ENSG00000010292

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315579 ENSG00000010292 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAPD2 protein_coding protein_coding 84.64794 83.04526 74.69484 5.524924 1.020575 -0.1528697 68.32017 73.57488 58.20276 6.285846 1.062982 -0.3380741 0.8055542 0.8839 0.7791 -0.1048 0.00510162 4.007283e-29 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000010292 E001 1.581167 0.2967035970 4.829255e-01 6.210250e-01 12 6491497 6492469 973 + 0.519 0.322 -1.068
ENSG00000010292 E002 1.397386 0.0315583426 1.474404e-01 2.582102e-01 12 6492866 6493355 490 + 0.519 0.262 -1.477
ENSG00000010292 E003 7.906362 0.0025665598 3.222156e-02 7.627964e-02 12 6493356 6493386 31 + 1.070 0.832 -0.890
ENSG00000010292 E004 25.925262 0.0096734913 2.377390e-03 8.390889e-03 12 6493387 6493400 14 + 1.551 1.304 -0.852
ENSG00000010292 E005 56.795980 0.0048241539 5.555650e-06 3.913716e-05 12 6493401 6493503 103 + 1.886 1.629 -0.869
ENSG00000010292 E006 50.110704 0.0101027479 1.171220e-05 7.661482e-05 12 6493504 6493547 44 + 1.853 1.554 -1.012
ENSG00000010292 E007 97.568154 0.0059150505 1.042447e-10 1.834201e-09 12 6493548 6493941 394 + 2.154 1.821 -1.120
ENSG00000010292 E008 17.504014 0.0010472731 7.588756e-03 2.274214e-02 12 6493942 6493966 25 + 1.374 1.162 -0.744
ENSG00000010292 E009 75.609080 0.0019013835 3.255436e-11 6.231510e-10 12 6493967 6494075 109 + 2.032 1.737 -0.995
ENSG00000010292 E010 64.436111 0.0091307912 9.029863e-07 7.569382e-06 12 6494076 6494092 17 + 1.970 1.660 -1.049
ENSG00000010292 E011 52.670478 0.0058333756 3.035990e-06 2.268693e-05 12 6494093 6494098 6 + 1.869 1.589 -0.945
ENSG00000010292 E012 51.756681 0.0068204437 1.282006e-05 8.307300e-05 12 6494099 6494101 3 + 1.857 1.586 -0.917
ENSG00000010292 E013 59.299607 0.0032672136 2.595959e-07 2.432590e-06 12 6494102 6494115 14 + 1.914 1.645 -0.909
ENSG00000010292 E014 236.335351 0.0038087845 1.120322e-10 1.961386e-09 12 6494116 6494154 39 + 2.494 2.255 -0.800
ENSG00000010292 E015 421.659092 0.0040368973 1.850350e-08 2.171622e-07 12 6495076 6495225 150 + 2.722 2.530 -0.640
ENSG00000010292 E016 194.179397 0.0057667939 5.184593e-03 1.643061e-02 12 6509717 6509724 8 + 2.347 2.227 -0.399
ENSG00000010292 E017 308.168091 0.0028790821 1.089595e-04 5.632826e-04 12 6509725 6509792 68 + 2.548 2.426 -0.407
ENSG00000010292 E018 295.325307 0.0012035009 9.896557e-08 1.005725e-06 12 6510075 6510133 59 + 2.538 2.401 -0.456
ENSG00000010292 E019 513.669800 0.0065709455 1.024508e-05 6.793726e-05 12 6510629 6510810 182 + 2.800 2.622 -0.591
ENSG00000010292 E020 453.994175 0.0082161871 6.894070e-05 3.749277e-04 12 6511110 6511224 115 + 2.746 2.569 -0.587
ENSG00000010292 E021 255.226022 0.0065002321 2.409958e-04 1.137559e-03 12 6511225 6511252 28 + 2.486 2.329 -0.524
ENSG00000010292 E022 460.656309 0.0013256590 3.418487e-13 9.009769e-12 12 6514265 6514392 128 + 2.749 2.579 -0.566
ENSG00000010292 E023 8.357202 0.0020394121 4.662428e-07 4.149985e-06 12 6514393 6514463 71 + 1.224 0.662 -2.133
ENSG00000010292 E024 482.839682 0.0008193488 6.398723e-19 3.605648e-17 12 6514464 6514587 124 + 2.776 2.593 -0.610
ENSG00000010292 E025 494.277110 0.0067771207 1.272926e-04 6.469192e-04 12 6514773 6514920 148 + 2.773 2.615 -0.526
ENSG00000010292 E026 563.326496 0.0069282120 9.200481e-03 2.678659e-02 12 6516828 6517025 198 + 2.799 2.696 -0.340
ENSG00000010292 E027 3.048607 0.0560841298 8.553208e-01 9.105558e-01 12 6517359 6517364 6 + 0.567 0.608 0.184
ENSG00000010292 E028 471.254831 0.0045709445 1.945976e-03 7.059059e-03 12 6517365 6517499 135 + 2.723 2.617 -0.352
