ENSG00000008130

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341426 ENSG00000008130 HEK293_OSMI2_2hA HEK293_TMG_2hB NADK protein_coding protein_coding 63.83403 83.54733 53.87629 3.242008 1.130772 -0.6328481 32.931015 44.470618 29.419970 4.645730 0.9752537 -0.5958908 0.4962083 0.5295333 0.5466333 0.0171000000 0.9172356 1.041047e-16 FALSE TRUE
ENST00000341991 ENSG00000008130 HEK293_OSMI2_2hA HEK293_TMG_2hB NADK protein_coding protein_coding 63.83403 83.54733 53.87629 3.242008 1.130772 -0.6328481 8.296306 17.052470 2.043228 3.157008 0.8895151 -3.0548611 0.1360000 0.2078333 0.0377000 -0.1701333333 0.0366953 1.041047e-16 FALSE TRUE
MSTRG.115.5 ENSG00000008130 HEK293_OSMI2_2hA HEK293_TMG_2hB NADK protein_coding   63.83403 83.54733 53.87629 3.242008 1.130772 -0.6328481 6.419821 9.106214 5.941261 1.089738 0.4937549 -0.6152394 0.1006000 0.1095667 0.1100000 0.0004333333 1.0000000 1.041047e-16 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000008130 E001 734.3190810 2.101406e-03 8.836841e-01 9.296032e-01 1 1751232 1752470 1239 - 2.819 2.824 0.017
ENSG00000008130 E002 1205.0060473 9.023347e-05 9.881529e-03 2.847405e-02 1 1752471 1752974 504 - 3.018 3.045 0.091
ENSG00000008130 E003 514.0776294 1.825688e-04 5.109520e-01 6.460932e-01 1 1752975 1753060 86 - 2.662 2.672 0.034
ENSG00000008130 E004 443.1719740 1.211945e-03 1.782260e-01 2.989241e-01 1 1753567 1753649 83 - 2.582 2.614 0.109
ENSG00000008130 E005 220.2395911 2.903577e-04 1.571894e-02 4.210420e-02 1 1754051 1754060 10 - 2.255 2.319 0.214
ENSG00000008130 E006 390.7862503 1.635152e-04 7.047372e-08 7.368527e-07 1 1754061 1754162 102 - 2.468 2.577 0.363
ENSG00000008130 E007 169.6815534 2.645231e-03 4.983975e-06 3.548420e-05 1 1754163 1754164 2 - 2.052 2.233 0.605
ENSG00000008130 E008 174.8805578 1.909951e-03 1.109943e-07 1.118129e-06 1 1754165 1754170 6 - 2.052 2.250 0.660
ENSG00000008130 E009 187.6202862 3.625589e-04 1.629303e-08 1.930977e-07 1 1754171 1754180 10 - 2.101 2.273 0.573
ENSG00000008130 E010 226.5753010 6.891721e-04 1.173434e-08 1.428686e-07 1 1754181 1754202 22 - 2.187 2.354 0.558
ENSG00000008130 E011 206.9293509 1.081439e-03 5.424666e-07 4.765901e-06 1 1754203 1754208 6 - 2.153 2.313 0.534
ENSG00000008130 E012 32.0311306 1.936084e-02 1.358571e-01 2.422899e-01 1 1754209 1754283 75 - 1.571 1.426 -0.498
ENSG00000008130 E013 396.1123323 1.405770e-04 3.095322e-04 1.418274e-03 1 1754284 1754342 59 - 2.504 2.575 0.234
ENSG00000008130 E014 359.0464890 4.833887e-04 2.066396e-03 7.430057e-03 1 1754343 1754383 41 - 2.465 2.534 0.230
ENSG00000008130 E015 623.1310335 1.641362e-04 2.264812e-03 8.045263e-03 1 1754544 1754698 155 - 2.718 2.766 0.159
ENSG00000008130 E016 35.0576720 5.946544e-04 2.118170e-17 9.905724e-16 1 1754699 1754896 198 - 1.804 1.305 -1.708
