ENSG00000007516

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000426824 ENSG00000007516 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP3 protein_coding protein_coding 4.029926 3.590688 3.465708 0.4905887 0.3870368 -0.05096568 0.69363197 1.17282707 0.11763541 0.20799928 0.11763541 -3.212139 0.17126250 0.331600000 0.03200000 -0.29960000 0.0242859444 0.0005458869 FALSE TRUE
ENST00000564213 ENSG00000007516 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP3 protein_coding processed_transcript 4.029926 3.590688 3.465708 0.4905887 0.3870368 -0.05096568 0.20393509 0.20986544 0.58874014 0.20986544 0.29456560 1.445309 0.04754167 0.046666667 0.15370000 0.10703333 0.5711167951 0.0005458869 FALSE FALSE
ENST00000565665 ENSG00000007516 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP3 protein_coding retained_intron 4.029926 3.590688 3.465708 0.4905887 0.3870368 -0.05096568 0.27808909 0.00000000 0.18404983 0.00000000 0.02769466 4.278355 0.06405833 0.000000000 0.05450000 0.05450000 0.0005458869 0.0005458869 FALSE TRUE
ENST00000566389 ENSG00000007516 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP3 protein_coding retained_intron 4.029926 3.590688 3.465708 0.4905887 0.3870368 -0.05096568 0.06521000 0.20446737 0.00000000 0.20446737 0.00000000 -4.422686 0.01752083 0.059033333 0.00000000 -0.05903333 0.7902562443 0.0005458869 FALSE FALSE
ENST00000567203 ENSG00000007516 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP3 protein_coding retained_intron 4.029926 3.590688 3.465708 0.4905887 0.3870368 -0.05096568 0.62249746 0.21539034 0.61362197 0.06674291 0.08027040 1.468246 0.13994583 0.057800000 0.17626667 0.11846667 0.0018549017 0.0005458869 FALSE FALSE
MSTRG.11774.1 ENSG00000007516 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP3 protein_coding   4.029926 3.590688 3.465708 0.4905887 0.3870368 -0.05096568 0.39080223 0.08815541 0.55088409 0.04415688 0.13546949 2.514563 0.10836250 0.028300000 0.16330000 0.13500000 0.0256286497 0.0005458869 FALSE TRUE
MSTRG.11774.14 ENSG00000007516 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP3 protein_coding   4.029926 3.590688 3.465708 0.4905887 0.3870368 -0.05096568 0.49852882 0.68338642 0.22028843 0.06885330 0.11903532 -1.590218 0.12071250 0.194866667 0.07116667 -0.12370000 0.3306097542 0.0005458869 TRUE TRUE
MSTRG.11774.15 ENSG00000007516 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP3 protein_coding   4.029926 3.590688 3.465708 0.4905887 0.3870368 -0.05096568 0.33291710 0.56435391 0.04777762 0.10789662 0.04777762 -3.313357 0.08488333 0.159100000 0.01760000 -0.14150000 0.0389734236 0.0005458869 FALSE TRUE
MSTRG.11774.7 ENSG00000007516 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP3 protein_coding   4.029926 3.590688 3.465708 0.4905887 0.3870368 -0.05096568 0.32349056 0.19266926 0.47766115 0.08772153 0.16903921 1.266752 0.08745000 0.054066667 0.15400000 0.09993333 0.3900471187 0.0005458869 FALSE TRUE
MSTRG.11774.8 ENSG00000007516 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP3 protein_coding   4.029926 3.590688 3.465708 0.4905887 0.3870368 -0.05096568 0.06699646 0.01332365 0.24614830 0.01332365 0.24614830 3.457114 0.01736250 0.002966667 0.06146667 0.05850000 0.8970364300 0.0005458869 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000007516 E001 0.0000000       16 1333638 1333642 5 +      
ENSG00000007516 E002 0.0000000       16 1333643 1333644 2 +      
ENSG00000007516 E003 0.2965864 0.2457283163 3.501452e-01   16 1333645 1333653 9 + 0.000 0.191 9.967
