ENSG00000011105

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000011898 ENSG00000011105 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN9 protein_coding protein_coding 12.90895 16.65823 11.62969 0.8358408 0.6334278 -0.5180479 7.137202 8.510015 5.410462 0.7023056 0.6387053 -0.6524402 0.54850833 0.5092000 0.4722333 -0.03696667 8.782602e-01 3.455523e-30 FALSE TRUE
ENST00000537971 ENSG00000011105 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN9 protein_coding protein_coding 12.90895 16.65823 11.62969 0.8358408 0.6334278 -0.5180479 3.186988 5.001784 2.486692 0.3976976 0.4649096 -1.0053063 0.24276250 0.3044000 0.2111333 -0.09326667 3.347375e-01 3.455523e-30 FALSE TRUE
ENST00000649909 ENSG00000011105 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN9 protein_coding protein_coding 12.90895 16.65823 11.62969 0.8358408 0.6334278 -0.5180479 1.365531 0.000000 3.042158 0.0000000 0.4659585 8.2536860 0.12014167 0.0000000 0.2589333 0.25893333 3.455523e-30 3.455523e-30 FALSE FALSE
MSTRG.6631.5 ENSG00000011105 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN9 protein_coding   12.90895 16.65823 11.62969 0.8358408 0.6334278 -0.5180479 0.381404 2.185736 0.000000 0.4148397 0.0000000 -7.7785610 0.02467917 0.1299667 0.0000000 -0.12996667 1.076776e-16 3.455523e-30 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000011105 E001 0.5244761 0.2622181945 3.176058e-01 4.605000e-01 12 3077355 3077376 22 + 0.281 0.093 -1.941
ENSG00000011105 E002 0.6727692 0.0680704814 5.072236e-01 6.428108e-01 12 3077377 3077378 2 + 0.281 0.166 -0.962
ENSG00000011105 E003 0.8942144 0.1307072664 7.800986e-01 8.586596e-01 12 3077379 3077384 6 + 0.281 0.232 -0.364
ENSG00000011105 E004 25.2239469 0.0008083026 5.772447e-01 7.025284e-01 12 3077385 3077427 43 + 1.399 1.373 -0.089
ENSG00000011105 E005 37.2411163 0.0007260689 7.038831e-02 1.439956e-01 12 3077428 3077453 26 + 1.607 1.515 -0.316
ENSG00000011105 E006 37.7445761 0.0035494588 3.908602e-02 8.935226e-02 12 3083653 3083719 67 + 1.626 1.509 -0.400
ENSG00000011105 E007 0.4031496 0.0246226777 4.638925e-01 6.036669e-01 12 3083720 3084210 491 + 0.000 0.167 10.137
ENSG00000011105 E008 10.7462190 0.0111217955 8.065833e-02 1.605801e-01 12 3199984 3201176 1193 + 1.151 0.973 -0.648
ENSG00000011105 E009 60.1431544 0.0039460410 1.906563e-02 4.947912e-02 12 3201177 3201256 80 + 1.825 1.713 -0.380
ENSG00000011105 E010 3.0893920 0.0057261347 9.889583e-01 9.971217e-01 12 3206280 3206418 139 + 0.571 0.580 0.040
ENSG00000011105 E011 0.0000000       12 3215251 3215355 105 +      
ENSG00000011105 E012 0.1515154 0.0422098931 2.445832e-01   12 3272912 3273246 335 + 0.163 0.000 -10.965
ENSG00000011105 E013 134.3247991 0.0002498290 5.551414e-06 3.911405e-05 12 3278421 3278612 192 + 2.175 2.049 -0.422
ENSG00000011105 E014 105.4508890 0.0003071854 9.548616e-05 5.008740e-04 12 3278992 3279066 75 + 2.067 1.945 -0.412
ENSG00000011105 E015 132.4562482 0.0002790106 3.843035e-03 1.270129e-02 12 3280382 3280483 102 + 2.136 2.059 -0.257
ENSG00000011105 E016 127.4953339 0.0005727310 4.907709e-02 1.075130e-01 12 3281198 3281329 132 + 2.100 2.049 -0.171
ENSG00000011105 E017 90.1543784 0.0003141788 2.874198e-01 4.279178e-01 12 3281734 3281817 84 + 1.936 1.910 -0.089
ENSG00000011105 E018 2.1068008 0.0086610577 1.318851e-01 2.367372e-01 12 3281818 3282108 291 + 0.621 0.380 -1.184
ENSG00000011105 E019 1232.4830191 0.0005043296 2.063063e-17 9.671890e-16 12 3283045 3286564 3520 + 2.988 3.075 0.291