ENSG00000011028

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303375 ENSG00000011028 HEK293_OSMI2_2hA HEK293_TMG_2hB MRC2 protein_coding protein_coding 3.616494 5.8791 3.295441 0.3977248 0.3879921 -0.8332042 2.3096238 3.0018092 2.82744227 0.54181834 0.03862054 -0.08603935 0.66792083 0.5185333 0.87873333 0.3602000 0.1541910978 0.0006079289 FALSE TRUE
ENST00000583597 ENSG00000011028 HEK293_OSMI2_2hA HEK293_TMG_2hB MRC2 protein_coding retained_intron 3.616494 5.8791 3.295441 0.3977248 0.3879921 -0.8332042 0.6851137 2.1588557 0.04364948 0.54338734 0.04364948 -5.33722601 0.15252917 0.3604667 0.01413333 -0.3463333 0.0006079289 0.0006079289 FALSE TRUE
ENST00000584265 ENSG00000011028 HEK293_OSMI2_2hA HEK293_TMG_2hB MRC2 protein_coding retained_intron 3.616494 5.8791 3.295441 0.3977248 0.3879921 -0.8332042 0.2371341 0.2233682 0.25932811 0.07459268 0.25932811 0.20675670 0.06518750 0.0372000 0.06410000 0.0269000 0.7491308636 0.0006079289 FALSE TRUE
MSTRG.14860.2 ENSG00000011028 HEK293_OSMI2_2hA HEK293_TMG_2hB MRC2 protein_coding   3.616494 5.8791 3.295441 0.3977248 0.3879921 -0.8332042 0.2464887 0.3451476 0.00000000 0.19861582 0.00000000 -5.15034693 0.07861667 0.0560000 0.00000000 -0.0560000 0.2153534877 0.0006079289 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000011028 E001 1.1374321 0.0123977131 6.979281e-02 1.430291e-01 17 62627670 62627684 15 + 0.491 0.178 -2.053
ENSG00000011028 E002 14.3009623 0.0100553170 1.542044e-06 1.229010e-05 17 62627685 62627920 236 + 1.404 0.936 -1.674
ENSG00000011028 E003 45.0079983 0.0117313819 3.312877e-05 1.949598e-04 17 62664548 62664949 402 + 1.808 1.515 -0.995
ENSG00000011028 E004 33.2389912 0.0035582236 1.666020e-02 4.419185e-02 17 62666094 62666267 174 + 1.602 1.452 -0.515
ENSG00000011028 E005 32.1036125 0.0008011392 5.907687e-03 1.836731e-02 17 62666455 62666619 165 + 1.593 1.432 -0.553
ENSG00000011028 E006 27.6544546 0.0029019379 1.026463e-03 4.049991e-03 17 62666757 62666870 114 + 1.564 1.347 -0.750
ENSG00000011028 E007 27.5604982 0.0007425449 1.030684e-03 4.064348e-03 17 62667390 62667533 144 + 1.554 1.347 -0.715
ENSG00000011028 E008 31.7940560 0.0007301926 1.097594e-01 2.052046e-01 17 62671649 62671837 189 + 1.544 1.452 -0.316
ENSG00000011028 E009 35.5739189 0.0007190683 9.641698e-01 9.814167e-01 17 62671998 62672152 155 + 1.528 1.539 0.038
ENSG00000011028 E010 36.5525168 0.0005791503 4.009379e-01 5.446099e-01 17 62674063 62674170 108 + 1.574 1.533 -0.142
ENSG00000011028 E011 34.0976649 0.0014768775 3.704301e-02 8.555263e-02 17 62675790 62675905 116 + 1.588 1.467 -0.414
ENSG00000011028 E012 17.2651474 0.0010759757 8.240647e-03 2.439512e-02 17 62676383 62676393 11 + 1.358 1.150 -0.732
ENSG00000011028 E013 31.3345064 0.0006963579 5.053360e-02 1.101079e-01 17 62676394 62676531 138 + 1.554 1.440 -0.393
ENSG00000011028 E014 1.5143539 0.0542181588 1.163954e-02 3.267506e-02 17 62676532 62676604 73 + 0.000 0.512 12.172
