ENSG00000007264

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310132 ENSG00000007264 HEK293_OSMI2_2hA HEK293_TMG_2hB MATK protein_coding protein_coding 44.80419 88.48651 24.37472 4.702408 0.143143 -1.859643 20.2072266 38.2308400 8.836068 4.8802905 0.6580204 -2.112006 0.46047500 0.428600000 0.36263333 -0.06596667 5.299257e-01 3.323443e-06 FALSE TRUE
ENST00000395040 ENSG00000007264 HEK293_OSMI2_2hA HEK293_TMG_2hB MATK protein_coding protein_coding 44.80419 88.48651 24.37472 4.702408 0.143143 -1.859643 8.2090557 14.8972858 5.017542 4.2852506 0.5842885 -1.568093 0.16892083 0.164133333 0.20560000 0.04146667 7.168149e-01 3.323443e-06 FALSE TRUE
ENST00000587180 ENSG00000007264 HEK293_OSMI2_2hA HEK293_TMG_2hB MATK protein_coding protein_coding 44.80419 88.48651 24.37472 4.702408 0.143143 -1.859643 1.1285074 0.8189502 1.663129 0.1029044 0.4353465 1.013191 0.03942917 0.009166667 0.06836667 0.05920000 3.323443e-06 3.323443e-06 FALSE FALSE
ENST00000619596 ENSG00000007264 HEK293_OSMI2_2hA HEK293_TMG_2hB MATK protein_coding protein_coding 44.80419 88.48651 24.37472 4.702408 0.143143 -1.859643 0.9984192 6.5660195 0.000000 6.1958780 0.0000000 -9.361071 0.01510417 0.081600000 0.00000000 -0.08160000 4.363450e-01 3.323443e-06 FALSE TRUE
MSTRG.16185.15 ENSG00000007264 HEK293_OSMI2_2hA HEK293_TMG_2hB MATK protein_coding   44.80419 88.48651 24.37472 4.702408 0.143143 -1.859643 4.1324335 7.8324990 3.336084 1.1282901 0.1375675 -1.228840 0.10281250 0.087700000 0.13686667 0.04916667 3.143612e-02 3.323443e-06 FALSE TRUE
MSTRG.16185.17 ENSG00000007264 HEK293_OSMI2_2hA HEK293_TMG_2hB MATK protein_coding   44.80419 88.48651 24.37472 4.702408 0.143143 -1.859643 2.9403891 6.0827195 1.381247 0.5126942 0.3208722 -2.130707 0.05891667 0.068700000 0.05673333 -0.01196667 7.140263e-01 3.323443e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000007264 E001 0.3299976 0.0274424043 1.000000e+00   19 3777970 3777972 3 - 0.000 0.115 8.350
ENSG00000007264 E002 2.5838282 0.0469887092 3.833508e-02 8.797870e-02 19 3777973 3777974 2 - 0.000 0.512 13.229
ENSG00000007264 E003 4.7958323 0.0637792544 6.964548e-01 7.968042e-01 19 3777975 3777976 2 - 0.716 0.645 -0.300
ENSG00000007264 E004 13.9020786 0.0012959475 7.305631e-01 8.224712e-01 19 3777977 3777983 7 - 1.005 1.040 0.131
ENSG00000007264 E005 21.0996273 0.0008764216 2.472356e-02 6.130793e-02 19 3777984 3777985 2 - 1.370 1.164 -0.722
ENSG00000007264 E006 36.5493202 0.0006088592 5.779060e-01 7.030823e-01 19 3777986 3777994 9 - 1.473 1.426 -0.162
ENSG00000007264 E007 537.8450164 0.0002633360 3.585422e-05 2.090442e-04 19 3777995 3778422 428 - 2.511 2.597 0.287
ENSG00000007264 E008 379.4345783 0.0008469970 3.110421e-02 7.410862e-02 19 3778509 3778592 84 - 2.385 2.442 0.190
ENSG00000007264 E009 245.7991903 0.0002092874 1.084369e-01 2.032294e-01 19 3778593 3778595 3 - 2.206 2.251 0.149
ENSG00000007264 E010 516.8043729 0.0002304273 1.013127e-03 4.004043e-03 19 3778992 3779132 141 - 2.509 2.577 0.226
ENSG00000007264 E011 371.9338355 0.0001787410 3.122233e-03 1.062537e-02 19 3779133 3779187 55 - 2.363 2.434 0.235
ENSG00000007264 E012 272.5533441 0.0001982396 4.092372e-03 1.340122e-02 19 3779378 3779388 11 - 2.219 2.301 0.271
ENSG00000007264 E013 405.3437039 0.0001438606 4.595350e-02 1.019469e-01 19 3779389 3779451 63 - 2.425 2.467 0.142
