ENSG00000007341

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343210 ENSG00000007341 HEK293_OSMI2_2hA HEK293_TMG_2hB ST7L protein_coding protein_coding 27.68061 25.15993 29.70935 1.362485 0.3980055 0.2397014 0.9037633 0.000000 1.838633 0.00000000 0.3650681 7.5303153 0.02797917 0.00000000 0.0616000 0.06160000 2.331859e-14 2.331859e-14 FALSE TRUE
ENST00000467335 ENSG00000007341 HEK293_OSMI2_2hA HEK293_TMG_2hB ST7L protein_coding processed_transcript 27.68061 25.15993 29.70935 1.362485 0.3980055 0.2397014 7.1984852 8.879475 3.807433 1.33918476 0.2869188 -1.2194953 0.27170833 0.34906667 0.1283667 -0.22070000 1.997114e-06 2.331859e-14 FALSE TRUE
ENST00000473206 ENSG00000007341 HEK293_OSMI2_2hA HEK293_TMG_2hB ST7L protein_coding processed_transcript 27.68061 25.15993 29.70935 1.362485 0.3980055 0.2397014 3.3395174 4.145156 3.536289 0.14423860 0.9556825 -0.2285926 0.12565000 0.16606667 0.1197000 -0.04636667 5.160251e-01 2.331859e-14 FALSE TRUE
ENST00000477332 ENSG00000007341 HEK293_OSMI2_2hA HEK293_TMG_2hB ST7L protein_coding processed_transcript 27.68061 25.15993 29.70935 1.362485 0.3980055 0.2397014 4.2336017 5.084121 4.612085 0.09267651 0.5131424 -0.1402894 0.16047500 0.20346667 0.1549667 -0.04850000 3.051177e-01 2.331859e-14 FALSE TRUE
ENST00000479436 ENSG00000007341 HEK293_OSMI2_2hA HEK293_TMG_2hB ST7L protein_coding processed_transcript 27.68061 25.15993 29.70935 1.362485 0.3980055 0.2397014 3.0580512 1.719488 4.154973 0.68358082 0.6816079 1.2679618 0.10186250 0.07023333 0.1398667 0.06963333 4.204359e-01 2.331859e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000007341 E001 0.9651910 0.0121989077 5.615862e-01 6.893588e-01 1 112523514 112523517 4 - 0.330 0.242 -0.611
ENSG00000007341 E002 100.1872787 0.0003312953 4.238023e-02 9.541520e-02 1 112523518 112525281 1764 - 2.027 1.989 -0.130
ENSG00000007341 E003 27.4599770 0.0010414343 5.798484e-04 2.459432e-03 1 112525282 112525529 248 - 1.546 1.347 -0.686
ENSG00000007341 E004 35.7040944 0.0037548537 5.252986e-05 2.943919e-04 1 112525530 112525875 346 - 1.662 1.426 -0.808
ENSG00000007341 E005 9.9035309 0.0194356774 8.786961e-02 1.718841e-01 1 112525876 112525878 3 - 1.112 0.929 -0.674
ENSG00000007341 E006 9.7176739 0.0065690211 3.744266e-02 8.629651e-02 1 112525879 112525882 4 - 1.112 0.908 -0.752
ENSG00000007341 E007 28.8811857 0.0007215101 1.523362e-01 2.648760e-01 1 112525883 112525985 103 - 1.505 1.444 -0.209
ENSG00000007341 E008 50.4567906 0.0004512132 6.213497e-02 1.302306e-01 1 112525986 112526111 126 - 1.741 1.681 -0.203
ENSG00000007341 E009 1.1748837 0.2384583819 1.291769e-01 2.330328e-01 1 112526886 112526952 67 - 0.475 0.136 -2.433
ENSG00000007341 E010 0.8450104 0.0171697901 8.246864e-01 8.895635e-01 1 112539159 112539275 117 - 0.268 0.242 -0.193
ENSG00000007341 E011 12.4255137 0.0013972582 2.409355e-01 3.752735e-01 1 112540779 112540872 94 - 1.166 1.085 -0.289
ENSG00000007341 E012 1.1112941 0.0792724586 9.071949e-01 9.450576e-01 1 112541790 112541793 4 - 0.330 0.325 -0.031
ENSG00000007341 E013 5.5722293 0.0046728208 7.995438e-02 1.594904e-01 1 112541794 112541950 157 - 0.909 0.707 -0.796
ENSG00000007341 E014 62.4337330 0.0004423370 6.437091e-04 2.693334e-03 1 112541951 112542090 140 - 1.858 1.737 -0.407
ENSG00000007341 E015 33.0889943 0.0034248239 3.347731e-04 1.519485e-03 1 112550601 112550693 93 - 1.623 1.414 -0.715
ENSG00000007341 E016 57.6831948 0.0004495696 1.302915e-06 1.055791e-05 1 112555868 112556018 151 - 1.854 1.660 -0.658
ENSG00000007341 E017 0.2214452 0.0445554304 4.009279e-01   1 112571275 112571351 77 - 0.000 0.138 10.716
ENSG00000007341 E018 0.7405235 0.0152918585 8.143079e-01 8.823450e-01 1 112572404 112572455 52 - 0.268 0.241 -0.198
ENSG00000007341 E019 2.2602777 0.0071273950 3.782668e-01 5.225389e-01 1 112575133 112575233 101 - 0.432 0.600 0.803
ENSG00000007341 E020 51.4770973 0.0007808177 7.502628e-06 5.127527e-05 1 112576986 112577088 103 - 1.807 1.615 -0.652
