ENSG00000010318

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327906 ENSG00000010318 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF7 protein_coding protein_coding 7.646474 6.167029 8.07812 0.5185999 0.2989776 0.3888913 1.2299083 1.0759748 1.35980402 0.06665419 0.03840310 0.33497888 0.16310000 0.17866667 0.168933333 -0.009733333 9.783465e-01 4.747903e-06 FALSE TRUE
ENST00000473145 ENSG00000010318 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF7 protein_coding retained_intron 7.646474 6.167029 8.07812 0.5185999 0.2989776 0.3888913 1.8475121 1.3426926 1.35976220 0.04968945 0.32325863 0.01809141 0.23694583 0.21993333 0.166933333 -0.053000000 5.630592e-01 4.747903e-06   FALSE
ENST00000482327 ENSG00000010318 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF7 protein_coding processed_transcript 7.646474 6.167029 8.07812 0.5185999 0.2989776 0.3888913 0.8986129 0.2388168 1.62220622 0.23881676 0.42076160 2.71366780 0.11640000 0.04530000 0.197566667 0.152266667 1.318817e-01 4.747903e-06   FALSE
MSTRG.23042.4 ENSG00000010318 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF7 protein_coding   7.646474 6.167029 8.07812 0.5185999 0.2989776 0.3888913 0.8028790 0.4555187 1.79966762 0.39628895 0.33745270 1.95881377 0.09896667 0.08446667 0.224066667 0.139600000 2.457850e-01 4.747903e-06 FALSE FALSE
MSTRG.23042.5 ENSG00000010318 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF7 protein_coding   7.646474 6.167029 8.07812 0.5185999 0.2989776 0.3888913 0.2449740 0.4596194 0.06955781 0.28763985 0.06955781 -2.56141641 0.03268333 0.07126667 0.009266667 -0.062000000 4.634006e-01 4.747903e-06 FALSE TRUE
MSTRG.23042.6 ENSG00000010318 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF7 protein_coding   7.646474 6.167029 8.07812 0.5185999 0.2989776 0.3888913 0.6353076 0.0000000 1.12452473 0.00000000 0.36995080 6.82594424 0.07499583 0.00000000 0.143033333 0.143033333 4.747903e-06 4.747903e-06   FALSE
MSTRG.23042.7 ENSG00000010318 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF7 protein_coding   7.646474 6.167029 8.07812 0.5185999 0.2989776 0.3888913 0.9612090 1.0643338 0.00000000 0.53501857 0.00000000 -6.74729848 0.13591250 0.16230000 0.000000000 -0.162300000 1.050990e-01 4.747903e-06   FALSE
MSTRG.23042.8 ENSG00000010318 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF7 protein_coding   7.646474 6.167029 8.07812 0.5185999 0.2989776 0.3888913 0.1488970 0.3886922 0.00000000 0.38869217 0.00000000 -5.31720336 0.02024167 0.05500000 0.000000000 -0.055000000 7.155867e-01 4.747903e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000010318 E001 31.030024 0.0011010810 4.758449e-03 1.525672e-02 3 52410660 52410889 230 + 1.586 1.415 -0.588
ENSG00000010318 E002 20.579881 0.0012582051 1.147997e-01 2.125389e-01 3 52410890 52410949 60 + 1.389 1.275 -0.398
ENSG00000010318 E003 17.763139 0.0010769490 1.093775e-01 2.046421e-01 3 52410950 52410989 40 + 1.334 1.211 -0.432
ENSG00000010318 E004 17.548110 0.0010715620 1.548152e-01 2.681633e-01 3 52410990 52411018 29 + 1.321 1.211 -0.386
