ENSG00000008838

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394126 ENSG00000008838 HEK293_OSMI2_2hA HEK293_TMG_2hB MED24 protein_coding protein_coding 88.72754 124.2863 61.28135 6.37155 3.896747 -1.020028 5.688792 8.835749 4.150488 1.2989576 0.5741449 -1.0882317 0.06497500 0.07036667 0.06720000 -0.003166667 9.491349e-01 1.018496e-10 FALSE TRUE
ENST00000394128 ENSG00000008838 HEK293_OSMI2_2hA HEK293_TMG_2hB MED24 protein_coding protein_coding 88.72754 124.2863 61.28135 6.37155 3.896747 -1.020028 21.700767 32.229748 14.703398 1.6877875 1.0159527 -1.1317100 0.24499167 0.25940000 0.24363333 -0.015766667 8.633740e-01 1.018496e-10 FALSE TRUE
ENST00000491466 ENSG00000008838 HEK293_OSMI2_2hA HEK293_TMG_2hB MED24 protein_coding nonsense_mediated_decay 88.72754 124.2863 61.28135 6.37155 3.896747 -1.020028 11.013789 23.715872 2.812474 2.4638113 0.5876752 -3.0714287 0.10439167 0.19240000 0.04563333 -0.146766667 1.288447e-06 1.018496e-10 FALSE TRUE
ENST00000501516 ENSG00000008838 HEK293_OSMI2_2hA HEK293_TMG_2hB MED24 protein_coding protein_coding 88.72754 124.2863 61.28135 6.37155 3.896747 -1.020028 10.126082 12.595626 6.208636 0.7091035 0.7237956 -1.0193977 0.11772500 0.10243333 0.10063333 -0.001800000 1.000000e+00 1.018496e-10 FALSE TRUE
ENST00000580921 ENSG00000008838 HEK293_OSMI2_2hA HEK293_TMG_2hB MED24 protein_coding retained_intron 88.72754 124.2863 61.28135 6.37155 3.896747 -1.020028 5.932176 5.051137 4.971549 0.3528711 1.3176840 -0.0228671 0.06931667 0.04056667 0.07916667 0.038600000 1.007128e-01 1.018496e-10 FALSE FALSE
MSTRG.14280.8 ENSG00000008838 HEK293_OSMI2_2hA HEK293_TMG_2hB MED24 protein_coding   88.72754 124.2863 61.28135 6.37155 3.896747 -1.020028 7.364691 8.353485 7.662427 2.4143265 0.1342322 -0.1244212 0.08942917 0.06560000 0.12600000 0.060400000 1.667959e-01 1.018496e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000008838 E001 0.6298062 0.0190015367 8.433070e-01 9.024214e-01 17 40019097 40019097 1 - 0.176 0.214 0.348
ENSG00000008838 E002 2.3270975 0.0066154452 2.299765e-01 3.624354e-01 17 40019098 40019103 6 - 0.301 0.523 1.227
ENSG00000008838 E003 6.5977229 0.0024874538 2.072000e-02 5.299790e-02 17 40019104 40019107 4 - 0.543 0.892 1.445
ENSG00000008838 E004 26.5371468 0.0011686657 8.045695e-06 5.459753e-05 17 40019108 40019144 37 - 1.060 1.453 1.387
ENSG00000008838 E005 72.8022133 0.0028098613 6.917189e-07 5.945738e-06 17 40019145 40019172 28 - 1.585 1.871 0.972
ENSG00000008838 E006 683.3796874 0.0025710674 3.063519e-10 4.978336e-09 17 40019173 40019448 276 - 2.631 2.820 0.632
ENSG00000008838 E007 464.7633078 0.0026214248 4.129784e-07 3.714277e-06 17 40019449 40019502 54 - 2.485 2.649 0.546
ENSG00000008838 E008 436.9765729 0.0008450334 1.282599e-07 1.276045e-06 17 40019503 40019528 26 - 2.485 2.615 0.432
ENSG00000008838 E009 687.2499523 0.0008533483 4.530006e-12 9.969749e-11 17 40019529 40019631 103 - 2.666 2.814 0.495