ENSG00000007516 E004 0.7362571 0.0783187905 4.725687e-01 0.6116299506 16 1333654 1333657 4 + 0.327 0.193 -0.998
ENSG00000007516 E005 5.7591687 0.0093733027 6.055514e-02 0.1275643531 16 1333658 1333749 92 + 0.965 0.719 -0.958
ENSG00000007516 E006 0.2955422 0.0293404288 8.440266e-01   16 1334504 1334756 253 + 0.138 0.108 -0.404
ENSG00000007516 E007 0.9630009 0.0351260119 2.670921e-01 0.4053821482 16 1336197 1336399 203 + 0.397 0.195 -1.401
ENSG00000007516 E008 8.9852616 0.0026737438 1.691045e-01 0.2870202291 16 1338540 1338680 141 + 1.074 0.922 -0.559
ENSG00000007516 E009 8.8947173 0.0018915937 4.796835e-01 0.6180208663 16 1338902 1338989 88 + 1.030 0.951 -0.294
ENSG00000007516 E010 1.1468953 0.0111750209 4.692241e-01 0.6085002602 16 1339113 1339163 51 + 0.397 0.267 -0.816
ENSG00000007516 E011 8.1118991 0.0252136213 4.436724e-01 0.5852579070 16 1339164 1339244 81 + 1.000 0.895 -0.391
ENSG00000007516 E012 1.0425102 0.0121989077 2.140039e-02 0.0544332023 16 1339245 1339386 142 + 0.511 0.108 -2.988
ENSG00000007516 E013 8.1775770 0.0024762580 2.859323e-01 0.4262955313 16 1339496 1339564 69 + 1.015 0.892 -0.460
ENSG00000007516 E014 7.4042070 0.0023842845 5.622992e-01 0.6899434392 16 1339565 1339579 15 + 0.947 0.876 -0.269
ENSG00000007516 E015 9.2487369 0.0019456953 3.950712e-01 0.5389150222 16 1339580 1339603 24 + 1.045 0.951 -0.348
ENSG00000007516 E016 10.5240418 0.0119876281 9.139491e-01 0.9495040925 16 1340922 1340981 60 + 1.060 1.048 -0.042
ENSG00000007516 E017 11.4705939 0.0241936538 7.511807e-01 0.8376845084 16 1341129 1341195 67 + 1.060 1.100 0.144
ENSG00000007516 E018 15.7986097 0.0012595569 8.092457e-01 0.8788647302 16 1341294 1341489 196 + 1.203 1.219 0.058
ENSG00000007516 E019 6.4172844 0.0120551975 8.729965e-01 0.9223756433 16 1341822 1341866 45 + 0.844 0.860 0.061
ENSG00000007516 E020 3.8925759 0.3175397944 1.966747e-01 0.3220933371 16 1341867 1341985 119 + 0.820 0.558 -1.102
ENSG00000007516 E021 9.5872579 0.0019073722 4.045559e-02 0.0918604237 16 1341986 1342063 78 + 1.125 0.908 -0.801
ENSG00000007516 E022 11.4820676 0.0014994652 1.184015e-03 0.0045868908 16 1342181 1342283 103 + 1.251 0.937 -1.139
ENSG00000007516 E023 1.3371074 0.0123603915 7.320784e-02 0.1486527623 16 1342284 1342421 138 + 0.511 0.195 -1.984
ENSG00000007516 E024 9.0013728 0.0020535437 6.557111e-03 0.0200736685 16 1342527 1342634 108 + 1.137 0.842 -1.095
ENSG00000007516 E025 8.2107163 0.0108234414 7.595753e-04 0.0031133550 16 1342719 1342814 96 + 1.149 0.744 -1.525
ENSG00000007516 E026 2.4220261 0.1189029142 1.151971e-01 0.2131370625 16 1342815 1342912 98 + 0.708 0.379 -1.557
ENSG00000007516 E027 8.7474748 0.0029882748 4.620645e-03 0.0148773303 16 1342913 1343016 104 + 1.149 0.841 -1.140
ENSG00000007516 E028 1.1468953 0.0111750209 4.692241e-01 0.6085002602 16 1343318 1343392 75 + 0.397 0.267 -0.816
ENSG00000007516 E029 13.6596086 0.0014037122 3.740695e-01 0.5184905390 16 1343393 1343513 121 + 1.203 1.120 -0.297
ENSG00000007516 E030 0.2987644 0.0274424043 1.377749e-01   16 1343890 1344021 132 + 0.243 0.000 -14.512
ENSG00000007516 E031 7.2579928 0.0023244086 7.624446e-02 0.1534976621 16 1344022 1344044 23 + 1.015 0.805 -0.796
ENSG00000007516 E032 15.4778750 0.0011974883 3.304450e-01 0.4740298953 16 1344045 1344146 102 + 1.251 1.164 -0.308
ENSG00000007516 E033 2.9987140 0.1746879286 1.846973e-01 0.3070944820 16 1344147 1344226 80 + 0.769 0.431 -1.523
