ENSG00000011143

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313863 ENSG00000011143 HEK293_OSMI2_2hA HEK293_TMG_2hB MKS1 protein_coding protein_coding 28.06426 31.36207 22.00568 1.042441 0.7867299 -0.5109493 1.393405 2.245765 1.255181 0.1048700 0.2195407 -0.8342730 0.05025833 0.07156667 0.05783333 -0.01373333 0.67069264 7.55212e-10 FALSE TRUE
ENST00000393119 ENSG00000011143 HEK293_OSMI2_2hA HEK293_TMG_2hB MKS1 protein_coding protein_coding 28.06426 31.36207 22.00568 1.042441 0.7867299 -0.5109493 7.860727 9.828910 3.268679 0.3806381 0.6348197 -1.5853836 0.26971250 0.31483333 0.15086667 -0.16396667 0.03244522 7.55212e-10 FALSE TRUE
ENST00000393120 ENSG00000011143 HEK293_OSMI2_2hA HEK293_TMG_2hB MKS1 protein_coding nonsense_mediated_decay 28.06426 31.36207 22.00568 1.042441 0.7867299 -0.5109493 1.461405 1.439296 2.042559 0.2425810 0.5003646 0.5020715 0.05424583 0.04560000 0.09146667 0.04586667 0.12654183 7.55212e-10 FALSE TRUE
ENST00000585134 ENSG00000011143 HEK293_OSMI2_2hA HEK293_TMG_2hB MKS1 protein_coding protein_coding 28.06426 31.36207 22.00568 1.042441 0.7867299 -0.5109493 4.637433 4.878678 3.903743 0.6651992 0.4374851 -0.3208955 0.16858333 0.15456667 0.17650000 0.02193333 0.76020901 7.55212e-10 FALSE TRUE
ENST00000677416 ENSG00000011143 HEK293_OSMI2_2hA HEK293_TMG_2hB MKS1 protein_coding retained_intron 28.06426 31.36207 22.00568 1.042441 0.7867299 -0.5109493 2.313307 1.567979 2.187290 0.2225138 0.1484442 0.4776475 0.08379167 0.05046667 0.09953333 0.04906667 0.02415911 7.55212e-10 TRUE TRUE
ENST00000678463 ENSG00000011143 HEK293_OSMI2_2hA HEK293_TMG_2hB MKS1 protein_coding protein_coding 28.06426 31.36207 22.00568 1.042441 0.7867299 -0.5109493 4.057533 5.309781 2.993210 0.1617898 0.5325891 -0.8248613 0.14382083 0.16976667 0.13466667 -0.03510000 0.47491536 7.55212e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000011143 E001 165.3544345 0.0075754459 3.123051e-02 7.434831e-02 17 58205441 58205739 299 - 2.114 2.230 0.387
ENSG00000011143 E002 71.1750088 0.0235182163 4.402547e-01 5.819288e-01 17 58205740 58205740 1 - 1.780 1.857 0.259
ENSG00000011143 E003 174.0320993 0.0044014316 1.146320e-02 3.226512e-02 17 58205741 58205887 147 - 2.137 2.252 0.382
ENSG00000011143 E004 238.8373101 0.0015723533 4.972151e-05 2.803867e-04 17 58205888 58206170 283 - 2.263 2.391 0.428
ENSG00000011143 E005 131.0942595 0.0099112667 2.128165e-02 5.417993e-02 17 58206283 58206380 98 - 1.994 2.140 0.488
ENSG00000011143 E006 10.4623316 0.0745868663 1.838297e-01 3.060199e-01 17 58206381 58206464 84 - 1.150 0.978 -0.626
ENSG00000011143 E007 77.8457587 0.0057180272 7.694792e-02 1.546108e-01 17 58206465 58206547 83 - 1.800 1.907 0.361
ENSG00000011143 E008 53.1067666 0.0033823720 4.701478e-08 5.099220e-07 17 58206548 58207084 537 - 1.880 1.586 -0.996
