ENSG00000008441

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360105 ENSG00000008441 HEK293_OSMI2_2hA HEK293_TMG_2hB NFIX protein_coding protein_coding 5.411643 6.836626 5.164581 0.8706211 0.2127867 -0.403951 0.5165679 0.73179768 0.8395965 0.10050522 0.1369990 0.19575215 0.09272917 0.11090000 0.1611000 0.05020000 0.47293984 0.03062416 FALSE TRUE
ENST00000397661 ENSG00000008441 HEK293_OSMI2_2hA HEK293_TMG_2hB NFIX protein_coding protein_coding 5.411643 6.836626 5.164581 0.8706211 0.2127867 -0.403951 1.4638330 0.57104634 2.5310963 0.35746153 0.6715716 2.12872593 0.28281667 0.08860000 0.5020333 0.41343333 0.16763715 0.03062416 FALSE TRUE
ENST00000585382 ENSG00000008441 HEK293_OSMI2_2hA HEK293_TMG_2hB NFIX protein_coding nonsense_mediated_decay 5.411643 6.836626 5.164581 0.8706211 0.2127867 -0.403951 0.3393428 0.09523474 0.7422214 0.09523474 0.2205555 2.83754624 0.06020417 0.01163333 0.1406333 0.12900000 0.03224734 0.03062416 TRUE FALSE
ENST00000587760 ENSG00000008441 HEK293_OSMI2_2hA HEK293_TMG_2hB NFIX protein_coding protein_coding 5.411643 6.836626 5.164581 0.8706211 0.2127867 -0.403951 2.5758072 4.62011963 0.5323897 0.73057250 0.5323897 -3.09364778 0.47120417 0.67023333 0.0969000 -0.57333333 0.03062416 0.03062416 FALSE TRUE
ENST00000592199 ENSG00000008441 HEK293_OSMI2_2hA HEK293_TMG_2hB NFIX protein_coding protein_coding 5.411643 6.836626 5.164581 0.8706211 0.2127867 -0.403951 0.3038140 0.48618234 0.5038288 0.22566666 0.1171439 0.05041743 0.05122083 0.06503333 0.0961000 0.03106667 0.67681467 0.03062416 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000008441 E001 2.5788255 0.0058452672 3.088997e-02 7.370385e-02 19 12995475 12995607 133 + 0.686 0.400 -1.350
ENSG00000008441 E002 12.8458834 0.0105160596 6.707299e-07 5.781589e-06 19 12995608 12995864 257 + 1.329 0.885 -1.606
ENSG00000008441 E003 0.0000000       19 13012188 13012206 19 +      
ENSG00000008441 E004 0.0000000       19 13012207 13012266 60 +      
ENSG00000008441 E005 0.5451131 0.5248716617 3.503265e-01 4.945145e-01 19 13023991 13024031 41 + 0.000 0.283 10.894
ENSG00000008441 E006 0.5451131 0.5248716617 3.503265e-01 4.945145e-01 19 13024032 13024034 3 + 0.000 0.283 10.894
ENSG00000008441 E007 0.0000000       19 13024580 13024580 1 +      
ENSG00000008441 E008 0.0000000       19 13024581 13024584 4 +      
ENSG00000008441 E009 0.0000000       19 13024585 13024612 28 +      
ENSG00000008441 E010 0.0000000       19 13024613 13024626 14 +      
ENSG00000008441 E011 0.0000000       19 13024627 13024680 54 +      
ENSG00000008441 E012 0.0000000       19 13024681 13024682 2 +      
ENSG00000008441 E013 0.0000000       19 13024683 13024684 2 +      
ENSG00000008441 E014 0.0000000       19 13024685 13024719 35 +      
ENSG00000008441 E015 0.0000000       19 13024720 13024723 4 +      
ENSG00000008441 E016 0.0000000       19 13024888 13024938 51 +      
ENSG00000008441 E017 0.0000000       19 13024939 13025020 82 +      
ENSG00000008441 E018 34.9855885 0.0072758256 1.968091e-05 1.222890e-04 19 13025021 13025175 155 + 1.658 1.443 -0.737
ENSG00000008441 E019 52.9228971 0.0049486746 4.958682e-04 2.144129e-03 19 13025176 13025368 193 + 1.785 1.671 -0.388
ENSG00000008441 E020 69.7608037 0.0003773616 2.827317e-05 1.691862e-04 19 13025369 13025552 184 + 1.891 1.799 -0.309
ENSG00000008441 E021 0.0000000       19 13070003 13070069 67 +      
ENSG00000008441 E022 54.8742354 0.0004760368 2.991677e-05 1.780989e-04 19 13073047 13073109 63 + 1.797 1.683 -0.387
ENSG00000008441 E023 55.9492510 0.0008734693 1.452532e-02 3.942207e-02 19 13073422 13073496 75 + 1.762 1.727 -0.117
ENSG00000008441 E024 62.4928936 0.0005069186 8.328131e-03 2.461257e-02 19 13073906 13074026 121 + 1.809 1.774 -0.120
ENSG00000008441 E025 60.8787477 0.0007589441 2.135926e-03 7.645626e-03 19 13075535 13075671 137 + 1.809 1.751 -0.195
ENSG00000008441 E026 38.2522826 0.0017181439 8.361732e-02 1.652054e-01 19 13078613 13078735 123 + 1.589 1.569 -0.070
ENSG00000008441 E027 70.9155877 0.0003615661 6.407468e-03 1.968085e-02 19 13081680 13081855 176 + 1.862 1.831 -0.105
ENSG00000008441 E028 6.5098167 0.0029989107 9.103556e-01 9.470192e-01 19 13087989 13088136 148 + 0.842 0.900 0.221
ENSG00000008441 E029 58.3151950 0.0008940054 1.000149e-01 1.905077e-01 19 13090299 13090390 92 + 1.756 1.760 0.013
ENSG00000008441 E030 627.9994420 0.0046307169 1.936921e-15 7.052543e-14 19 13094635 13098796 4162 + 2.631 2.878 0.822