ENSG00000007516 E034 14.8706834 0.0038367363 3.521904e-01 0.4964576340 16 1344227 1344317 91 + 1.242 1.156 -0.306
ENSG00000007516 E035 12.6045424 0.0015521603 2.910133e-01 0.4318294595 16 1344469 1344525 57 + 1.182 1.081 -0.364
ENSG00000007516 E036 5.6688027 0.0035294115 1.857456e-03 0.0067810598 16 1344526 1344600 75 + 1.015 0.614 -1.586
ENSG00000007516 E037 11.6218610 0.0015508669 3.160190e-01 0.4587827546 16 1344601 1344667 67 + 1.149 1.049 -0.361
ENSG00000007516 E038 10.2826362 0.0016941495 8.861800e-01 0.9312029897 16 1344668 1344698 31 + 1.045 1.027 -0.068
ENSG00000007516 E039 10.6072309 0.0016843963 7.667530e-02 0.1541716895 16 1344798 1344849 52 + 0.928 1.110 0.670
ENSG00000007516 E040 14.6002758 0.0013590429 7.149719e-02 0.1458278592 16 1344969 1345099 131 + 1.074 1.234 0.574
ENSG00000007516 E041 16.1420775 0.0044628655 2.586782e-01 0.3959904734 16 1345249 1345372 124 + 1.149 1.249 0.356
ENSG00000007516 E042 1.9218465 0.0160574959 6.515700e-01 0.7624193632 16 1345418 1345746 329 + 0.397 0.475 0.408
ENSG00000007516 E043 17.5954099 0.0010761728 1.942896e-02 0.0502657218 16 1345747 1345890 144 + 1.125 1.319 0.684
ENSG00000007516 E044 9.1494705 0.0019203672 7.011078e-01 0.8003974803 16 1345986 1346008 23 + 0.965 1.003 0.140
ENSG00000007516 E045 11.3521356 0.0015552764 3.199725e-01 0.4630602899 16 1346009 1346078 70 + 1.015 1.110 0.348
ENSG00000007516 E046 9.8203789 0.0019636589 8.216951e-01 0.8875312923 16 1346170 1346220 51 + 1.030 1.003 -0.101
ENSG00000007516 E047 6.5363800 0.0028789819 8.794209e-01 0.9265641839 16 1346221 1346237 17 + 0.844 0.860 0.059
ENSG00000007516 E048 19.1633421 0.0122678624 8.624064e-01 0.9152804805 16 1346238 1346361 124 + 1.269 1.287 0.061
ENSG00000007516 E049 12.9472835 0.0015497845 8.077508e-01 0.8778380264 16 1346442 1346458 17 + 1.137 1.111 -0.095
ENSG00000007516 E050 17.8468784 0.0010701388 5.504153e-01 0.6800571557 16 1346459 1346510 52 + 1.286 1.234 -0.182
ENSG00000007516 E051 18.7220857 0.0011387099 4.129002e-01 0.5564698023 16 1346605 1346684 80 + 1.233 1.295 0.218
ENSG00000007516 E052 0.2924217 0.0275097245 1.374547e-01   16 1346685 1346718 34 + 0.243 0.000 -14.511
ENSG00000007516 E053 2.1337555 0.0592432769 5.112661e-01 0.6463221197 16 1346719 1346846 128 + 0.559 0.432 -0.619
ENSG00000007516 E054 11.2434826 0.0037114536 3.767230e-01 0.5210484631 16 1346847 1346933 87 + 1.015 1.101 0.314
ENSG00000007516 E055 5.7079584 0.0030701227 4.425114e-01 0.5841250154 16 1346934 1346955 22 + 0.867 0.765 -0.400
ENSG00000007516 E056 3.3172727 0.0048799855 3.362765e-02 0.0790198288 16 1346956 1347091 136 + 0.795 0.475 -1.401
ENSG00000007516 E057 18.1651554 0.0010805116 2.138489e-01 0.3430691804 16 1347298 1347369 72 + 1.203 1.301 0.343
ENSG00000007516 E058 21.9552232 0.0008869674 2.832838e-03 0.0097726112 16 1347545 1347625 81 + 1.193 1.418 0.789
ENSG00000007516 E059 24.4883716 0.0008565773 6.707555e-02 0.1385002753 16 1347701 1347821 121 + 1.311 1.437 0.437
ENSG00000007516 E060 20.8076081 0.0044354861 1.639700e-01 0.2803095769 16 1347894 1348017 124 + 1.260 1.368 0.377
ENSG00000007516 E061 16.7063628 0.0012031437 7.017569e-01 0.8007862735 16 1348096 1348208 113 + 1.213 1.241 0.100
ENSG00000007516 E062 16.1106035 0.0011112955 1.336949e-02 0.0367793589 16 1348209 1348301 93 + 1.074 1.288 0.763
ENSG00000007516 E063 90.4190616 0.0004535235 1.847045e-05 0.0001155147 16 1348379 1349365 987 + 1.846 2.001 0.519
ENSG00000007516 E064 5.0917034 0.0038721935 1.380119e-01 0.2453104656 16 1349366 1349441 76 + 0.640 0.842 0.821