ENSG00000011143 E009 135.8685698 0.0004314891 5.099469e-01 6.452098e-01 17 58207085 58207218 134 - 2.094 2.120 0.088
ENSG00000011143 E010 17.6400032 0.0010587910 2.055278e-05 1.271483e-04 17 58207219 58207373 155 - 1.442 1.106 -1.180
ENSG00000011143 E011 14.8784411 0.0011746077 5.435960e-04 2.323144e-03 17 58207374 58207560 187 - 1.354 1.061 -1.037
ENSG00000011143 E012 4.8872657 0.0043010937 6.566123e-04 2.739939e-03 17 58207561 58207561 1 - 0.995 0.544 -1.827
ENSG00000011143 E013 5.2559599 0.0068795649 8.398942e-04 3.401283e-03 17 58207562 58207565 4 - 1.013 0.575 -1.757
ENSG00000011143 E014 45.2070583 0.0170652785 3.009822e-01 4.427600e-01 17 58207566 58207729 164 - 1.692 1.618 -0.252
ENSG00000011143 E015 68.4793050 0.0004372190 3.927318e-01 5.366396e-01 17 58207730 58207893 164 - 1.842 1.810 -0.109
ENSG00000011143 E016 178.9495833 0.0004175924 3.285273e-02 7.751424e-02 17 58207894 58208001 108 - 2.182 2.248 0.221
ENSG00000011143 E017 128.1131741 0.0002366530 2.057304e-01 3.333333e-01 17 58208105 58208140 36 - 2.053 2.100 0.156
ENSG00000011143 E018 136.9938404 0.0003434827 1.421552e-01 2.509703e-01 17 58208141 58208174 34 - 2.077 2.129 0.175
ENSG00000011143 E019 7.6935068 0.0344948067 2.018800e-01 3.285446e-01 17 58208175 58208250 76 - 1.013 0.836 -0.668
ENSG00000011143 E020 5.3423781 0.0030194635 4.502740e-05 2.564965e-04 17 58208251 58208512 262 - 1.063 0.544 -2.079
ENSG00000011143 E021 175.3710466 0.0002717714 7.498736e-02 1.515143e-01 17 58208513 58208583 71 - 2.182 2.237 0.186
ENSG00000011143 E022 6.6853646 0.0600417923 1.551416e-01 2.685787e-01 17 58208654 58208893 240 - 0.682 0.945 1.034
ENSG00000011143 E023 6.1394119 0.0093478215 5.174196e-01 6.518133e-01 17 58208968 58210658 1691 - 0.890 0.812 -0.302
ENSG00000011143 E024 159.7602782 0.0004799795 1.484690e-02 4.014702e-02 17 58210659 58210724 66 - 2.124 2.203 0.267
ENSG00000011143 E025 8.5810944 0.0020413809 6.232158e-03 1.922373e-02 17 58210725 58210979 255 - 1.136 0.845 -1.079
ENSG00000011143 E026 124.7455700 0.0008812202 3.621701e-03 1.207267e-02 17 58210980 58211022 43 - 1.994 2.104 0.367
ENSG00000011143 E027 16.7683578 0.0344049046 8.427065e-07 7.112863e-06 17 58211023 58211715 693 - 1.520 0.923 -2.125
ENSG00000011143 E028 1.4907137 0.0239819078 6.750660e-04 2.807913e-03 17 58211730 58211756 27 - 0.682 0.097 -3.929
ENSG00000011143 E029 1.1919493 0.0253149479 3.847518e-03 1.271412e-02 17 58211757 58211759 3 - 0.598 0.097 -3.567
ENSG00000011143 E030 1.4133945 0.0184424434 1.468738e-02 3.978380e-02 17 58211760 58211761 2 - 0.598 0.176 -2.564
ENSG00000011143 E031 1.5950989 0.0109652255 3.704314e-02 8.555263e-02 17 58211762 58211765 4 - 0.598 0.243 -1.979
