ENSG00000009950

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313375 ENSG00000009950 HEK293_OSMI2_2hA HEK293_TMG_2hB MLXIPL protein_coding protein_coding 4.78735 5.288151 3.735465 0.9409389 0.2347983 -0.5003443 0.89803232 1.1529542 0.0000000 0.39754445 0.00000000 -6.86165053 0.18376667 0.21920000 0.00000000 -0.219200000 1.693086e-05 1.693086e-05 FALSE TRUE
ENST00000345114 ENSG00000009950 HEK293_OSMI2_2hA HEK293_TMG_2hB MLXIPL protein_coding nonsense_mediated_decay 4.78735 5.288151 3.735465 0.9409389 0.2347983 -0.5003443 0.75432461 1.0634593 0.9154252 0.28771294 0.15445884 -0.21407927 0.15934167 0.20893333 0.24333333 0.034400000 8.400271e-01 1.693086e-05 TRUE TRUE
ENST00000434326 ENSG00000009950 HEK293_OSMI2_2hA HEK293_TMG_2hB MLXIPL protein_coding protein_coding 4.78735 5.288151 3.735465 0.9409389 0.2347983 -0.5003443 1.04442228 0.9839922 0.9286648 0.10861984 0.01590909 -0.08262438 0.21956250 0.19306667 0.25000000 0.056933333 5.280650e-01 1.693086e-05 FALSE TRUE
ENST00000456640 ENSG00000009950 HEK293_OSMI2_2hA HEK293_TMG_2hB MLXIPL protein_coding protein_coding 4.78735 5.288151 3.735465 0.9409389 0.2347983 -0.5003443 0.27131748 0.4509544 0.2479172 0.35243578 0.05085786 -0.83771629 0.05670417 0.06893333 0.06726667 -0.001666667 8.399363e-01 1.693086e-05 FALSE FALSE
ENST00000467221 ENSG00000009950 HEK293_OSMI2_2hA HEK293_TMG_2hB MLXIPL protein_coding retained_intron 4.78735 5.288151 3.735465 0.9409389 0.2347983 -0.5003443 0.06135598 0.0000000 0.2074967 0.00000000 0.11817258 4.44292132 0.01290833 0.00000000 0.05240000 0.052400000 1.322047e-01 1.693086e-05 TRUE TRUE
ENST00000476404 ENSG00000009950 HEK293_OSMI2_2hA HEK293_TMG_2hB MLXIPL protein_coding retained_intron 4.78735 5.288151 3.735465 0.9409389 0.2347983 -0.5003443 0.43021177 0.4578470 0.2797034 0.08283630 0.01346504 -0.69146007 0.09021667 0.09630000 0.07503333 -0.021266667 8.830279e-01 1.693086e-05 FALSE TRUE
ENST00000488212 ENSG00000009950 HEK293_OSMI2_2hA HEK293_TMG_2hB MLXIPL protein_coding retained_intron 4.78735 5.288151 3.735465 0.9409389 0.2347983 -0.5003443 0.13779947 0.4253585 0.0000000 0.42535855 0.00000000 -5.44413214 0.01978750 0.05933333 0.00000000 -0.059333333 8.214186e-01 1.693086e-05   FALSE
MSTRG.30039.10 ENSG00000009950 HEK293_OSMI2_2hA HEK293_TMG_2hB MLXIPL protein_coding   4.78735 5.288151 3.735465 0.9409389 0.2347983 -0.5003443 0.70478833 0.3274979 0.7168844 0.01997429 0.02181908 1.10684744 0.14990000 0.06663333 0.19346667 0.126833333 2.151759e-03 1.693086e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000009950 E001 0.3289534 0.0287231842 7.339402e-01   7 73593194 73593201 8 - 0.149 0.100 -0.668
ENSG00000009950 E002 51.8559239 0.0082233333 2.420953e-01 0.3766710424 7 73593202 73593508 307 - 1.648 1.729 0.275
ENSG00000009950 E003 53.7966244 0.0005085294 2.552558e-03 0.0089197349 7 73593509 73593615 107 - 1.606 1.762 0.528
ENSG00000009950 E004 37.1934465 0.0006405451 8.748975e-02 0.1713290035 7 73593616 73593672 57 - 1.479 1.585 0.363
ENSG00000009950 E005 30.6014802 0.0013874516 3.201081e-03 0.0108588687 7 73593673 73593709 37 - 1.333 1.538 0.710
ENSG00000009950 E006 31.8653632 0.0083393962 1.099559e-03 0.0043020201 7 73593710 73593751 42 - 1.298 1.565 0.922
ENSG00000009950 E007 28.7697469 0.0025427493 1.175608e-02 0.0329489795 7 73593752 73593773 22 - 1.316 1.502 0.643
ENSG00000009950 E008 31.7708297 0.0064532917 1.786352e-03 0.0065555844 7 73593774 73593810 37 - 1.307 1.554 0.853
ENSG00000009950 E009 62.3004371 0.0020039326 4.352035e-03 0.0141282119 7 73593811 73593983 173 - 1.668 1.818 0.507
ENSG00000009950 E010 18.6459594 0.0010178669 1.726453e-02 0.0455334583 7 73593984 73594273 290 - 1.380 1.196 -0.643
