ENSG00000008311

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000417368 ENSG00000008311 HEK293_OSMI2_2hA HEK293_TMG_2hB AASS protein_coding protein_coding 9.659746 2.892662 13.67897 0.2902198 0.5291832 2.237565 6.7736883 1.7466652 10.65109 0.1453752 0.09013041 2.601443 0.6212875 0.6084333 0.7811667 0.1727333 5.898892e-02 1.046795e-22 FALSE TRUE
ENST00000681213 ENSG00000008311 HEK293_OSMI2_2hA HEK293_TMG_2hB AASS protein_coding protein_coding 9.659746 2.892662 13.67897 0.2902198 0.5291832 2.237565 0.5352777 0.9836904 0.00000 0.2360550 0.00000000 -6.634724 0.1474417 0.3338333 0.0000000 -0.3338333 1.046795e-22 1.046795e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000008311 E001 0.0000000       7 122064583 122064650 68 -      
ENSG00000008311 E002 1.6209197 0.0087773682 2.987548e-03 1.022717e-02 7 122073549 122073564 16 - 0.199 0.729 2.902
ENSG00000008311 E003 2.6549091 0.0109025306 1.234027e-03 4.756320e-03 7 122073565 122073582 18 - 0.336 0.876 2.485
ENSG00000008311 E004 2.6549091 0.0109025306 1.234027e-03 4.756320e-03 7 122073583 122073586 4 - 0.336 0.876 2.485
ENSG00000008311 E005 204.2527697 0.0091712455 7.043581e-11 1.275215e-09 7 122073587 122074494 908 - 2.115 2.468 1.179
ENSG00000008311 E006 121.1189921 0.0141361403 5.929353e-01 7.153990e-01 7 122074495 122074895 401 - 1.970 2.036 0.223
ENSG00000008311 E007 52.2460791 0.0184774384 7.944093e-01 8.686528e-01 7 122074896 122074973 78 - 1.619 1.659 0.137
ENSG00000008311 E008 142.5237977 0.0002567811 7.105948e-01 8.077281e-01 7 122074974 122075646 673 - 2.052 2.061 0.031
ENSG00000008311 E009 56.5561795 0.0004459606 3.765990e-01 5.209225e-01 7 122075647 122076132 486 - 1.642 1.715 0.249
ENSG00000008311 E010 12.0056961 0.0014860110 6.455861e-01 7.576731e-01 7 122076133 122076148 16 - 1.001 1.076 0.272
ENSG00000008311 E011 19.4644044 0.0009730687 4.902736e-01 6.276201e-01 7 122076149 122076244 96 - 1.196 1.283 0.304
ENSG00000008311 E012 19.8052135 0.0008833616 5.438104e-01 6.743683e-01 7 122076245 122076302 58 - 1.204 1.283 0.276
ENSG00000008311 E013 89.9794610 0.0003855466 5.841482e-03 1.819432e-02 7 122076303 122076607 305 - 1.825 1.970 0.487
ENSG00000008311 E014 0.3332198 0.0287845533 2.589122e-01   7 122077836 122077837 2 - 0.059 0.237 2.319
ENSG00000008311 E015 96.1329190 0.0003403525 1.372952e-01 2.443094e-01 7 122077838 122078014 177 - 1.868 1.956 0.295
ENSG00000008311 E016 2.2226924 0.0619810585 2.570642e-01 3.941057e-01 7 122078015 122078861 847 - 0.483 0.237 -1.495
ENSG00000008311 E017 57.6680768 0.0004608471 6.684492e-01 7.754385e-01 7 122078862 122078950 89 - 1.662 1.709 0.160
ENSG00000008311 E018 1.0329332 0.1437075096 2.671087e-01 4.053846e-01 7 122078951 122079148 198 - 0.305 0.000 -11.040
ENSG00000008311 E019 1.2543784 0.1371342400 7.677661e-01 8.499195e-01 7 122079149 122079327 179 - 0.305 0.239 -0.474
ENSG00000008311 E020 0.4417471 0.6471760207 1.000000e+00 1.000000e+00 7 122079328 122079351 24 - 0.157 0.000 -9.597
ENSG00000008311 E021 0.2987644 0.0290785164 1.000000e+00   7 122079352 122079596 245 - 0.111 0.000 -9.234
ENSG00000008311 E022 58.5832044 0.0004792630 4.943427e-01 6.312934e-01 7 122079597 122079690 94 - 1.666 1.727 0.207
ENSG00000008311 E023 37.7131435 0.0006614933 5.235994e-01 6.572426e-01 7 122079691 122079712 22 - 1.479 1.546 0.229
ENSG00000008311 E024 59.0582152 0.0032870947 4.574948e-01 5.978301e-01 7 122081500 122081595 96 - 1.668 1.737 0.233
ENSG00000008311 E025 3.0236956 0.0258093752 7.827446e-01 8.605221e-01 7 122082788 122082891 104 - 0.541 0.502 -0.185
