ENSG00000006740

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340825 ENSG00000006740 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP44 protein_coding protein_coding 5.919166 6.983796 5.194223 0.1311077 0.1764576 -0.4263931 1.5420943 1.5239589 0.8063081 0.22463559 0.37680796 -0.9100741 0.25385000 0.21826667 0.15483333 -0.06343333 0.6368175497 0.0003212521 FALSE TRUE
ENST00000379672 ENSG00000006740 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP44 protein_coding protein_coding 5.919166 6.983796 5.194223 0.1311077 0.1764576 -0.4263931 0.7040386 0.6913464 1.5701471 0.47953833 0.27238566 1.1718599 0.12179167 0.10020000 0.30243333 0.20223333 0.1795065220 0.0003212521 FALSE TRUE
ENST00000544416 ENSG00000006740 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP44 protein_coding nonsense_mediated_decay 5.919166 6.983796 5.194223 0.1311077 0.1764576 -0.4263931 1.4999547 2.5589471 0.9691683 0.12469951 0.13701168 -1.3915484 0.24979583 0.36626667 0.18530000 -0.18096667 0.0003212521 0.0003212521 TRUE TRUE
ENST00000584974 ENSG00000006740 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP44 protein_coding retained_intron 5.919166 6.983796 5.194223 0.1311077 0.1764576 -0.4263931 0.3561023 0.4191721 0.2319280 0.03712999 0.05806903 -0.8269784 0.05862917 0.06023333 0.04516667 -0.01506667 0.7299038362 0.0003212521 FALSE FALSE
MSTRG.13681.4 ENSG00000006740 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP44 protein_coding   5.919166 6.983796 5.194223 0.1311077 0.1764576 -0.4263931 0.5880403 0.4323475 0.0000000 0.43234751 0.00000000 -5.4671083 0.10964583 0.05966667 0.00000000 -0.05966667 0.8489841770 0.0003212521 FALSE TRUE
MSTRG.13681.7 ENSG00000006740 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP44 protein_coding   5.919166 6.983796 5.194223 0.1311077 0.1764576 -0.4263931 0.7486934 0.8088551 1.3627527 0.46084984 0.09296084 0.7453917 0.12700000 0.11786667 0.26363333 0.14576667 0.5080969275 0.0003212521 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006740 E001 7.4859127 0.0334626438 2.234446e-03 7.949765e-03 17 12789498 12789538 41 + 1.114 0.708 -1.550
ENSG00000006740 E002 7.4859127 0.0334626438 2.234446e-03 7.949765e-03 17 12789539 12789539 1 + 1.114 0.708 -1.550
ENSG00000006740 E003 9.4798973 0.0741202563 1.730210e-03 6.377973e-03 17 12789540 12789649 110 + 1.231 0.757 -1.764
ENSG00000006740 E004 8.3832371 0.0021256053 3.702629e-05 2.151297e-04 17 12789650 12789759 110 + 1.171 0.730 -1.662
ENSG00000006740 E005 4.5662613 0.0035931900 4.812704e-01 6.195064e-01 17 12789760 12789771 12 + 0.785 0.705 -0.321
ENSG00000006740 E006 18.1246939 0.0019517828 1.441743e-01 2.536878e-01 17 12789772 12789891 120 + 1.322 1.224 -0.346
ENSG00000006740 E007 0.0000000       17 12790491 12790745 255 +      
ENSG00000006740 E008 17.1419213 0.0233740530 7.842064e-01 8.615631e-01 17 12894940 12894979 40 + 1.249 1.242 -0.025
ENSG00000006740 E009 30.7602792 0.0181055442 1.776314e-01 2.981618e-01 17 12896407 12896511 105 + 1.542 1.446 -0.327
ENSG00000006740 E010 35.5968729 0.0007020895 2.030526e-01 3.300420e-01 17 12908897 12908973 77 + 1.581 1.527 -0.185