ENSG00000008838 E010 396.9760237 0.0022910565 2.929271e-04 1.350946e-03 17 40019632 40019645 14 - 2.455 2.570 0.382
ENSG00000008838 E011 55.7932838 0.0062020381 2.292888e-01 3.615922e-01 17 40019646 40019784 139 - 1.755 1.681 -0.253
ENSG00000008838 E012 877.9672208 0.0008285618 7.695367e-07 6.551904e-06 17 40019785 40019933 149 - 2.812 2.910 0.326
ENSG00000008838 E013 7.4459461 0.0023785208 4.838934e-01 6.219151e-01 17 40019934 40020010 77 - 0.929 0.842 -0.332
ENSG00000008838 E014 690.3670873 0.0035179006 1.956032e-02 5.054070e-02 17 40020273 40020350 78 - 2.722 2.801 0.266
ENSG00000008838 E015 345.1842339 0.0047705744 1.844481e-01 3.068068e-01 17 40020351 40020353 3 - 2.438 2.495 0.190
ENSG00000008838 E016 38.4954881 0.0005612343 1.850628e-01 3.075780e-01 17 40020354 40020482 129 - 1.476 1.562 0.292
ENSG00000008838 E017 3.5450461 0.0052262741 1.088544e-02 3.089367e-02 17 40020483 40020527 45 - 0.844 0.464 -1.647
ENSG00000008838 E018 13.9604430 0.1269690185 8.947163e-01 9.367146e-01 17 40020528 40020619 92 - 1.096 1.142 0.165
ENSG00000008838 E019 4.1955925 0.0037101731 3.749337e-03 1.243763e-02 17 40021173 40021414 242 - 0.929 0.523 -1.681
ENSG00000008838 E020 704.1354542 0.0021060443 3.574149e-03 1.193906e-02 17 40021955 40022054 100 - 2.728 2.810 0.273
ENSG00000008838 E021 409.4772344 0.0018806667 1.222829e-01 2.232019e-01 17 40022394 40022411 18 - 2.518 2.566 0.158
ENSG00000008838 E022 551.5232738 0.0005445697 6.164261e-05 3.394769e-04 17 40022412 40022484 73 - 2.620 2.703 0.278
ENSG00000008838 E023 674.5365554 0.0004456578 6.959741e-09 8.833593e-08 17 40022645 40022826 182 - 2.687 2.796 0.364
ENSG00000008838 E024 242.5846134 0.0002178098 2.331289e-05 1.423364e-04 17 40023131 40023141 11 - 2.240 2.355 0.384
ENSG00000008838 E025 553.6226468 0.0032591274 3.214340e-03 1.089799e-02 17 40023142 40023288 147 - 2.612 2.710 0.327
ENSG00000008838 E026 438.8799588 0.0001814064 5.595773e-06 3.938998e-05 17 40023289 40023364 76 - 2.514 2.607 0.308
ENSG00000008838 E027 319.5487026 0.0005140578 1.587797e-04 7.863524e-04 17 40023365 40023395 31 - 2.374 2.470 0.321
ENSG00000008838 E028 15.3774883 0.0100752998 2.206434e-03 7.862506e-03 17 40023396 40023651 256 - 1.351 1.052 -1.064
ENSG00000008838 E029 274.8938372 0.0001905577 3.129380e-04 1.432389e-03 17 40026156 40026177 22 - 2.311 2.402 0.305
ENSG00000008838 E030 595.3427145 0.0001129325 1.177005e-04 6.033339e-04 17 40026178 40026302 125 - 2.665 2.731 0.220
ENSG00000008838 E031 315.3514759 0.0001655396 5.809257e-01 7.055735e-01 17 40026303 40026305 3 - 2.430 2.443 0.043
ENSG00000008838 E032 394.0432227 0.0001588920 9.305396e-01 9.603171e-01 17 40026306 40026331 26 - 2.534 2.537 0.007
ENSG00000008838 E033 4.1696434 0.0075951112 6.383131e-04 2.674182e-03 17 40026332 40026450 119 - 0.954 0.465 -2.060
