ENSG00000006831

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357103 ENSG00000006831 HEK293_OSMI2_2hA HEK293_TMG_2hB ADIPOR2 protein_coding protein_coding 50.72599 42.38559 52.24294 4.742238 0.505299 0.3015981 38.425607 35.740262 35.52298 3.997599 1.3390801 -0.008795004 0.7623833 0.8446333 0.6799667 -0.1646667 0.004119145 0.004119145 FALSE TRUE
MSTRG.6618.2 ENSG00000006831 HEK293_OSMI2_2hA HEK293_TMG_2hB ADIPOR2 protein_coding   50.72599 42.38559 52.24294 4.742238 0.505299 0.3015981 9.502728 4.676522 13.10462 1.319711 0.9391645 1.484586248 0.1837958 0.1096000 0.2510000 0.1414000 0.009635963 0.004119145 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006831 E001 0.0000000       12 1688574 1688717 144 +      
ENSG00000006831 E002 0.2214452 0.0598637572 4.387676e-01   12 1690907 1691025 119 + 0.000 0.141 8.978
ENSG00000006831 E003 2.4472807 0.0158130252 6.737226e-01 7.793345e-01 12 1691026 1691069 44 + 0.469 0.607 0.646
ENSG00000006831 E004 2.7805005 0.0312877288 6.831670e-01 7.864513e-01 12 1691070 1691080 11 + 0.509 0.646 0.621
ENSG00000006831 E005 31.3102024 0.0006224602 6.667158e-05 3.640135e-04 12 1691081 1691162 82 + 1.579 1.424 -0.535
ENSG00000006831 E006 58.4954300 0.0014581342 4.893939e-08 5.286777e-07 12 1691163 1691191 29 + 1.850 1.673 -0.598
ENSG00000006831 E007 47.8614036 0.0236783936 6.552423e-05 3.584778e-04 12 1691192 1691213 22 + 1.795 1.524 -0.922
ENSG00000006831 E008 8.5992729 0.0018920071 1.623371e-03 6.036169e-03 12 1702886 1702982 97 + 1.093 0.827 -0.996
ENSG00000006831 E009 0.0000000       12 1730725 1731056 332 +      
ENSG00000006831 E010 2.5733365 0.0057604876 2.425946e-01 3.772001e-01 12 1736079 1736240 162 + 0.426 0.682 1.191
ENSG00000006831 E011 331.8802863 0.0003912363 2.491722e-15 8.948800e-14 12 1754258 1754514 257 + 2.556 2.484 -0.241
ENSG00000006831 E012 0.0000000       12 1760729 1760980 252 +      
ENSG00000006831 E013 0.0000000       12 1772714 1772841 128 +      
ENSG00000006831 E014 233.6581969 0.0015584058 1.816882e-04 8.852181e-04 12 1772842 1772922 81 + 2.380 2.360 -0.067
ENSG00000006831 E015 175.6242361 0.0002906342 5.999608e-06 4.197043e-05 12 1772923 1772961 39 + 2.262 2.234 -0.095
ENSG00000006831 E016 351.1366220 0.0006222048 1.036939e-04 5.390327e-04 12 1777854 1778025 172 + 2.544 2.552 0.029
ENSG00000006831 E017 2.0628822 0.0072594736 2.236673e-01 3.547826e-01 12 1778026 1778607 582 + 0.544 0.402 -0.714
ENSG00000006831 E018 2.3625771 0.0063996411 2.682568e-01 4.066969e-01 12 1780148 1780450 303 + 0.577 0.463 -0.545
ENSG00000006831 E019 415.4697203 0.0017578270 1.071840e-02 3.049635e-02 12 1780451 1780637 187 + 2.609 2.632 0.079
ENSG00000006831 E020 447.3292503 0.0014362339 4.706207e-04 2.047672e-03 12 1780889 1781076 188 + 2.649 2.657 0.024
ENSG00000006831 E021 427.5626610 0.0008072519 1.267847e-04 6.446493e-04 12 1783880 1784073 194 + 2.628 2.640 0.040
ENSG00000006831 E022 3758.6345593 0.0040699357 1.330478e-07 1.319908e-06 12 1785944 1788674 2731 + 3.492 3.652 0.532