ENSG00000010295

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336604 ENSG00000010295 HEK293_OSMI2_2hA HEK293_TMG_2hB IFFO1 protein_coding protein_coding 25.58137 33.63539 17.1825 2.755333 0.8864793 -0.9686294 1.032724 0.5856015 1.119290 0.5856015 1.1192899 0.9229966 0.04357083 0.0178000 0.07260000 0.05480000 9.777812e-01 1.813859e-06 FALSE TRUE
ENST00000356896 ENSG00000010295 HEK293_OSMI2_2hA HEK293_TMG_2hB IFFO1 protein_coding protein_coding 25.58137 33.63539 17.1825 2.755333 0.8864793 -0.9686294 5.298344 10.2880919 2.677633 1.2256234 0.8949453 -1.9379691 0.19589167 0.3051333 0.15116667 -0.15396667 1.470090e-01 1.813859e-06 FALSE TRUE
ENST00000396830 ENSG00000010295 HEK293_OSMI2_2hA HEK293_TMG_2hB IFFO1 protein_coding retained_intron 25.58137 33.63539 17.1825 2.755333 0.8864793 -0.9686294 5.418808 7.8256875 2.829926 0.8735390 0.6556067 -1.4642064 0.20882917 0.2331000 0.16266667 -0.07043333 3.460770e-01 1.813859e-06 FALSE TRUE
ENST00000396840 ENSG00000010295 HEK293_OSMI2_2hA HEK293_TMG_2hB IFFO1 protein_coding protein_coding 25.58137 33.63539 17.1825 2.755333 0.8864793 -0.9686294 3.513837 5.6278690 1.729654 0.5465466 1.0162248 -1.6963494 0.12799167 0.1669667 0.09553333 -0.07143333 6.681583e-01 1.813859e-06 FALSE TRUE
ENST00000488007 ENSG00000010295 HEK293_OSMI2_2hA HEK293_TMG_2hB IFFO1 protein_coding retained_intron 25.58137 33.63539 17.1825 2.755333 0.8864793 -0.9686294 4.823933 4.6618245 3.644196 0.3431090 0.2794426 -0.3544323 0.19595833 0.1388333 0.21153333 0.07270000 3.599591e-04 1.813859e-06 FALSE TRUE
MSTRG.6697.13 ENSG00000010295 HEK293_OSMI2_2hA HEK293_TMG_2hB IFFO1 protein_coding   25.58137 33.63539 17.1825 2.755333 0.8864793 -0.9686294 3.721183 2.7790930 3.363255 0.4738647 0.1894800 0.2743453 0.15466667 0.0815000 0.19673333 0.11523333 1.813859e-06 1.813859e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000010295 E001 0.3686942 0.0285469306 5.593509e-01 6.874739e-01 12 6538961 6539527 567 - 0.172 0.086 -1.164
ENSG00000010295 E002 2.1852238 0.3110765621 3.275891e-01 4.710495e-01 12 6539528 6539538 11 - 0.595 0.381 -1.065
ENSG00000010295 E003 29.0229616 0.0044507967 4.466498e-02 9.958277e-02 12 6539539 6539576 38 - 1.291 1.452 0.561
ENSG00000010295 E004 32.9604689 0.0041162122 2.115914e-02 5.393325e-02 12 6539577 6539606 30 - 1.332 1.509 0.611
ENSG00000010295 E005 457.5746352 0.0002209441 1.789691e-11 3.571653e-10 12 6539607 6540096 490 - 2.511 2.636 0.415
ENSG00000010295 E006 78.5991213 0.0006992258 4.628491e-02 1.025560e-01 12 6540097 6540097 1 - 1.782 1.870 0.300
ENSG00000010295 E007 477.3238212 0.0002034377 6.123261e-02 1.287081e-01 12 6540098 6540588 491 - 2.600 2.631 0.103
ENSG00000010295 E008 235.2781517 0.0031817891 3.323438e-02 7.826494e-02 12 6541512 6541642 131 - 2.259 2.337 0.261
ENSG00000010295 E009 210.5243668 0.0001926282 1.654662e-03 6.136738e-03 12 6548065 6548157 93 - 2.207 2.290 0.279
ENSG00000010295 E010 95.5955592 0.0003146596 1.950788e-01 3.200829e-01 12 6548158 6548160 3 - 1.892 1.942 0.167
ENSG00000010295 E011 86.3960870 0.0003189141 1.517888e-04 7.548878e-04 12 6548161 6548424 264 - 1.991 1.838 -0.517
ENSG00000010295 E012 207.8287391 0.0031488694 2.671761e-02 6.540342e-02 12 6548425 6548545 121 - 2.203 2.287 0.282
ENSG00000010295 E013 214.9437488 0.0002048618 9.145066e-01 9.498905e-01 12 6548668 6548825 158 - 2.282 2.277 -0.018
ENSG00000010295 E014 26.8669251 0.0007634051 5.796644e-05 3.214703e-04 12 6548826 6548849 24 - 1.575 1.299 -0.952
ENSG00000010295 E015 67.1791403 0.0004525340 5.971768e-09 7.691438e-08 12 6548850 6549138 289 - 1.951 1.690 -0.878
ENSG00000010295 E016 72.5314453 0.0019773714 1.080465e-05 7.123148e-05 12 6549139 6549475 337 - 1.951 1.742 -0.702
ENSG00000010295 E017 49.1762236 0.0006448113 4.648452e-01 6.045247e-01 12 6549476 6549481 6 - 1.680 1.637 -0.144
ENSG00000010295 E018 44.2632164 0.0006767020 4.976642e-01 6.342055e-01 12 6549482 6549484 3 - 1.633 1.591 -0.141
ENSG00000010295 E019 229.1428337 0.0012821397 3.074062e-01 4.496420e-01 12 6549756 6549896 141 - 2.331 2.299 -0.106
ENSG00000010295 E020 9.6247109 0.0019548684 1.503842e-06 1.202407e-05 12 6549897 6550467 571 - 1.280 0.778 -1.852
ENSG00000010295 E021 181.7738689 0.0002683516 1.686028e-01 2.863432e-01 12 6550695 6550790 96 - 2.235 2.193 -0.140
ENSG00000010295 E022 141.1172267 0.0013687626 1.113923e-01 2.075932e-01 12 6550941 6551001 61 - 2.137 2.078 -0.196
ENSG00000010295 E023 14.7515973 0.0610083112 2.296372e-01 3.620061e-01 12 6551398 6551503 106 - 1.282 1.080 -0.716
ENSG00000010295 E024 10.3896087 0.0020854718 7.872255e-04 3.213547e-03 12 6551595 6551900 306 - 1.233 0.888 -1.257
ENSG00000010295 E025 321.1131052 0.0019690223 1.743020e-05 1.095841e-04 12 6555257 6556073 817 - 2.536 2.416 -0.398