ENSG00000010803

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326197 ENSG00000010803 HEK293_OSMI2_2hA HEK293_TMG_2hB SCMH1 protein_coding protein_coding 18.99845 24.93746 18.84404 0.9686795 0.2119429 -0.4040195 3.4193466 4.274928 3.4486332 0.7953900 0.3754219 -0.3090691 0.17406250 0.17240000 0.18283333 0.01043333 0.92878755 0.03983951 FALSE  
ENST00000337495 ENSG00000010803 HEK293_OSMI2_2hA HEK293_TMG_2hB SCMH1 protein_coding protein_coding 18.99845 24.93746 18.84404 0.9686795 0.2119429 -0.4040195 1.5950843 3.687550 0.4056908 1.4496651 0.4056908 -3.1529870 0.08131667 0.14830000 0.02110000 -0.12720000 0.12083853 0.03983951 FALSE  
ENST00000372597 ENSG00000010803 HEK293_OSMI2_2hA HEK293_TMG_2hB SCMH1 protein_coding protein_coding 18.99845 24.93746 18.84404 0.9686795 0.2119429 -0.4040195 1.4124048 2.129380 1.3077673 0.3337945 0.2780314 -0.6990969 0.07112917 0.08623333 0.06926667 -0.01696667 0.78104506 0.03983951 FALSE  
ENST00000482530 ENSG00000010803 HEK293_OSMI2_2hA HEK293_TMG_2hB SCMH1 protein_coding processed_transcript 18.99845 24.93746 18.84404 0.9686795 0.2119429 -0.4040195 1.3204534 1.121884 2.0180950 0.2111343 0.3975928 0.8413989 0.07179583 0.04463333 0.10750000 0.06286667 0.03983951 0.03983951 FALSE  
ENST00000695335 ENSG00000010803 HEK293_OSMI2_2hA HEK293_TMG_2hB SCMH1 protein_coding protein_coding 18.99845 24.93746 18.84404 0.9686795 0.2119429 -0.4040195 0.3566651 0.000000 1.3713169 0.0000000 0.7463171 7.1099006 0.01954167 0.00000000 0.07233333 0.07233333 0.15930556 0.03983951 FALSE  
ENST00000695336 ENSG00000010803 HEK293_OSMI2_2hA HEK293_TMG_2hB SCMH1 protein_coding protein_coding 18.99845 24.93746 18.84404 0.9686795 0.2119429 -0.4040195 1.7628379 2.576183 0.6481605 0.3848423 0.3403113 -1.9743132 0.09190833 0.10473333 0.03480000 -0.06993333 0.43269685 0.03983951 FALSE  
MSTRG.979.13 ENSG00000010803 HEK293_OSMI2_2hA HEK293_TMG_2hB SCMH1 protein_coding   18.99845 24.93746 18.84404 0.9686795 0.2119429 -0.4040195 4.7359188 5.195472 4.8254899 0.6114497 0.3896001 -0.1063668 0.25058750 0.20896667 0.25646667 0.04750000 0.56608218 0.03983951 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000010803 E001 0.1482932 0.0414638862 7.682918e-01   1 41027014 41027094 81 - 0.000 0.099 8.333
ENSG00000010803 E002 0.0000000       1 41027095 41027149 55 -      
ENSG00000010803 E003 0.3697384 0.0248595491 3.742767e-01 5.186950e-01 1 41027150 41027201 52 - 0.000 0.180 11.699
ENSG00000010803 E004 1.3994719 0.0100474825 1.204035e-02 3.362930e-02 1 41027202 41027203 2 - 0.000 0.485 13.759
ENSG00000010803 E005 9.4519293 0.0475972171 1.862265e-02 4.850291e-02 1 41027204 41027221 18 - 0.710 1.107 1.512
ENSG00000010803 E006 28.1345978 0.0209187998 4.573366e-03 1.474591e-02 1 41027222 41027246 25 - 1.223 1.529 1.065
ENSG00000010803 E007 52.1917816 0.0100771119 2.483317e-05 1.507440e-04 1 41027247 41027271 25 - 1.464 1.793 1.120
ENSG00000010803 E008 210.8882110 0.0024187514 2.019738e-07 1.933565e-06 1 41027272 41027475 204 - 2.164 2.361 0.660
ENSG00000010803 E009 128.5088685 0.0029664113 7.815130e-06 5.320945e-05 1 41027476 41027499 24 - 1.943 2.150 0.694
ENSG00000010803 E010 522.7061193 0.0017243101 5.811301e-09 7.500058e-08 1 41027500 41028156 657 - 2.588 2.742 0.515
