ENSG00000010810

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229471 ENSG00000010810 HEK293_OSMI2_2hA HEK293_TMG_2hB FYN protein_coding protein_coding 37.7936 43.68781 39.83643 0.2201877 0.8799679 -0.1331107 3.383690 6.043757 3.498636 0.8650308 0.5805306 -0.7869206 0.09183750 0.13840000 0.08830000 -0.05010000 3.057721e-01 1.063641e-35 FALSE TRUE
ENST00000368667 ENSG00000010810 HEK293_OSMI2_2hA HEK293_TMG_2hB FYN protein_coding protein_coding 37.7936 43.68781 39.83643 0.2201877 0.8799679 -0.1331107 13.123274 20.312202 8.617853 1.1240206 0.4043424 -1.2359832 0.34447083 0.46516667 0.21610000 -0.24906667 6.790405e-11 1.063641e-35 FALSE TRUE
ENST00000368678 ENSG00000010810 HEK293_OSMI2_2hA HEK293_TMG_2hB FYN protein_coding protein_coding 37.7936 43.68781 39.83643 0.2201877 0.8799679 -0.1331107 5.706721 5.811119 7.084129 0.3433092 0.7102659 0.2853290 0.15011667 0.13293333 0.17826667 0.04533333 2.667236e-01 1.063641e-35 FALSE TRUE
MSTRG.28818.10 ENSG00000010810 HEK293_OSMI2_2hA HEK293_TMG_2hB FYN protein_coding   37.7936 43.68781 39.83643 0.2201877 0.8799679 -0.1331107 3.830336 4.407595 3.793083 0.5342058 0.6487009 -0.2160918 0.10015833 0.10083333 0.09533333 -0.00550000 9.338926e-01 1.063641e-35 FALSE TRUE
MSTRG.28818.11 ENSG00000010810 HEK293_OSMI2_2hA HEK293_TMG_2hB FYN protein_coding   37.7936 43.68781 39.83643 0.2201877 0.8799679 -0.1331107 3.344711 1.478794 6.193133 0.7415990 1.1561954 2.0588531 0.09127083 0.03366667 0.15583333 0.12216667 3.478003e-01 1.063641e-35 FALSE TRUE
MSTRG.28818.12 ENSG00000010810 HEK293_OSMI2_2hA HEK293_TMG_2hB FYN protein_coding   37.7936 43.68781 39.83643 0.2201877 0.8799679 -0.1331107 1.288007 0.000000 3.589465 0.0000000 0.3766654 8.4916386 0.03170000 0.00000000 0.08976667 0.08976667 1.063641e-35 1.063641e-35 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000010810 E001 31.5265326 0.0340448539 1.030965e-01 1.951902e-01 6 111660332 111661281 950 - 1.590 1.438 -0.519
ENSG00000010810 E002 4.3781244 0.0318130155 5.967018e-01 7.186072e-01 6 111661282 111661285 4 - 0.673 0.765 0.377
ENSG00000010810 E003 342.7064520 0.0024783526 1.589364e-09 2.270518e-08 6 111661286 111661556 271 - 2.395 2.593 0.661
ENSG00000010810 E004 422.6026215 0.0025352501 2.144431e-07 2.043541e-06 6 111661557 111661759 203 - 2.509 2.675 0.550
ENSG00000010810 E005 392.9766030 0.0041554091 1.016536e-04 5.295160e-04 6 111661760 111661947 188 - 2.488 2.638 0.499
ENSG00000010810 E006 0.7341808 0.0460817674 4.551326e-01 5.956907e-01 6 111674465 111674498 34 - 0.325 0.195 -0.971
ENSG00000010810 E007 338.0967691 0.0002115250 2.037048e-07 1.948955e-06 6 111674499 111674630 132 - 2.446 2.562 0.386
ENSG00000010810 E008 0.0000000       6 111676419 111676544 126 -      
ENSG00000010810 E009 401.2296199 0.0001654477 6.100091e-04 2.569582e-03 6 111694375 111694528 154 - 2.548 2.621 0.243
