ENSG00000008869

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000233099 ENSG00000008869 HEK293_OSMI2_2hA HEK293_TMG_2hB HEATR5B protein_coding protein_coding 7.573956 3.359454 10.18257 0.6301561 0.2563925 1.59693 5.25410426 2.2241549 7.209430 0.3908275 0.07134357 1.692156 0.6841083 0.66623333 0.7092333 0.04300000 0.641088780 0.004757479 FALSE  
ENST00000425467 ENSG00000008869 HEK293_OSMI2_2hA HEK293_TMG_2hB HEATR5B protein_coding protein_coding 7.573956 3.359454 10.18257 0.6301561 0.2563925 1.59693 0.07861915 0.2168053 0.000000 0.1086838 0.00000000 -4.503383 0.0123625 0.05446667 0.0000000 -0.05446667 0.004757479 0.004757479 FALSE  
MSTRG.18216.4 ENSG00000008869 HEK293_OSMI2_2hA HEK293_TMG_2hB HEATR5B protein_coding   7.573956 3.359454 10.18257 0.6301561 0.2563925 1.59693 1.86657482 0.8697804 2.568303 0.1210203 0.33663714 1.551207 0.2591833 0.26646667 0.2509000 -0.01556667 0.932356575 0.004757479 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000008869 E001 0.8416995 0.0152242408 5.624337e-04 2.393650e-03 2 36968383 36968601 219 - 0.000 0.574 12.366
ENSG00000008869 E002 94.5949981 0.0049927506 1.175458e-20 8.136173e-19 2 36980895 36981579 685 - 1.756 2.212 1.531
ENSG00000008869 E003 72.6035491 0.0004588196 2.022726e-20 1.360793e-18 2 36981580 36981794 215 - 1.676 2.072 1.333
ENSG00000008869 E004 77.7715996 0.0015084283 2.384606e-16 9.801614e-15 2 36988646 36988859 214 - 1.723 2.086 1.223
ENSG00000008869 E005 52.0585994 0.0054218726 5.186078e-06 3.677523e-05 2 36990648 36990799 152 - 1.588 1.870 0.953
ENSG00000008869 E006 82.7581227 0.0016436029 3.110735e-05 1.844390e-04 2 37000586 37000813 228 - 1.824 2.015 0.641
ENSG00000008869 E007 74.1401735 0.0060148309 4.188309e-02 9.451046e-02 2 37002306 37002572 267 - 1.801 1.919 0.398
ENSG00000008869 E008 59.0761992 0.0019919212 4.258359e-01 5.687217e-01 2 37003542 37003686 145 - 1.726 1.777 0.171
ENSG00000008869 E009 52.0840292 0.0018405282 2.412675e-01 3.756762e-01 2 37005632 37005759 128 - 1.665 1.739 0.250
ENSG00000008869 E010 77.7317479 0.0004021880 2.152074e-02 5.468499e-02 2 37007050 37007304 255 - 1.825 1.933 0.361
ENSG00000008869 E011 0.7468662 0.0579263480 5.380994e-01 6.695654e-01 2 37008168 37008610 443 - 0.198 0.321 0.917
ENSG00000008869 E012 72.2192965 0.0009637379 7.719871e-01 8.528519e-01 2 37008611 37008848 238 - 1.823 1.846 0.079
ENSG00000008869 E013 59.4176118 0.0034215463 2.281579e-01 3.602316e-01 2 37013841 37014020 180 - 1.765 1.706 -0.198
ENSG00000008869 E014 39.3388222 0.0034290047 4.819729e-03 1.542944e-02 2 37019809 37019877 69 - 1.619 1.428 -0.655
ENSG00000008869 E015 56.5421397 0.0004182957 9.657252e-03 2.791999e-02 2 37020655 37020836 182 - 1.759 1.631 -0.434
ENSG00000008869 E016 64.4105637 0.0003635081 7.891222e-01 8.650035e-01 2 37027923 37028174 252 - 1.774 1.796 0.077
ENSG00000008869 E017 68.5934804 0.0007642074 3.638982e-01 5.083204e-01 2 37028681 37028920 240 - 1.818 1.784 -0.112
