ENSG00000008513

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399640 ENSG00000008513 HEK293_OSMI2_2hA HEK293_TMG_2hB ST3GAL1 protein_coding protein_coding 4.028164 4.7767 4.506097 0.1396722 0.6424115 -0.08395487 0.3036162 1.6079709 0.2653965 0.47711581 0.26539652 -2.5546035 0.06669167 0.33980000 0.06483333 -0.274966667 0.120539895 0.003886698 FALSE TRUE
ENST00000517668 ENSG00000008513 HEK293_OSMI2_2hA HEK293_TMG_2hB ST3GAL1 protein_coding protein_coding 4.028164 4.7767 4.506097 0.1396722 0.6424115 -0.08395487 0.2255930 0.0000000 0.4538398 0.00000000 0.45383978 5.5355546 0.05180417 0.00000000 0.07870000 0.078700000 0.803023335 0.003886698   FALSE
ENST00000521180 ENSG00000008513 HEK293_OSMI2_2hA HEK293_TMG_2hB ST3GAL1 protein_coding protein_coding 4.028164 4.7767 4.506097 0.1396722 0.6424115 -0.08395487 0.7857961 0.1372917 1.1181764 0.09449924 0.09935102 2.9372447 0.20691667 0.02876667 0.25653333 0.227766667 0.003886698 0.003886698 FALSE TRUE
ENST00000522285 ENSG00000008513 HEK293_OSMI2_2hA HEK293_TMG_2hB ST3GAL1 protein_coding processed_transcript 4.028164 4.7767 4.506097 0.1396722 0.6424115 -0.08395487 0.3331427 0.7121938 0.3318644 0.18853215 0.15153866 -1.0789621 0.08385833 0.14836667 0.08076667 -0.067600000 0.496479462 0.003886698 FALSE TRUE
ENST00000522652 ENSG00000008513 HEK293_OSMI2_2hA HEK293_TMG_2hB ST3GAL1 protein_coding protein_coding 4.028164 4.7767 4.506097 0.1396722 0.6424115 -0.08395487 2.1794122 2.1981660 2.0042460 0.28817129 0.14806878 -0.1326087 0.53927917 0.45776667 0.45540000 -0.002366667 0.998709646 0.003886698 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000008513 E001 0.0000000       8 133454848 133454852 5 -      
ENSG00000008513 E002 483.8455153 0.0003184868 1.091673e-24 1.158623e-22 8 133454853 133458872 4020 - 2.605 2.723 0.395
ENSG00000008513 E003 66.2290401 0.0003905036 4.360045e-01 5.781462e-01 8 133458873 133459714 842 - 1.801 1.829 0.094
ENSG00000008513 E004 33.5014085 0.0008043729 6.313334e-02 1.319319e-01 8 133459715 133459937 223 - 1.590 1.473 -0.397
ENSG00000008513 E005 23.8560437 0.0470612341 1.887823e-01 3.122179e-01 8 133461875 133461994 120 - 1.479 1.312 -0.577
ENSG00000008513 E006 20.4514557 0.0009893171 1.926589e-01 3.171011e-01 8 133463414 133463459 46 - 1.380 1.278 -0.357
ENSG00000008513 E007 26.6786225 0.0067319591 8.041316e-02 1.602065e-01 8 133464778 133464930 153 - 1.507 1.371 -0.471
ENSG00000008513 E008 13.5786591 0.0310729380 3.724862e-01 5.169472e-01 8 133464931 133464957 27 - 1.220 1.104 -0.417
ENSG00000008513 E009 0.4751703 0.0205517313 6.605702e-01 7.692208e-01 8 133465642 133465893 252 - 0.132 0.204 0.757
ENSG00000008513 E010 26.1076938 0.0137433385 1.028256e-01 1.947957e-01 8 133465894 133466090 197 - 1.497 1.353 -0.498
ENSG00000008513 E011 16.6234517 0.0054753837 8.615449e-02 1.692435e-01 8 133475719 133475808 90 - 1.318 1.162 -0.552
ENSG00000008513 E012 15.6667668 0.0011734547 7.270138e-01 8.198932e-01 8 133475809 133475876 68 - 1.238 1.203 -0.122
ENSG00000008513 E013 11.1745748 0.0016794727 9.305516e-01 9.603171e-01 8 133475877 133475883 7 - 1.078 1.082 0.013
ENSG00000008513 E014 21.5888918 0.0008970101 1.481246e-02 4.007205e-02 8 133475884 133476028 145 - 1.446 1.264 -0.632
ENSG00000008513 E015 13.6720618 0.0014037751 2.744657e-02 6.689744e-02 8 133476029 133476074 46 - 1.272 1.071 -0.716
ENSG00000008513 E016 1.9950157 0.0072617286 2.534121e-02 6.257337e-02 8 133476075 133476142 68 - 0.657 0.278 -1.979
ENSG00000008513 E017 1.9939715 0.0071780593 4.393156e-03 1.424559e-02 8 133476143 133476277 135 - 0.690 0.204 -2.701
ENSG00000008513 E018 31.9482558 0.0067905812 1.482371e-05 9.472487e-05 8 133476278 133476522 245 - 1.665 1.349 -1.085
ENSG00000008513 E019 14.9914770 0.0013095702 1.934872e-04 9.359267e-04 8 133476523 133476600 78 - 1.354 1.025 -1.172
ENSG00000008513 E020 0.1515154 0.0429094253 4.240755e-01   8 133476601 133476603 3 - 0.132 0.000 -10.948
ENSG00000008513 E021 0.1472490 0.0437381020 4.240099e-01   8 133488082 133488439 358 - 0.132 0.000 -10.933
ENSG00000008513 E022 0.0000000       8 133489538 133489700 163 -      
ENSG00000008513 E023 11.9074436 0.0483388370 1.755042e-02 4.615252e-02 8 133499135 133499189 55 - 1.279 0.938 -1.231
ENSG00000008513 E024 0.0000000       8 133499190 133499360 171 -      
ENSG00000008513 E025 0.0000000       8 133499361 133499421 61 -      
ENSG00000008513 E026 0.1515154 0.0429094253 4.240755e-01   8 133507199 133507321 123 - 0.132 0.000 -10.948
ENSG00000008513 E027 0.2214452 0.0401219340 5.572787e-01   8 133539637 133539729 93 - 0.000 0.114 9.812
ENSG00000008513 E028 0.0000000       8 133544058 133544089 32 -      
ENSG00000008513 E029 0.0000000       8 133545758 133545773 16 -      
ENSG00000008513 E030 18.8064212 0.0310435195 1.149978e-02 3.234838e-02 8 133545774 133545926 153 - 1.445 1.147 -1.042
ENSG00000008513 E031 4.6195533 0.0278504965 4.251302e-02 9.565392e-02 8 133566982 133567320 339 - 0.541 0.859 1.330
ENSG00000008513 E032 1.2167234 0.0108329526 7.576168e-02 1.527191e-01 8 133570110 133570379 270 - 0.132 0.446 2.343
ENSG00000008513 E033 32.4373301 0.0029592006 1.457059e-01 2.558111e-01 8 133571693 133571913 221 - 1.569 1.469 -0.342
ENSG00000008513 E034 11.4023289 0.0122306025 3.366787e-01 4.805525e-01 8 133571914 133571940 27 - 1.149 1.037 -0.405
ENSG00000008513 E035 0.2934659 0.0291578692 9.097996e-01   8 133572421 133573838 1418 - 0.132 0.114 -0.244