ENSG00000007264 E014 246.7281408 0.0004318077 4.207492e-01 5.639330e-01 19 3779533 3779541 9 - 2.230 2.251 0.068
ENSG00000007264 E015 445.3920654 0.0003900727 1.661258e-01 2.831696e-01 19 3779542 3779617 76 - 2.479 2.507 0.095
ENSG00000007264 E016 489.2379282 0.0001951644 5.739592e-02 1.221603e-01 19 3779698 3779788 91 - 2.512 2.548 0.123
ENSG00000007264 E017 253.6635075 0.0002443333 3.614630e-01 5.058548e-01 19 3779789 3779797 9 - 2.241 2.263 0.074
ENSG00000007264 E018 393.9995380 0.0003761759 4.678186e-01 6.072977e-01 19 3781607 3781672 66 - 2.469 2.447 -0.076
ENSG00000007264 E019 24.0983097 0.0008152763 1.907930e-09 2.682187e-08 19 3782292 3782426 135 - 1.612 1.151 -1.604
ENSG00000007264 E020 119.4362699 0.0015167571 4.595504e-02 1.019479e-01 19 3782427 3782671 245 - 2.014 1.921 -0.313
ENSG00000007264 E021 62.1695455 0.0057060506 4.260946e-01 5.689594e-01 19 3782787 3782817 31 - 1.706 1.649 -0.191
ENSG00000007264 E022 104.0941642 0.0003219679 9.732693e-01 9.873091e-01 19 3782818 3782937 120 - 1.881 1.874 -0.024
ENSG00000007264 E023 458.6662122 0.0001388125 3.565092e-05 2.079998e-04 19 3783126 3783219 94 - 2.593 2.500 -0.310
ENSG00000007264 E024 18.6689243 0.0015541755 8.766471e-02 1.715825e-01 19 3783220 3783297 78 - 1.299 1.131 -0.595
ENSG00000007264 E025 343.7344057 0.0002334141 1.710675e-03 6.315545e-03 19 3783814 3783871 58 - 2.461 2.377 -0.279
ENSG00000007264 E026 465.8087968 0.0008854023 9.994076e-02 1.904029e-01 19 3783872 3784020 149 - 2.560 2.515 -0.152
ENSG00000007264 E027 206.4629969 0.0031934218 5.056256e-01 6.413761e-01 19 3784021 3784033 13 - 2.197 2.165 -0.105
ENSG00000007264 E028 396.6251905 0.0010591026 9.556664e-02 1.837418e-01 19 3784124 3784239 116 - 2.493 2.444 -0.166
ENSG00000007264 E029 375.5583340 0.0015572741 2.163833e-02 5.492560e-02 19 3784338 3784451 114 - 2.487 2.416 -0.236
ENSG00000007264 E030 6.7622356 0.0134595117 1.585229e-06 1.260194e-05 19 3784452 3784573 122 - 1.216 0.588 -2.423
ENSG00000007264 E031 249.9553532 0.0059184729 2.871470e-02 6.943095e-02 19 3784825 3784884 60 - 2.339 2.235 -0.345
ENSG00000007264 E032 130.0003059 0.0018409485 7.944276e-01 8.686629e-01 19 3785064 3785096 33 - 1.981 1.964 -0.054
ENSG00000007264 E033 203.9705226 0.0021240176 2.726409e-01 4.115945e-01 19 3785097 3785246 150 - 2.128 2.168 0.136
ENSG00000007264 E034 102.7910359 0.0061302444 3.720716e-01 5.165464e-01 19 3785247 3785279 33 - 1.821 1.874 0.181
ENSG00000007264 E035 65.0651903 0.0038677495 9.965647e-01 1.000000e+00 19 3785280 3785286 7 - 1.674 1.670 -0.014
ENSG00000007264 E036 4.3157810 0.0037398161 9.348897e-02 1.805736e-01 19 3785613 3786024 412 - 0.820 0.553 -1.126
ENSG00000007264 E037 4.3833318 0.0042783927 8.632871e-01 9.158214e-01 19 3786025 3786168 144 - 0.654 0.620 -0.145
ENSG00000007264 E038 220.4091879 0.0166524961 3.621662e-01 5.065583e-01 19 3786169 3786413 245 - 2.246 2.190 -0.186
ENSG00000007264 E039 0.0000000       19 3787460 3787715 256 -      
ENSG00000007264 E040 0.0000000       19 3789273 3789404 132 -      
ENSG00000007264 E041 0.0000000       19 3793074 3793129 56 -      
ENSG00000007264 E042 0.0000000       19 3793130 3793398 269 -      
ENSG00000007264 E043 0.0000000       19 3793399 3793401 3 -      
ENSG00000007264 E044 0.0000000       19 3801532 3801686 155 -      
ENSG00000007264 E045 0.0000000       19 3801687 3801812 126 -      
ENSG00000007264 E046 0.0000000       19 3801895 3802129 235 -