ENSG00000008277

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265727 ENSG00000008277 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM22 protein_coding protein_coding 3.100867 0.6369643 3.913505 0.08620372 0.1921681 2.600385 0.1330224 0.0000000 0.2439807 0.00000000 0.132003898 4.6666468 0.05253750 0.0000000 0.06593333 0.06593333 0.60286566 0.04310361 FALSE TRUE
ENST00000398204 ENSG00000008277 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM22 protein_coding protein_coding 3.100867 0.6369643 3.913505 0.08620372 0.1921681 2.600385 0.6367495 0.1572383 1.0519363 0.09117065 0.284962322 2.6667202 0.26161250 0.2936667 0.26306667 -0.03060000 0.96308888 0.04310361 FALSE TRUE
ENST00000398209 ENSG00000008277 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM22 protein_coding protein_coding 3.100867 0.6369643 3.913505 0.08620372 0.1921681 2.600385 0.2940736 0.1310570 0.5906476 0.07236781 0.022921160 2.0902407 0.11199167 0.1832667 0.15216667 -0.03110000 0.79020425 0.04310361 FALSE TRUE
MSTRG.30194.10 ENSG00000008277 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM22 protein_coding   3.100867 0.6369643 3.913505 0.08620372 0.1921681 2.600385 0.2566135 0.0000000 0.2590622 0.00000000 0.259062240 4.7498680 0.06500833 0.0000000 0.06103333 0.06103333 1.00000000 0.04310361 FALSE TRUE
MSTRG.30194.12 ENSG00000008277 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM22 protein_coding   3.100867 0.6369643 3.913505 0.08620372 0.1921681 2.600385 0.4071602 0.1237554 1.2226075 0.06684255 0.002377159 3.2040441 0.12879167 0.1739000 0.31396667 0.14006667 0.35430221 0.04310361 FALSE TRUE
MSTRG.30194.13 ENSG00000008277 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM22 protein_coding   3.100867 0.6369643 3.913505 0.08620372 0.1921681 2.600385 0.5262469 0.0000000 0.0000000 0.00000000 0.000000000 0.0000000 0.09029583 0.0000000 0.00000000 0.00000000   0.04310361 FALSE TRUE
MSTRG.30194.4 ENSG00000008277 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM22 protein_coding   3.100867 0.6369643 3.913505 0.08620372 0.1921681 2.600385 0.4862730 0.1720974 0.1078994 0.04515372 0.107899410 -0.6271537 0.14959583 0.2640667 0.02756667 -0.23650000 0.04310361 0.04310361 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000008277 E001 1.0445865 0.0445798857 7.932726e-01 8.678135e-01 7 87934143 87934250 108 + 0.284 0.227 -0.430
ENSG00000008277 E002 3.4910280 0.0044645569 4.940346e-01 6.310445e-01 7 87934251 87934328 78 + 0.611 0.486 -0.577
ENSG00000008277 E003 3.0407481 0.0051260424 6.911561e-01 7.926908e-01 7 87934329 87934346 18 + 0.558 0.486 -0.343
ENSG00000008277 E004 4.5574836 0.0035409345 7.514093e-01 8.378571e-01 7 87934347 87934386 40 + 0.657 0.710 0.222
ENSG00000008277 E005 4.9888490 0.0368112731 9.326241e-01 9.615615e-01 7 87934387 87934419 33 + 0.699 0.711 0.050
ENSG00000008277 E006 6.1283575 0.0225738823 7.346713e-01 8.255753e-01 7 87934420 87934465 46 + 0.761 0.815 0.212