ENSG00000008838 E034 562.7203492 0.0001529000 4.865213e-01 6.242423e-01 17 40026647 40026746 100 - 2.682 2.695 0.042
ENSG00000008838 E035 5.1776205 0.0060941257 7.654454e-03 2.291293e-02 17 40026747 40026855 109 - 0.977 0.621 -1.415
ENSG00000008838 E036 654.9057510 0.0004273981 2.280951e-01 3.601505e-01 17 40026856 40027014 159 - 2.773 2.752 -0.068
ENSG00000008838 E037 273.2530435 0.0027590591 6.183640e-01 7.360203e-01 17 40027015 40027034 20 - 2.391 2.376 -0.050
ENSG00000008838 E038 10.1535671 0.0016446173 2.305912e-07 2.184896e-06 17 40027035 40027149 115 - 1.311 0.785 -1.934
ENSG00000008838 E039 395.5556171 0.0011981613 8.811691e-01 9.278259e-01 17 40027383 40027465 83 - 2.541 2.539 -0.007
ENSG00000008838 E040 2.7446327 0.0434186061 5.615393e-01 6.893192e-01 17 40027466 40027523 58 - 0.601 0.496 -0.486
ENSG00000008838 E041 296.4335418 0.0001853724 9.882986e-01 9.967495e-01 17 40027909 40027946 38 - 2.415 2.415 0.000
ENSG00000008838 E042 5.2853202 0.0031570191 5.955513e-07 5.191578e-06 17 40027947 40028059 113 - 1.113 0.464 -2.648
ENSG00000008838 E043 470.3704893 0.0003438126 5.134589e-01 6.482852e-01 17 40028826 40028968 143 - 2.604 2.618 0.047
ENSG00000008838 E044 13.0366962 0.0088604369 1.359824e-01 2.424517e-01 17 40028969 40029004 36 - 1.203 1.049 -0.555
ENSG00000008838 E045 498.2687492 0.0011014961 5.235073e-03 1.657146e-02 17 40029748 40029859 112 - 2.687 2.623 -0.211
ENSG00000008838 E046 256.2072194 0.0001940568 2.251506e-08 2.599592e-07 17 40031159 40031167 9 - 2.448 2.313 -0.450
ENSG00000008838 E047 425.1990435 0.0007921871 9.293160e-07 7.765013e-06 17 40031168 40031245 78 - 2.650 2.540 -0.366
ENSG00000008838 E048 424.0423845 0.0018662475 1.134558e-02 3.199110e-02 17 40031538 40031620 83 - 2.621 2.552 -0.228
ENSG00000008838 E049 308.5881511 0.0037623122 1.688269e-02 4.467441e-02 17 40032043 40032090 48 - 2.496 2.410 -0.287
ENSG00000008838 E050 5.3647132 0.0032655518 1.825480e-05 1.142792e-04 17 40032091 40032433 343 - 1.078 0.523 -2.233
ENSG00000008838 E051 258.1735690 0.0021516208 3.566307e-02 8.292843e-02 17 40032649 40032670 22 - 2.405 2.338 -0.224
ENSG00000008838 E052 210.2056909 0.0050710794 2.516578e-01 3.879205e-01 17 40032671 40032672 2 - 2.302 2.254 -0.161
ENSG00000008838 E053 293.4417081 0.0021996477 1.263795e-01 2.290990e-01 17 40032673 40032715 43 - 2.445 2.398 -0.156
ENSG00000008838 E054 304.9295445 0.0002552827 3.500304e-02 8.165823e-02 17 40032716 40032762 47 - 2.462 2.413 -0.162
ENSG00000008838 E055 420.4571189 0.0005747112 7.861134e-04 3.209630e-03 17 40033056 40033172 117 - 2.617 2.545 -0.240
ENSG00000008838 E056 247.6215776 0.0001872437 3.215494e-04 1.467127e-03 17 40033173 40033206 34 - 2.401 2.311 -0.297
ENSG00000008838 E057 367.1249964 0.0001733766 1.981604e-03 7.169630e-03 17 40033345 40033456 112 - 2.552 2.488 -0.214
ENSG00000008838 E058 16.1047272 0.0011412931 1.087372e-18 5.979663e-17 17 40033457 40033706 250 - 1.585 0.842 -2.655