ENSG00000007341 E021 53.3594516 0.0004722063 3.671552e-10 5.890621e-09 1 112578345 112578417 73 - 1.851 1.574 -0.939
ENSG00000007341 E022 35.7555411 0.0005545794 9.473151e-08 9.657536e-07 1 112581992 112581995 4 - 1.683 1.395 -0.986
ENSG00000007341 E023 54.6215317 0.0004929752 1.282163e-10 2.222546e-09 1 112581996 112582106 111 - 1.861 1.578 -0.959
ENSG00000007341 E024 42.1121278 0.0020442166 2.626161e-09 3.603116e-08 1 112582375 112582472 98 - 1.760 1.438 -1.098
ENSG00000007341 E025 16.5433927 0.0017294092 3.222664e-04 1.469938e-03 1 112583972 112583974 3 - 1.354 1.072 -1.000
ENSG00000007341 E026 43.7864954 0.0076039026 1.692972e-07 1.645943e-06 1 112583975 112584126 152 - 1.779 1.449 -1.124
ENSG00000007341 E027 1.7672237 0.0113277474 3.494588e-01 4.936686e-01 1 112591482 112591524 43 - 0.330 0.510 0.977
ENSG00000007341 E028 41.5625033 0.0006042750 9.426400e-07 7.863164e-06 1 112591525 112591603 79 - 1.729 1.488 -0.820
ENSG00000007341 E029 47.7340514 0.0004566831 2.998236e-10 4.879364e-09 1 112597971 112598021 51 - 1.807 1.509 -1.013
ENSG00000007341 E030 54.6786473 0.0004064667 3.896156e-10 6.225141e-09 1 112598022 112598086 65 - 1.856 1.583 -0.927
ENSG00000007341 E031 49.9069655 0.0004609475 1.420389e-08 1.702445e-07 1 112600794 112600848 55 - 1.813 1.556 -0.870
ENSG00000007341 E032 0.3030308 0.3648264142 3.626708e-01   1 112601532 112601558 27 - 0.196 0.000 -11.176
ENSG00000007341 E033 65.2249631 0.0055910949 8.173028e-08 8.443888e-07 1 112607104 112607240 137 - 1.631 1.960 1.110
ENSG00000007341 E034 81.4943994 0.0003504448 7.365291e-09 9.299735e-08 1 112607241 112607454 214 - 1.775 2.033 0.867
ENSG00000007341 E035 58.1144983 0.0025136232 1.542167e-04 7.658765e-04 1 112607455 112607597 143 - 1.648 1.872 0.755
ENSG00000007341 E036 0.0000000       1 112610455 112610458 4 -      
ENSG00000007341 E037 1.3274407 0.0299078126 3.461375e-01 4.903039e-01 1 112610459 112610487 29 - 0.268 0.456 1.125
ENSG00000007341 E038 44.2816656 0.0159832391 5.635828e-09 7.287991e-08 1 112610488 112610615 128 - 1.338 1.859 1.780
ENSG00000007341 E039 35.4471172 0.0122859538 6.269497e-10 9.663472e-09 1 112610616 112610657 42 - 1.229 1.772 1.869
ENSG00000007341 E040 46.9036217 0.0245604564 8.849631e-06 5.955723e-05 1 112610658 112610690 33 - 1.411 1.864 1.542
ENSG00000007341 E041 79.4990519 0.0140004152 3.361311e-10 5.421337e-09 1 112610691 112610840 150 - 1.617 2.096 1.615
ENSG00000007341 E042 261.0007539 0.0002406246 4.256750e-10 6.751745e-09 1 112610841 112611003 163 - 2.334 2.499 0.551
ENSG00000007341 E043 133.7152908 0.0024550845 6.433316e-03 1.974904e-02 1 112616813 112616844 32 - 2.061 2.191 0.434
ENSG00000007341 E044 130.1027277 0.0052325262 3.566173e-04 1.605820e-03 1 112616845 112616895 51 - 2.017 2.205 0.630
ENSG00000007341 E045 3.8284124 0.0195149053 4.039776e-02 9.175001e-02 1 112616896 112617286 391 - 0.807 0.509 -1.279
ENSG00000007341 E046 2.4119992 0.0063221398 5.985195e-04 2.527997e-03 1 112618007 112618217 211 - 0.721 0.138 -3.518
ENSG00000007341 E047 6.4238084 0.0031024320 2.041190e-01 3.313261e-01 1 112618247 112618369 123 - 0.924 0.794 -0.503
ENSG00000007341 E048 3.9803777 0.0042759628 2.811096e-01 4.209910e-01 1 112618784 112618908 125 - 0.766 0.638 -0.530
ENSG00000007341 E049 142.6285432 0.0038966850 6.292558e-02 1.315905e-01 1 112618909 112619139 231 - 2.105 2.208 0.346
ENSG00000007341 E050 4.0254120 0.0189050335 2.273542e-01 3.592352e-01 1 112619140 112619196 57 - 0.585 0.794 0.876
ENSG00000007341 E051 6.6094212 0.0796269740 7.198262e-01 8.145561e-01 1 112619197 112619396 200 - 0.825 0.929 0.398
ENSG00000007341 E052 3.6996093 0.0059439027 7.298097e-01 8.219210e-01 1 112619397 112619643 247 - 0.697 0.674 -0.099
ENSG00000007341 E053 4.9383192 0.0046464553 7.281970e-01 8.207071e-01 1 112619644 112619796 153 - 0.787 0.766 -0.081
ENSG00000007341 E054 1.6177966 0.0086206244 6.196486e-03 1.913238e-02 1 112619910 112620825 916 - 0.109 0.600 3.390