ENSG00000009413

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358835 ENSG00000009413 HEK293_OSMI2_2hA HEK293_TMG_2hB REV3L protein_coding protein_coding 4.836816 2.39561 5.98782 0.2308589 0.1141824 1.318035 0.2734080 0.37141887 0.1490846 0.18973586 0.07455532 -1.2615821 0.06290000 0.15383333 0.0248000 -0.1290333 6.102304e-01 1.503959e-08 FALSE TRUE
ENST00000368802 ENSG00000009413 HEK293_OSMI2_2hA HEK293_TMG_2hB REV3L protein_coding protein_coding 4.836816 2.39561 5.98782 0.2308589 0.1141824 1.318035 1.4877942 0.04685285 2.5398247 0.04685285 0.22940381 5.4870216 0.23541667 0.02153333 0.4252000 0.4036667 6.698076e-05 1.503959e-08 FALSE TRUE
ENST00000462119 ENSG00000009413 HEK293_OSMI2_2hA HEK293_TMG_2hB REV3L protein_coding processed_transcript 4.836816 2.39561 5.98782 0.2308589 0.1141824 1.318035 1.0417412 1.24707393 0.7204833 0.15994691 0.29429498 -0.7831463 0.30602917 0.52396667 0.1208667 -0.4031000 8.192045e-03 1.503959e-08 TRUE TRUE
ENST00000619481 ENSG00000009413 HEK293_OSMI2_2hA HEK293_TMG_2hB REV3L protein_coding protein_coding 4.836816 2.39561 5.98782 0.2308589 0.1141824 1.318035 0.1774722 0.00000000 0.4153799 0.00000000 0.41537986 5.4106798 0.02715833 0.00000000 0.0699000 0.0699000 9.709290e-01 1.503959e-08 FALSE TRUE
MSTRG.28807.8 ENSG00000009413 HEK293_OSMI2_2hA HEK293_TMG_2hB REV3L protein_coding   4.836816 2.39561 5.98782 0.2308589 0.1141824 1.318035 0.6253875 0.03833300 1.2890382 0.02478651 0.08076846 4.7482914 0.10457917 0.01666667 0.2149333 0.1982667 1.503959e-08 1.503959e-08 TRUE TRUE
MSTRG.28807.9 ENSG00000009413 HEK293_OSMI2_2hA HEK293_TMG_2hB REV3L protein_coding   4.836816 2.39561 5.98782 0.2308589 0.1141824 1.318035 0.9684574 0.59643743 0.6649151 0.05765070 0.39984386 0.1543473 0.21547083 0.24906667 0.1093667 -0.1397000 4.910295e-01 1.503959e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000009413 E001 0.0000000       6 111299028 111299030 3 -      
ENSG00000009413 E002 0.0000000       6 111299031 111299032 2 -      
ENSG00000009413 E003 0.0000000       6 111299033 111299051 19 -      
ENSG00000009413 E004 21.6065286 0.0169580264 3.671595e-15 1.288097e-13 6 111299052 111299353 302 - 0.971 1.690 2.521
ENSG00000009413 E005 25.8325097 0.0107527529 1.310354e-10 2.268921e-09 6 111299354 111299460 107 - 1.177 1.678 1.731
ENSG00000009413 E006 50.5345567 0.0045609268 2.918044e-10 4.758670e-09 6 111299461 111299759 299 - 1.537 1.876 1.148
ENSG00000009413 E007 66.5954749 0.0004763875 2.957387e-10 4.818681e-09 6 111299760 111300156 397 - 1.690 1.944 0.858
ENSG00000009413 E008 44.2975786 0.0025220929 3.939523e-04 1.751440e-03 6 111307361 111307570 210 - 1.541 1.724 0.621
ENSG00000009413 E009 0.0000000       6 111307731 111307735 5 -      