ENSG00000008277 E007 7.6063963 0.0314658655 2.976297e-01 4.389718e-01 7 87934466 87934550 85 + 0.816 0.969 0.585
ENSG00000008277 E008 0.1472490 0.0428576348 1.000000e+00   7 87934756 87935025 270 + 0.062 0.000 -8.998
ENSG00000008277 E009 5.4787665 0.0042689397 2.485266e-01 3.841909e-01 7 87935026 87935028 3 + 0.686 0.857 0.688
ENSG00000008277 E010 13.1807917 0.0014730422 3.295433e-01 4.730623e-01 7 87935029 87935186 158 + 1.042 1.149 0.386
ENSG00000008277 E011 2.8032920 0.0058091643 1.349977e-01 2.410840e-01 7 87964634 87964684 51 + 0.454 0.710 1.159
ENSG00000008277 E012 4.3835299 0.0070824230 2.386579e-01 3.725898e-01 7 87971294 87971375 82 + 0.627 0.813 0.765
ENSG00000008277 E013 12.2474201 0.0014219845 2.688821e-01 4.073483e-01 7 87978336 87978412 77 + 1.065 0.933 -0.489
ENSG00000008277 E014 7.0728252 0.0027090069 5.745087e-01 7.003117e-01 7 88075626 88075629 4 + 0.845 0.765 -0.318
ENSG00000008277 E015 11.0877612 0.0015687826 9.432041e-01 9.683817e-01 7 88075630 88075692 63 + 1.004 0.998 -0.022
ENSG00000008277 E016 0.0000000       7 88089919 88090014 96 +      
ENSG00000008277 E017 14.8261595 0.0011696918 4.480384e-01 5.893656e-01 7 88108176 88108258 83 + 1.134 1.054 -0.291
ENSG00000008277 E018 13.4566836 0.0013387277 7.433611e-01 8.320091e-01 7 88114584 88114647 64 + 1.088 1.054 -0.123
ENSG00000008277 E019 0.0000000       7 88114648 88114648 1 +      
ENSG00000008277 E020 12.3934502 0.0015789705 2.278395e-01 3.598429e-01 7 88116745 88116814 70 + 1.077 0.933 -0.531
ENSG00000008277 E021 12.6569281 0.0014603296 1.176933e-01 2.166553e-01 7 88125589 88125659 71 + 1.088 0.897 -0.708
ENSG00000008277 E022 12.5415926 0.0232801727 3.512283e-01 4.954406e-01 7 88128602 88128676 75 + 1.072 0.935 -0.503
ENSG00000008277 E023 11.8361151 0.0098463069 2.379233e-01 3.717217e-01 7 88130388 88130459 72 + 1.054 0.897 -0.583
ENSG00000008277 E024 18.1424673 0.0010599101 4.875258e-02 1.069468e-01 7 88131269 88131435 167 + 1.235 1.027 -0.747
ENSG00000008277 E025 0.2903454 0.3889498847 1.000000e+00   7 88131436 88132804 1369 + 0.116 0.000 -9.232
ENSG00000008277 E026 13.7428538 0.0013403218 5.268316e-02 1.139280e-01 7 88132867 88132951 85 + 1.129 0.896 -0.858
ENSG00000008277 E027 0.1817044 0.0391697579 9.266942e-02   7 88132952 88132982 31 + 0.000 0.227 10.841
ENSG00000008277 E028 11.1501824 0.0017461003 3.241587e-02 7.666083e-02 7 88134329 88134419 91 + 1.054 0.765 -1.099
ENSG00000008277 E029 10.5402185 0.0213727829 1.763550e-01 2.964974e-01 7 88135980 88136031 52 + 1.017 0.814 -0.767
ENSG00000008277 E030 12.2169045 0.0016635575 7.330948e-02 1.488145e-01 7 88143026 88143125 100 + 1.082 0.857 -0.840
ENSG00000008277 E031 10.8681637 0.0016348061 7.755093e-01 8.553726e-01 7 88145125 88145196 72 + 0.990 1.027 0.134
ENSG00000008277 E032 13.3886877 0.0014042522 7.827917e-01 8.605389e-01 7 88145415 88145507 93 + 1.071 1.104 0.118
