ENSG00000006712

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221265 ENSG00000006712 HEK293_OSMI2_2hA HEK293_TMG_2hB PAF1 protein_coding protein_coding 77.31552 105.9707 58.94908 6.955559 1.878318 -0.8460157 59.090871 95.276276 38.914580 6.1380420 0.7402782 -1.2915870 0.73879583 0.89920000 0.66096667 -0.23823333 3.526805e-33 3.526805e-33 FALSE TRUE
ENST00000598594 ENSG00000006712 HEK293_OSMI2_2hA HEK293_TMG_2hB PAF1 protein_coding retained_intron 77.31552 105.9707 58.94908 6.955559 1.878318 -0.8460157 3.920257 1.739121 2.485982 0.1520123 0.1678101 0.5129776 0.05629583 0.01650000 0.04226667 0.02576667 2.668347e-06 3.526805e-33   FALSE
MSTRG.17127.4 ENSG00000006712 HEK293_OSMI2_2hA HEK293_TMG_2hB PAF1 protein_coding   77.31552 105.9707 58.94908 6.955559 1.878318 -0.8460157 9.148608 5.781271 12.833575 0.8990384 1.0530288 1.1490949 0.13197917 0.05396667 0.21713333 0.16316667 5.577969e-20 3.526805e-33 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006712 E001 24.0708004 3.294503e-03 1.380032e-02 3.777422e-02 19 39385629 39385852 224 - 1.180 1.407 0.794
ENSG00000006712 E002 504.6009615 1.373120e-04 1.885353e-17 8.914275e-16 19 39385853 39386065 213 - 2.525 2.698 0.579
ENSG00000006712 E003 948.5419521 1.383604e-03 1.471631e-15 5.444173e-14 19 39386066 39386219 154 - 2.785 2.971 0.617
ENSG00000006712 E004 1168.7303641 1.850076e-03 3.103128e-11 5.962255e-10 19 39386220 39386364 145 - 2.892 3.057 0.546
ENSG00000006712 E005 747.7591276 2.982560e-03 1.337993e-04 6.757811e-04 19 39386365 39386403 39 - 2.731 2.854 0.412
ENSG00000006712 E006 13.3606167 2.796564e-02 1.829028e-02 4.776569e-02 19 39386404 39386481 78 - 1.290 1.015 -0.985
ENSG00000006712 E007 990.5591472 2.152228e-03 3.532675e-03 1.182011e-02 19 39386482 39386572 91 - 2.885 2.966 0.270
ENSG00000006712 E008 862.9268439 5.793598e-04 7.924552e-03 2.358949e-02 19 39386694 39386799 106 - 2.846 2.902 0.187
ENSG00000006712 E009 5.8364722 2.715497e-03 2.944150e-03 1.009960e-02 19 39387159 39387227 69 - 1.031 0.671 -1.400
ENSG00000006712 E010 902.0972463 4.442816e-04 2.901527e-01 4.309467e-01 19 39388339 39388467 129 - 2.887 2.914 0.091
ENSG00000006712 E011 400.9001853 5.164472e-04 6.820656e-01 7.856083e-01 19 39388560 39388561 2 - 2.541 2.561 0.066
ENSG00000006712 E012 823.0321262 8.902969e-05 2.465420e-01 3.819008e-01 19 39388562 39388676 115 - 2.871 2.868 -0.010
ENSG00000006712 E013 655.3080885 4.386610e-04 1.175665e-02 3.295010e-02 19 39388762 39388841 80 - 2.792 2.760 -0.107
ENSG00000006712 E014 410.8902805 3.586771e-04 2.597830e-02 6.390244e-02 19 39388842 39388865 24 - 2.592 2.560 -0.109
ENSG00000006712 E015 18.8244456 1.013738e-03 8.329039e-07 7.037336e-06 19 39388866 39388946 81 - 1.487 1.112 -1.314
ENSG00000006712 E016 585.9530150 1.048375e-04 9.488477e-04 3.783787e-03 19 39388947 39389015 69 - 2.751 2.711 -0.133
ENSG00000006712 E017 680.0258483 4.086286e-04 1.087333e-04 5.622822e-04 19 39389093 39389198 106 - 2.824 2.769 -0.185
ENSG00000006712 E018 327.4103984 1.497635e-03 6.844145e-03 2.082093e-02 19 39389282 39389293 12 - 2.514 2.448 -0.221
ENSG00000006712 E019 541.7631105 3.153454e-03 1.212401e-02 3.383304e-02 19 39389294 39389383 90 - 2.735 2.663 -0.240
ENSG00000006712 E020 495.9959015 3.165901e-03 1.241295e-03 4.780930e-03 19 39389480 39389546 67 - 2.713 2.618 -0.318
ENSG00000006712 E021 5.5251372 3.028050e-03 1.166599e-03 4.527380e-03 19 39389547 39389639 93 - 1.031 0.629 -1.580
ENSG00000006712 E022 631.3515774 3.718375e-03 5.492022e-06 3.872872e-05 19 39389640 39389761 122 - 2.847 2.708 -0.463
ENSG00000006712 E023 3.0612914 5.204961e-03 8.233951e-01 8.887159e-01 19 39389886 39390068 183 - 0.536 0.583 0.214
ENSG00000006712 E024 536.1252289 9.373215e-04 9.960796e-12 2.075270e-10 19 39390069 39390161 93 - 2.776 2.641 -0.449
ENSG00000006712 E025 13.3774988 1.322871e-02 8.694456e-04 3.507237e-03 19 39390162 39390259 98 - 1.332 0.995 -1.204
ENSG00000006712 E026 314.4986526 2.831480e-04 6.576283e-13 1.663805e-11 19 39390260 39390289 30 - 2.553 2.407 -0.486
ENSG00000006712 E027 502.1389502 7.189624e-04 5.644472e-11 1.038284e-09 19 39390818 39391189 372 - 2.741 2.615 -0.418
ENSG00000006712 E028 0.4751703 2.058951e-02 9.043177e-01 9.430823e-01 19 39391190 39391224 35 - 0.172 0.157 -0.165
ENSG00000006712 E029 0.1515154 4.409708e-02 2.127369e-01   19 39402914 39403013 100 - 0.172 0.000 -11.148
ENSG00000006712 E030 0.1472490 4.353140e-02 2.130966e-01   19 39413155 39413412 258 - 0.172 0.000 -11.148