ENSG00000008869 E018 54.0555740 0.0004231075 3.309833e-01 4.745578e-01 2 37032629 37032773 145 - 1.720 1.679 -0.139
ENSG00000008869 E019 55.7334170 0.0005085554 7.973243e-02 1.591398e-01 2 37037855 37038024 170 - 1.741 1.658 -0.282
ENSG00000008869 E020 56.6148825 0.0004152397 1.807337e-03 6.622206e-03 2 37040329 37040518 190 - 1.766 1.608 -0.537
ENSG00000008869 E021 0.0000000       2 37041024 37041132 109 -      
ENSG00000008869 E022 56.5267924 0.0013494618 1.213534e-03 4.686773e-03 2 37041133 37041292 160 - 1.769 1.596 -0.588
ENSG00000008869 E023 54.6006125 0.0008003738 2.451301e-01 3.801877e-01 2 37049653 37049843 191 - 1.726 1.673 -0.178
ENSG00000008869 E024 32.7815659 0.0029213641 9.912861e-01 9.986442e-01 2 37053502 37053607 106 - 1.492 1.502 0.034
ENSG00000008869 E025 37.0747517 0.0030351589 4.497553e-03 1.453585e-02 2 37056440 37056615 176 - 1.590 1.392 -0.680
ENSG00000008869 E026 34.3841379 0.0006067586 2.856457e-02 6.913940e-02 2 37057317 37057480 164 - 1.550 1.411 -0.479
ENSG00000008869 E027 33.9973707 0.0008465335 5.646406e-02 1.205358e-01 2 37058451 37058560 110 - 1.540 1.420 -0.415
ENSG00000008869 E028 31.5769917 0.0174161077 2.454621e-01 3.805872e-01 2 37058888 37058987 100 - 1.503 1.410 -0.320
ENSG00000008869 E029 38.8021994 0.0679548818 1.722118e-01 2.910807e-01 2 37060581 37060733 153 - 1.600 1.461 -0.477
ENSG00000008869 E030 31.1095034 0.0006810322 3.300068e-03 1.114917e-02 2 37061939 37062050 112 - 1.523 1.318 -0.710
ENSG00000008869 E031 41.3568889 0.0006156446 6.411881e-05 3.516011e-04 2 37064740 37064990 251 - 1.652 1.401 -0.861
ENSG00000008869 E032 31.8814174 0.0006324473 3.964917e-06 2.887035e-05 2 37065755 37065910 156 - 1.559 1.215 -1.196
ENSG00000008869 E033 46.8203909 0.0028500374 1.913033e-05 1.192127e-04 2 37068681 37068930 250 - 1.711 1.437 -0.938
ENSG00000008869 E034 48.9176279 0.0039402576 1.212929e-04 6.198701e-04 2 37070230 37070387 158 - 1.724 1.478 -0.840
ENSG00000008869 E035 33.1779128 0.0181663860 1.371079e-02 3.756281e-02 2 37072110 37072211 102 - 1.552 1.329 -0.770
ENSG00000008869 E036 21.7927224 0.0049816338 1.712871e-03 6.322667e-03 2 37072212 37072281 70 - 1.389 1.099 -1.025
ENSG00000008869 E037 28.1689019 0.0033641198 1.531687e-03 5.739077e-03 2 37075485 37075634 150 - 1.487 1.230 -0.894
ENSG00000008869 E038 5.0399190 0.0040943033 1.047890e-02 2.992812e-02 2 37075635 37076164 530 - 0.843 0.423 -1.858
ENSG00000008869 E039 22.8158395 0.0106329750 4.178934e-03 1.364647e-02 2 37076911 37077019 109 - 1.406 1.118 -1.013
ENSG00000008869 E040 38.7522130 0.0046336949 8.218315e-04 3.337481e-03 2 37079120 37079331 212 - 1.622 1.381 -0.824
ENSG00000008869 E041 33.2663101 0.0012631603 7.853582e-05 4.210782e-04 2 37083289 37083436 148 - 1.566 1.282 -0.983
ENSG00000008869 E042 15.2550453 0.0011439598 4.265024e-02 9.590571e-02 2 37084269 37084356 88 - 1.230 1.037 -0.693
ENSG00000008869 E043 1.2136174 0.0576923098 1.920244e-01 3.162931e-01 2 37084357 37084372 16 - 0.248 0.502 1.501
ENSG00000008869 E044 0.0000000       2 37091435 37091583 149 -