ENSG00000008952

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337002 ENSG00000008952 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC62 protein_coding protein_coding 70.37902 13.20222 128.4106 1.5517 6.010909 3.280932 10.986120 2.9837995 18.95475 0.2692088 0.2356015 2.663271 0.17331250 0.22763333 0.1482000 -0.07943333 0.0008705687 4.509231e-07 FALSE  
ENST00000460513 ENSG00000008952 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC62 protein_coding nonsense_mediated_decay 70.37902 13.20222 128.4106 1.5517 6.010909 3.280932 5.738979 0.7392185 11.78420 0.1028424 0.3137002 3.976548 0.06717083 0.05576667 0.0921000 0.03633333 0.0176545514 4.509231e-07    
ENST00000469515 ENSG00000008952 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC62 protein_coding nonsense_mediated_decay 70.37902 13.20222 128.4106 1.5517 6.010909 3.280932 8.525982 0.3250184 16.54723 0.3250184 1.4926911 5.627078 0.09136667 0.03183333 0.1287000 0.09686667 0.1238867275 4.509231e-07 FALSE  
ENST00000470355 ENSG00000008952 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC62 protein_coding processed_transcript 70.37902 13.20222 128.4106 1.5517 6.010909 3.280932 34.246963 5.9918507 59.67092 0.6753776 0.3936656 3.313791 0.48529167 0.45563333 0.4664333 0.01080000 0.9229218280 4.509231e-07 FALSE  
ENST00000481435 ENSG00000008952 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC62 protein_coding retained_intron 70.37902 13.20222 128.4106 1.5517 6.010909 3.280932 8.833432 2.7178275 16.18691 0.9280976 4.9676523 2.569894 0.15292917 0.19610000 0.1231333 -0.07296667 0.5026114851 4.509231e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000008952 E001 3.3111349 0.0678014374 6.112858e-01 7.304114e-01 3 169966635 169966800 166 + 0.544 0.431 -0.557
ENSG00000008952 E002 12.4525578 0.0173209139 2.032035e-01 3.302334e-01 3 169966801 169966806 6 + 1.021 0.841 -0.679
ENSG00000008952 E003 13.6350439 0.0165242749 1.219680e-01 2.227345e-01 3 169966807 169966807 1 + 1.060 0.841 -0.823
ENSG00000008952 E004 26.4391948 0.0008337329 1.420591e-01 2.508474e-01 3 169966808 169966813 6 + 1.317 1.188 -0.456
ENSG00000008952 E005 29.3962810 0.0009276000 2.903462e-01 4.311464e-01 3 169966814 169966814 1 + 1.355 1.274 -0.281
ENSG00000008952 E006 132.9930133 0.0002456531 1.066687e-03 4.190109e-03 3 169966815 169966825 11 + 2.002 1.868 -0.448
ENSG00000008952 E007 193.0476854 0.0002031751 2.326837e-04 1.102748e-03 3 169966826 169966858 33 + 2.161 2.039 -0.408
ENSG00000008952 E008 3.4019417 0.0486612575 9.612151e-01 9.795821e-01 3 169968385 169968523 139 + 0.528 0.550 0.103
ENSG00000008952 E009 3.1043377 0.0048668397 1.932758e-01 3.178900e-01 3 169969287 169969383 97 + 0.544 0.266 -1.562
ENSG00000008952 E010 0.8942170 0.0134985844 4.476909e-01 5.890576e-01 3 169975451 169975607 157 + 0.243 0.000 -9.642
ENSG00000008952 E011 190.9245214 0.0001871420 2.729814e-04 1.269715e-03 3 169975608 169975611 4 + 2.157 2.036 -0.404
ENSG00000008952 E012 291.1047120 0.0001605951 5.593978e-04 2.382613e-03 3 169975612 169975716 105 + 2.334 2.248 -0.287
ENSG00000008952 E013 281.2375710 0.0007861023 3.137834e-01 4.564220e-01 3 169976946 169977051 106 + 2.310 2.295 -0.047
ENSG00000008952 E014 1.1081867 0.3356192833 3.802714e-01 5.245594e-01 3 169982637 169982659 23 + 0.211 0.432 1.445
ENSG00000008952 E015 1.7058293 0.0618559274 6.496165e-01 7.608384e-01 3 169982660 169982706 47 + 0.328 0.431 0.591
ENSG00000008952 E016 205.9680220 0.0150222015 7.639293e-01 8.471276e-01 3 169982707 169982868 162 + 2.168 2.202 0.114
ENSG00000008952 E017 93.3555207 0.0124143065 6.036058e-01 7.243740e-01 3 169982869 169982911 43 + 1.825 1.883 0.194
ENSG00000008952 E018 184.5173659 0.0024538218 8.921976e-01 9.351219e-01 3 169983161 169983253 93 + 2.122 2.145 0.075
ENSG00000008952 E019 4.6610441 0.0526742481 8.188956e-02 1.625240e-01 3 169983254 169983939 686 + 0.677 0.267 -2.141
ENSG00000008952 E020 2.0743967 0.1014747693 3.835021e-01 5.277085e-01 3 169985129 169985189 61 + 0.352 0.552 1.034
ENSG00000008952 E021 185.6479119 0.0002046436 2.507030e-01 3.867698e-01 3 169985805 169985865 61 + 2.131 2.107 -0.079
ENSG00000008952 E022 0.2987644 0.0275581576 1.000000e+00   3 169985866 169985885 20 + 0.097 0.000 -7.831
ENSG00000008952 E023 276.5087897 0.0001476173 2.693936e-01 4.079079e-01 3 169988240 169988359 120 + 2.302 2.288 -0.047
ENSG00000008952 E024 815.6452225 0.0012697959 1.674097e-01 2.848357e-01 3 169992594 169993101 508 + 2.770 2.756 -0.044
ENSG00000008952 E025 518.0156635 0.0044198959 2.201711e-04 1.050199e-03 3 169993102 169993654 553 + 2.546 2.688 0.471
ENSG00000008952 E026 966.2570515 0.0005505158 2.152527e-06 1.662209e-05 3 169993655 169998373 4719 + 2.826 2.923 0.320