ENSG00000010318 E005 17.821981 0.0011843318 1.877090e-01 3.108525e-01 3 52411019 52411035 17 + 1.321 1.219 -0.355
ENSG00000010318 E006 24.241969 0.0011654862 1.170853e-02 3.283753e-02 3 52411036 52411058 23 + 1.492 1.324 -0.581
ENSG00000010318 E007 51.505357 0.0005436090 3.181327e-02 7.549468e-02 3 52411059 52411196 138 + 1.772 1.675 -0.326
ENSG00000010318 E008 39.450791 0.0007620201 4.735408e-01 6.124864e-01 3 52411197 52411247 51 + 1.628 1.594 -0.117
ENSG00000010318 E009 26.121671 0.0007784352 4.393196e-01 5.810738e-01 3 52411248 52411339 92 + 1.401 1.456 0.190
ENSG00000010318 E010 36.915137 0.0006838263 4.341014e-01 5.764861e-01 3 52412811 52412853 43 + 1.597 1.557 -0.137
ENSG00000010318 E011 43.827604 0.0005691846 1.938032e-01 3.185554e-01 3 52412854 52412920 67 + 1.681 1.619 -0.214
ENSG00000010318 E012 40.748768 0.0006933465 6.516942e-01 7.625034e-01 3 52413996 52414048 53 + 1.631 1.611 -0.068
ENSG00000010318 E013 30.441225 0.0006936179 3.585808e-01 5.029843e-01 3 52414496 52414522 27 + 1.523 1.470 -0.180
ENSG00000010318 E014 36.255252 0.0005691233 7.774483e-01 8.567778e-01 3 52414523 52414587 65 + 1.560 1.579 0.068
ENSG00000010318 E015 11.386508 0.0016274801 2.655870e-01 4.036604e-01 3 52414588 52414727 140 + 1.033 1.145 0.404
ENSG00000010318 E016 26.616899 0.0076056539 9.768553e-02 1.869656e-01 3 52414728 52414973 246 + 1.371 1.503 0.455
ENSG00000010318 E017 23.439289 0.0062835860 2.091744e-01 3.375336e-01 3 52415895 52416019 125 + 1.439 1.349 -0.312
ENSG00000010318 E018 10.091280 0.0017776209 2.795830e-01 4.193447e-01 3 52419833 52419919 87 + 0.977 1.092 0.419
ENSG00000010318 E019 6.735503 0.0025771993 6.791555e-01 7.834472e-01 3 52419920 52419934 15 + 0.858 0.910 0.202
ENSG00000010318 E020 14.155432 0.0012407099 9.755862e-01 9.887536e-01 3 52420311 52420435 125 + 1.177 1.184 0.023
ENSG00000010318 E021 15.115132 0.0012300112 2.094149e-01 3.378401e-01 3 52420903 52420991 89 + 1.148 1.260 0.395
ENSG00000010318 E022 9.755693 0.0084247080 3.661770e-02 8.474465e-02 3 52420992 52421015 24 + 0.895 1.133 0.877
ENSG00000010318 E023 12.784593 0.0035819391 3.413874e-02 8.003120e-02 3 52421016 52421062 47 + 1.020 1.227 0.744
ENSG00000010318 E024 13.999585 0.0062881433 2.082748e-01 3.364086e-01 3 52421648 52421754 107 + 1.106 1.227 0.434
ENSG00000010318 E025 4.499477 0.0037309662 4.846751e-01 6.226367e-01 3 52421755 52422221 467 + 0.692 0.791 0.404
ENSG00000010318 E026 4.611262 0.1042881367 1.865624e-01 3.094297e-01 3 52422222 52422338 117 + 0.596 0.850 1.044
ENSG00000010318 E027 5.819996 0.0786878949 4.117924e-01 5.553424e-01 3 52422339 52422759 421 + 0.747 0.891 0.564
ENSG00000010318 E028 8.341004 0.0026532321 1.800373e-02 4.714046e-02 3 52422760 52422836 77 + 0.794 1.068 1.035
ENSG00000010318 E029 6.379403 0.0026338241 2.627658e-02 6.450383e-02 3 52422837 52422881 45 + 0.692 0.975 1.105
ENSG00000010318 E030 31.550961 0.0036134315 9.771035e-08 9.940891e-07 3 52423091 52423641 551 + 1.278 1.649 1.279
ENSG00000010318 E031 2.442927 0.0831409290 8.082316e-01 8.781536e-01 3 52426475 52426595 121 + 0.517 0.585 0.314