ENSG00000008083

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341776 ENSG00000008083 HEK293_OSMI2_2hA HEK293_TMG_2hB JARID2 protein_coding protein_coding 7.986174 6.688887 6.992279 0.5123631 0.281046 0.06390318 4.4509595 2.727995 4.2898171 0.4327200 0.06924399 0.6511553 0.5435375 0.4033000 0.61490000 0.2116000 1.884503e-03 5.027119e-18 FALSE TRUE
ENST00000397311 ENSG00000008083 HEK293_OSMI2_2hA HEK293_TMG_2hB JARID2 protein_coding protein_coding 7.986174 6.688887 6.992279 0.5123631 0.281046 0.06390318 1.5372805 2.721234 0.8979680 0.3506041 0.22343575 -1.5888395 0.2054000 0.4178000 0.12683333 -0.2909667 4.440078e-03 5.027119e-18 FALSE TRUE
MSTRG.27673.5 ENSG00000008083 HEK293_OSMI2_2hA HEK293_TMG_2hB JARID2 protein_coding   7.986174 6.688887 6.992279 0.5123631 0.281046 0.06390318 1.1473435 1.211899 0.6098419 0.3678270 0.09221302 -0.9791525 0.1461792 0.1749333 0.08803333 -0.0869000 2.495372e-01 5.027119e-18 FALSE TRUE
MSTRG.27673.6 ENSG00000008083 HEK293_OSMI2_2hA HEK293_TMG_2hB JARID2 protein_coding   7.986174 6.688887 6.992279 0.5123631 0.281046 0.06390318 0.6373575 0.000000 1.1303814 0.0000000 0.11484354 6.8333725 0.0769875 0.0000000 0.16086667 0.1608667 5.027119e-18 5.027119e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000008083 E001 0.1482932 0.0413327262 5.221020e-01   6 15244800 15244945 146 + 0.000 0.120 9.817
ENSG00000008083 E002 0.2934659 0.0293153390 9.524860e-01   6 15244946 15244999 54 + 0.124 0.120 -0.057
ENSG00000008083 E003 0.1451727 0.0437571795 4.589292e-01   6 15245000 15245032 33 + 0.124 0.000 -11.529
ENSG00000008083 E004 0.0000000       6 15245314 15245484 171 +      
ENSG00000008083 E005 0.3299976 0.0274424043 2.235315e-01   6 15245485 15245519 35 + 0.000 0.214 12.075
ENSG00000008083 E006 2.9495220 0.0054947369 1.867288e-01 3.096312e-01 6 15245520 15245607 88 + 0.697 0.510 -0.833
ENSG00000008083 E007 34.1190797 0.0060667463 1.471007e-04 7.346386e-04 6 15246069 15246380 312 + 1.664 1.423 -0.824
ENSG00000008083 E008 44.0230316 0.0147734084 8.346683e-05 4.444097e-04 6 15246381 15246584 204 + 1.788 1.506 -0.960
ENSG00000008083 E009 4.0211889 0.0042369669 1.672294e-01 2.846026e-01 6 15248855 15248964 110 + 0.800 0.622 -0.734
ENSG00000008083 E010 43.7937883 0.0005151846 4.786178e-09 6.267988e-08 6 15374117 15374252 136 + 1.786 1.496 -0.985
ENSG00000008083 E011 35.7380822 0.0006245230 1.516422e-05 9.667249e-05 6 15410224 15410365 142 + 1.679 1.449 -0.785
ENSG00000008083 E012 47.2963435 0.0074941810 5.310912e-06 3.757044e-05 6 15452006 15452175 170 + 1.817 1.543 -0.929
ENSG00000008083 E013 58.8212564 0.0096968577 3.553643e-04 1.600825e-03 6 15468542 15468718 177 + 1.882 1.674 -0.705
ENSG00000008083 E014 57.4315108 0.0062852129 6.509358e-03 1.994627e-02 6 15487307 15487542 236 + 1.839 1.701 -0.464
ENSG00000008083 E015 15.0412335 0.0731430860 2.610147e-01 3.986203e-01 6 15496132 15496140 9 + 1.269 1.142 -0.451
ENSG00000008083 E016 125.9754615 0.0072964271 1.531316e-05 9.752680e-05 6 15496141 15497055 915 + 2.200 2.001 -0.665
ENSG00000008083 E017 33.5058558 0.0057800959 5.655167e-02 1.206820e-01 6 15497056 15497170 115 + 1.596 1.482 -0.390
ENSG00000008083 E018 106.4914736 0.0034164785 4.758452e-02 1.048848e-01 6 15500907 15501357 451 + 2.066 1.998 -0.227
ENSG00000008083 E019 40.5708669 0.0005673268 8.505687e-02 1.674998e-01 6 15501358 15501409 52 + 1.657 1.584 -0.251
ENSG00000008083 E020 55.7273637 0.0028998015 4.547523e-01 5.953510e-01 6 15504500 15504592 93 + 1.761 1.741 -0.070
ENSG00000008083 E021 0.1482932 0.0413327262 5.221020e-01   6 15505165 15505295 131 + 0.000 0.120 11.065
ENSG00000008083 E022 62.6913274 0.0004771481 3.051418e-01 4.471861e-01 6 15507136 15507254 119 + 1.817 1.792 -0.085
ENSG00000008083 E023 50.7896854 0.0004700010 3.669509e-02 8.489784e-02 6 15507346 15507416 71 + 1.759 1.678 -0.275
ENSG00000008083 E024 65.6440968 0.0003966378 1.934301e-01 3.180885e-01 6 15508340 15508454 115 + 1.845 1.810 -0.119
ENSG00000008083 E025 57.5185298 0.0006128496 6.676222e-01 7.747993e-01 6 15511296 15511401 106 + 1.743 1.783 0.134
ENSG00000008083 E026 79.1369097 0.0012446200 5.535871e-02 1.186078e-01 6 15512208 15512390 183 + 1.843 1.942 0.334
ENSG00000008083 E027 63.7759701 0.0009331207 9.448269e-02 1.821013e-01 6 15512915 15513045 131 + 1.754 1.849 0.321
ENSG00000008083 E028 73.5951031 0.0006377959 9.969088e-02 1.900129e-01 6 15513239 15513422 184 + 1.820 1.908 0.296
ENSG00000008083 E029 62.9450360 0.0004160144 3.660976e-01 5.104329e-01 6 15517161 15517268 108 + 1.771 1.831 0.201
ENSG00000008083 E030 73.2916969 0.0026440732 5.945700e-02 1.257053e-01 6 15520069 15520290 222 + 1.808 1.916 0.363
ENSG00000008083 E031 164.4298088 0.0014757159 3.019404e-07 2.792643e-06 6 15520291 15520910 620 + 2.108 2.290 0.608
ENSG00000008083 E032 275.2326007 0.0056489653 3.220015e-22 2.623586e-20 6 15520911 15522195 1285 + 2.179 2.575 1.322