ENSG00000010322

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000345716 ENSG00000010322 HEK293_OSMI2_2hA HEK293_TMG_2hB NISCH protein_coding protein_coding 51.40647 61.97065 41.96287 3.947374 2.281104 -0.5623609 16.417857 25.927708 11.300191 2.3057606 0.30044367 -1.1974277 0.30920000 0.41706667 0.27013333 -0.146933333 1.378902e-08 9.374404e-10 FALSE TRUE
ENST00000420808 ENSG00000010322 HEK293_OSMI2_2hA HEK293_TMG_2hB NISCH protein_coding protein_coding 51.40647 61.97065 41.96287 3.947374 2.281104 -0.5623609 6.453816 11.676144 3.764002 0.6907610 0.09935502 -1.6306318 0.12699583 0.18986667 0.09020000 -0.099666667 1.162092e-05 9.374404e-10 FALSE TRUE
ENST00000460759 ENSG00000010322 HEK293_OSMI2_2hA HEK293_TMG_2hB NISCH protein_coding retained_intron 51.40647 61.97065 41.96287 3.947374 2.281104 -0.5623609 5.195983 3.775631 5.323942 0.6022227 0.44477991 0.4946682 0.10110000 0.06033333 0.12666667 0.066333333 2.032158e-04 9.374404e-10 FALSE FALSE
ENST00000467594 ENSG00000010322 HEK293_OSMI2_2hA HEK293_TMG_2hB NISCH protein_coding retained_intron 51.40647 61.97065 41.96287 3.947374 2.281104 -0.5623609 4.974184 4.800015 4.260172 0.9654861 0.56328098 -0.1717472 0.09622083 0.07686667 0.10120000 0.024333333 5.400802e-01 9.374404e-10 FALSE TRUE
ENST00000488380 ENSG00000010322 HEK293_OSMI2_2hA HEK293_TMG_2hB NISCH protein_coding protein_coding 51.40647 61.97065 41.96287 3.947374 2.281104 -0.5623609 6.253421 4.869244 6.233740 0.4761445 0.51715321 0.3557527 0.12576250 0.07826667 0.14810000 0.069833333 7.512299e-08 9.374404e-10 FALSE TRUE
ENST00000489895 ENSG00000010322 HEK293_OSMI2_2hA HEK293_TMG_2hB NISCH protein_coding retained_intron 51.40647 61.97065 41.96287 3.947374 2.281104 -0.5623609 2.522673 2.134198 1.548461 0.1148110 0.10417517 -0.4603157 0.05102083 0.03470000 0.03686667 0.002166667 9.075111e-01 9.374404e-10 TRUE TRUE
MSTRG.23054.14 ENSG00000010322 HEK293_OSMI2_2hA HEK293_TMG_2hB NISCH protein_coding   51.40647 61.97065 41.96287 3.947374 2.281104 -0.5623609 3.295609 2.747089 3.999613 0.4718271 0.23120062 0.5403170 0.06590833 0.04383333 0.09583333 0.052000000 2.510079e-04 9.374404e-10 TRUE TRUE
MSTRG.23054.15 ENSG00000010322 HEK293_OSMI2_2hA HEK293_TMG_2hB NISCH protein_coding   51.40647 61.97065 41.96287 3.947374 2.281104 -0.5623609 3.193338 4.018408 2.398605 0.4120142 0.10755845 -0.7420122 0.06297500 0.06620000 0.05770000 -0.008500000 8.377083e-01 9.374404e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000010322 E001 0.3332198 0.0274424043 6.543021e-01   3 52455118 52455153 36 + 0.155 0.096 -0.797
ENSG00000010322 E002 0.0000000       3 52455485 52455520 36 +      
ENSG00000010322 E003 0.6923622 0.4924154784 8.699202e-01 9.203167e-01 3 52455521 52455573 53 + 0.155 0.243 0.804
ENSG00000010322 E004 1.2834466 0.3086059254 9.957530e-01 1.000000e+00 3 52455574 52455577 4 + 0.359 0.345 -0.084
ENSG00000010322 E005 2.1002426 0.0584273791 8.350293e-01 8.967595e-01 3 52455578 52455603 26 + 0.498 0.472 -0.129
