ENSG00000007392

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000293872 ENSG00000007392 HEK293_OSMI2_2hA HEK293_TMG_2hB LUC7L protein_coding protein_coding 62.90455 73.28493 64.30341 2.665203 1.168749 -0.1885939 28.730591 41.026198 30.454955 3.10316801 0.5480647 -0.4297465 0.44082500 0.55890000 0.47370000 -0.08520000 1.819146e-01 1.199596e-12 FALSE  
ENST00000337351 ENSG00000007392 HEK293_OSMI2_2hA HEK293_TMG_2hB LUC7L protein_coding protein_coding 62.90455 73.28493 64.30341 2.665203 1.168749 -0.1885939 3.597236 4.466956 3.029039 0.30512917 0.1452644 -0.5589030 0.05767083 0.06083333 0.04723333 -0.01360000 2.204909e-01 1.199596e-12 FALSE  
ENST00000397780 ENSG00000007392 HEK293_OSMI2_2hA HEK293_TMG_2hB LUC7L protein_coding protein_coding 62.90455 73.28493 64.30341 2.665203 1.168749 -0.1885939 4.802593 2.004423 6.211211 0.20881173 0.5217713 1.6268286 0.08077083 0.02723333 0.09653333 0.06930000 1.199596e-12 1.199596e-12 FALSE  
ENST00000397783 ENSG00000007392 HEK293_OSMI2_2hA HEK293_TMG_2hB LUC7L protein_coding protein_coding 62.90455 73.28493 64.30341 2.665203 1.168749 -0.1885939 7.178802 9.222406 6.539188 0.25698190 0.8792541 -0.4953906 0.11168333 0.12636667 0.10126667 -0.02510000 4.797386e-01 1.199596e-12 FALSE  
ENST00000490762 ENSG00000007392 HEK293_OSMI2_2hA HEK293_TMG_2hB LUC7L protein_coding retained_intron 62.90455 73.28493 64.30341 2.665203 1.168749 -0.1885939 3.269722 1.223329 4.019019 0.15370380 0.1680060 1.7078710 0.05607500 0.01683333 0.06243333 0.04560000 2.937070e-10 1.199596e-12 TRUE  
MSTRG.11707.19 ENSG00000007392 HEK293_OSMI2_2hA HEK293_TMG_2hB LUC7L protein_coding   62.90455 73.28493 64.30341 2.665203 1.168749 -0.1885939 3.394079 4.584956 2.810189 0.04037613 0.4063220 -0.7042593 0.05447917 0.06266667 0.04350000 -0.01916667 1.580489e-01 1.199596e-12 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000007392 E001 4.672750 0.0035340447 5.485104e-01 6.783583e-01 16 188969 188970 2 - 0.796 0.718 -0.314
ENSG00000007392 E002 5.115641 0.0032820221 7.837785e-01 8.612739e-01 16 188971 188974 4 - 0.796 0.763 -0.132
ENSG00000007392 E003 6.221749 0.0027223506 7.939474e-01 8.683233e-01 16 188975 188979 5 - 0.822 0.858 0.140
ENSG00000007392 E004 11.871198 0.0015409270 1.583465e-01 2.729281e-01 16 188980 188989 10 - 1.000 1.145 0.526
ENSG00000007392 E005 65.302692 0.0011344051 3.379257e-04 1.532179e-03 16 188990 189031 42 - 1.701 1.877 0.595
ENSG00000007392 E006 134.342966 0.0002533154 6.271863e-09 8.039145e-08 16 189032 189097 66 - 1.994 2.187 0.646
ENSG00000007392 E007 106.317378 0.0002689984 4.164637e-09 5.502323e-08 16 189098 189114 17 - 1.875 2.094 0.736
ENSG00000007392 E008 491.057843 0.0005626887 5.210647e-11 9.645705e-10 16 189115 189339 225 - 2.598 2.730 0.438
ENSG00000007392 E009 79.454473 0.0003282195 6.376198e-03 1.960069e-02 16 189340 189895 556 - 1.822 1.938 0.392
ENSG00000007392 E010 34.008001 0.0006201718 2.192562e-01 3.494769e-01 16 189896 189930 35 - 1.487 1.566 0.272
ENSG00000007392 E011 70.035206 0.0005592555 7.200393e-03 2.174546e-02 16 189931 189946 16 - 1.764 1.887 0.415
ENSG00000007392 E012 71.357945 0.0003401737 1.383123e-01 2.457569e-01 16 189947 189967 21 - 1.807 1.874 0.228
