ENSG00000006704

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265755 ENSG00000006704 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IRD1 protein_coding protein_coding 13.17799 21.26773 8.044405 0.5025668 0.5964738 -1.401494 2.7530953 4.757039 1.6261899 0.68542139 0.23527292 -1.5427533 0.21429583 0.22243333 0.20516667 -0.0172666667 9.103028e-01 1.309907e-10 FALSE TRUE
ENST00000424337 ENSG00000006704 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IRD1 protein_coding protein_coding 13.17799 21.26773 8.044405 0.5025668 0.5964738 -1.401494 5.2895731 6.523192 4.4439538 0.34393149 0.38013559 -0.5527014 0.44389167 0.30633333 0.56306667 0.2567333333 4.268281e-02 1.309907e-10 FALSE TRUE
ENST00000470715 ENSG00000006704 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IRD1 protein_coding protein_coding 13.17799 21.26773 8.044405 0.5025668 0.5964738 -1.401494 2.0424830 4.810365 0.0000000 1.18132717 0.00000000 -8.9129986 0.11652500 0.22686667 0.00000000 -0.2268666667 1.309907e-10 1.309907e-10 FALSE FALSE
ENST00000476977 ENSG00000006704 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IRD1 protein_coding protein_coding 13.17799 21.26773 8.044405 0.5025668 0.5964738 -1.401494 0.9253917 1.297034 0.5883079 0.09025990 0.05845177 -1.1273364 0.07553333 0.06093333 0.07286667 0.0119333333 7.007633e-01 1.309907e-10 FALSE TRUE
ENST00000486086 ENSG00000006704 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IRD1 protein_coding retained_intron 13.17799 21.26773 8.044405 0.5025668 0.5964738 -1.401494 1.1566490 2.118385 0.7076642 1.10878929 0.53061051 -1.5683784 0.07138333 0.10040000 0.07953333 -0.0208666667 9.519081e-01 1.309907e-10   FALSE
ENST00000489094 ENSG00000006704 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IRD1 protein_coding processed_transcript 13.17799 21.26773 8.044405 0.5025668 0.5964738 -1.401494 0.8279672 1.572638 0.6351245 0.03357165 0.33756817 -1.2946819 0.06336250 0.07410000 0.07386667 -0.0002333333 8.753512e-01 1.309907e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006704 E001 0.1482932 0.0414101593 1.0000000000   7 74453790 74453905 116 + 0.000 0.081 8.018
ENSG00000006704 E002 0.2934659 0.0299639838 0.5096443898   7 74453906 74453969 64 + 0.180 0.082 -1.310
ENSG00000006704 E003 31.4648354 0.0007923084 0.0096528894 0.0279094507 7 74453970 74454176 207 + 1.566 1.394 -0.591
ENSG00000006704 E004 0.4427912 0.1561312621 0.2122158305 0.3411367855 7 74505992 74507676 1685 + 0.306 0.081 -2.320
ENSG00000006704 E005 64.3635494 0.0016368256 0.0002530466 0.0011879898 7 74508075 74508203 129 + 1.876 1.695 -0.613
ENSG00000006704 E006 88.4587819 0.0013412045 0.0005634608 0.0023973312 7 74512830 74512971 142 + 1.990 1.842 -0.499
ENSG00000006704 E007 0.8051678 0.0168729022 0.6595121269 0.7683195827 7 74515345 74515440 96 + 0.180 0.261 0.690
ENSG00000006704 E008 76.7446759 0.0043984108 0.4862503794 0.6240510767 7 74515441 74515596 156 + 1.855 1.818 -0.128
ENSG00000006704 E009 91.4399180 0.0104532545 0.9992373581 1.0000000000 7 74518139 74518322 184 + 1.903 1.902 -0.002