ENSG00000010322 E006 2.1002426 0.0584273791 8.350293e-01 8.967595e-01 3 52455604 52455605 2 + 0.498 0.472 -0.129
ENSG00000010322 E007 2.4334624 0.0341364990 7.196350e-01 8.144030e-01 3 52455606 52455609 4 + 0.553 0.507 -0.218
ENSG00000010322 E008 2.7624158 0.1059257370 7.144522e-01 8.106587e-01 3 52455610 52455611 2 + 0.603 0.538 -0.296
ENSG00000010322 E009 6.9717128 0.0024351080 1.562720e-02 4.190473e-02 3 52455612 52455616 5 + 1.036 0.774 -0.999
ENSG00000010322 E010 95.6274024 0.0123127163 2.019501e-03 7.286011e-03 3 52455617 52455734 118 + 2.061 1.894 -0.562
ENSG00000010322 E011 139.7307751 0.0093832701 6.867538e-02 1.411728e-01 3 52457843 52457926 84 + 2.163 2.094 -0.231
ENSG00000010322 E012 115.3028787 0.0028567349 2.147236e-01 3.441121e-01 3 52458662 52458691 30 + 2.050 2.025 -0.082
ENSG00000010322 E013 196.1026325 0.0059519761 2.336050e-01 3.666805e-01 3 52458692 52458844 153 + 2.280 2.256 -0.078
ENSG00000010322 E014 0.5085815 0.2320786042 1.000000e+00 1.000000e+00 3 52470556 52470663 108 + 0.155 0.175 0.212
ENSG00000010322 E015 124.3209905 0.0029273349 7.741154e-01 8.543473e-01 3 52470859 52470907 49 + 2.054 2.071 0.054
ENSG00000010322 E016 2.1715232 0.0131896782 1.216463e-03 4.695981e-03 3 52471291 52471488 198 + 0.757 0.241 -2.671
ENSG00000010322 E017 224.9963607 0.0006980261 5.493406e-01 6.790792e-01 3 52471814 52471977 164 + 2.314 2.325 0.037
ENSG00000010322 E018 210.7358683 0.0029940873 2.024980e-01 3.293354e-01 3 52472303 52472398 96 + 2.307 2.290 -0.060
ENSG00000010322 E019 231.6104066 0.0013378365 1.617363e-01 2.773821e-01 3 52473734 52473829 96 + 2.344 2.330 -0.045
ENSG00000010322 E020 4.4599862 0.0105321588 6.243692e-02 1.307477e-01 3 52475616 52475905 290 + 0.845 0.599 -1.014
ENSG00000010322 E021 4.3640347 0.0037550484 1.048544e-03 4.127313e-03 3 52476298 52476446 149 + 0.941 0.508 -1.797
ENSG00000010322 E022 340.6738000 0.0001903356 7.510284e-05 4.047337e-04 3 52476447 52476599 153 + 2.536 2.482 -0.182
ENSG00000010322 E023 226.1777516 0.0009234959 4.276455e-06 3.088918e-05 3 52477574 52477642 69 + 2.391 2.290 -0.336
ENSG00000010322 E024 42.5431623 0.0005562239 4.101668e-03 1.342935e-02 3 52477643 52478096 454 + 1.694 1.563 -0.448
ENSG00000010322 E025 340.5506623 0.0001606564 9.909925e-07 8.228100e-06 3 52478097 52478220 124 + 2.548 2.475 -0.242
ENSG00000010322 E026 252.8277600 0.0005645908 6.625590e-03 2.025363e-02 3 52478221 52478282 62 + 2.400 2.358 -0.140
ENSG00000010322 E027 1.8498415 0.0974248347 1.089140e-01 2.039377e-01 3 52478283 52478372 90 + 0.603 0.302 -1.585
ENSG00000010322 E028 22.9652127 0.0257640664 6.709244e-06 4.639871e-05 3 52478373 52478448 76 + 1.597 1.146 -1.568
ENSG00000010322 E029 298.4671574 0.0002053186 3.930184e-01 5.369074e-01 3 52478449 52478577 129 + 2.411 2.457 0.154
ENSG00000010322 E030 1.0716524 0.0124345634 9.267033e-01 9.578529e-01 3 52478578 52478583 6 + 0.269 0.299 0.204
ENSG00000010322 E031 256.4767008 0.0001713130 2.480398e-01 3.836201e-01 3 52479749 52479862 114 + 2.340 2.395 0.182
