.865
ENSG00000011243 E025 20.9892811 0.0010837204 9.165019e-06 6.145272e-05 19 15399985 15400294 310 - 1.505 1.170 -1.166
ENSG00000011243 E026 572.1255537 0.0005574054 9.843794e-02 1.881336e-01 19 15400295 15400358 64 - 2.683 2.718 0.117
ENSG00000011243 E027 2.2455145 0.0067351908 9.827397e-01 9.932729e-01 19 15400359 15400399 41 - 0.468 0.473 0.026
ENSG00000011243 E028 3.4840354 0.0191783949 8.205164e-01 8.867992e-01 19 15400400 15400793 394 - 0.591 0.631 0.175
ENSG00000011243 E029 590.9966869 0.0001409608 8.981052e-01 9.389757e-01 19 15400794 15400864 71 - 2.723 2.723 0.002
ENSG00000011243 E030 428.6485293 0.0012573578 9.090742e-01 9.462454e-01 19 15400947 15400967 21 - 2.580 2.586 0.020
ENSG00000011243 E031 582.3032384 0.0005938147 9.267640e-01 9.579059e-01 19 15400968 15401043 76 - 2.714 2.718 0.015
ENSG00000011243 E032 639.8091720 0.0001328357 4.274796e-01 5.703311e-01 19 15401150 15401293 144 - 2.765 2.755 -0.033
ENSG00000011243 E033 416.0695466 0.0008397531 5.021540e-01 6.382394e-01 19 15401294 15401380 87 - 2.556 2.573 0.058
ENSG00000011243 E034 287.4210667 0.0031787866 3.195411e-01 4.626232e-01 19 15401381 15401430 50 - 2.381 2.418 0.124
ENSG00000011243 E035 268.3584567 0.0047998506 9.788768e-01 9.908456e-01 19 15401431 15401444 14 - 2.379 2.380 0.002
ENSG00000011243 E036 261.5263292 0.0048872925 7.600670e-01 8.442679e-01 19 15401445 15401452 8 - 2.377 2.366 -0.036
ENSG00000011243 E037 434.2425450 0.0027873624 8.846590e-01 9.302610e-01 19 15401453 15401539 87 - 2.583 2.590 0.021
ENSG00000011243 E038 395.9858145 0.0009184572 9.560707e-02 1.838009e-01 19 15401540 15401603 64 - 2.575 2.537 -0.127
ENSG00000011243 E039 20.7895961 0.0235398940 8.414559e-05 4.476840e-04 19 15401604 15403318 1715 - 1.548 1.131 -1.457
ENSG00000011243 E040 5.0248679 0.0037152419 9.085352e-01 9.458944e-01 19 15403319 15403474 156 - 0.729 0.748 0.077
ENSG00000011243 E041 500.4066980 0.0017497493 4.019330e-02 9.139521e-02 19 15403475 15403555 81 - 2.687 2.634 -0.174
ENSG00000011243 E042 533.4430834 0.0011331913 5.915271e-04 2.502356e-03 19 15403556 15403652 97 - 2.732 2.656 -0.253
ENSG00000011243 E043 271.9878591 0.0007615443 3.483750e-04 1.573606e-03 19 15403653 15403657 5 - 2.451 2.360 -0.303
ENSG00000011243 E044 451.3791843 0.0010973558 4.001445e-05 2.306242e-04 19 15403658 15403715 58 - 2.672 2.578 -0.314
ENSG00000011243 E045 11.8550664 0.0015743365 7.458526e-07 6.368000e-06 19 15403716 15403805 90 - 1.348 0.879 -1.697
ENSG00000011243 E046 21.6747523 0.0033043338 2.194113e-14 6.863741e-13 19 15403806 15404009 204 - 1.644 1.061 -2.037
ENSG00000011243 E047 414.8969534 0.0002710562 5.284478e-13 1.355074e-11 19 15404010 15404042 33 - 2.666 2.528 -0.460
ENSG00000011243 E048 1.0631447 0.0120482403 6.931567e-02 1.422267e-01 19 15404161 15404285 125 - 0.000 0.364 13.228
ENSG00000011243 E049 508.6573815 0.0002489448 2.027659e-13 5.518372e-12 19 15410520 15410594 75 - 2.747 2.618 -0.427
ENSG00000011243 E050 0.8104533 0.0149119682 6.734571e-01 7.791511e-01 19 15417635 15417698 64 - 0.294 0.219 -0.560
ENSG00000011243 E051 372.4556079 0.0001877263 4.934470e-11 9.178406e-10 19 15418911 15419058 148 - 2.612 2.482 -0.431
ENSG00000011243 E052 2.9475303 0.0122520799 1.850933e-01 3.076044e-01 19 15419059 15419141 83 - 0.688 0.474 -0.970