ENSG00000009413 E010 2.3467817 0.0071076056 2.177090e-02 5.519997e-02 6 111308014 111308245 232 - 0.351 0.714 1.746
ENSG00000009413 E011 41.6567374 0.0005462937 1.520195e-04 7.559161e-04 6 111309853 111310099 247 - 1.514 1.703 0.644
ENSG00000009413 E012 31.6085070 0.0007165109 9.111108e-02 1.768716e-01 6 111311069 111311259 191 - 1.436 1.521 0.290
ENSG00000009413 E013 26.2868468 0.0146279255 2.008603e-01 3.272648e-01 6 111313352 111313489 138 - 1.356 1.446 0.309
ENSG00000009413 E014 29.5945149 0.0007166900 4.965136e-02 1.085426e-01 6 111315267 111315381 115 - 1.398 1.505 0.368
ENSG00000009413 E015 1.1855920 0.0122531407 6.722879e-01 7.782974e-01 6 111315382 111315637 256 - 0.276 0.341 0.425
ENSG00000009413 E016 31.8108755 0.0006731551 2.948976e-02 7.094643e-02 6 111322569 111322678 110 - 1.428 1.544 0.397
ENSG00000009413 E017 40.1648198 0.0005644382 1.853858e-04 9.008561e-04 6 111329532 111329738 207 - 1.497 1.687 0.649
ENSG00000009413 E018 25.3427650 0.0034077964 3.690236e-02 8.527430e-02 6 111331676 111331784 109 - 1.321 1.454 0.464
ENSG00000009413 E019 35.3694063 0.0007187396 2.690794e-01 4.075518e-01 6 111333123 111333367 245 - 1.495 1.536 0.142
ENSG00000009413 E020 33.2602761 0.0006097101 3.420569e-01 4.860471e-01 6 111335469 111335610 142 - 1.472 1.505 0.114
ENSG00000009413 E021 19.1166605 0.0010249676 9.172680e-01 9.517387e-01 6 111343925 111343949 25 - 1.257 1.217 -0.139
ENSG00000009413 E022 29.1970901 0.0006594295 1.332868e-01 2.386968e-01 6 111343950 111344043 94 - 1.404 1.480 0.261
ENSG00000009413 E023 0.1482932 0.0440501851 1.226551e-01   6 111348953 111349217 265 - 0.000 0.203 15.446
ENSG00000009413 E024 29.2808422 0.0006981035 4.606798e-01 6.006704e-01 6 111349218 111349336 119 - 1.422 1.444 0.076
ENSG00000009413 E025 25.7303533 0.0007608150 4.101671e-01 5.537731e-01 6 111351676 111351791 116 - 1.363 1.395 0.112
ENSG00000009413 E026 0.1817044 0.0389282080 1.226622e-01   6 111356668 111357013 346 - 0.000 0.203 15.451
ENSG00000009413 E027 17.3094360 0.0011951191 3.509555e-01 4.951516e-01 6 111357014 111357080 67 - 1.193 1.248 0.195
ENSG00000009413 E028 12.0141272 0.0014619438 9.349387e-01 9.630503e-01 6 111357081 111357125 45 - 1.067 1.046 -0.075
ENSG00000009413 E029 28.6056179 0.0007496189 7.561323e-01 8.412833e-01 6 111358822 111359014 193 - 1.413 1.406 -0.026
ENSG00000009413 E030 26.6416159 0.0081959218 7.764456e-01 8.560490e-01 6 111363853 111363978 126 - 1.398 1.341 -0.197
ENSG00000009413 E031 4.2619440 0.0038673069 3.714809e-02 8.576171e-02 6 111364944 111365042 99 - 0.750 0.341 -1.956
ENSG00000009413 E032 21.4856113 0.0048493138 5.710764e-01 6.974417e-01 6 111365265 111365344 80 - 1.317 1.233 -0.294
ENSG00000009413 E033 47.9623688 0.0005189941 3.557187e-01 5.000656e-01 6 111367115 111367625 511 - 1.652 1.565 -0.296