ENSG00000008130 E017 480.7767787 6.717925e-04 5.965376e-01 7.184695e-01 1 1755374 1755476 103 - 2.633 2.643 0.034
ENSG00000008130 E018 35.0067046 5.689272e-04 3.551474e-18 1.827311e-16 1 1756004 1756257 254 - 1.807 1.295 -1.754
ENSG00000008130 E019 411.1260686 1.548644e-04 1.306211e-02 3.605680e-02 1 1756258 1756343 86 - 2.606 2.557 -0.162
ENSG00000008130 E020 385.2150106 1.710121e-04 1.355182e-02 3.719980e-02 1 1756503 1756587 85 - 2.577 2.527 -0.167
ENSG00000008130 E021 243.5142390 1.599038e-04 1.700749e-03 6.285885e-03 1 1756588 1756608 21 - 2.398 2.321 -0.258
ENSG00000008130 E022 16.3509203 2.734739e-02 5.286220e-07 4.653618e-06 1 1756609 1756657 49 - 1.518 0.944 -2.038
ENSG00000008130 E023 17.1654507 8.802128e-03 1.216131e-08 1.476685e-07 1 1756658 1756738 81 - 1.519 0.996 -1.846
ENSG00000008130 E024 13.5379384 1.702123e-02 1.361272e-05 8.765767e-05 1 1756739 1756770 32 - 1.400 0.931 -1.680
ENSG00000008130 E025 10.4650162 5.722585e-02 8.559445e-04 3.458593e-03 1 1756771 1756778 8 - 1.311 0.812 -1.826
ENSG00000008130 E026 20.0595974 1.039589e-02 7.701589e-06 5.251567e-05 1 1756779 1756882 104 - 1.525 1.125 -1.396
ENSG00000008130 E027 17.6064680 2.414011e-03 7.990230e-08 8.269914e-07 1 1756883 1757106 224 - 1.494 1.052 -1.555
ENSG00000008130 E028 6.1162852 4.142377e-03 2.916261e-05 1.740359e-04 1 1757107 1757180 74 - 1.116 0.598 -2.025
ENSG00000008130 E029 469.6610490 1.723542e-04 3.854580e-04 1.718532e-03 1 1757181 1757310 130 - 2.674 2.610 -0.216
ENSG00000008130 E030 10.9581600 3.831064e-02 1.090063e-05 7.179929e-05 1 1758365 1758575 211 - 1.366 0.779 -2.150
ENSG00000008130 E031 5.1417578 2.270680e-02 1.244082e-04 6.340633e-04 1 1759101 1759243 143 - 1.067 0.516 -2.226
ENSG00000008130 E032 6.9612200 2.321076e-03 1.583444e-04 7.843197e-04 1 1759734 1759902 169 - 1.131 0.688 -1.692
ENSG00000008130 E033 10.9010097 1.638846e-03 3.457187e-05 2.024399e-04 1 1761665 1761951 287 - 1.281 0.869 -1.502
ENSG00000008130 E034 409.3724603 3.192498e-04 5.208868e-05 2.921787e-04 1 1761952 1762035 84 - 2.626 2.544 -0.272
ENSG00000008130 E035 455.7329229 2.252909e-04 4.386109e-11 8.218943e-10 1 1765228 1765446 219 - 2.697 2.576 -0.404
ENSG00000008130 E036 119.6360357 6.175866e-03 1.320826e-10 2.285801e-09 1 1778289 1778470 182 - 2.239 1.917 -1.078
ENSG00000008130 E037 6.0261257 5.479244e-03 5.484145e-01 6.782575e-01 1 1778746 1778867 122 - 0.875 0.795 -0.310
ENSG00000008130 E038 0.0000000       1 1779157 1779196 40 -      
ENSG00000008130 E039 0.1482932 4.120136e-02 1.000000e+00   1 1779905 1780029 125 - 0.000 0.089 8.735
ENSG00000008130 E040 0.0000000       1 1780030 1780069 40 -      
ENSG00000008130 E041 0.1817044 3.968967e-02 1.000000e+00   1 1780282 1780457 176 - 0.000 0.089 8.765