ENSG00000006740 E011 41.1102895 0.0107571037 2.063169e-01 3.340983e-01 17 12915900 12916011 112 + 1.653 1.580 -0.247
ENSG00000006740 E012 41.4407061 0.0106451152 8.054823e-02 1.604098e-01 17 12919755 12919831 77 + 1.673 1.568 -0.360
ENSG00000006740 E013 43.5758344 0.0005511144 6.148699e-02 1.291382e-01 17 12928929 12929046 118 + 1.681 1.602 -0.266
ENSG00000006740 E014 0.9619687 0.0132153728 7.424558e-01 8.313400e-01 17 12929047 12929381 335 + 0.320 0.272 -0.322
ENSG00000006740 E015 33.2856031 0.0062054404 6.048689e-01 7.252962e-01 17 12941056 12941124 69 + 1.528 1.513 -0.051
ENSG00000006740 E016 33.6267205 0.0012003491 1.575339e-01 2.718335e-01 17 12943588 12943669 82 + 1.568 1.503 -0.223
ENSG00000006740 E017 34.9037479 0.0027392335 1.060443e-01 1.996737e-01 17 12944069 12944196 128 + 1.589 1.508 -0.277
ENSG00000006740 E018 35.0549190 0.0170081937 2.127210e-01 3.417530e-01 17 12949140 12949251 112 + 1.593 1.506 -0.296
ENSG00000006740 E019 24.4903308 0.0007978351 1.937058e-01 3.184367e-01 17 12949649 12949680 32 + 1.434 1.364 -0.243
ENSG00000006740 E020 32.6821455 0.0007006596 1.590292e-03 5.927832e-03 17 12949681 12949730 50 + 1.609 1.439 -0.581
ENSG00000006740 E021 40.6598052 0.0005160679 4.581621e-02 1.016923e-01 17 12952501 12952581 81 + 1.660 1.573 -0.298
ENSG00000006740 E022 0.4460135 0.0281898270 5.090412e-02 1.107751e-01 17 12955764 12955866 103 + 0.320 0.000 -13.422
ENSG00000006740 E023 48.8379201 0.0005042793 2.027522e-01 3.296627e-01 17 12955867 12955980 114 + 1.712 1.669 -0.146
ENSG00000006740 E024 42.5841057 0.0006256865 1.424230e-01 2.513424e-01 17 12956655 12956746 92 + 1.660 1.602 -0.197
ENSG00000006740 E025 38.5280337 0.0005767415 4.625221e-02 1.025015e-01 17 12958717 12958897 181 + 1.504 1.638 0.459
ENSG00000006740 E026 0.9609220 0.0920910392 4.465557e-02 9.956998e-02 17 12958898 12959045 148 + 0.000 0.392 12.476
ENSG00000006740 E027 0.2955422 0.0298842987 8.422644e-01   17 12973302 12973319 18 + 0.135 0.111 -0.324
ENSG00000006740 E028 0.1817044 0.0393741920 6.182042e-01   17 12973712 12973731 20 + 0.000 0.111 10.496
ENSG00000006740 E029 23.3128370 0.0008828679 5.428567e-01 6.735649e-01 17 12974089 12974310 222 + 1.337 1.401 0.221
ENSG00000006740 E030 18.1997846 0.0016199099 3.936101e-01 5.375025e-01 17 12980058 12980107 50 + 1.307 1.259 -0.168
ENSG00000006740 E031 23.3911364 0.0008843555 2.633704e-01 4.012541e-01 17 12980108 12980233 126 + 1.315 1.416 0.350
ENSG00000006740 E032 0.4407149 0.0228409845 4.217856e-01 5.649224e-01 17 12980907 12981047 141 + 0.237 0.111 -1.323
ENSG00000006740 E033 0.4782907 0.0218652532 1.343944e-01 2.402648e-01 17 12984489 12984530 42 + 0.000 0.272 12.169
ENSG00000006740 E034 64.2344752 0.0013549600 1.464782e-02 3.970278e-02 17 12984531 12984908 378 + 1.718 1.854 0.458
ENSG00000006740 E035 23.3196817 0.0113249692 7.020388e-02 1.436959e-01 17 12984909 12987100 2192 + 1.266 1.449 0.635
ENSG00000006740 E036 8.3191376 0.0394875024 8.111111e-01 8.801741e-01 17 12987101 12987152 52 + 0.972 0.969 -0.011
ENSG00000006740 E037 19.7603874 0.0298060556 4.808578e-02 1.057805e-01 17 12987153 12988916 1764 + 1.149 1.392 0.854
ENSG00000006740 E038 314.5839852 0.0035347349 2.052439e-09 2.867043e-08 17 12990032 12991643 1612 + 2.365 2.557 0.640