ENSG00000009335

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348165 ENSG00000009335 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE3C protein_coding protein_coding 39.38252 34.89564 52.15427 6.576701 1.476339 0.579602 14.623163 7.690635 25.2950558 0.4260842 2.5612366 1.7163764 0.3518125 0.2343000 0.4847 0.25040000 7.273881e-03 1.638475e-16 FALSE TRUE
ENST00000474153 ENSG00000009335 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE3C protein_coding retained_intron 39.38252 34.89564 52.15427 6.576701 1.476339 0.579602 3.353157 9.928121 0.3314503 3.6951782 0.0920922 -4.8632256 0.1038667 0.2663000 0.0063 -0.26000000 1.638475e-16 1.638475e-16 FALSE TRUE
MSTRG.30997.9 ENSG00000009335 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE3C protein_coding   39.38252 34.89564 52.15427 6.576701 1.476339 0.579602 14.879979 13.606967 16.3648226 2.8345719 1.6189187 0.2660739 0.3864958 0.3884667 0.3152 -0.07326667 4.218649e-01 1.638475e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000009335 E001 0.3289534 0.0330574369 7.074806e-01   7 157138916 157138925 10 + 0.092 0.160 0.911
ENSG00000009335 E002 19.8755176 0.0411010488 1.817910e-01 3.034794e-01 7 157138926 157138986 61 + 1.359 1.212 -0.514
ENSG00000009335 E003 22.1180028 0.0432706587 1.555462e-01 2.691267e-01 7 157138987 157138999 13 + 1.406 1.249 -0.548
ENSG00000009335 E004 25.8220700 0.0444387738 9.237905e-02 1.788255e-01 7 157139000 157139081 82 + 1.480 1.291 -0.656
ENSG00000009335 E005 22.8288059 0.0393230249 4.395451e-02 9.829604e-02 7 157139082 157139141 60 + 1.438 1.214 -0.779
ENSG00000009335 E006 11.5646360 0.0057804557 8.532102e-08 8.776095e-07 7 157139142 157139170 29 + 1.240 0.615 -2.390
ENSG00000009335 E007 9.7295032 0.1186885086 2.866627e-02 6.934216e-02 7 157139171 157139194 24 + 1.142 0.732 -1.550
ENSG00000009335 E008 8.7169665 0.1141811882 1.094935e-01 2.048244e-01 7 157139195 157139209 15 + 1.069 0.797 -1.027
ENSG00000009335 E009 9.5608430 0.0650452704 2.690508e-01 4.075224e-01 7 157139210 157139211 2 + 1.069 0.928 -0.520
ENSG00000009335 E010 41.7874496 0.0065298562 3.060722e-04 1.404050e-03 7 157139212 157139278 67 + 1.694 1.493 -0.685
ENSG00000009335 E011 79.9257539 0.0004983386 3.319995e-09 4.468655e-08 7 157139279 157139338 60 + 1.968 1.767 -0.675
ENSG00000009335 E012 118.5632211 0.0002470273 2.013668e-14 6.333775e-13 7 157163810 157163863 54 + 2.143 1.929 -0.718
ENSG00000009335 E013 0.4804688 0.0217590799 9.217907e-01 9.546456e-01 7 157164419 157164530 112 + 0.169 0.160 -0.089
ENSG00000009335 E014 1.3413738 0.2451746352 6.147695e-01 7.331704e-01 7 157167238 157167361 124 + 0.386 0.283 -0.635
ENSG00000009335 E015 82.4132932 0.0004629965 1.879203e-09 2.646123e-08 7 157169048 157169051 4 + 1.981 1.780 -0.675
ENSG00000009335 E016 147.7807163 0.0021265753 2.184038e-09 3.038105e-08 7 157169052 157169122 71 + 2.227 2.045 -0.609
ENSG00000009335 E017 223.5187591 0.0028299404 1.047233e-08 1.285609e-07 7 157170304 157170450 147 + 2.399 2.238 -0.539
ENSG00000009335 E018 200.1409800 0.0019789934 3.510997e-07 3.202445e-06 7 157174919 157175034 116 + 2.341 2.215 -0.420
ENSG00000009335 E019 222.8097433 0.0019745373 1.483002e-06 1.187348e-05 7 157178690 157178847 158 + 2.382 2.270 -0.372