ENSG00000010322 E032 0.8449086 0.0145204782 4.659988e-01 6.055801e-01 3 52480139 52480183 45 + 0.155 0.298 1.202
ENSG00000010322 E033 238.1346821 0.0002352554 1.882241e-01 3.115013e-01 3 52480184 52480295 112 + 2.305 2.365 0.200
ENSG00000010322 E034 120.7649191 0.0002795355 6.728040e-18 3.363967e-16 3 52480296 52480878 583 + 2.208 1.951 -0.860
ENSG00000010322 E035 172.5808131 0.0024299517 7.460644e-01 8.339263e-01 3 52480879 52481037 159 + 2.182 2.222 0.133
ENSG00000010322 E036 136.0201270 0.0067796237 5.644996e-01 6.917876e-01 3 52481038 52481109 72 + 2.069 2.126 0.192
ENSG00000010322 E037 263.6802308 0.0016181685 2.181655e-01 3.482042e-01 3 52481110 52481394 285 + 2.347 2.412 0.217
ENSG00000010322 E038 304.4612754 0.0038034228 1.004270e-01 1.911217e-01 3 52481395 52481914 520 + 2.393 2.482 0.298
ENSG00000010322 E039 76.4091983 0.0065168952 5.327152e-12 1.158869e-10 3 52482642 52482767 126 + 2.061 1.705 -1.202
ENSG00000010322 E040 66.1740193 0.0045477644 1.525531e-07 1.495510e-06 3 52484204 52484512 309 + 1.951 1.694 -0.868
ENSG00000010322 E041 171.8557945 0.0010800261 1.959528e-02 5.061781e-02 3 52484513 52484637 125 + 2.237 2.190 -0.157
ENSG00000010322 E042 101.7190025 0.0008333752 6.869922e-03 2.088727e-02 3 52485778 52485781 4 + 2.028 1.951 -0.257
ENSG00000010322 E043 100.1455925 0.0031919708 3.914239e-03 1.290265e-02 3 52485782 52485784 3 + 2.036 1.935 -0.340
ENSG00000010322 E044 142.5378608 0.0002657596 2.961773e-04 1.364441e-03 3 52485785 52485827 43 + 2.179 2.093 -0.288
ENSG00000010322 E045 1.1092308 0.0166487004 2.445569e-01 3.795317e-01 3 52486470 52486552 83 + 0.434 0.241 -1.214
ENSG00000010322 E046 462.8711549 0.0007487150 3.118005e-02 7.425009e-02 3 52487196 52487649 454 + 2.645 2.628 -0.057
ENSG00000010322 E047 778.1885183 0.0012707058 5.531883e-01 6.823752e-01 3 52487650 52488605 956 + 2.829 2.873 0.143
ENSG00000010322 E048 319.9650277 0.0028778424 8.502218e-03 2.504384e-02 3 52489336 52489572 237 + 2.387 2.508 0.404
ENSG00000010322 E049 214.1546496 0.0005876651 6.886687e-05 3.745800e-04 3 52489573 52489678 106 + 2.195 2.337 0.475
ENSG00000010322 E050 65.1400315 0.0099872708 8.751405e-03 2.566329e-02 3 52489679 52490074 396 + 1.879 1.736 -0.482
ENSG00000010322 E051 148.4523385 0.0003649768 7.427172e-03 2.232890e-02 3 52490075 52490128 54 + 2.058 2.172 0.382
ENSG00000010322 E052 237.3966364 0.0014754808 6.414032e-02 1.335956e-01 3 52490129 52490231 103 + 2.285 2.371 0.285
ENSG00000010322 E053 315.1568443 0.0088949581 2.295520e-01 3.618989e-01 3 52490705 52490833 129 + 2.402 2.498 0.320
ENSG00000010322 E054 379.8706462 0.0056697284 2.586101e-02 6.365526e-02 3 52491352 52491513 162 + 2.459 2.586 0.424
ENSG00000010322 E055 11.6802196 0.0016639573 4.403451e-01 5.820239e-01 3 52491514 52491577 64 + 1.100 1.047 -0.193
ENSG00000010322 E056 1402.2681944 0.0052458319 1.555674e-06 1.238935e-05 3 52491872 52493068 1197 + 2.979 3.170 0.635