ENSG00000006715

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310301 ENSG00000006715 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS41 protein_coding protein_coding 15.00373 4.538771 20.56903 0.2755393 0.7525213 2.177626 2.9542776 1.04928078 4.824239 0.18478013 0.3586651 2.190204 0.19535000 0.2305667 0.23400000 0.003433333 9.968011e-01 2.502873e-13 FALSE TRUE
ENST00000395969 ENSG00000006715 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS41 protein_coding protein_coding 15.00373 4.538771 20.56903 0.2755393 0.7525213 2.177626 5.7079539 2.94427494 7.118121 0.16052846 0.6587379 1.270718 0.44824167 0.6494333 0.34470000 -0.304733333 8.118574e-10 2.502873e-13 FALSE TRUE
ENST00000414632 ENSG00000006715 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS41 protein_coding protein_coding 15.00373 4.538771 20.56903 0.2755393 0.7525213 2.177626 2.0779764 0.00000000 2.196197 0.00000000 0.1156055 7.785418 0.10133750 0.0000000 0.10666667 0.106666667 2.502873e-13 2.502873e-13 FALSE FALSE
ENST00000482217 ENSG00000006715 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS41 protein_coding retained_intron 15.00373 4.538771 20.56903 0.2755393 0.7525213 2.177626 0.7778179 0.09247655 1.019296 0.05780829 0.3865072 3.328293 0.05264167 0.0198000 0.05053333 0.030733333 5.107242e-01 2.502873e-13 FALSE FALSE
MSTRG.29750.2 ENSG00000006715 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS41 protein_coding   15.00373 4.538771 20.56903 0.2755393 0.7525213 2.177626 2.6063694 0.28704501 4.727827 0.15822959 0.2418506 3.995472 0.12927500 0.0625000 0.23046667 0.167966667 2.480165e-02 2.502873e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006715 E001 0.5932625 0.1988439971 4.307552e-01 5.733680e-01 7 38708519 38708636 118 - 0.226 0.000 -10.558
ENSG00000006715 E002 0.5202097 0.0216656269 6.215061e-01 7.384684e-01 7 38708637 38708686 50 - 0.127 0.210 0.871
ENSG00000006715 E003 2.1766303 0.0091194680 4.874650e-03 1.558077e-02 7 38722974 38723072 99 - 0.306 0.775 2.280
ENSG00000006715 E004 2.3186825 0.0099412331 3.611544e-02 8.380938e-02 7 38723073 38723075 3 - 0.373 0.728 1.673
ENSG00000006715 E005 22.9610639 0.0163887638 8.873108e-02 1.731820e-01 7 38723076 38723234 159 - 1.276 1.456 0.625
ENSG00000006715 E006 162.5869155 0.0004633136 2.185872e-02 5.538410e-02 7 38723235 38725554 2320 - 2.171 2.098 -0.243
ENSG00000006715 E007 161.1235248 0.0003042336 2.531004e-30 4.359010e-28 7 38725555 38726108 554 - 2.041 2.378 1.129
ENSG00000006715 E008 61.8779111 0.0052866244 9.864224e-09 1.217981e-07 7 38726109 38726235 127 - 1.627 1.955 1.109
ENSG00000006715 E009 65.0711778 0.0015534008 1.986648e-06 1.546470e-05 7 38726236 38726318 83 - 1.684 1.923 0.806
ENSG00000006715 E010 43.3116478 0.0007205165 4.673709e-02 1.033572e-01 7 38726319 38726326 8 - 1.555 1.678 0.417
ENSG00000006715 E011 78.6269479 0.0003930457 2.853964e-04 1.320458e-03 7 38726909 38726988 80 - 1.797 1.960 0.548
ENSG00000006715 E012 1.2629112 0.0143969980 5.137374e-01 6.485072e-01 7 38726989 38727186 198 - 0.341 0.210 -0.937
ENSG00000006715 E013 1.2502363 0.0235614676 4.501693e-02 1.002341e-01 7 38728341 38728434 94 - 0.179 0.544 2.290
ENSG00000006715 E014 52.9997485 0.0006178365 2.480217e-04 1.166943e-03 7 38728542 38728586 45 - 1.620 1.817 0.667
ENSG00000006715 E015 78.5213137 0.0006765878 6.437919e-06 4.470837e-05 7 38728692 38728791 100 - 1.782 1.985 0.683
ENSG00000006715 E016 0.0000000       7 38741284 38741351 68 -      
ENSG00000006715 E017 0.1482932 0.0406103466 1.216199e-01   7 38741981 38741984 4 - 0.000 0.210 13.008
ENSG00000006715 E018 102.6488433 0.0039172748 1.523236e-02 4.101256e-02 7 38741985 38742121 137 - 1.921 2.042 0.404
ENSG00000006715 E019 106.9833766 0.0014686828 1.672850e-01 2.846665e-01 7 38743402 38743542 141 - 1.955 2.018 0.209
ENSG00000006715 E020 66.6640938 0.0005990906 5.574724e-01 6.858690e-01 7 38745559 38745613 55 - 1.759 1.792 0.113