ENSG00000006704 E010 143.4756720 0.0025833851 0.1496977015 0.2612721033 7 74519409 74519719 311 + 2.136 2.079 -0.189
ENSG00000006704 E011 86.8846835 0.0083115086 0.0428797028 0.0963210815 7 74521208 74521297 90 + 1.967 1.848 -0.403
ENSG00000006704 E012 89.6844369 0.0003208194 0.0380007247 0.0873531595 7 74524071 74524154 84 + 1.955 1.869 -0.287
ENSG00000006704 E013 125.3185991 0.0002964242 0.0274035484 0.0668106303 7 74529734 74529917 184 + 2.091 2.014 -0.259
ENSG00000006704 E014 57.7288029 0.0170704107 0.2569637375 0.3939931787 7 74535113 74535138 26 + 1.773 1.682 -0.309
ENSG00000006704 E015 102.8467276 0.0083517489 0.2052093813 0.3326741542 7 74536167 74536275 109 + 2.008 1.935 -0.244
ENSG00000006704 E016 71.6977310 0.0004173569 0.8804625658 0.9273316120 7 74538136 74538173 38 + 1.796 1.801 0.019
ENSG00000006704 E017 99.9469135 0.0004387915 0.5453426400 0.6757135728 7 74538680 74538760 81 + 1.924 1.947 0.077
ENSG00000006704 E018 103.4964204 0.0004164136 0.4461928616 0.5876943193 7 74539879 74539968 90 + 1.979 1.948 -0.103
ENSG00000006704 E019 72.2444951 0.0003570168 0.2336825399 0.3667644324 7 74544755 74544802 48 + 1.840 1.784 -0.188
ENSG00000006704 E020 52.3352705 0.0012032443 0.5562911492 0.6849678475 7 74545744 74545761 18 + 1.682 1.649 -0.114
ENSG00000006704 E021 72.6584455 0.0058642495 0.7700756606 0.8515457657 7 74545762 74545809 48 + 1.810 1.796 -0.047
ENSG00000006704 E022 138.2414173 0.0003282320 0.4080791490 0.5516598034 7 74547103 74547286 184 + 2.098 2.069 -0.097
ENSG00000006704 E023 82.6209479 0.0003886712 0.9402255152 0.9664635116 7 74555174 74555223 50 + 1.855 1.857 0.006
ENSG00000006704 E024 27.2521049 0.0007718058 0.1531375768 0.2659381114 7 74555393 74555437 45 + 1.300 1.409 0.378
ENSG00000006704 E025 62.6232140 0.0004062538 0.6951845485 0.7958230575 7 74555438 74555494 57 + 1.754 1.734 -0.070
ENSG00000006704 E026 100.7930314 0.0003444169 0.1269993266 0.2299629284 7 74557639 74557722 84 + 1.894 1.954 0.203
ENSG00000006704 E027 152.3890886 0.0027157289 0.0759362574 0.1530091361 7 74558861 74559044 184 + 2.063 2.137 0.246
ENSG00000006704 E028 85.5724782 0.0003518419 0.0427329779 0.0960564126 7 74559627 74559655 29 + 1.803 1.891 0.297
ENSG00000006704 E029 0.0000000       7 74559656 74559660 5 +      
ENSG00000006704 E030 108.8801909 0.0006189197 0.0519743758 0.1126834161 7 74589851 74589928 78 + 1.913 1.990 0.258
ENSG00000006704 E031 153.9997467 0.0020330523 0.0051618472 0.0163686597 7 74590825 74591017 193 + 2.040 2.149 0.367
ENSG00000006704 E032 85.5770928 0.0029983615 0.0053275770 0.0168229601 7 74595014 74595051 38 + 1.762 1.907 0.487
ENSG00000006704 E033 4.3708891 0.0921081574 0.5578341472 0.6861669687 7 74600960 74601043 84 + 0.749 0.655 -0.389
ENSG00000006704 E034 142.4103722 0.0004556009 0.0001527979 0.0007594477 7 74601044 74601180 137 + 1.990 2.123 0.445
ENSG00000006704 E035 79.8646071 0.0075395302 0.3083410153 0.4506196845 7 74601181 74602364 1184 + 1.796 1.858 0.211
ENSG00000006704 E036 103.7947566 0.0057582940 0.0026381459 0.0091844244 7 74602365 74602605 241 + 1.830 1.994 0.553