ENSG00000011028 E015 33.2341500 0.0006556807 4.454395e-02 9.935968e-02 17 62677269 62677486 218 + 1.404 1.542 0.477
ENSG00000011028 E016 27.4395819 0.0007684062 1.209162e-01 2.212573e-01 17 62678504 62678617 114 + 1.342 1.459 0.406
ENSG00000011028 E017 16.6172871 0.0010960095 9.945308e-01 1.000000e+00 17 62678618 62678646 29 + 1.207 1.215 0.030
ENSG00000011028 E018 23.2538902 0.0017842790 3.502236e-01 4.944246e-01 17 62679800 62679902 103 + 1.389 1.327 -0.215
ENSG00000011028 E019 25.6517684 0.0008085573 6.705378e-02 1.384674e-01 17 62680170 62680308 139 + 1.470 1.352 -0.410
ENSG00000011028 E020 19.5278889 0.0009774101 8.726106e-02 1.709833e-01 17 62680418 62680453 36 + 1.366 1.241 -0.438
ENSG00000011028 E021 0.1451727 0.0425673450 2.944933e-01   17 62680631 62680799 169 + 0.152 0.000 -10.994
ENSG00000011028 E022 26.5558928 0.0171517326 9.684808e-02 1.856704e-01 17 62680800 62680960 161 + 1.506 1.365 -0.486
ENSG00000011028 E023 18.5241281 0.0015594892 2.239238e-01 3.550942e-01 17 62681062 62681129 68 + 1.325 1.234 -0.317
ENSG00000011028 E024 0.8417882 0.0156705525 8.972949e-01 9.384079e-01 17 62681453 62681457 5 + 0.265 0.245 -0.146
ENSG00000011028 E025 1.2051969 0.0781538166 6.459368e-01 7.579861e-01 17 62681458 62681836 379 + 0.264 0.355 0.596
ENSG00000011028 E026 24.2111008 0.0008290382 7.949600e-01 8.690299e-01 17 62681837 62681937 101 + 1.381 1.371 -0.038
ENSG00000011028 E027 2.0177265 0.0070526402 7.844992e-01 8.617410e-01 17 62682056 62682234 179 + 0.428 0.480 0.268
ENSG00000011028 E028 36.9334487 0.0006082345 6.435834e-01 7.560862e-01 17 62682235 62682377 143 + 1.528 1.564 0.122
ENSG00000011028 E029 39.4745268 0.0005917683 1.168987e-01 2.155441e-01 17 62688289 62688403 115 + 1.511 1.612 0.343
ENSG00000011028 E030 47.2849751 0.0006184630 1.287846e-01 2.324668e-01 17 62688501 62688664 164 + 1.593 1.683 0.307
ENSG00000011028 E031 19.4590977 0.0010414919 9.916152e-01 9.988596e-01 17 62688852 62688857 6 + 1.280 1.288 0.031
ENSG00000011028 E032 35.6145614 0.0126215111 6.426730e-01 7.554116e-01 17 62688858 62688960 103 + 1.500 1.553 0.182
ENSG00000011028 E033 0.6653823 0.0170722210 1.281160e-01 2.315401e-01 17 62689371 62689437 67 + 0.354 0.098 -2.316
ENSG00000011028 E034 45.8009185 0.0005430135 3.129176e-02 7.446838e-02 17 62689522 62689760 239 + 1.549 1.677 0.435
ENSG00000011028 E035 39.8070625 0.0008459907 1.141184e-02 3.214348e-02 17 62689894 62690062 169 + 1.470 1.630 0.547
ENSG00000011028 E036 34.8532002 0.0210281016 2.392717e-01 3.732558e-01 17 62690156 62690305 150 + 1.451 1.564 0.389
ENSG00000011028 E037 42.5543148 0.0284903084 1.810449e-01 3.025246e-01 17 62690642 62690761 120 + 1.516 1.653 0.464
ENSG00000011028 E038 48.2984426 0.0029248642 3.438334e-01 4.878828e-01 17 62690949 62691128 180 + 1.620 1.684 0.218
ENSG00000011028 E039 24.2456423 0.0008096569 8.490893e-01 9.063360e-01 17 62692112 62692138 27 + 1.358 1.380 0.076
ENSG00000011028 E040 196.2802872 0.0027519303 2.055954e-11 4.065703e-10 17 62692231 62693597 1367 + 2.093 2.336 0.811