ENSG00000010361

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313777 ENSG00000010361 HEK293_OSMI2_2hA HEK293_TMG_2hB FUZ protein_coding protein_coding 71.55192 126.9821 53.87952 6.031802 1.185751 -1.236663 12.391309 24.250463 4.506739 1.6965872 2.9409427 -2.4252537 0.15159583 0.19073333 0.08616667 -0.10456667 0.6032709445 3.768524e-14 FALSE  
ENST00000377092 ENSG00000010361 HEK293_OSMI2_2hA HEK293_TMG_2hB FUZ protein_coding nonsense_mediated_decay 71.55192 126.9821 53.87952 6.031802 1.185751 -1.236663 5.397245 8.830624 4.903374 1.2952358 0.3037579 -0.8474343 0.07667083 0.06893333 0.09090000 0.02196667 0.2360587008 3.768524e-14 FALSE  
ENST00000525800 ENSG00000010361 HEK293_OSMI2_2hA HEK293_TMG_2hB FUZ protein_coding nonsense_mediated_decay 71.55192 126.9821 53.87952 6.031802 1.185751 -1.236663 3.167410 4.685838 2.585207 0.7189501 0.1716649 -0.8555332 0.05009583 0.03670000 0.04816667 0.01146667 0.4298584976 3.768524e-14    
ENST00000533418 ENSG00000010361 HEK293_OSMI2_2hA HEK293_TMG_2hB FUZ protein_coding protein_coding 71.55192 126.9821 53.87952 6.031802 1.185751 -1.236663 8.926456 18.143024 6.926687 1.6724238 2.4232756 -1.3878913 0.12304583 0.14446667 0.12676667 -0.01770000 0.8441347094 3.768524e-14 FALSE  
MSTRG.17519.10 ENSG00000010361 HEK293_OSMI2_2hA HEK293_TMG_2hB FUZ protein_coding   71.55192 126.9821 53.87952 6.031802 1.185751 -1.236663 12.809228 20.512554 12.337461 1.4041231 0.3971260 -0.7329959 0.18067500 0.16126667 0.22916667 0.06790000 0.0003711552 3.768524e-14 FALSE  
MSTRG.17519.11 ENSG00000010361 HEK293_OSMI2_2hA HEK293_TMG_2hB FUZ protein_coding   71.55192 126.9821 53.87952 6.031802 1.185751 -1.236663 8.524387 17.382014 8.294577 1.8931500 2.5017938 -1.0664463 0.11003750 0.13613333 0.15203333 0.01590000 0.9875871834 3.768524e-14 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000010361 E001 0.9535482 0.0462896711 7.940350e-01 8.683839e-01 19 49806866 49806868 3 - 0.192 0.247 0.457
ENSG00000010361 E002 10.9100040 0.0018760485 1.596934e-02 4.266034e-02 19 49806869 49806884 16 - 0.737 1.058 1.226
ENSG00000010361 E003 11.9763710 0.0018588669 1.455951e-02 3.949845e-02 19 49806885 49806889 5 - 0.780 1.093 1.182
ENSG00000010361 E004 17.7802042 0.0010009951 7.357353e-02 1.492465e-01 19 49806890 49806892 3 - 1.043 1.229 0.668
ENSG00000010361 E005 28.6697470 0.0007364702 3.935686e-02 8.983288e-02 19 49806893 49806919 27 - 1.249 1.422 0.605
ENSG00000010361 E006 449.2103380 0.0041289076 7.944179e-05 4.252376e-04 19 49806920 49807239 320 - 2.444 2.602 0.526
ENSG00000010361 E007 322.3863539 0.0027920089 8.078929e-07 6.843411e-06 19 49807240 49807263 24 - 2.276 2.463 0.624
ENSG00000010361 E008 241.9497290 0.0005746479 1.744355e-09 2.471674e-08 19 49807264 49807266 3 - 2.146 2.340 0.649
ENSG00000010361 E009 237.4954102 0.0004213001 2.001601e-09 2.801399e-08 19 49807267 49807267 1 - 2.140 2.331 0.638
ENSG00000010361 E010 290.2575871 0.0022924421 5.638020e-08 6.005378e-07 19 49807268 49807283 16 - 2.219 2.420 0.673
ENSG00000010361 E011 314.0977997 0.0028706909 1.007835e-07 1.022281e-06 19 49807284 49807297 14 - 2.250 2.455 0.683
ENSG00000010361 E012 634.5301145 0.0014025012 8.786710e-04 3.539552e-03 19 49807298 49807374 77 - 2.650 2.740 0.299
ENSG00000010361 E013 5.3328291 0.0030952900 9.317665e-01 9.610159e-01 19 49807375 49807395 21 - 0.737 0.730 -0.030
ENSG00000010361 E014 20.5963063 0.0009697504 4.001379e-01 5.438536e-01 19 49807570 49807891 322 - 1.300 1.234 -0.231
ENSG00000010361 E015 27.2487205 0.0007810647 2.916013e-02 7.030965e-02 19 49808115 49808122 8 - 1.485 1.333 -0.527
