ENSG00000011009

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374502 ENSG00000011009 HEK293_OSMI2_2hA HEK293_TMG_2hB LYPLA2 protein_coding protein_coding 78.7289 143.6475 40.77346 3.637806 1.742189 -1.816577 6.891301 10.75906 3.952905 0.2905403 0.3906944 -1.442262 0.0957125 0.07503333 0.0965 0.02146667 0.1316384275 2.00953e-05 FALSE TRUE
ENST00000374514 ENSG00000011009 HEK293_OSMI2_2hA HEK293_TMG_2hB LYPLA2 protein_coding protein_coding 78.7289 143.6475 40.77346 3.637806 1.742189 -1.816577 64.270406 123.61628 30.732221 2.6937864 1.1047883 -2.007692 0.7899000 0.86073333 0.7545 -0.10623333 0.0000200953 2.00953e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000011009 E001 4.529656 7.453657e-03 2.253399e-04 0.0010718313 1 23791145 23791155 11 + 1.026 0.519 -2.059
ENSG00000011009 E002 102.726660 5.603241e-03 1.121550e-01 0.2086948659 1 23791156 23791186 31 + 1.961 1.885 -0.255
ENSG00000011009 E003 184.875927 2.552293e-03 6.685902e-01 0.7755616730 1 23791187 23791202 16 + 2.154 2.149 -0.017
ENSG00000011009 E004 302.458722 4.669778e-04 2.375082e-02 0.0593033319 1 23791203 23791220 18 + 2.298 2.374 0.256
ENSG00000011009 E005 401.201058 5.266480e-04 9.444774e-02 0.1820505867 1 23791221 23791250 30 + 2.438 2.493 0.183
ENSG00000011009 E006 4.834875 7.859428e-03 3.864166e-04 0.0017222791 1 23791971 23791991 21 + 1.026 0.541 -1.958
ENSG00000011009 E007 4.502801 9.165489e-03 1.467938e-04 0.0007332869 1 23791992 23792017 26 + 1.026 0.498 -2.164
ENSG00000011009 E008 23.157857 1.195353e-03 3.963790e-05 0.0002286627 1 23792552 23792656 105 + 1.502 1.187 -1.097
ENSG00000011009 E009 632.397054 1.182299e-03 6.226661e-01 0.7394220628 1 23792657 23792760 104 + 2.660 2.686 0.084
ENSG00000011009 E010 487.528997 1.574349e-04 7.401025e-01 0.8296045089 1 23793008 23793039 32 + 2.562 2.568 0.019
ENSG00000011009 E011 606.619176 2.660030e-04 2.981096e-02 0.0715918881 1 23793151 23793216 66 + 2.685 2.657 -0.095
ENSG00000011009 E012 2.475294 3.374043e-02 1.223371e-02 0.0340959778 1 23793653 23793704 52 + 0.787 0.364 -1.968
ENSG00000011009 E013 589.167315 2.723077e-04 9.681798e-05 0.0005071440 1 23793705 23793752 48 + 2.699 2.638 -0.203
ENSG00000011009 E014 648.250400 1.669903e-03 2.151234e-01 0.3445730997 1 23793860 23793930 71 + 2.705 2.690 -0.053
ENSG00000011009 E015 526.522379 1.311509e-04 8.154035e-02 0.1619599111 1 23794063 23794091 29 + 2.619 2.598 -0.071
ENSG00000011009 E016 583.428889 1.194686e-04 2.436984e-01 0.3785312119 1 23794092 23794136 45 + 2.653 2.644 -0.030
ENSG00000011009 E017 716.347742 1.348239e-04 1.479235e-01 0.2588528190 1 23794224 23794325 102 + 2.704 2.742 0.125
ENSG00000011009 E018 55.400499 5.783989e-04 2.310334e-01 0.3637074206 1 23794326 23794426 101 + 1.679 1.621 -0.197
ENSG00000011009 E019 774.170995 9.858775e-05 6.297262e-01 0.7450366505 1 23794427 23794551 125 + 2.765 2.770 0.016
ENSG00000011009 E020 549.830131 1.476401e-04 8.459291e-02 0.1667465623 1 23794552 23794600 49 + 2.637 2.616 -0.068
ENSG00000011009 E021 77.903149 5.496404e-03 1.448468e-02 0.0393264263 1 23794601 23794681 81 + 1.888 1.756 -0.446
ENSG00000011009 E022 1995.786317 2.143039e-03 2.690145e-04 0.0012536034 1 23794682 23795539 858 + 3.105 3.196 0.305