ENSG00000010810 E010 297.7116507 0.0016535019 1.446501e-01 2.543511e-01 6 111694628 111694700 73 - 2.434 2.486 0.173
ENSG00000010810 E011 166.8899194 0.0005875553 4.181026e-02 9.437872e-02 6 111694701 111694704 4 - 2.172 2.243 0.235
ENSG00000010810 E012 185.4448228 0.0003609844 1.282066e-01 2.316508e-01 6 111696277 111696281 5 - 2.230 2.281 0.171
ENSG00000010810 E013 220.0993056 0.0003722224 1.122395e-01 2.088110e-01 6 111696282 111696299 18 - 2.305 2.355 0.167
ENSG00000010810 E014 421.6665636 0.0009426847 5.543377e-02 1.187324e-01 6 111696300 111696456 157 - 2.584 2.636 0.175
ENSG00000010810 E015 3.5482828 0.0045748298 1.901306e-02 4.936230e-02 6 111696457 111696815 359 - 0.817 0.477 -1.478
ENSG00000010810 E016 129.4116603 0.0012769488 4.759345e-01 6.146132e-01 6 111699515 111699670 156 - 2.117 2.101 -0.053
ENSG00000010810 E017 3.6212339 0.0044476128 3.433921e-02 8.041162e-02 6 111699935 111700103 169 - 0.817 0.516 -1.287
ENSG00000010810 E018 203.7990900 0.0005619471 4.797197e-01 6.180457e-01 6 111700104 111700186 83 - 2.284 2.313 0.094
ENSG00000010810 E019 178.3037329 0.0002291674 1.154730e-01 2.135334e-01 6 111700187 111700268 82 - 2.211 2.263 0.175
ENSG00000010810 E020 5.1915217 0.0233702947 7.162111e-09 9.064942e-08 6 111702416 111702877 462 - 1.110 0.197 -4.376
ENSG00000010810 E021 1.0414660 0.0130245519 1.223960e-03 4.721460e-03 6 111702878 111702884 7 - 0.556 0.000 -13.308
ENSG00000010810 E022 317.9137694 0.0001425639 8.056734e-01 8.764650e-01 6 111702885 111703022 138 - 2.490 2.494 0.014
ENSG00000010810 E023 147.5538827 0.0003416824 7.971878e-01 8.705957e-01 6 111703023 111703034 12 - 2.148 2.164 0.055
ENSG00000010810 E024 168.6065401 0.0019520571 5.623781e-01 6.899927e-01 6 111703999 111704019 21 - 2.198 2.226 0.095
ENSG00000010810 E025 252.8787477 0.0016042778 5.387415e-01 6.701392e-01 6 111704020 111704086 67 - 2.397 2.387 -0.033
ENSG00000010810 E026 159.5404585 0.0008881032 9.108300e-02 1.768334e-01 6 111704087 111704087 1 - 2.221 2.176 -0.148
ENSG00000010810 E027 184.2605588 0.0004321186 1.338046e-02 3.680259e-02 6 111704088 111704102 15 - 2.292 2.232 -0.199
ENSG00000010810 E028 170.3228926 0.0002881959 9.337311e-04 3.732304e-03 6 111707922 111707929 8 - 2.271 2.187 -0.279
ENSG00000010810 E029 186.0054077 0.0007588809 7.656309e-03 2.291667e-02 6 111707930 111707945 16 - 2.300 2.231 -0.229
ENSG00000010810 E030 234.4000407 0.0016478984 9.864366e-02 1.884225e-01 6 111707946 111708010 65 - 2.385 2.343 -0.140
ENSG00000010810 E031 135.5993169 0.0020145771 1.259499e-01 2.285060e-01 6 111708011 111708016 6 - 2.153 2.104 -0.166
ENSG00000010810 E032 137.7819225 0.0034231088 2.051215e-01 3.325659e-01 6 111708017 111708020 4 - 2.158 2.112 -0.153
ENSG00000010810 E033 0.2998086 0.0293439907 8.335827e-01   6 111708021 111708227 207 - 0.137 0.109 -0.382
ENSG00000010810 E034 1.6543203 0.0097839923 4.899448e-02 1.073717e-01 6 111708947 111709064 118 - 0.599 0.268 -1.796
