ENSG00000007255

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000006275 ENSG00000007255 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC6A protein_coding protein_coding 59.01208 116.1725 34.50192 3.179592 0.930418 -1.751227 13.93957 28.68476 9.117535 1.3427606 0.2044077 -1.652490 0.2445375 0.2470667 0.2648667 0.017800000 0.75582020 0.004689889 FALSE  
ENST00000585934 ENSG00000007255 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC6A protein_coding protein_coding 59.01208 116.1725 34.50192 3.179592 0.930418 -1.751227 15.52140 27.24870 10.995397 1.6280928 0.3312084 -1.308506 0.2758625 0.2341667 0.3197000 0.085533333 0.01327521 0.004689889 FALSE  
ENST00000588062 ENSG00000007255 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC6A protein_coding protein_coding 59.01208 116.1725 34.50192 3.179592 0.930418 -1.751227 13.44345 26.68961 7.676994 0.7796349 0.5596484 -1.796327 0.2225917 0.2304000 0.2219667 -0.008433333 0.90200691 0.004689889 FALSE  
ENST00000592647 ENSG00000007255 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC6A protein_coding protein_coding 59.01208 116.1725 34.50192 3.179592 0.930418 -1.751227 13.85307 29.21826 6.377791 2.2604239 1.0204445 -2.193975 0.2206667 0.2510667 0.1836667 -0.067400000 0.29701509 0.004689889 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000007255 E001 1.104976 0.0141505122 0.629656266 0.74498183 19 45162928 45162932 5 - 0.356 0.263 -0.608
ENSG00000007255 E002 27.397939 0.0087944601 0.237129404 0.37086670 19 45162933 45162945 13 - 1.432 1.330 -0.354
ENSG00000007255 E003 345.242471 0.0002483479 0.470230553 0.60943231 19 45162946 45163140 195 - 2.411 2.427 0.056
ENSG00000007255 E004 410.973291 0.0001398913 0.020123903 0.05174425 19 45163141 45163223 83 - 2.457 2.507 0.165
ENSG00000007255 E005 491.961740 0.0001377011 0.603861702 0.72453078 19 45163916 45164009 94 - 2.568 2.577 0.031
ENSG00000007255 E006 429.353262 0.0001817643 0.463319299 0.60312020 19 45164164 45164247 84 - 2.531 2.515 -0.052
ENSG00000007255 E007 9.548185 0.0018285523 0.624903681 0.74113617 19 45164248 45164284 37 - 0.866 0.930 0.243
ENSG00000007255 E008 3.786019 0.0050461821 0.832782477 0.89523769 19 45164725 45164852 128 - 0.620 0.584 -0.161
ENSG00000007255 E009 545.508819 0.0002769104 0.112920209 0.20980341 19 45164853 45164970 118 - 2.644 2.614 -0.098
ENSG00000007255 E010 258.472674 0.0002114323 0.003495165 0.01171136 19 45165127 45165194 68 - 2.360 2.282 -0.257
ENSG00000007255 E011 199.969297 0.0002617174 0.024438907 0.06073006 19 45178093 45178134 42 - 2.126 2.198 0.241
ENSG00000007255 E012 403.795410 0.0001927086 0.792872845 0.86755246 19 45178135 45178237 103 - 2.486 2.491 0.017