ENSG00000009335 E020 244.8953271 0.0006773752 2.208843e-09 3.069679e-08 7 157181518 157181671 154 + 2.422 2.315 -0.356
ENSG00000009335 E021 293.0436332 0.0016672552 8.039600e-03 2.387807e-02 7 157182108 157182328 221 + 2.472 2.443 -0.097
ENSG00000009335 E022 262.4936166 0.0011944580 3.001270e-03 1.026858e-02 7 157183878 157184029 152 + 2.427 2.397 -0.100
ENSG00000009335 E023 296.4733173 0.0011361639 2.576501e-03 8.993781e-03 7 157186834 157187021 188 + 2.478 2.451 -0.090
ENSG00000009335 E024 0.8920389 0.0133249056 8.195871e-01 8.860881e-01 7 157188949 157189296 348 + 0.290 0.277 -0.092
ENSG00000009335 E025 245.2397881 0.0002077015 9.447995e-07 7.879097e-06 7 157201721 157201807 87 + 2.409 2.346 -0.210
ENSG00000009335 E026 326.1984249 0.0001770698 2.084802e-08 2.422172e-07 7 157207398 157207512 115 + 2.531 2.469 -0.207
ENSG00000009335 E027 249.9186825 0.0002343417 1.042241e-10 1.834010e-09 7 157207513 157207555 43 + 2.431 2.330 -0.335
ENSG00000009335 E028 516.5563893 0.0003056418 2.598230e-07 2.434597e-06 7 157207703 157207935 233 + 2.722 2.685 -0.124
ENSG00000009335 E029 290.3759142 0.0001931157 5.368053e-02 1.156900e-01 7 157216867 157216971 105 + 2.454 2.467 0.042
ENSG00000009335 E030 7.6316832 0.0045162677 1.685237e-01 2.862400e-01 7 157216972 157217245 274 + 0.841 1.051 0.788
ENSG00000009335 E031 3.7610089 0.0048425624 5.513896e-01 6.808658e-01 7 157220668 157220688 21 + 0.702 0.659 -0.179
ENSG00000009335 E032 224.3630428 0.0003918268 3.120671e-03 1.062128e-02 7 157220689 157220776 88 + 2.356 2.335 -0.070
ENSG00000009335 E033 22.4532744 0.0127314877 8.853571e-02 1.728872e-01 7 157220777 157223253 2477 + 1.402 1.285 -0.406
ENSG00000009335 E034 212.4261639 0.0004161977 3.641840e-01 5.085545e-01 7 157223254 157223351 98 + 2.313 2.344 0.105
ENSG00000009335 E035 244.3809467 0.0002263121 2.606635e-02 6.408265e-02 7 157225407 157225499 93 + 2.383 2.386 0.007
ENSG00000009335 E036 116.1461610 0.0002438200 7.042122e-01 8.028015e-01 7 157225500 157225501 2 + 2.036 2.104 0.227
ENSG00000009335 E037 164.7074157 0.0002077111 3.293026e-01 4.727992e-01 7 157225502 157225539 38 + 2.180 2.262 0.276
ENSG00000009335 E038 439.6285643 0.0001790363 9.310663e-02 1.799820e-01 7 157231080 157231327 248 + 2.604 2.689 0.281
ENSG00000009335 E039 13.3946810 0.0030726989 7.350695e-01 8.259101e-01 7 157231328 157231815 488 + 1.140 1.158 0.063
ENSG00000009335 E040 412.1044150 0.0003865497 6.128355e-02 1.287995e-01 7 157248368 157248580 213 + 2.574 2.664 0.302
ENSG00000009335 E041 1.8695366 0.0818249360 8.381524e-01 8.987996e-01 7 157248581 157248624 44 + 0.462 0.444 -0.090
ENSG00000009335 E042 357.3140152 0.0001706508 1.208379e-04 6.178444e-04 7 157253954 157254142 189 + 2.495 2.625 0.431
ENSG00000009335 E043 197.2537912 0.0012440656 6.542408e-06 4.536084e-05 7 157254244 157254310 67 + 2.208 2.396 0.626
ENSG00000009335 E044 5.3014982 0.0039486063 2.416546e-02 6.014918e-02 7 157256687 157256913 227 + 0.636 0.976 1.349
ENSG00000009335 E045 236.4747021 0.0001863871 2.210833e-06 1.703553e-05 7 157256914 157257044 131 + 2.299 2.465 0.554
ENSG00000009335 E046 1953.8880209 0.0044974970 4.054862e-15 1.413397e-13 7 157267585 157269370 1786 + 3.159 3.422 0.873