ENSG00000010292 E029 359.030111 0.0046408915 2.470005e-03 8.673656e-03 12 6517596 6517683 88 + 2.608 2.498 -0.367
ENSG00000010292 E030 193.960750 0.0036891135 1.476013e-02 3.995060e-02 12 6517779 6517792 14 + 2.329 2.240 -0.299
ENSG00000010292 E031 555.203347 0.0020343212 5.132583e-04 2.209340e-03 12 6517793 6517959 167 + 2.783 2.695 -0.291
ENSG00000010292 E032 1.988785 0.0200735564 9.442030e-02 1.820106e-01 12 6517960 6518203 244 + 0.610 0.324 -1.471
ENSG00000010292 E033 0.628762 0.0172671820 7.363007e-01 8.268178e-01 12 6520970 6520985 16 + 0.247 0.191 -0.477
ENSG00000010292 E034 594.429089 0.0010859441 1.652691e-04 8.148060e-04 12 6520986 6521110 125 + 2.806 2.729 -0.258
ENSG00000010292 E035 631.733299 0.0005145104 1.531874e-03 5.739552e-03 12 6521798 6521919 122 + 2.818 2.766 -0.175
ENSG00000010292 E036 603.495566 0.0001296787 7.635612e-02 1.536735e-01 12 6521920 6522037 118 + 2.782 2.759 -0.077
ENSG00000010292 E037 476.026116 0.0001180918 3.771862e-02 8.680580e-02 12 6522828 6522883 56 + 2.684 2.652 -0.105
ENSG00000010292 E038 567.198511 0.0001064823 2.685157e-01 4.069821e-01 12 6522884 6523002 119 + 2.748 2.735 -0.045
ENSG00000010292 E039 2.149764 0.0338735618 1.813952e-01 3.029922e-01 12 6523200 6523261 62 + 0.610 0.377 -1.150
ENSG00000010292 E040 482.797094 0.0001273748 1.764985e-01 2.966969e-01 12 6523262 6523346 85 + 2.682 2.663 -0.064
ENSG00000010292 E041 539.553446 0.0001065272 4.631097e-01 6.029480e-01 12 6525583 6525716 134 + 2.723 2.716 -0.026
ENSG00000010292 E042 698.243596 0.0003419758 6.603342e-01 7.690172e-01 12 6526068 6526200 133 + 2.824 2.835 0.037
ENSG00000010292 E043 542.134969 0.0021582549 3.183592e-01 4.613246e-01 12 6526287 6526371 85 + 2.702 2.733 0.104
ENSG00000010292 E044 757.217741 0.0015325082 9.753534e-03 2.815704e-02 12 6526448 6526615 168 + 2.826 2.889 0.211
ENSG00000010292 E045 772.796878 0.0001186814 1.243234e-08 1.506697e-07 12 6526891 6527063 173 + 2.821 2.905 0.277
ENSG00000010292 E046 674.823576 0.0001221156 9.017841e-07 7.560308e-06 12 6527777 6527888 112 + 2.766 2.843 0.255
ENSG00000010292 E047 671.881324 0.0014226878 4.158961e-03 1.358875e-02 12 6527968 6528091 124 + 2.769 2.838 0.228
ENSG00000010292 E048 812.915694 0.0023297997 4.884690e-02 1.071053e-01 12 6528173 6528328 156 + 2.861 2.915 0.180
ENSG00000010292 E049 29.132417 0.0009645610 6.088199e-01 7.284377e-01 12 6528547 6528678 132 + 1.439 1.477 0.130
ENSG00000010292 E050 845.694024 0.0006420317 3.228549e-07 2.967392e-06 12 6528679 6528856 178 + 2.853 2.946 0.307
ENSG00000010292 E051 654.952243 0.0015783104 8.802596e-08 9.030789e-07 12 6528945 6529039 95 + 2.716 2.848 0.440
ENSG00000010292 E052 22.057289 0.0015000311 5.534136e-11 1.019516e-09 12 6529040 6529171 132 + 1.587 1.100 -1.698
ENSG00000010292 E053 27.657938 0.0137357929 1.047537e-05 6.932849e-05 12 6529260 6529512 253 + 1.635 1.255 -1.312
ENSG00000010292 E054 705.362830 0.0003960248 2.084107e-15 7.550733e-14 12 6529513 6529593 81 + 2.744 2.881 0.456
ENSG00000010292 E055 909.893239 0.0001383337 9.167325e-35 2.218036e-32 12 6529775 6529958 184 + 2.833 3.002 0.561
ENSG00000010292 E056 861.635865 0.0032561620 4.913339e-07 4.351037e-06 12 6530691 6530817 127 + 2.818 2.973 0.515
ENSG00000010292 E057 985.665845 0.0030239453 2.488719e-07 2.342294e-06 12 6530921 6531076 156 + 2.879 3.031 0.506
ENSG00000010292 E058 493.560483 0.0033288414 5.027785e-06 3.577358e-05 12 6531327 6531338 12 + 2.578 2.732 0.513
ENSG00000010292 E059 1453.200557 0.0033139004 4.912618e-19 2.804100e-17 12 6531339 6532001 663 + 2.967 3.229 0.872