ENSG00000008311 E026 0.3268771 0.0286775043 2.588007e-01   7 122085578 122085718 141 - 0.059 0.237 2.319
ENSG00000008311 E027 66.5317117 0.0003707372 9.740485e-01 9.878034e-01 7 122086012 122086115 104 - 1.726 1.750 0.083
ENSG00000008311 E028 50.0003314 0.0004993082 7.824666e-01 8.603298e-01 7 122086116 122086179 64 - 1.607 1.613 0.018
ENSG00000008311 E029 0.0000000       7 122086180 122086239 60 -      
ENSG00000008311 E030 0.1472490 0.0424110201 1.000000e+00   7 122087597 122087694 98 - 0.059 0.000 -8.266
ENSG00000008311 E031 58.5375465 0.0003944248 1.764764e-01 2.966699e-01 7 122091703 122091843 141 - 1.686 1.628 -0.197
ENSG00000008311 E032 51.0224660 0.0004486823 4.562512e-01 5.966989e-01 7 122092843 122092951 109 - 1.621 1.597 -0.083
ENSG00000008311 E033 0.2966881 0.0290785164 1.000000e+00   7 122092952 122092982 31 - 0.111 0.000 -9.233
ENSG00000008311 E034 50.1473057 0.0005775709 2.142134e-01 3.434938e-01 7 122093048 122093158 111 - 1.621 1.564 -0.196
ENSG00000008311 E035 54.0452867 0.0006777138 1.247607e-01 2.267916e-01 7 122098450 122098576 127 - 1.655 1.581 -0.252
ENSG00000008311 E036 0.9631146 0.0138920172 3.526457e-01 4.968923e-01 7 122098577 122098744 168 - 0.199 0.390 1.319
ENSG00000008311 E037 23.9506601 0.0007971881 1.922664e-02 4.982712e-02 7 122098745 122098748 4 - 1.333 1.126 -0.734
ENSG00000008311 E038 46.7106781 0.0005456649 6.629101e-01 7.711140e-01 7 122098749 122098866 118 - 1.578 1.572 -0.020
ENSG00000008311 E039 24.1944044 0.0104667704 2.974772e-01 4.388221e-01 7 122098867 122100679 1813 - 1.319 1.231 -0.309
ENSG00000008311 E040 9.5070123 0.0045177966 4.053290e-04 1.795253e-03 7 122100680 122101370 691 - 1.001 0.390 -2.635
ENSG00000008311 E041 38.0724894 0.0012680081 9.892842e-01 9.973187e-01 7 122101371 122101438 68 - 1.485 1.509 0.080
ENSG00000008311 E042 3.5190149 0.0566180383 2.892987e-01 4.299852e-01 7 122101439 122101620 182 - 0.609 0.391 -1.068
ENSG00000008311 E043 42.1817364 0.0017202087 2.845202e-01 4.247724e-01 7 122101621 122101680 60 - 1.544 1.489 -0.187
ENSG00000008311 E044 53.1622486 0.0005106381 8.965450e-02 1.745950e-01 7 122113118 122113229 112 - 1.649 1.564 -0.291
ENSG00000008311 E045 59.1713411 0.0004136265 7.061556e-04 2.920740e-03 7 122113598 122113720 123 - 1.711 1.518 -0.657
ENSG00000008311 E046 60.9547531 0.0004046941 1.000205e-05 6.647225e-05 7 122115074 122115222 149 - 1.733 1.468 -0.904
ENSG00000008311 E047 48.5444331 0.0004462304 3.688143e-02 8.524256e-02 7 122116633 122116760 128 - 1.617 1.499 -0.403
ENSG00000008311 E048 39.1673688 0.0005706928 6.181125e-02 1.296712e-01 7 122116879 122116957 79 - 1.527 1.410 -0.402
ENSG00000008311 E049 59.0329537 0.0004480811 1.495082e-01 2.610014e-01 7 122118307 122118453 147 - 1.691 1.628 -0.215
ENSG00000008311 E050 44.5162492 0.0013078071 7.897005e-02 1.578676e-01 7 122118563 122118630 68 - 1.580 1.478 -0.349
ENSG00000008311 E051 46.2770476 0.0040800700 1.159532e-02 3.257216e-02 7 122126375 122126459 85 - 1.606 1.434 -0.589
ENSG00000008311 E052 68.3778479 0.0068642933 3.967847e-03 1.305249e-02 7 122129361 122129537 177 - 1.772 1.589 -0.619
ENSG00000008311 E053 62.0973969 0.0144682821 2.515881e-03 8.811725e-03 7 122133517 122133734 218 - 1.737 1.500 -0.807
ENSG00000008311 E054 22.3204036 0.0643623159 5.926009e-01 7.151231e-01 7 122133735 122133741 7 - 1.280 1.234 -0.160
ENSG00000008311 E055 0.0000000       7 122133742 122133822 81 -      
ENSG00000008311 E056 29.2135241 0.0019502759 8.053538e-01 8.762001e-01 7 122144161 122144308 148 - 1.383 1.385 0.006