ENSG00000006715 E021 6.2930509 0.1342991069 2.795616e-01 4.193324e-01 7 38745614 38745998 385 - 0.864 0.608 -1.045
ENSG00000006715 E022 86.4765580 0.0031158083 8.972757e-01 9.383984e-01 7 38752176 38752313 138 - 1.879 1.876 -0.013
ENSG00000006715 E023 55.0470648 0.0004667773 2.436164e-01 3.784255e-01 7 38754702 38754752 51 - 1.704 1.642 -0.208
ENSG00000006715 E024 41.6346802 0.0005377821 1.228664e-01 2.240458e-01 7 38754895 38754936 42 - 1.595 1.498 -0.331
ENSG00000006715 E025 69.4859592 0.0014510492 3.032809e-01 4.451788e-01 7 38756838 38756982 145 - 1.801 1.750 -0.172
ENSG00000006715 E026 46.6997315 0.0005042365 8.479352e-01 9.055768e-01 7 38758354 38758401 48 - 1.615 1.630 0.052
ENSG00000006715 E027 53.4624644 0.0017272178 5.879044e-01 7.111589e-01 7 38758402 38758481 80 - 1.666 1.700 0.117
ENSG00000006715 E028 44.3900053 0.0050304520 3.441446e-01 4.881996e-01 7 38763455 38763547 93 - 1.577 1.643 0.223
ENSG00000006715 E029 48.0828898 0.0260907461 7.904043e-01 8.659200e-01 7 38765580 38765661 82 - 1.624 1.644 0.068
ENSG00000006715 E030 0.2955422 0.0285334028 3.484405e-01   7 38765662 38765753 92 - 0.068 0.210 1.866
ENSG00000006715 E031 47.4535125 0.0097233975 7.495201e-01 8.364564e-01 7 38767537 38767598 62 - 1.630 1.604 -0.090
ENSG00000006715 E032 52.2533128 0.0004629431 6.177924e-03 1.908254e-02 7 38771198 38771254 57 - 1.701 1.539 -0.551
ENSG00000006715 E033 64.4317502 0.0025224735 1.034142e-01 1.956881e-01 7 38772522 38772598 77 - 1.776 1.684 -0.313
ENSG00000006715 E034 51.7133286 0.0026576469 8.597410e-02 1.689496e-01 7 38772599 38772637 39 - 1.684 1.577 -0.366
ENSG00000006715 E035 51.8859129 0.0011910207 1.043428e-02 2.982637e-02 7 38774115 38774157 43 - 1.695 1.539 -0.531
ENSG00000006715 E036 68.0227386 0.0101101449 1.153786e-02 3.243672e-02 7 38774158 38774244 87 - 1.816 1.631 -0.628
ENSG00000006715 E037 0.1451727 0.0424902524 1.000000e+00   7 38775189 38775672 484 - 0.068 0.000 -9.742
ENSG00000006715 E038 60.6057325 0.0006176593 5.917551e-03 1.839267e-02 7 38776679 38776776 98 - 1.762 1.611 -0.515
ENSG00000006715 E039 53.7664852 0.0004583386 2.091994e-02 5.342129e-02 7 38789801 38789867 67 - 1.708 1.576 -0.448
ENSG00000006715 E040 49.7610506 0.0004557752 4.180181e-02 9.436752e-02 7 38795465 38795491 27 - 1.673 1.554 -0.406
ENSG00000006715 E041 57.3778180 0.0003918639 3.525943e-02 8.214510e-02 7 38795492 38795541 50 - 1.732 1.617 -0.390
ENSG00000006715 E042 59.5478947 0.0008393304 1.047737e-02 2.992601e-02 7 38795542 38795611 70 - 1.753 1.611 -0.484
ENSG00000006715 E043 0.4375944 0.0235039274 5.549718e-01 6.838805e-01 7 38796415 38796526 112 - 0.179 0.000 -11.309
ENSG00000006715 E044 78.4325097 0.0003452928 7.191576e-04 2.967465e-03 7 38796745 38796864 120 - 1.874 1.711 -0.553
ENSG00000006715 E045 0.0000000       7 38796932 38797041 110 -      
ENSG00000006715 E046 0.0000000       7 38817803 38817816 14 -      
ENSG00000006715 E047 54.5980911 0.0004543619 1.293767e-03 4.955273e-03 7 38817817 38817882 66 - 1.727 1.539 -0.639
ENSG00000006715 E048 32.0881742 0.0006599213 9.797542e-03 2.826384e-02 7 38821203 38821217 15 - 1.503 1.307 -0.677
ENSG00000006715 E049 43.4262939 0.0005131900 2.823816e-05 1.689927e-04 7 38821218 38821265 48 - 1.646 1.357 -0.991
ENSG00000006715 E050 49.9918196 0.0004239820 5.924179e-05 3.276745e-04 7 38830254 38830328 75 - 1.698 1.443 -0.870
ENSG00000006715 E051 0.0000000       7 38831216 38831346 131 -      
ENSG00000006715 E052 55.1872739 0.0004846499 3.749920e-04 1.677317e-03 7 38862545 38862622 78 - 1.733 1.523 -0.716
ENSG00000006715 E053 56.7508326 0.0004271789 9.541028e-06 6.372357e-05 7 38869146 38869253 108 - 1.755 1.489 -0.904
ENSG00000006715 E054 37.1603872 0.0005686870 4.617723e-04 2.013487e-03 7 38898091 38898129 39 - 1.575 1.320 -0.880
ENSG00000006715 E055 29.2063691 0.0007090414 1.104439e-02 3.126655e-02 7 38909154 38909191 38 - 1.466 1.265 -0.699
ENSG00000006715 E056 0.0000000       7 38929472 38929560 89 -      
ENSG00000006715 E057 0.0000000       7 38932278 38932394 117 -