ENSG00000009413 E034 44.7999060 0.0005467715 1.760515e-01 2.960739e-01 6 111367626 111368028 403 - 1.629 1.513 -0.397
ENSG00000009413 E035 25.1228010 0.0069510200 1.532373e-01 2.660796e-01 6 111372596 111372694 99 - 1.395 1.235 -0.558
ENSG00000009413 E036 207.8406786 0.0204170768 1.057170e-06 8.728598e-06 6 111372695 111376529 3835 - 2.333 1.984 -1.170
ENSG00000009413 E037 19.1122860 0.0060944539 4.381845e-08 4.780188e-07 6 111376530 111376757 228 - 1.359 0.600 -2.877
ENSG00000009413 E038 16.8821049 0.0014186554 2.337244e-07 2.212150e-06 6 111377701 111377843 143 - 1.305 0.600 -2.689
ENSG00000009413 E039 22.4833464 0.0009527030 1.392064e-07 1.376063e-06 6 111379982 111380219 238 - 1.413 0.804 -2.215
ENSG00000009413 E040 14.9823644 0.0332829976 1.095749e-04 5.660625e-04 6 111381325 111381444 120 - 1.253 0.600 -2.502
ENSG00000009413 E041 0.0000000       6 111387746 111387764 19 -      
ENSG00000009413 E042 15.4711505 0.0035968268 1.937019e-04 9.368703e-04 6 111387765 111387902 138 - 1.253 0.761 -1.826
ENSG00000009413 E043 8.0777753 0.0020917987 1.026148e-03 4.048832e-03 6 111387903 111387913 11 - 1.003 0.445 -2.343
ENSG00000009413 E044 12.6385974 0.0067029147 1.275586e-04 6.480688e-04 6 111388001 111388085 85 - 1.178 0.600 -2.238
ENSG00000009413 E045 16.5613281 0.0011082465 1.442908e-04 7.221861e-04 6 111389106 111389210 105 - 1.278 0.804 -1.744
ENSG00000009413 E046 14.1718068 0.0109898753 5.215265e-04 2.240298e-03 6 111390086 111390180 95 - 1.217 0.714 -1.891
ENSG00000009413 E047 0.0000000       6 111392695 111392875 181 -      
ENSG00000009413 E048 12.1780326 0.0014955859 5.079078e-04 2.189642e-03 6 111392876 111392972 97 - 1.156 0.660 -1.899
ENSG00000009413 E049 0.0000000       6 111405427 111405469 43 -      
ENSG00000009413 E050 15.4239846 0.0011355833 1.641184e-06 1.300529e-05 6 111405470 111405630 161 - 1.265 0.600 -2.548
ENSG00000009413 E051 0.1515154 0.0423038856 1.000000e+00   6 111405631 111405632 2 - 0.071 0.000 -12.237
ENSG00000009413 E052 10.4317970 0.0018666725 3.900831e-05 2.254219e-04 6 111411480 111411554 75 - 1.111 0.445 -2.737
ENSG00000009413 E053 0.0000000       6 111411555 111411556 2 -      
ENSG00000009413 E054 14.5023830 0.0013307190 1.116649e-04 5.754312e-04 6 111416283 111416472 190 - 1.230 0.713 -1.941
ENSG00000009413 E055 0.0000000       6 111460300 111460406 107 -      
ENSG00000009413 E056 4.1781828 0.0037008210 3.703972e-02 8.554892e-02 6 111472013 111472140 128 - 0.750 0.341 -1.956
ENSG00000009413 E057 10.3626674 0.0055257939 8.183553e-02 1.624372e-01 6 111482750 111483229 480 - 1.060 0.804 -0.967
ENSG00000009413 E058 1.1458512 0.0114080945 6.725715e-01 7.785030e-01 6 111483599 111483715 117 - 0.276 0.341 0.424