ENSG00000010803 E011 112.7157800 0.0003432597 2.007419e-01 3.271254e-01 1 41028157 41028191 35 - 1.991 2.051 0.200
ENSG00000010803 E012 189.6660993 0.0013396263 2.939114e-01 4.349710e-01 1 41028192 41028319 128 - 2.222 2.270 0.159
ENSG00000010803 E013 141.3480250 0.0007487088 6.020861e-01 7.231010e-01 1 41028584 41028641 58 - 2.108 2.139 0.107
ENSG00000010803 E014 145.7899545 0.0002712886 8.190733e-01 8.857448e-01 1 41028642 41028711 70 - 2.128 2.150 0.072
ENSG00000010803 E015 89.3261182 0.0003501619 3.130737e-01 4.555997e-01 1 41028712 41028726 15 - 1.895 1.950 0.182
ENSG00000010803 E016 50.5667998 0.0041317619 9.240409e-01 9.561504e-01 1 41033983 41034048 66 - 1.670 1.690 0.067
ENSG00000010803 E017 2.5389803 0.0059550560 7.369286e-01 8.272409e-01 1 41034049 41034102 54 - 0.486 0.552 0.315
ENSG00000010803 E018 198.6298483 0.0002396644 1.747788e-01 2.944196e-01 1 41037362 41037541 180 - 2.242 2.293 0.169
ENSG00000010803 E019 9.8453499 0.0018185117 3.228850e-03 1.094092e-02 1 41041311 41041421 111 - 1.177 0.885 -1.071
ENSG00000010803 E020 13.4851566 0.0014474036 2.508441e-03 8.788589e-03 1 41041422 41041565 144 - 1.292 1.032 -0.929
ENSG00000010803 E021 1.3952953 0.5203248119 8.916545e-01 9.347955e-01 1 41045713 41045836 124 - 0.423 0.318 -0.607
ENSG00000010803 E022 73.2651115 0.0003790094 8.918658e-01 9.349393e-01 1 41046407 41046417 11 - 1.832 1.852 0.068
ENSG00000010803 E023 220.4858711 0.0002132973 9.779594e-01 9.903435e-01 1 41046418 41046598 181 - 2.312 2.326 0.047
ENSG00000010803 E024 0.6695470 0.0194764013 6.024288e-01 7.234117e-01 1 41046599 41046669 71 - 0.150 0.248 0.898
ENSG00000010803 E025 210.7604416 0.0020326489 5.765161e-01 7.019277e-01 1 41048690 41048890 201 - 2.302 2.298 -0.011
ENSG00000010803 E026 143.3885053 0.0019406000 1.088019e-01 2.037703e-01 1 41070595 41070721 127 - 2.160 2.116 -0.146
ENSG00000010803 E027 186.9814163 0.0038558033 2.451763e-01 3.802406e-01 1 41075219 41075451 233 - 2.270 2.240 -0.102
ENSG00000010803 E028 198.8448235 0.0002804483 1.064980e-06 8.786572e-06 1 41113283 41113526 244 - 2.348 2.237 -0.370
ENSG00000010803 E029 119.5012791 0.0002651374 9.419778e-07 7.859024e-06 1 41116922 41117010 89 - 2.146 2.000 -0.489
ENSG00000010803 E030 200.5326444 0.0002093771 4.829185e-08 5.224571e-07 1 41142878 41143112 235 - 2.357 2.233 -0.413
ENSG00000010803 E031 57.0939934 0.0005063944 4.365088e-03 1.416282e-02 1 41151614 41151684 71 - 1.815 1.695 -0.408
ENSG00000010803 E032 35.3003831 0.0061922375 7.193345e-03 2.172819e-02 1 41152599 41152741 143 - 1.643 1.473 -0.580
ENSG00000010803 E033 40.9900949 0.0005545640 9.254038e-06 6.199476e-05 1 41159725 41159933 209 - 1.734 1.506 -0.777
ENSG00000010803 E034 66.3368562 0.0003783158 1.380281e-04 6.948424e-04 1 41160875 41160898 24 - 1.898 1.746 -0.513
ENSG00000010803 E035 86.2294945 0.0003242745 1.660576e-06 1.314302e-05 1 41161364 41161432 69 - 2.019 1.850 -0.569
ENSG00000010803 E036 5.1274554 0.0745248277 5.404585e-01 6.716131e-01 1 41162779 41163017 239 - 0.804 0.720 -0.340
ENSG00000010803 E037 0.0000000       1 41185984 41186120 137 -      
ENSG00000010803 E038 81.3272244 0.0006818512 3.685879e-07 3.347774e-06 1 41186121 41186250 130 - 2.006 1.814 -0.643
ENSG00000010803 E039 38.3694140 0.0077731137 3.322930e-01 4.759277e-01 1 41242059 41242306 248 - 1.604 1.551 -0.182