ENSG00000007392 E013 363.569920 0.0001458426 9.030268e-13 2.233948e-11 16 189968 190000 33 - 2.459 2.603 0.479
ENSG00000007392 E014 573.780463 0.0010436469 2.802584e-10 4.582610e-09 16 190001 190121 121 - 2.661 2.796 0.449
ENSG00000007392 E015 300.170004 0.0020196927 4.022226e-06 2.923680e-05 16 190122 190135 14 - 2.376 2.517 0.471
ENSG00000007392 E016 342.920309 0.0024491390 2.482243e-04 1.167780e-03 16 190541 190570 30 - 2.451 2.566 0.382
ENSG00000007392 E017 11.006222 0.0015324766 4.093844e-01 5.529964e-01 16 190571 190595 25 - 1.114 1.036 -0.283
ENSG00000007392 E018 13.490334 0.0029580310 9.669870e-01 9.833161e-01 16 190662 190802 141 - 1.139 1.146 0.025
ENSG00000007392 E019 525.584806 0.0005787974 7.196286e-06 4.941158e-05 16 192927 193015 89 - 2.655 2.743 0.295
ENSG00000007392 E020 680.866664 0.0001471589 1.128238e-01 2.096614e-01 16 199062 199238 177 - 2.807 2.833 0.087
ENSG00000007392 E021 621.701502 0.0007853920 4.094730e-01 5.530806e-01 16 206004 206147 144 - 2.773 2.791 0.059
ENSG00000007392 E022 542.159804 0.0009782273 3.234232e-02 7.651675e-02 16 208078 208188 111 - 2.750 2.708 -0.139
ENSG00000007392 E023 7.305871 0.0023096236 2.548737e-01 3.916592e-01 16 208189 208508 320 - 0.822 0.963 0.538
ENSG00000007392 E024 9.062986 0.0103014730 9.784475e-02 1.872231e-01 16 208601 208632 32 - 1.102 0.919 -0.672
ENSG00000007392 E025 8.757892 0.0056338159 1.484134e-01 2.595178e-01 16 208633 208664 32 - 1.075 0.920 -0.573
ENSG00000007392 E026 14.942772 0.0014829510 1.206579e-01 2.209020e-01 16 208665 209773 1109 - 1.102 1.246 0.515
ENSG00000007392 E027 2.924641 0.0091408682 8.763207e-01 9.246220e-01 16 220171 220648 478 - 0.603 0.582 -0.093
ENSG00000007392 E028 470.232864 0.0003188768 1.544767e-11 3.118623e-10 16 220649 220747 99 - 2.730 2.614 -0.386
ENSG00000007392 E029 395.072405 0.0003424289 1.712653e-09 2.430390e-08 16 227242 227336 95 - 2.653 2.541 -0.374
ENSG00000007392 E030 131.874865 0.0011942084 1.525509e-60 1.551998e-57 16 227337 227986 650 - 2.376 1.794 -1.950
ENSG00000007392 E031 48.289524 0.0004712090 4.960756e-31 8.959012e-29 16 227987 228123 137 - 1.949 1.346 -2.054
ENSG00000007392 E032 39.918686 0.0005394184 7.517725e-28 1.051854e-25 16 228124 228228 105 - 1.877 1.253 -2.135
ENSG00000007392 E033 37.758293 0.0163943045 6.584608e-11 1.197039e-09 16 228229 228332 104 - 1.831 1.270 -1.921
ENSG00000007392 E034 52.666869 0.0006867785 3.443413e-10 5.546202e-09 16 228333 228402 70 - 1.877 1.573 -1.030
ENSG00000007392 E035 20.938988 0.0100413184 9.436543e-08 9.624878e-07 16 228403 228488 86 - 1.555 1.081 -1.661
ENSG00000007392 E036 32.433421 0.0044770362 6.961896e-17 3.057988e-15 16 228489 228700 212 - 1.775 1.188 -2.022
ENSG00000007392 E037 18.393010 0.0103928154 7.345409e-10 1.117185e-08 16 228701 228789 89 - 1.541 0.962 -2.048
ENSG00000007392 E038 35.294207 0.0024680783 2.196599e-26 2.695202e-24 16 228790 229278 489 - 1.843 1.145 -2.404
ENSG00000007392 E039 316.737799 0.0006933572 2.015060e-07 1.929380e-06 16 229279 229498 220 - 2.559 2.442 -0.388
ENSG00000007392 E040 3.112548 0.1127656314 9.535273e-01 9.749093e-01 16 231221 231391 171 - 0.603 0.610 0.032