ENSG00000011143 E032 11.8572103 0.0014729155 2.802419e-09 3.826653e-08 17 58211766 58212377 612 - 1.377 0.813 -2.052
ENSG00000011143 E033 148.1264001 0.0003072738 6.144877e-03 1.899130e-02 17 58212378 58212434 57 - 2.083 2.174 0.303
ENSG00000011143 E034 1.9865846 0.0073623959 3.264122e-05 1.924792e-04 17 58212435 58212981 547 - 0.784 0.097 -4.340
ENSG00000011143 E035 194.7793921 0.0010845656 1.903404e-01 3.141967e-01 17 58212982 58213090 109 - 2.236 2.280 0.145
ENSG00000011143 E036 0.8450104 0.0159933670 3.038689e-01 4.458527e-01 17 58213091 58213764 674 - 0.356 0.177 -1.339
ENSG00000011143 E037 173.4861657 0.0031566592 5.043628e-01 6.402612e-01 17 58213765 58213858 94 - 2.197 2.225 0.094
ENSG00000011143 E038 91.2851756 0.0033858970 9.868443e-01 9.958387e-01 17 58213859 58213869 11 - 1.939 1.944 0.018
ENSG00000011143 E039 0.6998377 0.0177042927 6.003303e-01 7.215685e-01 17 58213870 58214258 389 - 0.266 0.177 -0.754
ENSG00000011143 E040 150.3011761 0.0004968542 8.287170e-03 2.451025e-02 17 58214259 58214344 86 - 2.205 2.130 -0.253
ENSG00000011143 E041 111.9995516 0.0029219156 9.065815e-02 1.761638e-01 17 58214345 58214387 43 - 2.072 2.006 -0.223
ENSG00000011143 E042 3.7537223 0.0154870671 3.536995e-04 1.594487e-03 17 58214388 58214740 353 - 0.935 0.399 -2.340
ENSG00000011143 E043 147.5601037 0.0026857041 3.077327e-01 4.499666e-01 17 58214741 58214838 98 - 2.170 2.135 -0.116
ENSG00000011143 E044 7.6944794 0.0036969613 2.772963e-02 6.747798e-02 17 58214839 58214898 60 - 1.064 0.814 -0.940
ENSG00000011143 E045 6.7776402 0.0024733621 4.164106e-04 1.837333e-03 17 58214899 58215300 402 - 1.094 0.677 -1.604
ENSG00000011143 E046 4.5287131 0.0034512125 6.896425e-03 2.095507e-02 17 58215301 58215444 144 - 0.935 0.574 -1.468
ENSG00000011143 E047 3.6503933 0.0041405304 8.915884e-04 3.584727e-03 17 58215445 58215464 20 - 0.913 0.440 -2.038
ENSG00000011143 E048 20.5890836 0.0430735829 2.669302e-02 6.535168e-02 17 58215465 58216087 623 - 1.468 1.218 -0.870
ENSG00000011143 E049 213.6977935 0.0019137125 1.550347e-01 2.684624e-01 17 58216088 58216243 156 - 2.332 2.290 -0.139
ENSG00000011143 E050 1.6733605 0.1328294826 2.967408e-01 4.380031e-01 17 58216244 58216665 422 - 0.550 0.347 -1.058
ENSG00000011143 E051 166.7760734 0.0002235795 2.079736e-03 7.471455e-03 17 58216666 58216736 71 - 2.251 2.169 -0.273
ENSG00000011143 E052 170.9223174 0.0015239439 2.956356e-03 1.013340e-02 17 58218620 58218729 110 - 2.267 2.173 -0.313
ENSG00000011143 E053 1.3015312 0.0209452393 4.604676e-01 6.005100e-01 17 58219148 58219150 3 - 0.430 0.301 -0.758
ENSG00000011143 E054 112.5629133 0.0043422698 6.853004e-02 1.409322e-01 17 58219151 58219255 105 - 2.079 1.997 -0.274
ENSG00000011143 E055 0.0000000       17 58219462 58219605 144 -