ENSG00000009950 E011 40.5942142 0.0009212438 6.933660e-01 0.7944077555 7 73594274 73594403 130 - 1.606 1.588 -0.064
ENSG00000009950 E012 34.5318565 0.0007017582 6.462588e-01 0.7582275378 7 73595637 73595760 124 - 1.540 1.515 -0.083
ENSG00000009950 E013 25.7708898 0.0132372101 5.051954e-01 0.6410204920 7 73595842 73595912 71 - 1.435 1.383 -0.182
ENSG00000009950 E014 15.4372383 0.0299223584 6.956672e-01 0.7962160518 7 73595913 73595915 3 - 1.220 1.177 -0.154
ENSG00000009950 E015 19.1605997 0.0194149891 7.083059e-01 0.8060019845 7 73595916 73595969 54 - 1.251 1.294 0.150
ENSG00000009950 E016 19.9144238 0.0010649182 7.607300e-01 0.8447368366 7 73596153 73596173 21 - 1.307 1.286 -0.073
ENSG00000009950 E017 35.1423593 0.0061289148 2.814719e-01 0.4213711782 7 73596174 73596266 93 - 1.574 1.504 -0.240
ENSG00000009950 E018 22.6250446 0.0009515378 1.393198e-01 0.2471182229 7 73596267 73596272 6 - 1.409 1.304 -0.365
ENSG00000009950 E019 31.0442245 0.0020403261 7.884557e-02 0.1576719936 7 73596364 73596479 116 - 1.545 1.434 -0.382
ENSG00000009950 E020 11.0965218 0.0015478755 2.654355e-05 0.0001599172 7 73596480 73596638 159 - 1.280 0.872 -1.484
ENSG00000009950 E021 12.2469043 0.0015026669 6.484783e-01 0.7599714107 7 73596639 73596709 71 - 1.124 1.083 -0.149
ENSG00000009950 E022 15.9037354 0.0011589034 5.516244e-01 0.6810448276 7 73596710 73596786 77 - 1.230 1.182 -0.172
ENSG00000009950 E023 5.3487274 0.0032150781 3.400016e-01 0.4839426010 7 73596787 73596789 3 - 0.855 0.732 -0.487
ENSG00000009950 E024 4.2456529 0.0277362831 3.463005e-01 0.4904393767 7 73596790 73596864 75 - 0.802 0.661 -0.574
ENSG00000009950 E025 15.4263104 0.0012466701 5.198883e-01 0.6539447518 7 73596865 73596932 68 - 1.150 1.210 0.214
ENSG00000009950 E026 22.7503537 0.0008630544 5.331652e-01 0.6654054257 7 73597182 73597644 463 - 1.316 1.366 0.173
ENSG00000009950 E027 9.3593881 0.0018580965 9.685592e-01 0.9843349178 7 73597645 73597713 69 - 0.983 0.990 0.027
ENSG00000009950 E028 11.8619385 0.0015167634 6.126916e-01 0.7315714239 7 73599526 73599591 66 - 1.111 1.064 -0.168
ENSG00000009950 E029 15.6915554 0.0016672818 2.952143e-01 0.4363401389 7 73599592 73599695 104 - 1.261 1.174 -0.307
ENSG00000009950 E030 17.3536286 0.0011096964 4.193470e-03 0.0136878061 7 73605688 73605768 81 - 1.372 1.143 -0.805
ENSG00000009950 E031 11.6372617 0.0015093125 8.900635e-02 0.1736104999 7 73605910 73605925 16 - 1.175 1.013 -0.585
ENSG00000009950 E032 23.2984311 0.0010945796 1.189822e-01 0.2184844941 7 73605926 73606111 186 - 1.429 1.320 -0.379
ENSG00000009950 E033 9.9782069 0.0160229328 2.267451e-01 0.3585058675 7 73606112 73606824 713 - 0.924 1.072 0.547
ENSG00000009950 E034 14.2227773 0.0031265297 3.078041e-01 0.4500443450 7 73606974 73607018 45 - 1.209 1.119 -0.322
ENSG00000009950 E035 9.3921129 0.0021084749 3.239784e-02 0.0766232202 7 73607019 73607135 117 - 1.124 0.902 -0.820
ENSG00000009950 E036 13.2514392 0.0014360012 1.449131e-03 0.0054705405 7 73607136 73607330 195 - 1.289 1.002 -1.030
ENSG00000009950 E037 10.1864620 0.0490068679 8.999982e-01 0.9401973063 7 73607331 73607378 48 - 1.018 1.013 -0.016
ENSG00000009950 E038 10.0873849 0.0293686886 6.867034e-01 0.7891653082 7 73607379 73607420 42 - 0.964 1.031 0.249
ENSG00000009950 E039 10.9691960 0.0092817431 4.221678e-01 0.5653303948 7 73607590 73607672 83 - 1.097 1.015 -0.299
ENSG00000009950 E040 18.5257628 0.0014452752 9.642673e-02 0.1849955432 7 73616071 73616177 107 - 1.341 1.211 -0.457
ENSG00000009950 E041 21.0220127 0.0008755181 1.115978e-02 0.0315493757 7 73624200 73624543 344 - 1.429 1.244 -0.645