ENSG00000008277 E033 15.7767138 0.0044122281 6.305815e-01 7.457412e-01 7 88148977 88149057 81 + 1.154 1.104 -0.180
ENSG00000008277 E034 14.0058981 0.0013479689 8.431279e-01 9.022823e-01 7 88150981 88151031 51 + 1.098 1.079 -0.069
ENSG00000008277 E035 16.1995872 0.0011363722 3.458630e-01 4.900104e-01 7 88151257 88151320 64 + 1.176 1.079 -0.348
ENSG00000008277 E036 18.7839136 0.0009344939 2.680852e-01 4.064963e-01 7 88153221 88153326 106 + 1.235 1.127 -0.384
ENSG00000008277 E037 19.0594958 0.0010158016 3.674599e-01 5.118426e-01 7 88155887 88156006 120 + 1.235 1.148 -0.306
ENSG00000008277 E038 12.5057594 0.0017105361 7.547785e-01 8.403051e-01 7 88163012 88163030 19 + 1.042 1.080 0.138
ENSG00000008277 E039 16.9130904 0.0015228810 5.807652e-01 7.054644e-01 7 88163031 88163180 150 + 1.181 1.127 -0.193
ENSG00000008277 E040 15.6391806 0.0016054346 7.516572e-01 8.380466e-01 7 88165832 88165946 115 + 1.134 1.169 0.124
ENSG00000008277 E041 14.9637964 0.0197105582 8.440891e-01 9.029422e-01 7 88168137 88168227 91 + 1.130 1.102 -0.102
ENSG00000008277 E042 8.0977433 0.0137807380 8.146604e-01 8.825798e-01 7 88171544 88171561 18 + 0.891 0.856 -0.133
ENSG00000008277 E043 0.5838113 0.4741885307 6.865964e-01 7.890854e-01 7 88178935 88179042 108 + 0.164 0.223 0.549
ENSG00000008277 E044 0.5838113 0.4741885307 6.865964e-01 7.890854e-01 7 88179043 88179129 87 + 0.164 0.223 0.549
ENSG00000008277 E045 15.4498374 0.0035539719 8.856012e-01 9.308290e-01 7 88181505 88181605 101 + 1.139 1.126 -0.046
ENSG00000008277 E046 12.7723857 0.0076761426 8.921369e-01 9.351076e-01 7 88181958 88182004 47 + 1.059 1.079 0.070
ENSG00000008277 E047 7.9426519 0.0277883086 4.619697e-01 6.018966e-01 7 88182005 88182024 20 + 0.855 0.964 0.415
ENSG00000008277 E048 1.6231864 0.0103102130 8.946401e-01 9.366814e-01 7 88182025 88183554 1530 + 0.349 0.376 0.162
ENSG00000008277 E049 0.9169173 0.0634968462 4.049144e-01 5.485949e-01 7 88184292 88184402 111 + 0.208 0.375 1.157
ENSG00000008277 E050 0.7394793 0.0158180707 9.423046e-01 9.677595e-01 7 88185830 88186614 785 + 0.208 0.227 0.159
ENSG00000008277 E051 5.1285353 0.0309436751 5.147393e-01 6.494733e-01 7 88186615 88186701 87 + 0.699 0.810 0.449
ENSG00000008277 E052 18.7550429 0.0041483863 8.080563e-01 8.780412e-01 7 88193116 88193239 124 + 1.215 1.242 0.098
ENSG00000008277 E053 24.1813235 0.0041064428 2.866108e-01 4.270355e-01 7 88196471 88196735 265 + 1.338 1.243 -0.332
ENSG00000008277 E054 16.5934679 0.0013412226 3.602191e-01 5.045352e-01 7 88196736 88197144 409 + 1.134 1.226 0.327
ENSG00000008277 E055 8.3420156 0.0126468203 4.954081e-01 6.322235e-01 7 88197145 88197239 95 + 0.873 0.966 0.350
ENSG00000008277 E056 113.6564705 0.0010010753 2.909615e-01 4.317813e-01 7 88197240 88200118 2879 + 1.963 2.006 0.145
ENSG00000008277 E057 49.7415399 0.0020198702 1.082097e-07 1.092111e-06 7 88200119 88203062 2944 + 1.537 1.835 1.014