ENSG00000011114

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334746 ENSG00000011114 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD7 protein_coding protein_coding 8.186052 4.406735 12.99249 0.5016825 0.7668277 1.557736 1.477164 0.2559633 2.701022 0.1120442 0.1740903 3.3495379 0.15012917 0.0575000 0.20960000 0.15210000 4.970851e-03 1.736126e-10 FALSE TRUE
ENST00000355125 ENSG00000011114 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD7 protein_coding nonsense_mediated_decay 8.186052 4.406735 12.99249 0.5016825 0.7668277 1.557736 4.137814 3.3707263 4.944424 0.4574640 0.2227895 0.5513842 0.56531667 0.7622667 0.38210000 -0.38016667 1.736126e-10 1.736126e-10 FALSE TRUE
ENST00000553975 ENSG00000011114 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD7 protein_coding protein_coding 8.186052 4.406735 12.99249 0.5016825 0.7668277 1.557736 0.371626 0.0000000 1.266115 0.0000000 0.1027317 6.9956143 0.03095417 0.0000000 0.09863333 0.09863333 3.449476e-09 1.736126e-10 FALSE TRUE
ENST00000555525 ENSG00000011114 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD7 protein_coding protein_coding 8.186052 4.406735 12.99249 0.5016825 0.7668277 1.557736 1.510897 0.5338068 2.913776 0.0545595 0.2923214 2.4266668 0.17645417 0.1218000 0.22340000 0.10160000 8.978043e-03 1.736126e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000011114 E001 721.8467260 0.0055314116 9.808469e-27 1.234674e-24 14 93237550 93242032 4483 - 2.673 3.046 1.241
ENSG00000011114 E002 27.6426954 0.0111333694 3.342606e-01 4.779942e-01 14 93242033 93242037 5 - 1.347 1.557 0.723
ENSG00000011114 E003 86.9995154 0.0039477849 3.228139e-01 4.661539e-01 14 93242038 93242379 342 - 1.874 1.952 0.262
ENSG00000011114 E004 38.4239183 0.0083181565 2.067600e-01 3.346725e-01 14 93242380 93242435 56 - 1.541 1.572 0.106
ENSG00000011114 E005 143.9989909 0.0002377469 2.800863e-05 1.677357e-04 14 93242436 93243088 653 - 2.113 2.110 -0.011
ENSG00000011114 E006 80.8126157 0.0030242010 6.356362e-02 1.326278e-01 14 93245825 93246286 462 - 1.854 1.892 0.126
ENSG00000011114 E007 40.3560590 0.0112331255 4.457588e-01 5.872945e-01 14 93248476 93248654 179 - 1.548 1.608 0.203
ENSG00000011114 E008 56.2634700 0.0004438234 5.907323e-05 3.268949e-04 14 93251463 93251652 190 - 1.728 1.643 -0.288
ENSG00000011114 E009 53.5056253 0.0004263582 2.846450e-06 2.141586e-05 14 93253647 93253790 144 - 1.718 1.588 -0.443
ENSG00000011114 E010 2.5734027 0.1027699187 3.847125e-01 5.288632e-01 14 93255510 93257194 1685 - 0.545 0.441 -0.513
ENSG00000011114 E011 61.3172992 0.0083418463 4.364749e-07 3.905392e-06 14 93257195 93257355 161 - 1.797 1.565 -0.786
ENSG00000011114 E012 40.8333034 0.0225274041 1.851254e-02 4.825792e-02 14 93261602 93261677 76 - 1.600 1.489 -0.383
ENSG00000011114 E013 51.7762413 0.0099309756 2.736122e-06 2.066622e-05 14 93263785 93263993 209 - 1.726 1.490 -0.803
ENSG00000011114 E014 4.2740300 0.0104589892 3.215196e-01 4.647779e-01 14 93287628 93287671 44 - 0.588 0.839 1.037
ENSG00000011114 E015 48.0898122 0.0016685969 4.467394e-01 5.882102e-01 14 93287672 93288707 1036 - 1.586 1.756 0.575
ENSG00000011114 E016 0.7342825 0.0168425062 1.340354e-01 2.397564e-01 14 93288708 93288730 23 - 0.278 0.000 -10.101
ENSG00000011114 E017 130.9905668 0.0077616982 6.500739e-10 9.987393e-09 14 93293858 93294617 760 - 2.119 1.898 -0.741
ENSG00000011114 E018 69.5738601 0.0004998782 1.471868e-17 7.061054e-16 14 93294618 93294852 235 - 1.865 1.539 -1.106
ENSG00000011114 E019 37.1995265 0.0006481106 2.459065e-11 4.807662e-10 14 93294853 93294937 85 - 1.604 1.243 -1.249
ENSG00000011114 E020 42.1523564 0.0005235499 9.919455e-10 1.472274e-08 14 93295970 93296157 188 - 1.645 1.369 -0.947
ENSG00000011114 E021 0.0000000       14 93296158 93296158 1 -      
ENSG00000011114 E022 2.1005493 0.0068189334 4.159261e-02 9.398708e-02 14 93324768 93324865 98 - 0.523 0.201 -1.989
ENSG00000011114 E023 0.5202097 0.0215103774 8.771882e-01 9.251224e-01 14 93332304 93332346 43 - 0.133 0.201 0.714
ENSG00000011114 E024 19.6929632 0.0539614190 2.902877e-02 7.006514e-02 14 93332820 93334778 1959 - 1.310 1.112 -0.701