ENSG00000009954

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000339594 ENSG00000009954 HEK293_OSMI2_2hA HEK293_TMG_2hB BAZ1B protein_coding protein_coding 43.81136 32.83402 55.43414 3.51145 1.020609 0.7554045 28.41255 24.276191 33.80889 2.106230 0.8073407 0.4776932 0.6603750 0.7423667 0.6097667 -0.1326000 4.751001e-05 4.751001e-05 FALSE TRUE
ENST00000404251 ENSG00000009954 HEK293_OSMI2_2hA HEK293_TMG_2hB BAZ1B protein_coding protein_coding 43.81136 32.83402 55.43414 3.51145 1.020609 0.7554045 15.19501 8.523868 21.44520 1.474303 0.1719309 1.3300556 0.3352583 0.2565333 0.3870667 0.1305333 1.682780e-04 4.751001e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000009954 E001 1577.778200 0.0062088875 5.909141e-19 3.343695e-17 7 73440406 73441564 1159 - 3.034 3.334 0.994
ENSG00000009954 E002 405.044405 0.0008404777 3.254560e-23 2.957154e-21 7 73441565 73441693 129 - 2.499 2.710 0.705
ENSG00000009954 E003 521.899396 0.0001418953 8.268674e-31 1.473636e-28 7 73441694 73442180 487 - 2.628 2.805 0.590
ENSG00000009954 E004 698.534303 0.0006990692 1.729002e-03 6.374140e-03 7 73442181 73442553 373 - 2.822 2.869 0.159
ENSG00000009954 E005 341.231153 0.0002816309 4.049407e-04 1.793743e-03 7 73442725 73442828 104 - 2.504 2.568 0.215
ENSG00000009954 E006 339.063128 0.0018306271 1.194743e-03 4.622780e-03 7 73443984 73444129 146 - 2.492 2.573 0.272
ENSG00000009954 E007 347.781871 0.0022260964 5.783399e-04 2.453638e-03 7 73447264 73447379 116 - 2.498 2.589 0.306
ENSG00000009954 E008 385.807083 0.0006328396 1.485642e-04 7.406981e-04 7 73449542 73449689 148 - 2.552 2.626 0.245
ENSG00000009954 E009 419.488365 0.0001863499 8.068289e-02 1.606138e-01 7 73450847 73450994 148 - 2.611 2.635 0.080
ENSG00000009954 E010 477.730873 0.0015804015 9.800434e-01 9.915453e-01 7 73459536 73459718 183 - 2.683 2.674 -0.029
ENSG00000009954 E011 2.972524 0.0728451561 7.217304e-01 8.160011e-01 7 73462464 73462921 458 - 0.570 0.617 0.207
ENSG00000009954 E012 478.715877 0.0017565971 3.631809e-02 8.418600e-02 7 73462922 73463099 178 - 2.708 2.645 -0.211
ENSG00000009954 E013 340.134854 0.0011795082 3.718855e-02 8.582777e-02 7 73465439 73465537 99 - 2.558 2.498 -0.200
ENSG00000009954 E014 367.376306 0.0013570544 1.759459e-04 8.608801e-04 7 73466296 73466401 106 - 2.610 2.507 -0.341
ENSG00000009954 E015 343.652761 0.0024419982 7.566438e-03 2.268625e-02 7 73469517 73469650 134 - 2.575 2.488 -0.293
ENSG00000009954 E016 353.157294 0.0001820292 5.479668e-06 3.865311e-05 7 73470345 73470483 139 - 2.591 2.494 -0.324
ENSG00000009954 E017 1811.531616 0.0036218149 7.205569e-13 1.807566e-11 7 73476868 73478569 1702 - 3.336 3.141 -0.647
ENSG00000009954 E018 275.080274 0.0035215462 2.807017e-11 5.433544e-10 7 73489194 73489391 198 - 2.536 2.286 -0.835
ENSG00000009954 E019 221.824953 0.0143140339 2.618542e-04 1.224181e-03 7 73492800 73492921 122 - 2.438 2.202 -0.785
ENSG00000009954 E020 339.608419 0.0123000654 2.467107e-07 2.323107e-06 7 73498497 73498698 202 - 2.642 2.344 -0.995
ENSG00000009954 E021 250.776227 0.0048406908 2.411788e-15 8.678176e-14 7 73508327 73508471 145 - 2.522 2.183 -1.134
ENSG00000009954 E022 184.804249 0.0045053436 1.123811e-16 4.799429e-15 7 73510736 73510852 117 - 2.399 2.028 -1.239
ENSG00000009954 E023 123.647795 0.0191757559 5.918884e-07 5.162829e-06 7 73521827 73522293 467 - 2.229 1.843 -1.297