ENSG00000007376

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000007264 ENSG00000007376 HEK293_OSMI2_2hA HEK293_TMG_2hB RPUSD1 protein_coding protein_coding 126.7185 228.17 75.52422 14.00543 1.822028 -1.59497 62.001295 120.809236 30.267728 6.1157296 1.87576873 -1.9965213 0.45866667 0.53020000 0.40166667 -0.12853333 1.454063e-02 4.172998e-14 FALSE TRUE
ENST00000561734 ENSG00000007376 HEK293_OSMI2_2hA HEK293_TMG_2hB RPUSD1 protein_coding protein_coding 126.7185 228.17 75.52422 14.00543 1.822028 -1.59497 10.658475 9.874847 8.908757 0.8191559 1.00652305 -0.1483761 0.10682500 0.04340000 0.11803333 0.07463333 2.280697e-06 4.172998e-14 FALSE TRUE
ENST00000562070 ENSG00000007376 HEK293_OSMI2_2hA HEK293_TMG_2hB RPUSD1 protein_coding protein_coding 126.7185 228.17 75.52422 14.00543 1.822028 -1.59497 8.759146 12.415470 6.269787 1.3611111 0.05878453 -0.9845130 0.08116250 0.05416667 0.08310000 0.02893333 4.779968e-04 4.172998e-14 FALSE TRUE
ENST00000565809 ENSG00000007376 HEK293_OSMI2_2hA HEK293_TMG_2hB RPUSD1 protein_coding protein_coding 126.7185 228.17 75.52422 14.00543 1.822028 -1.59497 9.130031 15.318423 6.396624 2.5205120 0.52801567 -1.2585731 0.07422917 0.06646667 0.08446667 0.01800000 4.577429e-01 4.172998e-14 FALSE FALSE
ENST00000567114 ENSG00000007376 HEK293_OSMI2_2hA HEK293_TMG_2hB RPUSD1 protein_coding protein_coding 126.7185 228.17 75.52422 14.00543 1.822028 -1.59497 20.334131 47.756884 12.679933 2.0749869 0.56167206 -1.9123263 0.14543333 0.21030000 0.16773333 -0.04256667 7.358841e-02 4.172998e-14 FALSE TRUE
MSTRG.11750.8 ENSG00000007376 HEK293_OSMI2_2hA HEK293_TMG_2hB RPUSD1 protein_coding   126.7185 228.17 75.52422 14.00543 1.822028 -1.59497 4.615056 3.441793 5.162825 2.0348729 1.78418355 0.5836066 0.04272083 0.01433333 0.06733333 0.05300000 3.792799e-02 4.172998e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000007376 E001 92.06501 0.0063673082 2.892663e-01 4.299438e-01 16 784974 784990 17 - 1.813 1.882 0.234
ENSG00000007376 E002 210.13719 0.0035500208 5.446967e-04 2.327060e-03 16 784991 785013 23 - 2.094 2.250 0.521
ENSG00000007376 E003 859.38243 0.0034818234 2.307835e-03 8.176322e-03 16 785014 785139 126 - 2.747 2.851 0.347
ENSG00000007376 E004 1746.16846 0.0021662898 1.021569e-03 4.033370e-03 16 785140 785327 188 - 3.071 3.155 0.278
ENSG00000007376 E005 1055.89594 0.0028998031 1.441364e-02 3.916498e-02 16 785328 785383 56 - 2.858 2.936 0.257
ENSG00000007376 E006 678.29301 0.0016047300 2.755822e-01 4.149141e-01 16 785384 785387 4 - 2.702 2.735 0.110
ENSG00000007376 E007 3607.60692 0.0002115066 2.821271e-06 2.124583e-05 16 785388 785967 580 - 3.416 3.462 0.154
ENSG00000007376 E008 721.64198 0.0007352220 4.391050e-01 5.808895e-01 16 785968 785982 15 - 2.738 2.758 0.066
ENSG00000007376 E009 1433.14079 0.0005558862 9.471163e-03 2.746618e-02 16 785983 786148 166 - 3.015 3.060 0.152
ENSG00000007376 E010 799.79777 0.0002078039 2.275071e-01 3.594257e-01 16 786149 786193 45 - 2.778 2.801 0.077
ENSG00000007376 E011 1394.40540 0.0005321107 3.966139e-01 5.403735e-01 16 786194 786377 184 - 3.025 3.043 0.060
ENSG00000007376 E012 193.78541 0.0017329392 5.217040e-06 3.696296e-05 16 786378 786825 448 - 2.304 2.148 -0.521
ENSG00000007376 E013 45.51871 0.0004830901 1.881890e-03 6.858629e-03 16 786826 786826 1 - 1.703 1.522 -0.616
ENSG00000007376 E014 640.81152 0.0001242924 5.481314e-01 6.780092e-01 16 786827 786840 14 - 2.707 2.699 -0.028
ENSG00000007376 E015 887.71589 0.0001029744 5.203254e-02 1.127747e-01 16 786841 786928 88 - 2.864 2.837 -0.088
ENSG00000007376 E016 74.82211 0.0013849982 7.052700e-05 3.826540e-04 16 787068 787076 9 - 1.920 1.728 -0.647
ENSG00000007376 E017 915.13689 0.0001227240 1.464031e-04 7.315598e-04 16 787077 787179 103 - 2.897 2.844 -0.176
ENSG00000007376 E018 35.66588 0.0005869404 1.151187e-09 1.686820e-08 16 787180 787241 62 - 1.733 1.357 -1.287
ENSG00000007376 E019 18.13481 0.0473822939 6.859776e-02 1.410423e-01 16 787344 787353 10 - 1.369 1.122 -0.869
ENSG00000007376 E020 640.83433 0.0007266014 2.047713e-06 1.589380e-05 16 787354 787396 43 - 2.775 2.682 -0.312
ENSG00000007376 E021 754.16423 0.0020507488 2.058473e-02 5.271828e-02 16 787397 787477 81 - 2.818 2.763 -0.183
ENSG00000007376 E022 508.92833 0.0029150702 3.270294e-02 7.720506e-02 16 787556 787603 48 - 2.652 2.590 -0.205
ENSG00000007376 E023 493.82126 0.0048931425 1.352293e-02 3.713405e-02 16 787604 787645 42 - 2.659 2.572 -0.288
ENSG00000007376 E024 528.76868 0.0072036085 4.850615e-04 2.103114e-03 16 787646 787744 99 - 2.733 2.589 -0.481
ENSG00000007376 E025 73.17956 0.0044143485 2.602941e-23 2.382220e-21 16 787745 787981 237 - 2.125 1.605 -1.751
ENSG00000007376 E026 431.61447 0.0147086107 7.555029e-03 2.265899e-02 16 788256 788397 142 - 2.649 2.500 -0.498