ENSG00000010810 E035 164.2570950 0.0005822356 9.633940e-02 1.848823e-01 6 111714347 111714370 24 - 2.230 2.189 -0.137
ENSG00000010810 E036 155.4134845 0.0012742917 1.490038e-01 2.603245e-01 6 111714371 111714381 11 - 2.206 2.166 -0.131
ENSG00000010810 E037 231.7904276 0.0012043966 9.800592e-03 2.827135e-02 6 111714382 111714429 48 - 2.393 2.328 -0.216
ENSG00000010810 E038 179.2364191 0.0011519887 1.606165e-02 4.287368e-02 6 111714430 111714443 14 - 2.282 2.217 -0.218
ENSG00000010810 E039 1.0287911 0.0128253749 7.339590e-01 8.250588e-01 6 111714444 111714492 49 - 0.325 0.269 -0.378
ENSG00000010810 E040 0.6330284 0.0592357877 7.823719e-01 8.602603e-01 6 111719657 111719804 148 - 0.241 0.196 -0.385
ENSG00000010810 E041 226.5318795 0.0012667069 1.829027e-02 4.776569e-02 6 111719805 111719855 51 - 2.380 2.320 -0.198
ENSG00000010810 E042 134.1673868 0.0038160782 7.380107e-02 1.495944e-01 6 111719856 111719857 2 - 2.158 2.091 -0.227
ENSG00000010810 E043 330.1134090 0.0003437513 1.462889e-06 1.172781e-05 6 111719858 111720062 205 - 2.562 2.471 -0.305
ENSG00000010810 E044 14.0484140 0.0107671740 1.390457e-01 2.467707e-01 6 111740981 111741093 113 - 1.239 1.096 -0.508
ENSG00000010810 E045 0.4449813 0.0213730122 4.147617e-01 5.581548e-01 6 111741094 111741097 4 - 0.241 0.109 -1.381
ENSG00000010810 E046 0.9974562 0.0125835217 7.312614e-01 8.229639e-01 6 111754434 111754677 244 - 0.325 0.269 -0.379
ENSG00000010810 E047 0.0000000       6 111758834 111759039 206 -      
ENSG00000010810 E048 0.0000000       6 111759040 111759131 92 -      
ENSG00000010810 E049 0.0000000       6 111759845 111759925 81 -      
ENSG00000010810 E050 139.1170427 0.0002171504 5.810936e-05 3.221728e-04 6 111780566 111780635 70 - 2.201 2.088 -0.376
ENSG00000010810 E051 0.0000000       6 111781056 111781080 25 -      
ENSG00000010810 E052 0.0000000       6 111793623 111793912 290 -      
ENSG00000010810 E053 0.0000000       6 111798355 111798423 69 -      
ENSG00000010810 E054 0.3666179 0.0306425556 8.394839e-01 8.997075e-01 6 111813892 111814107 216 - 0.137 0.109 -0.376
ENSG00000010810 E055 1.3704194 0.0191385321 4.807661e-03 1.539522e-02 6 111818615 111818740 126 - 0.599 0.109 -3.380
ENSG00000010810 E056 0.0000000       6 111819860 111820078 219 -      
ENSG00000010810 E057 0.0000000       6 111844777 111844944 168 -      
ENSG00000010810 E058 68.6831309 0.0004091059 3.020589e-07 2.793564e-06 6 111846589 111846629 41 - 1.946 1.735 -0.709
ENSG00000010810 E059 0.1482932 0.0414582610 6.259100e-01   6 111858289 111858383 95 - 0.000 0.109 9.463
ENSG00000010810 E060 92.6800205 0.0041544414 5.552093e-11 1.022482e-09 6 111872968 111873205 238 - 2.119 1.812 -1.031
ENSG00000010810 E061 20.2528980 0.0042269789 7.614369e-17 3.325310e-15 6 111873206 111873269 64 - 1.606 0.896 -2.519
ENSG00000010810 E062 35.5754011 0.0050763935 3.869996e-14 1.166708e-12 6 111873270 111873452 183 - 1.786 1.274 -1.758