ENSG00000010361 E016 39.6282806 0.0005496030 8.677640e-02 1.702502e-01 19 49808123 49808159 37 - 1.602 1.502 -0.343
ENSG00000010361 E017 9.8651039 0.0088538248 1.779721e-03 6.535175e-03 19 49808160 49808413 254 - 1.206 0.861 -1.266
ENSG00000010361 E018 670.8460315 0.0008847530 5.117149e-02 1.112470e-01 19 49808414 49808488 75 - 2.705 2.755 0.165
ENSG00000010361 E019 25.5881542 0.0306419169 2.164745e-01 3.461673e-01 19 49808489 49808491 3 - 1.206 1.369 0.570
ENSG00000010361 E020 537.2451397 0.0009324690 3.317601e-01 4.753945e-01 19 49808574 49808618 45 - 2.625 2.655 0.100
ENSG00000010361 E021 412.8350118 0.0001820004 4.791755e-01 6.175609e-01 19 49808619 49808638 20 - 2.516 2.537 0.072
ENSG00000010361 E022 3.1804121 0.0148770038 4.043675e-01 5.480829e-01 19 49808639 49808639 1 - 0.427 0.585 0.768
ENSG00000010361 E023 644.9558496 0.0012562365 1.792225e-01 3.001552e-01 19 49808717 49808823 107 - 2.695 2.735 0.133
ENSG00000010361 E024 3.2793875 0.1137036022 6.898606e-01 7.916746e-01 19 49808824 49808825 2 - 0.509 0.585 0.353
ENSG00000010361 E025 602.6711252 0.0001291366 7.728320e-03 2.309682e-02 19 49809163 49809258 96 - 2.653 2.707 0.179
ENSG00000010361 E026 272.3777921 0.0001657931 7.959659e-01 8.697175e-01 19 49809378 49809394 17 - 2.342 2.355 0.044
ENSG00000010361 E027 607.2465891 0.0008591325 6.651338e-01 7.728347e-01 19 49809395 49809575 181 - 2.700 2.699 -0.005
ENSG00000010361 E028 15.8793678 0.0215814998 9.487712e-05 4.979275e-04 19 49809714 49809865 152 - 1.435 1.015 -1.490
ENSG00000010361 E029 17.7058769 0.0010068212 4.972851e-09 6.494050e-08 19 49811036 49811362 327 - 1.508 1.036 -1.661
ENSG00000010361 E030 326.9921926 0.0001454191 5.323857e-01 6.647567e-01 19 49811363 49811364 2 - 2.437 2.429 -0.027
ENSG00000010361 E031 343.2280151 0.0001605178 3.478345e-01 4.920418e-01 19 49811365 49811380 16 - 2.464 2.449 -0.049
ENSG00000010361 E032 294.0866704 0.0001754841 9.096065e-01 9.465491e-01 19 49811381 49811383 3 - 2.383 2.386 0.013
ENSG00000010361 E033 484.4273387 0.0008581416 4.088109e-02 9.267107e-02 19 49811384 49811430 47 - 2.632 2.592 -0.131
ENSG00000010361 E034 478.2157325 0.0001876278 6.004408e-06 4.199494e-05 19 49811431 49811467 37 - 2.656 2.577 -0.265
ENSG00000010361 E035 13.5673793 0.0012985036 6.775708e-01 7.822574e-01 19 49811468 49811491 24 - 1.043 1.093 0.183
ENSG00000010361 E036 645.5577302 0.0005562261 4.939010e-06 3.519051e-05 19 49811631 49811699 69 - 2.786 2.707 -0.263
ENSG00000010361 E037 400.2126051 0.0002567231 7.077511e-06 4.867719e-05 19 49812251 49812279 29 - 2.586 2.498 -0.293
ENSG00000010361 E038 507.7999013 0.0001673386 2.428187e-07 2.290014e-06 19 49812280 49812335 56 - 2.689 2.600 -0.294
ENSG00000010361 E039 54.1482518 0.0022739243 2.808891e-02 6.818876e-02 19 49812447 49812614 168 - 1.745 1.626 -0.404
ENSG00000010361 E040 254.0814920 0.0009692417 1.457751e-02 3.953992e-02 19 49812615 49812637 23 - 2.372 2.308 -0.215
ENSG00000010361 E041 348.8400626 0.0001821939 2.582421e-08 2.946470e-07 19 49812638 49812685 48 - 2.546 2.431 -0.383
ENSG00000010361 E042 279.5324063 0.0005397092 4.662634e-09 6.116765e-08 19 49812686 49812736 51 - 2.471 2.328 -0.478
ENSG00000010361 E043 477.0922004 0.0031439346 7.508010e-02 1.516596e-01 19 49812996 49813132 137 - 2.634 2.585 -0.165
ENSG00000010361 E044 413.1016993 0.0017664222 8.297800e-04 3.365576e-03 19 49813133 49813309 177 - 2.597 2.512 -0.284
ENSG00000010361 E045 0.1482932 0.0415714638 1.000000e+00   19 49813607 49813812 206 - 0.000 0.075 7.486
ENSG00000010361 E046 0.0000000       19 49817351 49817376 26 -