ENSG00000008838 E059 8.6912727 0.0401402869 1.035479e-05 6.859997e-05 17 40033707 40033771 65 - 1.289 0.667 -2.337
ENSG00000008838 E060 46.3061736 0.0004973405 6.926660e-04 2.872165e-03 17 40034916 40034972 57 - 1.747 1.564 -0.623
ENSG00000008838 E061 217.4827055 0.0001948859 7.879847e-03 2.347708e-02 17 40035117 40035142 26 - 2.330 2.259 -0.236
ENSG00000008838 E062 248.6491175 0.0001639867 4.650301e-01 6.047360e-01 17 40035143 40035197 55 - 2.350 2.332 -0.061
ENSG00000008838 E063 239.0183673 0.0002224541 3.878363e-01 5.319723e-01 17 40035198 40035261 64 - 2.336 2.313 -0.074
ENSG00000008838 E064 169.7818505 0.0005460469 9.302082e-02 1.798436e-01 17 40035262 40035284 23 - 2.209 2.156 -0.175
ENSG00000008838 E065 156.8652813 0.0002448958 1.615236e-04 7.985638e-04 17 40035285 40035295 11 - 2.219 2.103 -0.389
ENSG00000008838 E066 230.3766217 0.0002451164 3.110876e-06 2.318988e-05 17 40035296 40035321 26 - 2.388 2.268 -0.401
ENSG00000008838 E067 256.0561899 0.0005235013 1.731438e-09 2.455024e-08 17 40035322 40035349 28 - 2.457 2.303 -0.514
ENSG00000008838 E068 347.8863760 0.0016043796 9.224105e-08 9.424944e-07 17 40035722 40035795 74 - 2.587 2.440 -0.489
ENSG00000008838 E069 0.8878743 0.0131176192 2.950770e-04 1.359835e-03 17 40035901 40036115 215 - 0.601 0.000 -13.138
ENSG00000008838 E070 200.3553706 0.0014742694 8.321911e-05 4.432402e-04 17 40036116 40036120 5 - 2.334 2.208 -0.421
ENSG00000008838 E071 303.7122338 0.0026924099 1.237082e-05 8.045091e-05 17 40036121 40036154 34 - 2.525 2.383 -0.473
ENSG00000008838 E072 375.8035250 0.0030213792 5.768783e-06 4.049499e-05 17 40053298 40053347 50 - 2.620 2.474 -0.486
ENSG00000008838 E073 327.3978987 0.0035580477 3.354014e-04 1.522044e-03 17 40053348 40053380 33 - 2.545 2.421 -0.413
ENSG00000008838 E074 510.6926617 0.0049183262 2.365105e-05 1.442523e-04 17 40053469 40053635 167 - 2.759 2.605 -0.512
ENSG00000008838 E075 123.7554990 0.0119254909 4.619021e-04 2.013992e-03 17 40053636 40053657 22 - 2.182 1.970 -0.710
ENSG00000008838 E076 20.5693418 0.0226835595 5.538212e-01 6.829032e-01 17 40053658 40053679 22 - 1.322 1.255 -0.234
ENSG00000008838 E077 24.5729430 0.0360548631 5.740299e-01 6.999038e-01 17 40053680 40053768 89 - 1.389 1.329 -0.207
ENSG00000008838 E078 16.6798903 0.0286849631 9.444482e-01 9.691728e-01 17 40053769 40053870 102 - 1.176 1.190 0.049
ENSG00000008838 E079 26.1587241 0.0138704318 2.112220e-02 5.385584e-02 17 40053871 40054092 222 - 1.511 1.309 -0.701
ENSG00000008838 E080 17.1248179 0.0010815642 4.395425e-04 1.926387e-03 17 40054315 40054360 46 - 1.397 1.103 -1.037
ENSG00000008838 E081 196.7611284 0.0125131885 2.409878e-04 1.137550e-03 17 40054361 40054742 382 - 2.384 2.171 -0.713
ENSG00000008838 E082 0.0000000       17 40056549 40056690 142 -      
ENSG00000008838 E083 0.0000000       17 40061134 40061215 82 -